PL2633867T3 - Szczepionka do ochrony przeciw lawsonia intracellularis, mycoplasma hyopneumoniae i cirkowirusowi świń - Google Patents
Szczepionka do ochrony przeciw lawsonia intracellularis, mycoplasma hyopneumoniae i cirkowirusowi świńInfo
- Publication number
- PL2633867T3 PL2633867T3 PL13169835T PL13169835T PL2633867T3 PL 2633867 T3 PL2633867 T3 PL 2633867T3 PL 13169835 T PL13169835 T PL 13169835T PL 13169835 T PL13169835 T PL 13169835T PL 2633867 T3 PL2633867 T3 PL 2633867T3
- Authority
- PL
- Poland
- Prior art keywords
- vaccine
- protection against
- mycoplasma hyopneumoniae
- lawsonia intracellularis
- against lawsonia
- Prior art date
Links
- 241001148567 Lawsonia intracellularis Species 0.000 title 1
- 241000204045 Mycoplasma hyopneumoniae Species 0.000 title 1
- 241000202347 Porcine circovirus Species 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4618808P | 2008-04-18 | 2008-04-18 | |
| EP08154765 | 2008-04-18 | ||
| EP13169835.9A EP2633867B1 (en) | 2008-04-18 | 2009-04-16 | Vaccine for protection against lawsonia intracellularis, mycoplasma hyopneumoniae and porcine circo virus |
| EP09732113.7A EP2291195B2 (en) | 2008-04-18 | 2009-04-16 | Vaccine for protection against lawsonia intracellularis, mycoplasma hyopneumoniae and porcine circo virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2633867T3 true PL2633867T3 (pl) | 2018-07-31 |
Family
ID=39496087
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09732113T PL2291195T5 (pl) | 2008-04-18 | 2009-04-16 | Szczepionka do ochrony przeciw Lawsonia Intracellularis, Mycoplasma Hyopneumoniae i Cirkowirusowi świń |
| PL13169835T PL2633867T3 (pl) | 2008-04-18 | 2009-04-16 | Szczepionka do ochrony przeciw lawsonia intracellularis, mycoplasma hyopneumoniae i cirkowirusowi świń |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09732113T PL2291195T5 (pl) | 2008-04-18 | 2009-04-16 | Szczepionka do ochrony przeciw Lawsonia Intracellularis, Mycoplasma Hyopneumoniae i Cirkowirusowi świń |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20110033497A1 (pl) |
| EP (2) | EP2291195B2 (pl) |
| JP (2) | JP6026107B2 (pl) |
| CN (2) | CN106729695A (pl) |
| BR (1) | BRPI0909770B1 (pl) |
| CA (1) | CA2718787C (pl) |
| DK (2) | DK2633867T3 (pl) |
| ES (2) | ES2534502T5 (pl) |
| HU (1) | HUE038425T2 (pl) |
| PL (2) | PL2291195T5 (pl) |
| RU (1) | RU2496520C2 (pl) |
| TW (1) | TWI449533B (pl) |
| WO (1) | WO2009127684A1 (pl) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8834891B2 (en) | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
| TWI551295B (zh) | 2008-04-18 | 2016-10-01 | 英特威特國際股份有限公司 | 防備胞內勞森菌(Lawsonia intracellularis)用疫苗 |
| EP2318041B1 (en) * | 2008-07-22 | 2015-02-25 | Intervet International BV | Lawsonia intracellularis bacterium of a novel serotype, vaccine based on that bacterium, antibodies suitable for diagnosing the novel lawsonia intracellularis serotype and hybridomas for producing the said antibodies |
| AR078253A1 (es) | 2009-09-02 | 2011-10-26 | Boehringer Ingelheim Vetmed | Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad |
| ES2559445T3 (es) | 2010-05-11 | 2016-02-12 | Intervet International B.V. | Vacuna contra Mycoplasma hyopneumoniae apta para la administración en presencia de anticuerpos de origen materno |
| RU2565443C2 (ru) | 2011-06-27 | 2015-10-20 | Интервет Интернэшнл Б.В. | Водная композиция, содержащая биологический антиген и полимер акриловой кислоты |
| WO2013104550A1 (de) * | 2012-01-13 | 2013-07-18 | Boehringer Ingelheim Vetmedica Gmbh | Kit zur herstellung eines impfstoffs |
| US9474692B2 (en) * | 2012-01-13 | 2016-10-25 | Boehringer Ingelheim Vetmedica Gmbh | Kit for the preparation of a vaccinating agent |
| UA114503C2 (uk) * | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
| US9120859B2 (en) | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
| UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
| CN104450559B (zh) * | 2012-06-29 | 2017-09-22 | 普莱柯生物工程股份有限公司 | 新的猪肺炎支原体菌株及其疫苗组合物 |
| CN103031258B (zh) * | 2012-06-29 | 2014-12-17 | 普莱柯生物工程股份有限公司 | 新的猪肺炎支原体菌株及其疫苗组合物 |
| EP2684959A1 (en) * | 2012-07-10 | 2014-01-15 | Laboratorios Hipra, S.A. | Vectors for transforming Mycoplasma hyopneumoniae, transformed M.hyopneumoniae strains, and use thereof |
| DK3076997T3 (en) * | 2013-12-03 | 2018-12-10 | Intervet Int Bv | SVINEVACCINE v PRRS AND LAWSONIA INTRACELLULARIS |
| MX370584B (es) | 2013-12-03 | 2019-12-17 | Intervet Int Bv | Vacuna contra lawsonia intracellularis y circovirus porcino 2. |
| PL3076996T3 (pl) * | 2013-12-03 | 2020-05-18 | Intervet International B.V. | Szczepionka przeciwko cirkowirusowi świń typu 2 |
| ES2800033T3 (es) | 2015-02-04 | 2020-12-23 | Intervet Int Bv | Una vacuna para usar contra la infección asintomática por Lawsonia en un cerdo |
| JP2018504423A (ja) * | 2015-02-04 | 2018-02-15 | インターベット インターナショナル ベー. フェー. | 豚における無症候性ローソニア感染症に対する使用のためのワクチン |
| US11654191B2 (en) * | 2016-03-23 | 2023-05-23 | Intervet Inc. | Vaccine for intradermal application against PCV2 and PRRS virus infection |
| EP3432919A1 (en) * | 2016-03-23 | 2019-01-30 | Intervet International B.V. | A combination vaccine against pcv2 virus and mycoplasma hyopneumoniae infection |
| WO2018115435A1 (en) * | 2016-12-23 | 2018-06-28 | Intervet International B.V. | Combination vaccine for swine |
| CN110446502B (zh) * | 2017-04-13 | 2024-01-26 | 英特维特国际股份有限公司 | 用于联合非混合使用的含猪病原体的疫苗 |
| CL2017002196A1 (es) * | 2017-08-30 | 2017-11-17 | Univ De Concepción | Vacuna recombinante contra enteropatía proliferativa en animales. |
| CN120771270A (zh) * | 2017-12-04 | 2025-10-14 | 英特维特国际股份有限公司 | 具有复制子颗粒和油佐剂的疫苗 |
| CN118976103A (zh) | 2017-12-18 | 2024-11-19 | 英特维特国际股份有限公司 | 猪甲型流感病毒疫苗 |
| BR112022025735A2 (pt) | 2020-06-19 | 2023-01-03 | Intervet Int Bv | Vacina de vírus da influenza a suína compreendendo um construto de ácido nucleico compreendendo a primeira, segunda e terceira sequências de ácido nucleico codificando antígenos de neuraminidase distintos do vírus |
| JP2023530135A (ja) | 2020-06-19 | 2023-07-13 | インターベット インターナショナル ベー. フェー. | 特定のウイルス系統の抗原をエンコードする核酸構築物を含むブタインフルエンザaウイルスワクチン |
| CN115697398A (zh) | 2020-06-19 | 2023-02-03 | 英特维特国际股份有限公司 | 包含两种不同rna复制子颗粒的甲型猪流感病毒疫苗 |
| US20230265130A1 (en) | 2020-06-19 | 2023-08-24 | Intervet Inc. | Swine influenza a virus vaccine comprising a nucleic acid construct having a specific order of genes |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE115862T1 (de) * | 1989-02-04 | 1995-01-15 | Akzo Nobel Nv | Tocole als impfstoffadjuvans. |
| US5714375A (en) | 1995-06-05 | 1998-02-03 | Nobl Laboratories, Inc. | Ileal symbiont intracellularis propagation in suspended host cells |
| US5885823A (en) | 1995-06-05 | 1999-03-23 | Nobl Laboratories, Inc. | Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents |
| CN1145697C (zh) * | 1995-11-30 | 2004-04-14 | 维多利亚农业服务控股公司 | 治疗和诊断组合物 |
| HUP0303655A2 (hu) * | 2000-09-29 | 2004-03-01 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Proliferatív ileitis elleni hatékonyabb vakcinák, előállításuk és alkalmazásuk |
| DE60120621T2 (de) * | 2000-12-20 | 2006-12-14 | Intervet International B. V. | Lawsonia intracellularis Impfstoff |
| US7321065B2 (en) * | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
| TW200510524A (en) * | 2003-07-25 | 2005-03-16 | Boehringer Ingelheim Vetmed | Lawsonia intracellularis of european origin and vaccines, diagnostic agents and methods of use thereof |
| US7312065B2 (en) * | 2003-07-25 | 2007-12-25 | Boehringer Ingelheim Vetmedica, Inc. | Lawsonia intracellularis of European origin and vaccines, diagnostic agents and methods of use thereof |
| MXPA06008217A (es) | 2004-01-22 | 2007-05-23 | Intervet Int Bv | Vacunas con subunidad de lawsonia intracellularis. |
| US20070212373A1 (en) * | 2004-12-08 | 2007-09-13 | Akzo Nobel N.V. | Lawsonia Intracellularis 26 Kd Subunit Vaccine |
| US8834891B2 (en) | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
| BRPI0615862A2 (pt) * | 2005-09-09 | 2011-05-31 | Intervet Int Bv | vacina contra pcv-2, e, método para a manufatura de uma vacina |
| DK1968630T5 (en) | 2005-12-29 | 2018-08-13 | Boehringer Ingelheim Vetmedica Inc | MULTIVALENT PCV2 IMMUNOGENIC COMPOSITIONS. |
| SG170792A1 (en) | 2005-12-29 | 2011-05-30 | Boehringer Ingelheim Vetmed | Use of a pcv2 immunogenic composition for lessening clinical symptoms in pigs |
| WO2007103042A2 (en) | 2006-03-03 | 2007-09-13 | Merial Limited | Mycoplasma hyopneumoniae vaccine |
| PL2007419T3 (pl) | 2006-04-10 | 2012-09-28 | Intervet Int Bv | Szczepionka przeciwko mykoplazmie i PRRSV |
| WO2007138036A1 (en) | 2006-05-30 | 2007-12-06 | Intervet International B.V. | Vaccine against rickettsia-like organisms |
| CN101980720A (zh) | 2008-01-23 | 2011-02-23 | 贝林格尔.英格海姆维特梅迪卡有限公司 | Pcv2猪肺炎支原体致免疫组合物及其制备方法 |
-
2009
- 2009-03-30 TW TW098110513A patent/TWI449533B/zh active
- 2009-04-16 CN CN201611239977.4A patent/CN106729695A/zh active Pending
- 2009-04-16 HU HUE13169835A patent/HUE038425T2/hu unknown
- 2009-04-16 ES ES09732113T patent/ES2534502T5/es active Active
- 2009-04-16 PL PL09732113T patent/PL2291195T5/pl unknown
- 2009-04-16 DK DK13169835.9T patent/DK2633867T3/en active
- 2009-04-16 CN CN200980112991XA patent/CN102006884A/zh active Pending
- 2009-04-16 US US12/988,088 patent/US20110033497A1/en not_active Abandoned
- 2009-04-16 EP EP09732113.7A patent/EP2291195B2/en active Active
- 2009-04-16 CA CA2718787A patent/CA2718787C/en active Active
- 2009-04-16 PL PL13169835T patent/PL2633867T3/pl unknown
- 2009-04-16 RU RU2010146950/15A patent/RU2496520C2/ru active
- 2009-04-16 ES ES13169835.9T patent/ES2666844T3/es active Active
- 2009-04-16 JP JP2011504463A patent/JP6026107B2/ja active Active
- 2009-04-16 EP EP13169835.9A patent/EP2633867B1/en not_active Revoked
- 2009-04-16 WO PCT/EP2009/054517 patent/WO2009127684A1/en not_active Ceased
- 2009-04-16 DK DK09732113.7T patent/DK2291195T4/da active
- 2009-04-16 BR BRPI0909770-8A patent/BRPI0909770B1/pt active IP Right Grant
-
2013
- 2013-02-05 US US13/759,421 patent/US9084768B2/en active Active
-
2014
- 2014-09-05 JP JP2014180911A patent/JP6078504B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0909770A2 (pt) | 2015-08-11 |
| JP2015028038A (ja) | 2015-02-12 |
| BRPI0909770B1 (pt) | 2021-09-28 |
| TWI449533B (zh) | 2014-08-21 |
| CN102006884A (zh) | 2011-04-06 |
| DK2633867T3 (en) | 2018-05-28 |
| CN106729695A (zh) | 2017-05-31 |
| DK2291195T4 (da) | 2020-02-10 |
| EP2291195B2 (en) | 2019-11-13 |
| ES2534502T3 (es) | 2015-04-23 |
| CA2718787C (en) | 2018-04-10 |
| PL2291195T3 (pl) | 2015-07-31 |
| TW201000123A (en) | 2010-01-01 |
| DK2291195T3 (en) | 2015-05-11 |
| RU2010146950A (ru) | 2012-05-27 |
| ES2534502T5 (es) | 2020-06-26 |
| US20130183338A1 (en) | 2013-07-18 |
| CA2718787A1 (en) | 2009-10-22 |
| RU2496520C2 (ru) | 2013-10-27 |
| JP2011516601A (ja) | 2011-05-26 |
| HUE038425T2 (hu) | 2018-10-29 |
| EP2633867B1 (en) | 2018-03-21 |
| US20110033497A1 (en) | 2011-02-10 |
| EP2633867A1 (en) | 2013-09-04 |
| WO2009127684A1 (en) | 2009-10-22 |
| PL2291195T5 (pl) | 2020-06-29 |
| EP2291195B1 (en) | 2015-02-25 |
| JP6078504B2 (ja) | 2017-02-08 |
| ES2666844T3 (es) | 2018-05-08 |
| US9084768B2 (en) | 2015-07-21 |
| JP6026107B2 (ja) | 2016-11-16 |
| EP2291195A1 (en) | 2011-03-09 |
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