PL2499139T3 - N1-pirazolospiroketonowe inhibitory karboksylazy acetylo-CoA - Google Patents

N1-pirazolospiroketonowe inhibitory karboksylazy acetylo-CoA

Info

Publication number: PL2499139T3
Authority: PL; Poland
Prior art keywords: coa carboxylase; carboxylase inhibitors; pyrazolospiroketone; acetyl; pyrazolospiroketone acetyl
Prior art date: 2009-11-10

Application number

PL10776438T

Other languages

English (en)

Inventor

Scott William Bagley

David Andrew Griffith

Daniel Wei-Shung Kung

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-11-10

Filing date

2010-10-29

Publication date

2014-04-30

2010-10-29 Application filed by Pfizer filed Critical Pfizer

2014-04-30 Publication of PL2499139T3 publication Critical patent/PL2499139T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)

PL10776438T 2009-11-10 2010-10-29 N1-pirazolospiroketonowe inhibitory karboksylazy acetylo-CoA PL2499139T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US25982309P	2009-11-10	2009-11-10
EP10776438.3A EP2499139B1 (en)	2009-11-10	2010-10-29	N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors
PCT/IB2010/054908 WO2011058474A1 (en)	2009-11-10	2010-10-29	N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors

Publications (1)

Publication Number	Publication Date
PL2499139T3 true PL2499139T3 (pl)	2014-04-30

Family

ID=43357094

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL10776438T PL2499139T3 (pl)	2009-11-10	2010-10-29	N1-pirazolospiroketonowe inhibitory karboksylazy acetylo-CoA

Country Status (40)

Country	Link
US (4)	US8288405B2 (pl)
EP (3)	EP2947082A1 (pl)
JP (1)	JP5114610B1 (pl)
KR (2)	KR101550557B1 (pl)
CN (1)	CN102695708B (pl)
AP (1)	AP3283A (pl)
AR (1)	AR078944A1 (pl)
AU (1)	AU2010317501B2 (pl)
BR (1)	BR112012011072A2 (pl)
CA (1)	CA2778886C (pl)
CL (1)	CL2012000999A1 (pl)
CO (1)	CO6541569A2 (pl)
CR (1)	CR20120190A (pl)
CU (1)	CU24077B1 (pl)
DK (1)	DK2499139T3 (pl)
DO (1)	DOP2012000128A (pl)
EA (1)	EA020153B1 (pl)
EC (1)	ECSP12011880A (pl)
ES (1)	ES2444543T3 (pl)
GE (1)	GEP20146169B (pl)
HK (1)	HK1173724A1 (pl)
HN (1)	HN2012000973A (pl)
HR (1)	HRP20140025T1 (pl)
IL (1)	IL219373A (pl)
MA (1)	MA33734B1 (pl)
MX (1)	MX2012005429A (pl)
NI (1)	NI201200089A (pl)
NZ (1)	NZ599815A (pl)
PE (1)	PE20121469A1 (pl)
PH (1)	PH12012500903A1 (pl)
PL (1)	PL2499139T3 (pl)
PT (1)	PT2499139E (pl)
RS (1)	RS53156B (pl)
SI (1)	SI2499139T1 (pl)
TN (1)	TN2012000192A1 (pl)
TW (1)	TWI394756B (pl)
UA (1)	UA102336C2 (pl)
UY (1)	UY33020A (pl)
WO (1)	WO2011058474A1 (pl)
ZA (1)	ZA201204231B (pl)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2724774C (en)	2008-05-28	2013-06-25	Pfizer Inc.	Pyrazolospiroketone acetyl-coa carboxylase inhibitors
MX2011013816A (es)	2009-06-29	2012-04-11	Incyte Corp	Pirimidinonas como inhibidores de pi3k.
KR101550557B1 (ko)	2009-11-10	2015-09-04	화이자 인코포레이티드	N1-피라졸로스피로케톤 아세틸-coa 카복실라아제 억제제
WO2011075643A1 (en)	2009-12-18	2011-06-23	Incyte Corporation	Substituted heteroaryl fused derivatives as pi3k inhibitors
EP2345643A1 (en) *	2009-12-29	2011-07-20	Polichem S.A.	New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof
WO2011130342A1 (en)	2010-04-14	2011-10-20	Incyte Corporation	FUSED DERIVATIVES AS ΡI3Κδ INHIBITORS
US9062055B2 (en)	2010-06-21	2015-06-23	Incyte Corporation	Fused pyrrole derivatives as PI3K inhibitors
WO2012042433A1 (en)	2010-09-30	2012-04-05	Pfizer Inc.	N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS
DK2632925T3 (en)	2010-10-29	2015-06-29	Pfizer	N1 / N2-lactam acetyl-CoA carboxylase inhibitors
AR084366A1 (es)	2010-12-20	2013-05-08	Incyte Corp	N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k
WO2012125629A1 (en)	2011-03-14	2012-09-20	Incyte Corporation	Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
WO2012135009A1 (en)	2011-03-25	2012-10-04	Incyte Corporation	Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
CN106117205B (zh) *	2011-04-22	2018-09-21	辉瑞大药厂	用作乙酰辅酶a羧化酶抑制剂类的吡唑并螺酮衍生物
MY179332A (en)	2011-09-02	2020-11-04	Incyte Holdings Corp	Heterocyclylamines as pl3k inhibitors
AR090548A1 (es)	2012-04-02	2014-11-19	Incyte Corp	Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
TW201444798A (zh)	2013-02-28	2014-12-01	必治妥美雅史谷比公司	作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
US9828345B2 (en)	2013-02-28	2017-11-28	Bristol-Myers Squibb Company	Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors
EP2969007B1 (en)	2013-03-14	2019-05-08	Celgene Quanticel Research, Inc.	Histone demethylase inhibitors
RU2016106829A (ru)	2013-09-12	2017-10-17	Пфайзер Инк.	Применение ингибиторов ацетил-СоА карбоксилазы для лечения обыкновенных угрей
WO2015056782A1 (ja)	2013-10-17	2015-04-23	塩野義製薬株式会社	新規アルキレン誘導体
US10077277B2 (en)	2014-06-11	2018-09-18	Incyte Corporation	Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
US9896436B2 (en)	2014-09-16	2018-02-20	Celgene Quanticel Research, Inc.	Histone demethylase inhibitors
ES2911292T3 (es)	2014-09-16	2022-05-18	Celgene Quanticel Res Inc	Inhibidores de desmetilasas de histonas
SG11201702119PA (en) *	2014-09-17	2017-04-27	Quanticel Pharmaceuticals Inc	Histone demethylase inhibitors
CA2966834C (en)	2014-11-10	2022-08-30	National University Corporation Yokohama National University	Oxygen-generating anode
MD3262046T2 (ro)	2015-02-27	2021-03-31	Incyte Corp	Săruri de inhibitori ai PI3K și procedee pentru prepararea lor
WO2016183063A1 (en)	2015-05-11	2016-11-17	Incyte Corporation	Crystalline forms of a pi3k inhibitor
WO2016183060A1 (en)	2015-05-11	2016-11-17	Incyte Corporation	Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US11541046B2 (en)	2017-06-30	2023-01-03	Quixgen, Inc.	Spirolactone compounds
FI3713942T3 (fi)	2017-11-21	2023-05-04	Pfizer	4-(4-(1-isopropyyli-7-okso-1,4,6,7-tetrahydrospiro[indatsoli-5,4'-piperidiini]-1'-karbonyyli)-6-metoksipyridin-2-yyli)bentsoehapon kiteinen 2-amino-2-(hydroksimetyyli)propaani-1,3-diolisuola
US11465991B2 (en)	2018-03-15	2022-10-11	Yale University	Pyrazole-containing macrophage migration inhibitory factor inhibitors
CN112469418A (zh)	2018-06-01	2021-03-09	因赛特公司	治疗pi3k相关病症的给药方案
WO2021235508A1 (ja)	2020-05-21	2021-11-25	塩野義製薬株式会社	脂肪性肝疾患の治療用医薬
US10989621B1 (en)	2020-08-20	2021-04-27	Trinity Bay Equipment Holdings, LLC	Online pipe integrity testing system and method
CN112028834B (zh) *	2020-09-11	2022-03-29	济南悟通生物科技有限公司	一种阿贝西利的中间体的合成方法
WO2023090411A1 (ja)	2021-11-19	2023-05-25	塩野義製薬株式会社	心疾患または骨格筋の疾患の治療用医薬
CN115124542A (zh) *	2022-07-08	2022-09-30	河南师范大学	羟基苯取代吡唑酮并吲唑[螺]吡唑酮类化合物的合成方法
WO2024023727A1 (en) *	2022-07-29	2024-02-01	Pfizer Inc.	Novel acc inhibitors

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US984083A (en)	1910-03-28	1911-02-14	William J Faber	Floor-plane.
PT901786E (pt)	1997-08-11	2007-08-07	Pfizer Prod Inc	Disperções farmacêuticas sólidas com biodisponibilidade melhorada
WO2002068388A2 (en)	2001-02-28	2002-09-06	Merck & Co., Inc.	Acylated piperidine derivatives as melanocortin-4 receptor agonists
ATE303178T1 (de)	2002-02-27	2005-09-15	Pfizer Prod Inc	Acc-hemmer
US7105526B2 (en)	2002-06-28	2006-09-12	Banyu Pharmaceuticals Co., Ltd.	Benzimidazole derivatives
WO2004092179A1 (ja)	2003-04-14	2004-10-28	Nippon Soda Co. Ltd.	スピロ誘導体、製造法および抗酸化薬
JP2005119987A (ja)	2003-10-15	2005-05-12	Ajinomoto Co Inc	アシルスルホンアミド誘導体
US20050267221A1 (en)	2004-05-14	2005-12-01	Research Development Foundation	Use of curcumin and analogues thereof as inhibitors of ACC2
CN1950374A (zh)	2004-05-25	2007-04-18	辉瑞产品公司	四氮杂苯并[e]甘菊环衍生物及其类似物
PA8660701A1 (es)	2005-02-04	2006-09-22	Pfizer Prod Inc	Agonistas de pyy y sus usos
WO2007011809A1 (en)	2005-07-19	2007-01-25	Merck & Co., Inc.	Spirochromanone derivatives as acetyl coenzyme a carboxylase (acc) inhibitors
EP1911753A1 (en) *	2005-07-29	2008-04-16	Takeda Pharmaceutical Company Limited	Spiro-cyclic compound
DE102006016566B4 (de) *	2005-09-22	2008-06-12	Beru Ag	Zusammengesetzter Leiter, insbesondere für Glühkerzen für Dieselmotoren
CA2629406A1 (en)	2005-11-18	2007-05-31	Merck & Co., Inc.	Spirohydantoin aryl cgrp receptor antagonists
CN101384568B (zh)	2006-02-15	2012-12-12	雅培制药有限公司	乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用
RS20090249A (en) *	2006-11-29	2010-06-30	Pfizer Products Inc.	Spiroketone acetyl-coa carboxylase inhibotors
PE20081559A1 (es) *	2007-01-12	2008-11-20	Merck & Co Inc	DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA
EP2123652A1 (en) *	2007-02-20	2009-11-25	Takeda Pharmaceutical Company Limited	Heterocyclic compound
MX2009010951A (es) *	2007-04-12	2009-10-29	Pfizer	Derivados de 3-amino-pirrolo[3,4-c]pirazol-5(1h,4h,6h)-carbaldehid o como inhibidores de proteina quinasa c.
WO2009014455A1 (en) *	2007-07-20	2009-01-29	Mark Jonathon Brownlee	Email response time expectation system
US7981904B2 (en) *	2008-03-20	2011-07-19	Takeda Pharmaceutical Company Limited	Acetyl CoA carboxylase inhibitors
CA2724603A1 (en) *	2008-05-28	2009-12-03	Pfizer Inc.	Pyrazolospiroketone acetyl-coa carboxylase inhibitors
CA2724774C (en) *	2008-05-28	2013-06-25	Pfizer Inc.	Pyrazolospiroketone acetyl-coa carboxylase inhibitors
CA2729412A1 (en)	2008-07-04	2010-01-07	Banyu Pharmaceutical Co., Ltd.	Novel spirochromanone carboxylic acids
AU2009271634A1 (en) *	2008-07-14	2010-01-21	Cropsolution, Inc.	Modulators of acetyl-coenzyme a carboxylase and methods of use thereof
ES2652289T3 (es) *	2008-09-18	2018-02-01	Auspex Pharmaceuticals, Inc.	Derivados deuterados de benzoquinolina como inhibidores del transportador de monoamina vesicular 2
EP2499140A1 (en)	2009-11-10	2012-09-19	Pfizer Inc.	N2-pyrazolospiroketone acetyl-coa carboxylase inhibitors
KR101550557B1 (ko) *	2009-11-10	2015-09-04	화이자 인코포레이티드	N1-피라졸로스피로케톤 아세틸-coa 카복실라아제 억제제
WO2012042433A1 (en) *	2010-09-30	2012-04-05	Pfizer Inc.	N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS
CN106117205B (zh) *	2011-04-22	2018-09-21	辉瑞大药厂	用作乙酰辅酶a羧化酶抑制剂类的吡唑并螺酮衍生物

2010
- 2010-10-29 KR KR1020147003056A patent/KR101550557B1/ko not_active Expired - Fee Related
- 2010-10-29 AU AU2010317501A patent/AU2010317501B2/en not_active Ceased
- 2010-10-29 WO PCT/IB2010/054908 patent/WO2011058474A1/en active Application Filing
- 2010-10-29 GE GEAP201012700A patent/GEP20146169B/en unknown
- 2010-10-29 KR KR1020127014916A patent/KR101478517B1/ko not_active Expired - Fee Related
- 2010-10-29 MX MX2012005429A patent/MX2012005429A/es active IP Right Grant
- 2010-10-29 EP EP15172294.9A patent/EP2947082A1/en not_active Withdrawn
- 2010-10-29 RS RS20140068A patent/RS53156B/en unknown
- 2010-10-29 EA EA201290191A patent/EA020153B1/ru not_active IP Right Cessation
- 2010-10-29 SI SI201030476T patent/SI2499139T1/sl unknown
- 2010-10-29 CN CN201080059647.1A patent/CN102695708B/zh not_active Expired - Fee Related
- 2010-10-29 PE PE2012000630A patent/PE20121469A1/es not_active Application Discontinuation
- 2010-10-29 PT PT107764383T patent/PT2499139E/pt unknown
- 2010-10-29 EP EP13183518.3A patent/EP2676958B1/en active Active
- 2010-10-29 PH PH1/2012/500903A patent/PH12012500903A1/en unknown
- 2010-10-29 NZ NZ599815A patent/NZ599815A/xx not_active IP Right Cessation
- 2010-10-29 EP EP10776438.3A patent/EP2499139B1/en active Active
- 2010-10-29 AP AP2012006269A patent/AP3283A/xx active
- 2010-10-29 CA CA2778886A patent/CA2778886C/en active Active
- 2010-10-29 UA UAA201205709A patent/UA102336C2/uk unknown
- 2010-10-29 BR BR112012011072A patent/BR112012011072A2/pt not_active IP Right Cessation
- 2010-10-29 DK DK10776438.3T patent/DK2499139T3/da active
- 2010-10-29 PL PL10776438T patent/PL2499139T3/pl unknown
- 2010-10-29 JP JP2012538444A patent/JP5114610B1/ja active Active
- 2010-10-29 ES ES10776438.3T patent/ES2444543T3/es active Active
- 2010-10-29 CU CU2012000071A patent/CU24077B1/es active IP Right Grant
- 2010-11-05 TW TW099138179A patent/TWI394756B/zh not_active IP Right Cessation
- 2010-11-08 AR ARP100104147A patent/AR078944A1/es unknown
- 2010-11-08 US US12/941,133 patent/US8288405B2/en active Active
- 2010-11-10 UY UY0001033020A patent/UY33020A/es not_active Application Discontinuation
2012
- 2012-04-18 CR CR20120190A patent/CR20120190A/es unknown
- 2012-04-19 CL CL2012000999A patent/CL2012000999A1/es unknown
- 2012-04-23 IL IL219373A patent/IL219373A/en not_active IP Right Cessation
- 2012-04-25 TN TNP2012000192A patent/TN2012000192A1/fr unknown
- 2012-05-07 HN HN2012000973A patent/HN2012000973A/es unknown
- 2012-05-08 DO DO2012000128A patent/DOP2012000128A/es unknown
- 2012-05-09 NI NI201200089A patent/NI201200089A/es unknown
- 2012-05-10 MA MA34850A patent/MA33734B1/fr unknown
- 2012-05-10 EC ECSP12011880 patent/ECSP12011880A/es unknown
- 2012-05-10 CO CO12077270A patent/CO6541569A2/es unknown
- 2012-06-08 ZA ZA2012/04231A patent/ZA201204231B/en unknown
- 2012-10-04 US US13/644,415 patent/US8507681B2/en active Active
2013
- 2013-01-11 HK HK13100478.6A patent/HK1173724A1/xx not_active IP Right Cessation
- 2013-07-11 US US13/939,450 patent/US8802690B2/en active Active
2014
- 2014-01-08 HR HRP20140025AT patent/HRP20140025T1/hr unknown
- 2014-05-09 US US14/273,912 patent/US9139587B2/en active Active

Also Published As

Publication number	Publication date
HN2012000973A (es)	2015-03-02
US8802690B2 (en)	2014-08-12
IL219373A0 (en)	2012-06-28
US8288405B2 (en)	2012-10-16
NI201200089A (es)	2012-08-20
EP2947082A1 (en)	2015-11-25
CR20120190A (es)	2012-05-24
WO2011058474A8 (en)	2012-04-26
HK1173724A1 (en)	2013-05-24
EP2499139B1 (en)	2013-12-11
ZA201204231B (en)	2013-02-27
AP3283A (en)	2015-05-31
DK2499139T3 (da)	2014-01-27
PT2499139E (pt)	2014-02-10
AR078944A1 (es)	2011-12-14
US9139587B2 (en)	2015-09-22
KR101550557B1 (ko)	2015-09-04
MX2012005429A (es)	2012-06-19
CN102695708B (zh)	2014-10-15
UY33020A (es)	2011-06-30
CA2778886A1 (en)	2011-05-19
CA2778886C (en)	2014-01-07
CL2012000999A1 (es)	2012-07-20
KR20140034919A (ko)	2014-03-20
UA102336C2 (uk)	2013-06-25
EP2676958A1 (en)	2013-12-25
AP2012006269A0 (en)	2012-06-30
EA020153B1 (ru)	2014-09-30
MA33734B1 (fr)	2012-11-01
ES2444543T3 (es)	2014-02-25
PE20121469A1 (es)	2012-11-01
JP2013510192A (ja)	2013-03-21
PH12012500903A1 (en)	2014-09-24
ECSP12011880A (es)	2012-07-31
KR101478517B1 (ko)	2015-01-02
EA201290191A1 (ru)	2012-12-28
AU2010317501B2 (en)	2013-06-06
TWI394756B (zh)	2013-05-01
SI2499139T1 (sl)	2014-01-31
CO6541569A2 (es)	2012-10-16
CU24077B1 (es)	2015-03-30
JP5114610B1 (ja)	2013-01-09
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TW201127838A (en)	2011-08-16
KR20120099460A (ko)	2012-09-10
US8507681B2 (en)	2013-08-13
BR112012011072A2 (pt)	2017-06-20
CN102695708A (zh)	2012-09-26
TN2012000192A1 (fr)	2013-12-12
RS53156B (en)	2014-06-30
EP2676958B1 (en)	2015-07-01
WO2011058474A1 (en)	2011-05-19
US20130296319A1 (en)	2013-11-07
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HRP20140025T1 (hr)	2014-02-14
GEP20146169B (en)	2014-09-25
CU20120071A7 (es)	2013-05-31
IL219373A (en)	2014-04-30

Publication	Publication Date	Title
AP3283A (en)	2015-05-31	N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors
HK1209733A1 (en)	2016-04-08	N1/n2-lactam acetyl-coa carboxylase inhibitors n1/n2- a
PL2621493T3 (pl)	2017-01-31	N1-pirazolospiroketonowe inhibitory karboksylazy acetylo-CoA
GB2497438B (en)	2014-05-14	Level
HK1179477A1 (en)	2013-10-04	Kinase inhibitors
ZA201203842B (en)	2013-01-30	Kinase inhibitors
ZA200903268B (en)	2010-07-28	Spiroketone acetyl-coa carboxylase inhibitors
EP2552208A4 (en)	2014-07-09	IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS
EP2552214A4 (en)	2013-10-16	PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS
AP3499A (en)	2015-12-31	Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors
EP2552211A4 (en)	2013-10-23	INDAZOLYL-PYRIMIDINE AS KINASEHEMMER
GB201009731D0 (en)	2010-07-21	Kinase inhibitors
GB0914726D0 (en)	2009-09-30	Kinase inhibitors
GB0903650D0 (en)	2009-04-15	Glyoalase inhibitors
GB0902661D0 (en)	2009-04-01	Inhibitors
GB0915927D0 (en)	2009-10-14	Novel inhibitors
GB201018597D0 (en)	2010-12-22	Inhibitors
GB201104990D0 (en)	2011-05-11	Screw-fix level