[go: up one dir, main page]

PL2455381T3 - Triazolopirydynowy związek i jego działanie jako inhibitora hydroksylazy prolinowej i środka indukującego wytwarzanie erytropoetyny - Google Patents

Triazolopirydynowy związek i jego działanie jako inhibitora hydroksylazy prolinowej i środka indukującego wytwarzanie erytropoetyny

Info

Publication number
PL2455381T3
PL2455381T3 PL10799914T PL10799914T PL2455381T3 PL 2455381 T3 PL2455381 T3 PL 2455381T3 PL 10799914 T PL10799914 T PL 10799914T PL 10799914 T PL10799914 T PL 10799914T PL 2455381 T3 PL2455381 T3 PL 2455381T3
Authority
PL
Poland
Prior art keywords
action
prolyl hydroxylase
hydroxylase inhibitor
erythropoietin production
production inducer
Prior art date
Application number
PL10799914T
Other languages
English (en)
Inventor
Ikuo Mitani
Yosuke Ogoshi
Takuya Matsui
Masahiro Yokota
Masakazu Terashita
Dai Motoda
Kazuhito Ueyama
Hiroyuki Abe
Takahiro Hotta
Takashi Ito
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of PL2455381T3 publication Critical patent/PL2455381T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
PL10799914T 2009-07-17 2010-07-16 Triazolopirydynowy związek i jego działanie jako inhibitora hydroksylazy prolinowej i środka indukującego wytwarzanie erytropoetyny PL2455381T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2009169565 2009-07-17
US27312709P 2009-07-30 2009-07-30
PCT/JP2010/062037 WO2011007856A1 (ja) 2009-07-17 2010-07-16 トリアゾロピリジン化合物、ならびにそのプロリル水酸化酵素阻害剤およびエリスロポエチン産生誘導剤としての作用
EP10799914.6A EP2455381B9 (en) 2009-07-17 2010-07-16 Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer

Publications (1)

Publication Number Publication Date
PL2455381T3 true PL2455381T3 (pl) 2014-10-31

Family

ID=43449466

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10799914T PL2455381T3 (pl) 2009-07-17 2010-07-16 Triazolopirydynowy związek i jego działanie jako inhibitora hydroksylazy prolinowej i środka indukującego wytwarzanie erytropoetyny

Country Status (28)

Country Link
US (3) US8283465B2 (pl)
EP (3) EP2455381B9 (pl)
JP (9) JP5021797B2 (pl)
KR (4) KR101706803B1 (pl)
CN (1) CN102471337B (pl)
AR (1) AR077417A1 (pl)
AU (1) AU2010271732B2 (pl)
BR (1) BR112012001157A2 (pl)
CA (1) CA2768505C (pl)
CO (1) CO6430426A2 (pl)
DK (1) DK2455381T5 (pl)
ES (1) ES2477968T3 (pl)
HR (1) HRP20140705T1 (pl)
IL (1) IL217541A (pl)
ME (1) ME01858B (pl)
MX (1) MX2012000766A (pl)
MY (1) MY160814A (pl)
NZ (1) NZ598242A (pl)
PE (1) PE20120629A1 (pl)
PL (1) PL2455381T3 (pl)
PT (1) PT2455381E (pl)
RS (1) RS53499B1 (pl)
RU (1) RU2538963C2 (pl)
SG (1) SG178049A1 (pl)
SI (1) SI2455381T1 (pl)
SM (1) SMT201500122B (pl)
TW (1) TWI485150B (pl)
WO (1) WO2011007856A1 (pl)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2455381E (pt) * 2009-07-17 2014-06-24 Japan Tobacco Inc Composto de triazolopiridina e sua acção como inibidor da prolil-hidroxilase e indutor da produção de eritropoietina
JP2011168582A (ja) * 2010-01-21 2011-09-01 Ishihara Sangyo Kaisha Ltd トリアゾロピリジン誘導体又はその塩、それらの製造方法及びそれらを含有する有害生物防除剤
WO2012065297A1 (en) * 2010-11-16 2012-05-24 Impact Therapeutics, Inc. 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF
EP2923700B1 (en) 2012-11-26 2018-11-07 Tohoku University Erythropoietin expression promoter
UA117122C2 (uk) 2012-12-24 2018-06-25 Каділа Хелткере Лімітед Хінолонові похідні
MX391198B (es) 2013-06-13 2025-03-21 Akebia Therapeutics Inc Composiciones y metodos para tratar anemia
RU2534804C1 (ru) * 2013-08-05 2014-12-10 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") ЗАМЕЩЕННЫЕ [1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ, ПРОЯВЛЯЮЩИЕ СВОЙСТВА АНТАГОНИСТОВ АДЕНОЗИНОВЫХ А2А РЕЦЕПТОРОВ, И ИХ ПРИМЕНЕНИЕ
BR112016006994A8 (pt) * 2013-10-03 2020-02-27 Kura Oncology Inc inibidores de erk, seus usos e composições farmacêuticas os compreendendo
AU2015311333B2 (en) 2014-09-02 2017-11-16 Sunshine Lake Pharma Co., Ltd. Quinolinone compound and use thereof
JP2018039733A (ja) * 2014-12-22 2018-03-15 株式会社富士薬品 新規複素環誘導体
GB201504565D0 (en) * 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
CN106146395B (zh) * 2015-03-27 2019-01-01 沈阳三生制药有限责任公司 3-羟基吡啶化合物、其制备方法及其制药用途
KR102473897B1 (ko) 2015-05-28 2022-12-06 니뽄 다바코 산교 가부시키가이샤 당뇨병성 신증을 치료 또는 예방하는 방법
KR102523786B1 (ko) * 2016-11-25 2023-04-20 니뽄 다바코 산교 가부시키가이샤 트리아졸로피리딘 화합물의 제조 방법
US11021478B2 (en) 2017-05-09 2021-06-01 Kind Pharmaceutical Indolizine derivatives and their application in medicine
PE20200846A1 (es) * 2017-10-04 2020-08-18 Japan Tobacco Inc Compuesto de heteroarilo con contenido de nitrogeno y su uso farmaceutico
CN107739378A (zh) * 2017-11-14 2018-02-27 杭州安道药业有限公司 吲哚嗪衍生物及其在医药上的应用
PL3808747T3 (pl) * 2018-09-13 2025-03-17 Kissei Pharmaceutical Co., Ltd. Związek imidazopirydynonowy
CN110105355B (zh) * 2019-05-24 2021-09-21 烟台大学 一种1,2,3-三唑-[1,5-a]并喹啉类化合物的制备方法
EP4091670A4 (en) * 2020-03-11 2024-02-28 Kissei Pharmaceutical Co., Ltd. CRYSTAL OF AN IMIDAZOPYRIDINONE COMPOUND OR SALT THEREOF
JP7504822B2 (ja) * 2020-03-12 2024-06-24 キッセイ薬品工業株式会社 イミダゾピリジノン化合物を含む医薬組成物
EP4138825A1 (en) 2020-04-20 2023-03-01 Akebia Therapeutics Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer
WO2022150623A1 (en) 2021-01-08 2022-07-14 Akebia Therapeutics, Inc. Compounds and composition for the treatment of anemia
CN113387948B (zh) * 2021-02-06 2022-06-10 成都诺和晟泰生物科技有限公司 一种稠环杂芳基衍生物及其药物组合物和治疗方法及用途
EP4347022A1 (en) 2021-05-27 2024-04-10 Keryx Biopharmaceuticals, Inc. Pediatric formulations of ferric citrate
CN113582843A (zh) * 2021-09-09 2021-11-02 无锡捷化医药科技有限公司 一种5-氯-2-氟-3-羟基苯甲酸乙酯的制备方法
CN116496269B (zh) * 2021-12-02 2025-02-28 苏中药业集团股份有限公司 一种脯氨酰羟化酶抑制剂及其用途
CN114031619A (zh) * 2021-12-17 2022-02-11 山东汇海医药化工有限公司 一种图卡替尼中间体的制备方法
CN119948024A (zh) * 2022-09-19 2025-05-06 苏中药业集团股份有限公司 一种脯氨酰羟化酶抑制剂及其用途
TW202448441A (zh) * 2023-06-02 2024-12-16 大陸商蘇中藥業集團股份有限公司 脯氨醯羥化酶抑制劑及其用途
TW202506675A (zh) * 2023-08-08 2025-02-16 美商富曼西公司 用於防治和對抗無脊椎有害生物的連接的雙環化合物
CN117486878A (zh) * 2023-10-27 2024-02-02 扬州市普林斯医药科技有限公司 一种恩那司他的制备方法
WO2025137158A1 (en) * 2023-12-19 2025-06-26 Akebia Therapeutics, Inc. Derivatives of ([1,2,4]triazolo[5,1-a]isoquinoline-5-carbonyl)glycinate as phd inhibitor compounds, compositions, and methods of use

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19746287A1 (de) * 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
US6355653B1 (en) * 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
US6514989B1 (en) * 2001-07-20 2003-02-04 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
CA2462806A1 (en) * 2001-10-08 2003-04-17 F. Hoffmann-La Roche Ag 8-amino-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid amide
EP1660439A2 (en) 2003-08-08 2006-05-31 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
JP4787254B2 (ja) * 2004-08-05 2011-10-05 エフ．ホフマン−ラ ロシュ アーゲー インドール、インダゾールまたはインドリン誘導体
FR2889383A1 (fr) * 2005-08-01 2007-02-02 France Telecom Procede et dispositif de detection pour systeme mimo, systeme mimo, programme et support d'information
PE20071020A1 (es) 2006-03-07 2007-12-11 Smithkline Beecham Corp Compuestos derivados de glicina n-sustituidos como inhibidores de prolil hidroxilasa
JP2009537558A (ja) * 2006-05-16 2009-10-29 スミスクライン・ビーチャム・コーポレイション プロリルヒドロキシラーゼ阻害剤
JO2934B1 (en) * 2006-06-23 2015-09-15 سميث كلاين بيتشام كوربوريشن Prolyl hydroxylase inhibitors
DK2044005T3 (da) * 2006-06-26 2011-01-24 Warner Chilcott Co Llc Prolylhydroxylasehæmmere og fremgangsmåder til anvendelse af disse
AU2007272009A1 (en) 2006-07-12 2008-01-17 Syngenta Limited Triazolopyridine derivatives as herbicides
CL2008000066A1 (es) 2007-01-12 2008-08-01 Smithkline Beecham Corp Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem
US8048894B2 (en) 2007-04-18 2011-11-01 Amgen Inc. Quinolones and azaquinolones that inhibit prolyl hydroxylase
AU2008248165B2 (en) 2007-05-04 2011-12-08 Amgen Inc. Diazaquinolones that inhibit prolyl hydroxylase activity
CA2692265A1 (en) 2007-07-03 2009-01-08 Astellas Pharma Inc. Amide compounds
EA201000920A1 (ru) * 2007-11-30 2011-02-28 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Ингибиторы пролилгидроксилазы
US20100305133A1 (en) * 2007-11-30 2010-12-02 Smithkline Beecham Corporation Prolyl Hydroxylase Inhibitors
US8324241B2 (en) * 2008-04-11 2012-12-04 Bristol-Myers Squibb Company Triazolo compounds useful as DGAT1 inhibitors
JP2011519858A (ja) * 2008-04-30 2011-07-14 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー プロリルヒドロキシラ−ゼ阻害剤
JP2011521960A (ja) 2008-05-29 2011-07-28 サートリス ファーマシューティカルズ， インコーポレイテッド サーチュイン調節薬としてのイミダゾピリジンおよび関連する類似体
HUE027770T2 (en) 2008-12-19 2016-11-28 Leo Pharma As Triazolopyridines as inhibitors of phosphodiesterase for the treatment of skin diseases
PT2455381E (pt) * 2009-07-17 2014-06-24 Japan Tobacco Inc Composto de triazolopiridina e sua acção como inibidor da prolil-hidroxilase e indutor da produção de eritropoietina

Also Published As

Publication number Publication date
TW201105671A (en) 2011-02-16
IL217541A0 (en) 2012-02-29
NZ598242A (en) 2013-09-27
PT2455381E (pt) 2014-06-24
TWI485150B (zh) 2015-05-21
EP2455381B1 (en) 2014-05-28
DK2455381T5 (en) 2015-02-09
SI2455381T1 (sl) 2014-08-29
CN102471337A (zh) 2012-05-23
SMT201500122B (it) 2015-07-09
JP2020111612A (ja) 2020-07-27
US20110077267A1 (en) 2011-03-31
MX2012000766A (es) 2012-02-08
PE20120629A1 (es) 2012-05-30
HRP20140705T1 (hr) 2014-09-12
KR20120051704A (ko) 2012-05-22
JP6434575B2 (ja) 2018-12-05
KR101850661B1 (ko) 2018-04-19
EP2455381A1 (en) 2012-05-23
EP2746282A1 (en) 2014-06-25
AU2010271732A1 (en) 2012-03-08
RS53499B1 (en) 2015-02-27
AU2010271732B2 (en) 2016-08-25
EP2455381B9 (en) 2014-10-22
CO6430426A2 (es) 2012-04-30
IL217541A (en) 2014-07-31
BR112012001157A2 (pt) 2016-02-23
RU2538963C2 (ru) 2015-01-10
KR20180042443A (ko) 2018-04-25
JP2022126843A (ja) 2022-08-30
JP5021797B2 (ja) 2012-09-12
DK2455381T3 (da) 2014-07-21
HK1168346A1 (en) 2012-12-28
EP2455381A4 (en) 2012-12-12
EP3594213A1 (en) 2020-01-15
JP2016040321A (ja) 2016-03-24
CN102471337B (zh) 2014-12-10
JP2017214404A (ja) 2017-12-07
JP2019019144A (ja) 2019-02-07
ME01858B (me) 2014-12-20
JP2024091878A (ja) 2024-07-05
ES2477968T3 (es) 2014-07-18
RU2012105467A (ru) 2013-08-27
MY160814A (en) 2017-03-31
CA2768505C (en) 2018-06-12
US20130096155A1 (en) 2013-04-18
JP2012144571A (ja) 2012-08-02
KR20170018105A (ko) 2017-02-15
KR20230165366A (ko) 2023-12-05
CA2768505A1 (en) 2011-01-20
US20160145254A1 (en) 2016-05-26
KR101706803B1 (ko) 2017-02-14
JP2015003933A (ja) 2015-01-08
SG178049A1 (en) 2012-03-29
ES2477968T9 (es) 2014-11-13
WO2011007856A1 (ja) 2011-01-20
US8283465B2 (en) 2012-10-09
AR077417A1 (es) 2011-08-24
JP2011037841A (ja) 2011-02-24

Similar Documents

Publication Publication Date Title
PT2455381E (pt) Composto de triazolopiridina e sua acção como inibidor da prolil-hidroxilase e indutor da produção de eritropoietina
ZA201204104B (en) Prolyl hydroxylase inhibitors
PT2294066E (pt) Benzoimidazoles como inibidores da prolil-hidroxilase
ZA201401310B (en) Polymorphic forms of compounds as prolyl hydroxylase inhibitor,and uses thereof
AU2012289429A8 (en) Polymorphic forms of compounds as prolyl hydroxylase inhibitor, and uses thereof
EP2326178A4 (en) INHIBITORS OF PROLYL-HYDROXYLASE
IL211441A (en) Variety of endolysin, methods of manufacture and use thereof
IL212762A0 (en) Thiochromene derivatives as hif hydroxylase inhibitors
EP2273879A4 (en) PROLYLHYDROXYLASEHEMMER
PT2374802E (pt) Inibidor de produção de quinurenina
IL211018A0 (en) Novel inhibitors
EP2326179A4 (en) PROLYLHYDROXYLASEHEMMER
SI2297115T1 (sl) Dialkoksikinazolinski derivati kot inhibitorji kdr
PL2216455T3 (pl) Element łączący dla drewnianej konstrukcji zespolonej, drewniana konstrukcja zespolona i sposób jej wytwarzania
IL218967A (en) Phenyllaxadiazole derivatives as pgds barriers
EP2285778A4 (en) NIKOTINAMIDDERIVATE
EP2301922A4 (en) pyridone
TWI369343B (en) 4-trimethylammonio-butyrates as cpt2 inhibitors
SI2496236T1 (sl) Prolilhidroksilazni inhibitorji
TH0901003380A (th) สารประกอบฟีแนนธรีโนน, องค์ประกอบ และวิธี
AU2008902241A0 (en) Efflorescence Inhibitor
HK1154582A (en) Nicotinamide derivatives
AU2008901989A0 (en) Nicotinamide derivatives
AU2008902553A0 (en) Iron Mouse
GB0807881D0 (en) Oxidation process