[go: up one dir, main page]

PL2326621T3 - SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS - Google Patents

SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS

Info

Publication number
PL2326621T3
PL2326621T3 PL09788983.6T PL09788983T PL2326621T3 PL 2326621 T3 PL2326621 T3 PL 2326621T3 PL 09788983 T PL09788983 T PL 09788983T PL 2326621 T3 PL2326621 T3 PL 2326621T3
Authority
PL
Poland
Prior art keywords
tetrahydrocyclopenta
indol
autoimmune
substituted
treatment
Prior art date
Application number
PL09788983.6T
Other languages
Polish (pl)
Inventor
Robert M. Jones
Daniel J. Buzard
Sangdon Han
Sun Hee Kim
Juerg Lehmann
Brett Ullman
Jeanne V. Moody
Xiuwen Zhu
Scott Stirn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2326621T3 publication Critical patent/PL2326621T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/02—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C255/03—Mononitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
PL09788983.6T 2008-07-23 2009-07-22 SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS PL2326621T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13567208P 2008-07-23 2008-07-23
US20937409P 2009-03-06 2009-03-06

Publications (1)

Publication Number Publication Date
PL2326621T3 true PL2326621T3 (en) 2016-12-30

Family

ID=41134563

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09788983.6T PL2326621T3 (en) 2008-07-23 2009-07-22 SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS

Country Status (28)

Country Link
US (8) US8580841B2 (en)
EP (1) EP2326621B1 (en)
JP (6) JP5449351B2 (en)
KR (8) KR20180023049A (en)
CN (2) CN104311472B9 (en)
AU (1) AU2009274569C1 (en)
BR (1) BRPI0916812B8 (en)
CA (1) CA2730500C (en)
CY (1) CY1117974T1 (en)
DK (1) DK2326621T3 (en)
EA (1) EA019252B1 (en)
ES (1) ES2589731T3 (en)
FI (1) FIC20240026I1 (en)
FR (1) FR24C1031I1 (en)
HK (1) HK1157333A1 (en)
HR (1) HRP20161133T1 (en)
HU (2) HUE030424T2 (en)
IL (1) IL210577A (en)
LT (1) LT2326621T (en)
MX (2) MX2011000879A (en)
NL (1) NL301284I2 (en)
NZ (1) NZ590474A (en)
PL (1) PL2326621T3 (en)
PT (1) PT2326621T (en)
SI (1) SI2326621T1 (en)
SM (1) SMT201600317B (en)
WO (1) WO2010011316A1 (en)
ZA (1) ZA201100571B (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011506600A (en) * 2007-12-18 2011-03-03 アリーナ ファーマシューティカルズ， インコーポレイテッド Tetrahydrocyclopenta [b] indol-3-ylcarboxylic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
WO2009094157A1 (en) * 2008-01-25 2009-07-30 Arena Pharmaceuticals, Inc. Dihydro- 1h- pyrrolo [1,2-a] indol-1-yl carboxylic derivatives which act as s1p1 agonists
SI2326621T1 (en) 2008-07-23 2016-10-28 Arena Pharmaceuticals, Inc. SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA(b)INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
CA2733671C (en) 2008-08-27 2018-01-02 Arena Pharmaceuticals, Inc. Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
US9216972B2 (en) 2009-10-29 2015-12-22 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds
SG10201500639TA (en) 2010-01-27 2015-03-30 Arena Pharm Inc Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
CA2789480A1 (en) 2010-03-03 2011-09-09 Arena Pharmaceuticals, Inc. Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
US8987307B2 (en) 2011-03-03 2015-03-24 Hoffmann-La Roche Inc. 3-amino-pyridines as GPBAR1 agonists
MX2014009713A (en) 2012-04-04 2014-09-12 Hoffmann La Roche 1,2- pyridazine, 1,6- pyridazine or pyrimidine - benzamide derivatives as gpbar1 modulators.
WO2014088939A1 (en) 2012-12-06 2014-06-12 3M Innovative Properties Company Discrete coating of liquid on a liquid-coated substrate and use in forming laminates
KR102173963B1 (en) 2012-12-06 2020-11-04 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Precision coating of viscous liquids and use in forming laminates
CN116850181A (en) * 2015-01-06 2023-10-10 艾尼纳制药公司 Treatment and S1P 1 Methods of receptor-related disorders
EA201890096A1 (en) * 2015-06-22 2018-08-31 Арена Фармасьютикалз, Инк. CRYSTALLINE L-ARGININE SALT (R) -2- (7- (4-CYCLOPENTHYL-3- (TRIFTLOMETHYL) BENZYLOXY) -1,2,3,4-TETRAHYDROCYCLOPENT [b] INDOL-3-IL) ACETIC ACID ) FOR APPLICATION IN DISORDERS RELATED TO S1P RECEPTOR
WO2017004608A1 (en) 2015-07-02 2017-01-05 Exelixis, Inc. Oxadiazole modulators of s1p methods of making and using
WO2017004609A1 (en) 2015-07-02 2017-01-05 Exelixis, Inc. Thiadiazole modulators of s1p and methods of making and using
KR102482825B1 (en) 2016-09-02 2022-12-29 브리스톨-마이어스 스큅 컴퍼니 Substituted tricyclic heterocyclic compounds
MA47504A (en) * 2017-02-16 2019-12-25 Arena Pharm Inc COMPOUNDS AND TREATMENT METHODS FOR PRIMITIVE BILIARY ANGIOCHOLITIS
AU2018222747A1 (en) 2017-02-16 2019-09-05 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
EP3615003A4 (en) * 2017-04-24 2021-05-26 University Of Massachusetts Lowell DIAGNOSIS AND TREATMENT OF VITILIGO
EP3653594A4 (en) 2017-07-13 2021-03-31 Toray Fine Chemicals Co., Ltd. Production method for cycloalkyl(trifluoromethyl)benzene
US11059784B2 (en) 2017-08-09 2021-07-13 Bristol-Myers Squibb Company Oxime ether compounds
US11046646B2 (en) 2017-08-09 2021-06-29 Bristol-Myers Squibb Company Alkylphenyl compounds
JP7397011B2 (en) 2018-06-06 2023-12-12 アリーナ ファーマシューティカルズ， インコーポレイテッド Methods of treating conditions associated with S1P1 receptors
US11555015B2 (en) 2018-09-06 2023-01-17 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
ES2951870T3 (en) * 2018-10-03 2023-10-25 Arena Pharm Inc Etrasimod for use in procedures for the treatment of scleroderma
CA3120706A1 (en) * 2018-11-30 2020-06-04 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
EP3892616A4 (en) * 2018-12-06 2022-07-27 Shanghai Jemincare Pharmaceuticals Co., Ltd. Aromatic ring derivative as immunoregulation and preparation method and application of aromatic ring derivative
JP2022516662A (en) 2019-01-08 2022-03-01 アリーナ ファーマシューティカルズ， インコーポレイテッド How to treat conditions associated with the S1P1 receptor
CN115038438A (en) * 2019-10-01 2022-09-09 艾尼纳制药公司 Methods of treating disorders associated with S1P1 receptors
JP2023501217A (en) 2019-10-31 2023-01-18 イドーシア ファーマシューティカルズ リミテッド Combinations of CXCR7 antagonists with S1P1 receptor modulators
AU2020389144A1 (en) 2019-11-20 2022-06-09 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
JPWO2021157682A1 (en) 2020-02-06 2021-08-12
WO2022002225A1 (en) * 2020-07-03 2022-01-06 上海美迪西生物医药股份有限公司 Indole derivative and application thereof
KR20230106644A (en) * 2020-11-09 2023-07-13 아레나 파마슈티칼스, 인크. How to Treat Conditions Associated with the S1P1 Receptor
CN112812052B (en) * 2021-02-02 2023-12-01 成都阿奇生物医药科技有限公司 Compound for treating ulcerative colitis and preparation method and application thereof
EP4450488A4 (en) * 2021-12-17 2025-03-26 Shanghai Jemincare Pharmaceutical Co Ltd CRYSTALLINE FORM OF AN AROMATIC RING DERIVATIVE, PRODUCTION PROCESS AND USE THEREOF
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator
CN118541151A (en) 2022-01-13 2024-08-23 艾尼纳制药公司 Is Qu Mode for use in combination with hormonal therapy for the treatment of S1P1 receptor related disorders
WO2023170585A1 (en) * 2022-03-09 2023-09-14 Arena Pharmaceuticals, Inc. Novel s1p1 receptor agonist, crystalline salts, processes for preparing, and uses related thereto
WO2023214312A1 (en) 2022-05-06 2023-11-09 Arena Pharmaceuticals, Inc. Methods of treating atopic dermatitis with etrasimod
WO2025007928A1 (en) * 2023-07-05 2025-01-09 苏州湃芮生物科技有限公司 Indole compound, preparation method therefor and use thereof
CN116854622A (en) * 2023-07-10 2023-10-10 青岛科技大学 Synthesis method of polysubstituted 2, 4-dihydro-cyclopenta [ b ] indole compound

Family Cites Families (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL293572A (en) 1962-06-07
US3843681A (en) * 1971-06-01 1974-10-22 American Home Prod 1-carboxamido pyrano(thiopyrano)(3,4-6)indole derivatives
DE2226703A1 (en) 1972-05-25 1973-12-13 Schering Ag NEW TETRAHYDROCARBAZOLE DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION
US4057559A (en) * 1973-10-01 1977-11-08 American Home Products Corporation Carbazole acetic acid derivatives
US4810699A (en) * 1987-02-20 1989-03-07 American Home Products Corporation Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them
US4782076A (en) * 1988-03-01 1988-11-01 American Home Products Corporation Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives, composition and use
PT95692A (en) * 1989-10-27 1991-09-13 American Home Prod PROCESS FOR THE PREPARATION OF INDOLE-, INDENO-, PYRANOINDOLE- AND TETRA-HYDROCARBAZOLE-ALCANOIC ACID DERIVATIVES, OR WHICH ARE USEFUL AS PLA2 INHIBITORS AND LIPOXIGENASE
US5221678A (en) * 1990-07-26 1993-06-22 Merck Frosst Canada, Inc. (quinolin-2-ylmethoxy)tetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes
US5998499A (en) 1994-03-25 1999-12-07 Dentsply G.M.B.H. Liquid crystalline (meth)acrylate compounds, composition and method
US5776967A (en) * 1996-07-26 1998-07-07 American Home Products Corporation Pyranoindole inhibitors of COX--2
US5830911A (en) 1996-08-14 1998-11-03 American Home Products Corporation Pyranoindole and tetrahydrocarbazole inhibitors of COX-2
US6861448B2 (en) * 1998-01-14 2005-03-01 Virtual Drug Development, Inc. NAD synthetase inhibitors and uses thereof
JP4038266B2 (en) * 1998-02-17 2008-01-23 オイレス工業株式会社 Viscous shear damper
IL145922A0 (en) 1999-04-28 2002-07-25 Aventis Pharma Gmbh Di-aryl acid derivatives as ppar receptor ligands
US6410583B1 (en) * 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
WO2002039987A2 (en) 2000-11-14 2002-05-23 Neurosearch A/S Use of malaria parasite anion channel blockers for treating malaria
AU2002237988B2 (en) 2001-01-30 2008-01-03 University Of Virginia Patent Foundation Agonists and antagonists of sphingosine-1-phosphate receptors
KR100876047B1 (en) * 2001-03-29 2008-12-26 오사까 가스 가부시키가이샤 Photoactive Compound and Photosensitive Resin Composition
CA2446593A1 (en) * 2001-05-10 2002-11-21 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives and pharmaceutical compositions comprising the same as an active ingredient
JP4217620B2 (en) 2001-09-27 2009-02-04 杏林製薬株式会社 Diaryl sulfide derivatives and their addition salts and immunosuppressants
EP1469863A2 (en) 2002-01-18 2004-10-27 Merck & Co., Inc. Selective s1p1/edg1 receptor agonists
EP1470137B1 (en) * 2002-01-18 2009-09-02 Merck & Co., Inc. Edg receptor agonists
CA2473441A1 (en) * 2002-01-18 2003-07-24 The Genetics Company Inc. Beta-secretase inhibitors
CA2477449A1 (en) 2002-03-01 2003-09-12 Merck & Co., Inc. Aminoalkylphosphonates and related compounds as edg receptor agonists
CA2477423A1 (en) 2002-03-01 2003-09-12 Merck & Co., Inc. Aminoalkylphosphonates and related compounds as edg receptor agonists
JP2005533058A (en) 2002-06-17 2005-11-04 メルク　エンド　カムパニー　インコーポレーテッド 1-((5-Aryl-1,2,4-oxadiazol-3-yl) benzyl) azetidine-3-carboxylate and 1-((5-aryl-1,2,4) as EDG receptor agonists -Oxadiazol-3-yl) benzyl) pyrrolidine-3-carboxylate
AU2003252478A1 (en) * 2002-07-10 2004-02-02 Ono Pharmaceutical Co., Ltd. Ccr4 antagonist and medicinal use thereof
CA2533587A1 (en) 2002-07-30 2004-02-05 University Of Virginia Patent Foundation Compounds active in sphingosine 1-phosphate signaling
AU2003277576A1 (en) * 2002-11-08 2004-06-07 Takeda Pharmaceutical Company Limited Receptor function controlling agent
AU2003297232B2 (en) 2002-12-20 2010-02-04 Merck Sharp & Dohme Corp. 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles
US7256206B2 (en) 2003-02-11 2007-08-14 Irm Llc Bicyclic compounds and compositions
EP2172472B1 (en) * 2003-02-18 2012-12-26 Kyorin Pharmaceutical Co., Ltd. Aminophosphonic acid derivative, salt thereof and modulator of S1P receptor
ATE547395T1 (en) 2003-04-30 2012-03-15 Novartis Pharma Gmbh AMINOPROPANOL DERIVATIVES AS MODULATORS OF THE SPHINGOSINE-1 PHOSPHATE RECEPTOR
JP2006525366A (en) * 2003-04-30 2006-11-09 ジ インスチチュート フォー ファーマシューティカル ディスカバリー、エルエルシー Heterocyclic carboxylic acid substituent
MXPA05011597A (en) * 2003-04-30 2005-12-15 Novartis Ag Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators.
WO2004103279A2 (en) 2003-05-15 2004-12-02 Merck & Co., Inc. 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists
WO2004104205A2 (en) 2003-05-16 2004-12-02 Merck & Co., Inc. Enzymatic preparation of chiral indole esters
ES2558761T3 (en) 2003-05-19 2016-02-08 Novartis Ag Immunosuppressive compounds and compositions
WO2004103309A2 (en) * 2003-05-19 2004-12-02 Irm Llc Immunosuppressant compounds and compositions
EP2644195A1 (en) * 2003-05-19 2013-10-02 Irm Llc Immunosuppressant Compounds and Compositions
MY150088A (en) * 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
GB0313612D0 (en) 2003-06-12 2003-07-16 Novartis Ag Organic compounds
JPWO2005012221A1 (en) * 2003-08-04 2006-09-14 小野薬品工業株式会社 Diphenyl ether compound, its production method and use
ATE449069T1 (en) 2003-08-28 2009-12-15 Novartis Pharma Gmbh AMINOPROPANOL DERIVATIVES
WO2005020882A2 (en) 2003-08-29 2005-03-10 Ono Pharmaceutical Co Compound capable of binding s1p receptor and pharmaceutical use thereof
US7825109B2 (en) * 2003-08-29 2010-11-02 Ono Pharmaceutical Co., Ltd. Compound capable of binding S1P receptor and pharmaceutical use thereof
JPWO2005023771A1 (en) * 2003-09-05 2006-11-02 小野薬品工業株式会社 Chemokine receptor antagonist and its pharmaceutical use
CA2539438A1 (en) 2003-10-01 2005-04-14 Merck And Co., Inc. 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists
WO2005041899A2 (en) 2003-11-03 2005-05-12 University Of Virginia Patent Foundation Orally available sphingosine 1-phosphate receptor agonists and antagonists
WO2005044780A1 (en) 2003-11-10 2005-05-19 Kyorin Pharmaceutical Co., Ltd. Aminocarboxylic acid derivative, addition salt thereof, and s1p receptor control agent
EP1697333A4 (en) 2003-12-17 2009-07-08 Merck & Co Inc (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists
EP1695955B1 (en) * 2003-12-19 2011-10-12 Ono Pharmaceutical Co., Ltd. Compounds having lysophosphatidic acid receptor antagonism and uses thereof
GB0329498D0 (en) 2003-12-19 2004-01-28 Novartis Ag Organic compounds
GB0401332D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
RU2332212C2 (en) 2004-02-24 2008-08-27 Санкио Компани, Лимитед Aminoalcohol
WO2005082841A1 (en) 2004-02-24 2005-09-09 Irm Llc Immunosuppressant compounds and compositions
TW200538433A (en) 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
WO2005085214A1 (en) * 2004-03-05 2005-09-15 Banyu Pharmaceutical Co., Ltd Diaryl-substituted five-membered heterocycle derivative
GB0405289D0 (en) 2004-03-09 2004-04-21 Novartis Ag Organic compounds
BRPI0509384A (en) 2004-04-02 2007-09-18 Merck & Co Inc asymmetric hydrogenation process for the preparation of a compound or a salt thereof, and a compound or a salt thereof
WO2005123677A1 (en) 2004-06-16 2005-12-29 Actelion Pharmaceuticals Ltd 4-carbonyl substituted 1,1,2-trimethyl-1a,4,5,5a-tetrahydro-1h-4-aza-cyclopropa'a!pentalene derivatives as agonists for the g-protein-coupled receptor s1p1/edg1 and immunosuppressive agents
EP1760071A4 (en) 2004-06-23 2008-03-05 Ono Pharmaceutical Co Compound having s1p receptor binding potency and use thereof
WO2006009092A1 (en) 2004-07-16 2006-01-26 Kyorin Pharmaceutical Co., Ltd. Method of effectively using medicine and method concerning prevention of side effect
JP2007284350A (en) * 2004-07-27 2007-11-01 Takeda Chem Ind Ltd Therapeutic agent for diabetes
WO2006010379A1 (en) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
TW200611687A (en) 2004-07-29 2006-04-16 Sankyo Co Pharmaceutical compositions used for immunosuppressant
WO2006013948A1 (en) 2004-08-04 2006-02-09 Taisho Pharmaceutical Co., Ltd. Triazole derivative
US20060223866A1 (en) 2004-08-13 2006-10-05 Praecis Pharmaceuticals, Inc. Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
KR20070058455A (en) 2004-08-13 2007-06-08 프래시스 파마슈티컬즈 인코포레이티드 Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
EP1793819A2 (en) 2004-09-23 2007-06-13 Wyeth a Corporation of the State of Delaware Carbazole and cyclopentaindole derivatives to treat infection with hepatitis c virus
JP2008515987A (en) * 2004-10-12 2008-05-15 フォーブス メディ−テック（リサーチ） インコーポレーテッド Compounds and methods for treating insulin resistance and myocardial myopathy
WO2006047195A2 (en) 2004-10-22 2006-05-04 Merck & Co., Inc. 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as s1p receptor agonists
ATE397582T1 (en) 2004-10-22 2008-06-15 Bioprojet Soc Civ NEW DICARBONIC ACID DERIVATIVES
EP1844043A2 (en) * 2004-11-18 2007-10-17 The Institutes for Pharmaceutical Discovery, LLC Heterocycle substituted carboxylic acids for the treatment of diabetes
US20080051418A1 (en) * 2004-11-26 2008-02-28 Tsuyoshi Maekawa Arylalkanoic Acid Derivative
MX2007006706A (en) 2004-12-06 2007-10-18 Univ Virginia Aryl amide sphingosine 1-phosphate analogs.
WO2006064757A1 (en) 2004-12-13 2006-06-22 Ono Pharmaceutical Co., Ltd. Aminocarboxylic acid derivative and medicinal use thereof
WO2006079406A1 (en) 2005-01-25 2006-08-03 Merck Patent Gmbh Mesogenic compounds, liquid crystal medium and liquid crystal display
CA2596990A1 (en) 2005-02-14 2006-08-24 University Of Virginia Patent Foundation Sphingosine 1-phosphate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups
MX2007011672A (en) 2005-03-23 2007-11-15 Actelion Pharmaceuticals Ltd NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-l-PHOSPHATE-1 RECEPTOR AGONISTS.
ES2365747T3 (en) 2005-03-23 2011-10-10 Actelion Pharmaceuticals Ltd. BENZO [C] THIOPHENE HYDROGEN DERIVED AS IMMUNOMODULATORS.
US7846964B2 (en) 2005-03-23 2010-12-07 Actelion Pharmaceuticals Ltd. Thiophene derivatives as spingosine-1-phosphate-1 receptor agonists
MX2007015422A (en) 2005-06-08 2008-02-21 Novartis Ag POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS.
TWI418350B (en) * 2005-06-24 2013-12-11 Sankyo Co Use of pharmaceutical compositions comprising ppar modulator
WO2006137019A1 (en) 2005-06-24 2006-12-28 Actelion Pharmaceuticals Ltd Novel thiophene derivatives
US20070060573A1 (en) * 2005-08-10 2007-03-15 Lars Wortmann Acyltryptophanols
US20090221547A1 (en) 2005-08-23 2009-09-03 Irm Llc Immunosuppressant Compounds and Compositions
JPWO2007037196A1 (en) 2005-09-29 2009-04-09 山本化成株式会社 Indoline compound and method for producing the same
AR057894A1 (en) 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd THIOPHEN DERIVATIVES
WO2007061458A2 (en) 2005-11-23 2007-05-31 Epix Delaware, Inc. S1p receptor modulating compounds and use thereof
TWI404706B (en) 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd Novel thiophene derivatives
TW200736234A (en) 2006-01-17 2007-10-01 Astrazeneca Ab Chemical compounds
EP1979345B1 (en) 2006-01-24 2009-11-04 Actelion Pharmaceuticals Ltd. Novel pyridine derivatives
GB0601744D0 (en) 2006-01-27 2006-03-08 Novartis Ag Organic compounds
TWI389683B (en) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
TW200806611A (en) 2006-02-09 2008-02-01 Daiichi Seiyaku Co Novel amidopropionic acid derivatives and medicine containing the same
CA2641718A1 (en) 2006-02-09 2007-08-16 University Of Virginia Patent Foundation Bicyclic sphingosine 1-phosphate analogs
US20070191371A1 (en) * 2006-02-14 2007-08-16 Kalypsys, Inc. Heterocyclic modulators of ppar
CN101460458A (en) * 2006-02-15 2009-06-17 阿勒根公司 Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
EP1984334B1 (en) 2006-02-15 2014-04-09 Allergan, Inc. Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (s1p) receptor antagonist biological activity
RU2008137553A (en) 2006-02-21 2010-03-27 Юниверсити Оф Вирджиния Пэтент Фаундейшн (Us) Phenyl Cycloalkyl Compounds Containing Heterocyclic Structures
US7649098B2 (en) 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
AU2007225208A1 (en) * 2006-03-14 2007-09-20 Amgen Inc. Bicyclic carboxylic acid derivatives useful for treating metabolic disorders
AR060050A1 (en) 2006-03-21 2008-05-21 Epix Delaware Inc MODULATING COMPOUNDS OF THE S1P RECEIVER AND USE OF THE SAME
JP2007262009A (en) 2006-03-29 2007-10-11 Dai Ichi Seiyaku Co Ltd Heteroaryl lower carboxylic acid derivative
MX356221B (en) 2006-04-03 2018-05-18 Astellas Pharma Inc Hetero compound.
GB0607389D0 (en) 2006-04-12 2006-05-24 Novartis Ag Organic compounds
JPWO2007129745A1 (en) 2006-05-09 2009-09-17 第一三共株式会社 Heteroarylamide lower carboxylic acid derivatives
WO2007129473A1 (en) 2006-05-09 2007-11-15 Daiichi Sankyo Company, Limited Bicyclic aryl derivative
MX2008013990A (en) 2006-05-09 2009-01-29 Pfizer Prod Inc Cycloalkylamino acid derivatives and pharmaceutical compositions thereof.
AR062156A1 (en) 2006-08-01 2008-10-22 Praecis Pharm Inc S1P-1 RECEPTOR AGONIST AND SELECTIVE COMPOUNDS
US20080070866A1 (en) 2006-08-01 2008-03-20 Praecis Pharmaceuticals Incorporated Chemical compounds
EP2099768A2 (en) 2006-08-04 2009-09-16 Praecis Pharmaceuticals Incorporated Agonists of the sphingosine-1-phosphate receptor
ES2438265T3 (en) 2006-08-08 2014-01-16 Kyorin Pharmaceutical Co., Ltd. Aminophosphoric acid ester derivative and S1P receptor modulator containing it as active ingredient
JP2010501555A (en) 2006-08-24 2010-01-21 プリーシス・ファーマシューティカルズ・インコーポレイテッド S1P-1 receptor agonist
JP2009269819A (en) 2006-08-25 2009-11-19 Asahi Kasei Pharma Kk Amine compound
AR061841A1 (en) 2006-09-07 2008-09-24 Actelion Pharmaceuticals Ltd DERIVATIVES OF THIOFEN-OXADIAZOLS, AGONISTS OF THE S1P1 / EDG1 RECEPTOR, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES AS IMMUNOMODULATING AGENTS.
WO2008030843A1 (en) 2006-09-07 2008-03-13 Allergan, Inc. Heteroaromatic compounds having sphingosine-1-phosphate (s1p) receptor agonist and/or antagonist biological activity
MY149853A (en) 2006-09-07 2013-10-31 Actelion Pharmaceuticals Ltd Pyridin-4-yl derivatives as immunomodulating agents
BRPI0716598A2 (en) 2006-09-08 2013-12-10 Novartis Ag N-BIARILA (HETERO) ARYLPHONAMIDE DERIVATIVES USEFUL IN TREATMENT OF DISEASES MEASURED BY LYMPHOCYTE INTERACTIONS
AU2007298593A1 (en) 2006-09-21 2008-03-27 Actelion Pharmaceuticals Ltd Phenyl derivatives and their use as immunomodulators
RU2009127095A (en) 2006-12-15 2011-01-20 Эбботт Лэборетриз (Us) NEW OXADIAZOLE COMPOUNDS
TW200838497A (en) 2006-12-21 2008-10-01 Abbott Lab Sphingosine-1-phosphate receptor agonist and antagonist compounds
JO2701B1 (en) 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Compounds
GB0625648D0 (en) 2006-12-21 2007-01-31 Glaxo Group Ltd Compounds
AU2008206495A1 (en) 2007-01-11 2008-07-24 Allergan, Inc. 6-substituted indole-3-carboxylic acid amide compounds having Sphingosine-1-Phosphate (S1P) receptor antagonist biological activity
WO2008091967A1 (en) 2007-01-26 2008-07-31 Smithkline Beecham Corporation Chemical compounds
WO2008097819A2 (en) 2007-02-05 2008-08-14 Smithkline Beecham Corporation Chemical compounds
EP2125797B1 (en) 2007-03-16 2014-01-15 Actelion Pharmaceuticals Ltd. Amino- pyridine derivatives as s1p1 /edg1 receptor agonists
MX2009010060A (en) 2007-03-21 2010-01-20 Epix Pharm Inc Sip receptor modulating compounds and use thereof.
AU2008240773B2 (en) 2007-04-19 2013-10-03 Glaxo Group Limited Oxadiazole substituted indazole derivatives for use as sphingosine 1-phosphate (S1P) agonists
EP2014653A1 (en) 2007-06-15 2009-01-14 Bioprojet Novel dicarboxylic acid derivatives as S1P1 receptor agonists
US20090069288A1 (en) 2007-07-16 2009-03-12 Breinlinger Eric C Novel therapeutic compounds
WO2009019506A1 (en) 2007-08-03 2009-02-12 Astrazeneca Ab Heterocyclyc sulfonamides having edg-1 antagonistic activity
US8399448B2 (en) 2007-08-08 2013-03-19 Merck Serono Sa 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis
TW200930368A (en) 2007-11-15 2009-07-16 Astrazeneca Ab Bis-(sulfonylamino) derivatives in therapy
JP2011506600A (en) * 2007-12-18 2011-03-03 アリーナ ファーマシューティカルズ， インコーポレイテッド Tetrahydrocyclopenta [b] indol-3-ylcarboxylic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
WO2009094157A1 (en) 2008-01-25 2009-07-30 Arena Pharmaceuticals, Inc. Dihydro- 1h- pyrrolo [1,2-a] indol-1-yl carboxylic derivatives which act as s1p1 agonists
AR070398A1 (en) 2008-02-22 2010-03-31 Gruenenthal Chemie INDOL SUBSTITUTED DERIVATIVES
DK2291080T3 (en) 2008-05-14 2015-12-07 Scripps Research Inst Novel modulator of sphingosinphosphatreceptorer
WO2009151626A1 (en) 2008-06-13 2009-12-17 Arena Pharmaceuticals, Inc. Substituted (1, 2, 4-0xadiaz0l-3-yl) indolin-1-yl carboxylic acid derivatives useful as s1p1 agonists
WO2009151621A1 (en) 2008-06-13 2009-12-17 Arena Pharmaceuticals, Inc. Substituted (1, 2, 4-0xadiaz0l-3-yl) indolin-1-yl carboxylic acid derivatives useful as s1p1 agonists
SI2326621T1 (en) * 2008-07-23 2016-10-28 Arena Pharmaceuticals, Inc. SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA(b)INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
CA2733671C (en) 2008-08-27 2018-01-02 Arena Pharmaceuticals, Inc. Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
US20100216762A1 (en) 2009-02-10 2010-08-26 Abbott Laboratories Agonists and Antagonists of the S1P5 Receptor, and Methods of Use Thereof
WO2011005290A1 (en) 2009-06-23 2011-01-13 Arena Pharmaceuticals, Inc. Disubstituted oxadiazole derivatives useful in the treatment of autoimmune and inflammatory disorders
WO2011005295A1 (en) 2009-06-24 2011-01-13 Arena Pharmaceuticals, Inc. Modulators of the sphingosine-1-phosphate (s1p) receptor useful for the treatment of disorders related thereto
US9216972B2 (en) 2009-10-29 2015-12-22 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds
SG10201500639TA (en) 2010-01-27 2015-03-30 Arena Pharm Inc Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
CA2789480A1 (en) 2010-03-03 2011-09-09 Arena Pharmaceuticals, Inc. Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
WO2012015758A2 (en) 2010-07-30 2012-02-02 Saint Louis University Methods of treating pain

Also Published As

Publication number Publication date
KR20220084423A (en) 2022-06-21
JP2016029067A (en) 2016-03-03
EA201170251A1 (en) 2011-08-30
DK2326621T3 (en) 2016-09-12
US20230257349A1 (en) 2023-08-17
FR24C1031I1 (en) 2024-08-30
JP2014144948A (en) 2014-08-14
US9522133B2 (en) 2016-12-20
KR20210099206A (en) 2021-08-11
IL210577A (en) 2015-04-30
HRP20161133T1 (en) 2016-12-02
HK1157333A1 (en) 2012-06-29
AU2009274569B2 (en) 2014-11-13
SMT201600317B (en) 2016-11-10
AU2009274569C1 (en) 2015-06-25
CA2730500A1 (en) 2010-01-28
CN102164891B (en) 2014-09-03
JP2019206570A (en) 2019-12-05
WO2010011316A1 (en) 2010-01-28
KR20110034675A (en) 2011-04-05
BRPI0916812A2 (en) 2020-09-15
IL210577A0 (en) 2011-03-31
MX2011000879A (en) 2011-06-20
AU2009274569A1 (en) 2010-01-28
BRPI0916812B1 (en) 2021-11-09
MX354134B (en) 2018-02-14
US8580841B2 (en) 2013-11-12
FIC20240026I1 (en) 2024-07-18
US9126932B2 (en) 2015-09-08
KR20190132565A (en) 2019-11-27
KR20190004843A (en) 2019-01-14
BRPI0916812B8 (en) 2022-10-18
US20150335618A1 (en) 2015-11-26
US20140038987A1 (en) 2014-02-06
CY1117974T1 (en) 2017-05-17
PT2326621T (en) 2016-09-12
US20110130409A1 (en) 2011-06-02
JP2018090603A (en) 2018-06-14
CN104311472A (en) 2015-01-28
NL301284I2 (en) 2024-09-04
JP2011529049A (en) 2011-12-01
SI2326621T1 (en) 2016-10-28
CN102164891A (en) 2011-08-24
ZA201100571B (en) 2012-06-27
CN104311472B (en) 2019-12-31
HUS2400026I1 (en) 2024-08-28
CN104311472B9 (en) 2020-03-17
KR20180023049A (en) 2018-03-06
JP5449351B2 (en) 2014-03-19
US20250074874A1 (en) 2025-03-06
ES2589731T3 (en) 2016-11-16
KR20200117058A (en) 2020-10-13
US20170217885A1 (en) 2017-08-03
KR101728374B1 (en) 2017-04-19
CA2730500C (en) 2017-11-28
JP2021107425A (en) 2021-07-29
EA019252B1 (en) 2014-02-28
US20190135752A1 (en) 2019-05-09
EP2326621B1 (en) 2016-06-08
HUE030424T2 (en) 2017-05-29
LT2326621T (en) 2016-09-26
EP2326621A1 (en) 2011-06-01
NZ590474A (en) 2012-10-26
US20200407316A1 (en) 2020-12-31
KR20170044760A (en) 2017-04-25

Similar Documents

Publication Publication Date Title
HK1157333A1 (en) Substituted 1,2,3,4- tetrahydrocyclopenta[b]indol-3-yl) acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders 1234-[b]-3-
HK1219306A1 (en) Methods and compositions for sleep disorders and other disorders
IL233869A0 (en) Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
IL184356A0 (en) Indoles useful in the treatment of inflammation
IL195906A0 (en) Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
HK1155168A1 (en) Oxo-heterocyclic substituted carboxylic acid derivates and the use thereof
ZA200907215B (en) Uses of oligomers of lactic acid in the treatment of gynaecological disorders
IL200444A (en) (3-fluoroalkyl-pyrazol-4-yl)-nitrile derivatives and their use for producing (3-fluoroalkyl-pyrazol-4-yl)-carboxylic acid derivatives
IL206880A0 (en) Cadherin-11 antagonists and methods for the treatment of inflammatory joint disorders
HK1127608A1 (en) Piperazinyl derivatives useful in the treatment of gpr38 receptor mediated diseases
PT1994005E (en) Tetrahydronaphthaline derivatives, methods for the production and use thereof as anti-inflammatory agents
HK1146221A1 (en) Alpha-aminoamide derivatives useful in the treatment of psychiatric disorders
HK1134032A1 (en) New combination for use in the treatment of inflammatory disorders
ZA201108106B (en) Use of phthalimide derivatives in the treatment of diseases
EP1744740A4 (en) Phenoxyalkycarboxylic acid derivatives in the treatment of inflammatory diseases
ZA201007763B (en) 1-amino-alkylcyclohexane derivatives for the treatment of sleep disorders
RS55143B1 (en) Substituted 1,2,3,4- tetrahydrocyclopenta[b]indol-3-yl) acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
IL206128A0 (en) Use of 4-oxobutanoic acid derivatives in the treatment of pathologies associated with immunological disorders
IL246841A0 (en) [2.2.2] bicyclic derivatives and methods of use
ZA200904249B (en) New combination for use in the treatment of inflammatory disorders
TH0801004418A (en) 2,3-substituted indole derivatives and methods of their use
ZA200810373B (en) Piperazinyl derivatives useful in the treatment of GPR38 receptor mediated diseases