[go: up one dir, main page]

PL2089511T3 - Rozrost in vitro komórek pochodzących z tkanki pępowinowej wykorzystujących mikronośniki - Google Patents

Rozrost in vitro komórek pochodzących z tkanki pępowinowej wykorzystujących mikronośniki

Info

Publication number
PL2089511T3
PL2089511T3 PL07867434T PL07867434T PL2089511T3 PL 2089511 T3 PL2089511 T3 PL 2089511T3 PL 07867434 T PL07867434 T PL 07867434T PL 07867434 T PL07867434 T PL 07867434T PL 2089511 T3 PL2089511 T3 PL 2089511T3
Authority
PL
Poland
Prior art keywords
microcarriers
postpartum
derived cells
vitro expansion
vitro
Prior art date
Application number
PL07867434T
Other languages
English (en)
Inventor
Alexander M Harmon
Klaudyne L S Hong
Anthony J Kihm
Anna Gosiewska
Original Assignee
Depuy Synthes Products Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Depuy Synthes Products Llc filed Critical Depuy Synthes Products Llc
Publication of PL2089511T3 publication Critical patent/PL2089511T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16—Particles; Beads; Granular material; Encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
PL07867434T 2006-11-13 2007-11-13 Rozrost in vitro komórek pochodzących z tkanki pępowinowej wykorzystujących mikronośniki PL2089511T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86555806P 2006-11-13 2006-11-13
EP07867434.8A EP2089511B1 (en) 2006-11-13 2007-11-13 In vitro expansion of postpartum-derived cells using microcarriers
PCT/US2007/023846 WO2008060541A2 (en) 2006-11-13 2007-11-13 In vitro expansion of postpartum-derived cells using microcarriers

Publications (1)

Publication Number Publication Date
PL2089511T3 true PL2089511T3 (pl) 2015-02-27

Family

ID=39402235

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07867434T PL2089511T3 (pl) 2006-11-13 2007-11-13 Rozrost in vitro komórek pochodzących z tkanki pępowinowej wykorzystujących mikronośniki

Country Status (9)

Country Link
US (1) US9102915B2 (pl)
EP (1) EP2089511B1 (pl)
JP (2) JP5670053B2 (pl)
CN (1) CN101611139B (pl)
AU (1) AU2007319820B2 (pl)
CA (1) CA2669589C (pl)
ES (1) ES2524443T3 (pl)
PL (1) PL2089511T3 (pl)
WO (1) WO2008060541A2 (pl)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002354893A1 (en) * 2001-07-20 2003-03-03 Technion Research And Development Foundation Ltd. Methods of generating human cardiac cells and tissues and uses thereof
US9579351B2 (en) 2003-06-27 2017-02-28 DePuy Synthes Products, Inc. Postpartum cells derived from placental tissue, and methods of making and using the same
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US8491883B2 (en) 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
DK1835924T3 (da) 2004-12-23 2013-11-04 Ethicon Inc Behandling af parkinsons sygdom og beslægtede sygdomme under anvendelse af postpartum opnåede celler
ES2621847T3 (es) 2004-12-23 2017-07-05 DePuy Synthes Products, Inc. Células posparto derivadas de tejido de cordón umbilical, y métodos de elaboración y uso de las mismas
CA2856662C (en) 2005-10-13 2017-09-05 Anthrogenesis Corporation Immunomodulation using placental stem cells
JP5289970B2 (ja) 2005-12-16 2013-09-11 エシコン・インコーポレイテッド 組織適合性不適合な移植における逆免疫反応を抑制するための組成物および方法
US8741638B2 (en) * 2005-12-19 2014-06-03 DePuy Synthes Products, LLC In vitro expansion of postpartum-derived cells in roller bottles
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
PT2471906T (pt) 2005-12-29 2019-02-06 Celularity Inc Populações de células estaminais da placenta
DK2078073T3 (da) 2006-10-12 2013-10-28 Ethicon Inc Nyreafledte celler og fremgangsmåder til anvendelse deraf til vævsreparation og -regenerering
PL2089511T3 (pl) 2006-11-13 2015-02-27 Depuy Synthes Products Llc Rozrost in vitro komórek pochodzących z tkanki pępowinowej wykorzystujących mikronośniki
CN101657206B (zh) 2007-02-12 2013-07-03 人类起源公司 利用胎盘干细胞治疗炎性疾病
US8399253B2 (en) * 2007-04-28 2013-03-19 Hyunjin Yang Proliferation culture methods using micro-scaffolds for regulations of cell-to-cell signals
EP3524253A1 (en) 2007-09-28 2019-08-14 Celularity, Inc. Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
PT103843B (pt) * 2007-10-04 2008-08-12 Medinfar Produtos Farmaceutico Método de isolamento de células precursoras a partir do cordão umbilical humano
EP2203186B1 (en) 2007-10-05 2014-09-24 DePuy Synthes Products, LLC Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells
US8236538B2 (en) 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
US20090233334A1 (en) * 2008-03-11 2009-09-17 Excellgene Sa Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale
US20120028352A1 (en) * 2008-03-17 2012-02-02 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
US8691569B2 (en) * 2008-03-17 2014-04-08 Agency For Science, Technology And Research Microcarriers for stem cell culture
US8828720B2 (en) * 2008-03-17 2014-09-09 Agency For Science, Technology And Research Microcarriers for stem cell culture
US8716018B2 (en) 2008-03-17 2014-05-06 Agency For Science, Technology And Research Microcarriers for stem cell culture
US9458431B2 (en) 2008-03-17 2016-10-04 Agency For Science, Technology And Research Microcarriers for stem cell culture
US20120219531A1 (en) * 2008-03-17 2012-08-30 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
WO2010021715A1 (en) 2008-08-20 2010-02-25 Anthrogenesis Corporation Treatment of stroke using isolated placental cells
MX339624B (es) 2008-08-20 2016-06-02 Anthrogenesis Corp Composiciones mejoradas de celulas y metodos para preparar las mismas.
ES2426241T3 (es) 2008-08-22 2013-10-22 Anthrogenesis Corporation Métodos y composiciones para el tratamiento de defectos óseos con poblaciones de células placentarias
RU2562154C2 (ru) 2008-11-19 2015-09-10 Антродженезис Корпорейшн Амниотические адгезивные клетки
US20100151575A1 (en) * 2008-12-15 2010-06-17 Colter David C Method of Making Conditioned Media from Kidney Derived Cells
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
BRPI0923068B1 (pt) 2008-12-19 2021-05-25 Advanced Technologies And Regenerative Medicine, Llc Uso de células derivadas de tecido de cordão umbilical para tratar um paciente tendo uma doença, distúrbio ou injúria pulmonar
WO2010111663A1 (en) 2009-03-26 2010-09-30 Ethicon, Inc. Human umbilical cord tissue cells as therapy for alzheimer' s disease
US20100247495A1 (en) * 2009-03-30 2010-09-30 Tom Ichim Treatment of Muscular Dystrophy
US20120189702A1 (en) * 2009-08-06 2012-07-26 Albert Einstein College Of Medicine Of Yeshiva University Cell therapy for treatment of liver failure
US8278101B2 (en) * 2009-12-07 2012-10-02 Synthecon, Inc. Stem cell bioprocessing and cell expansion
EP3284818B1 (en) 2010-01-26 2022-03-09 Celularity Inc. Treatment of bone-related cancers using placental stem cells
RS55287B1 (sr) 2010-04-07 2017-03-31 Anthrogenesis Corp Angiogeneza korišćenjem matičnih ćelija iz placente
TW201138792A (en) 2010-04-08 2011-11-16 Anthrogenesis Corp Treatment of sarcoidosis using placental stem cells
CA3071304C (en) * 2010-05-25 2023-09-05 Cook Biotech Incorporated Methods, substrates, and systems useful for cell seeding of medical grafts
CN102146356A (zh) * 2010-06-24 2011-08-10 辽宁成大生物股份有限公司 一种再生微载体的方法
AU2011279201B2 (en) 2010-07-13 2016-01-21 Celularity Inc. Methods of generating natural killer cells
EP2606115A4 (en) * 2010-08-16 2017-07-19 Kiyatec Inc. Bioreactor system
WO2012092485A1 (en) 2010-12-31 2012-07-05 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory rna molecules
JP2012165719A (ja) * 2011-02-16 2012-09-06 National Institute Of Advanced Industrial Science & Technology 擬微小重力環境下での三次元癌組織モデルの構築方法
WO2012166844A2 (en) 2011-06-01 2012-12-06 Anthrogenesis Corporation Treatment of pain using placental stem cells
US20140170748A1 (en) 2012-12-14 2014-06-19 DePuy Synthes Products, LLC Nutrient Enriched Media for hUTC Growth
CN105142651A (zh) 2013-02-05 2015-12-09 人类起源公司 来自胎盘的自然杀伤细胞
EP3489644A1 (en) * 2013-02-19 2019-05-29 Abbott Point Of Care, Inc. Biologic fluid sample analysis cartridge with non-reflective beads
EP3862422A1 (en) * 2013-06-24 2021-08-11 Celularity Inc. Extracellular matrix composition beads for cell culture
EP3394242A2 (en) * 2015-12-22 2018-10-31 Corning Incorporated Cell separation device and method for using same
RU2748057C2 (ru) 2016-01-14 2021-05-19 Депуи Синтез Продактс, Инк. Композиция и способы криоконсервации клеток hutc
WO2017210236A1 (en) 2016-05-31 2017-12-07 Corning Incorporated Vessels and spinner flasks with reduced impeller wobble for culturing cells
WO2018075940A1 (en) * 2016-10-21 2018-04-26 Georgia Tech Research Corporation Methods and systems for t cell expansion
WO2018186185A1 (ja) 2017-04-06 2018-10-11 日機装株式会社 細胞の培養方法、細胞支持複合体の製造方法、培養細胞及び細胞支持複合体
JP6978585B2 (ja) * 2018-03-22 2021-12-08 日機装株式会社 細胞の培養方法
WO2020155668A1 (zh) * 2019-01-31 2020-08-06 北京华龛生物科技有限公司 一种用于干细胞大规模制备的三维培养方法
CN111424011A (zh) * 2020-04-17 2020-07-17 深圳市旷逸生物科技有限公司 一种能够维持脐带间充质干细胞细胞形态的三维培养方法
CN114761533A (zh) * 2020-09-15 2022-07-15 株式会社Lg化学 细胞培养用微载体和用于制备其的方法
WO2024253069A1 (ja) * 2023-06-06 2024-12-12 東ソー株式会社 温度応答性マイクロキャリア

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1220832B (de) * 1964-09-22 1966-07-14 Siemens Ag Ziehduese zum Ziehen von Halbleiterkristallen aus einer Schmelze
US3665061A (en) 1969-07-16 1972-05-23 United States Banknote Corp Process for producing collagen sponges
US4216144A (en) 1977-10-20 1980-08-05 Ashmead H H Soluble iron proteinates
JPS6040439B2 (ja) 1978-03-29 1985-09-11 大正製薬株式会社 ヒドロコルチゾン誘導体
US4487865A (en) 1983-12-15 1984-12-11 Biomatrix, Inc. Polymeric articles modified with hyaluronate
US5266476A (en) * 1985-06-18 1993-11-30 Yeda Research & Development Co., Ltd. Fibrous matrix for in vitro cell cultivation
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US4925677A (en) 1988-08-31 1990-05-15 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5284766A (en) * 1989-02-10 1994-02-08 Kao Corporation Bed material for cell culture
NL9100038A (nl) 1991-01-11 1992-08-03 Stamicarbon Enzym-gekatalyseerde bereiding van optisch aktieve carbonzuren.
DE4406073A1 (de) 1994-02-24 1995-08-31 Univ Ludwigs Albert Verfahren zur Herstellung von humanen, klonogenen Fibroblasten, Verfahren zur Gentransfizierung von Fibroblasten und so erhaltene Fibroblasten
US5919702A (en) 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
CA2290381A1 (en) 1997-05-21 1998-11-26 Sloan-Kettering Institute For Cancer Research Method for increasing the concentration of ascorbic acid in brain tissues of a subject
US7560280B2 (en) 2000-11-03 2009-07-14 Kourion Therapeutics Gmbh Human cord blood derived unrestricted somatic stem cells (USSC)
CA3046566A1 (en) 2001-02-14 2002-08-22 Anthrogenesis Corporation Post-partum mammalian placental stem cells for use in the treatment of neurological or renal diseases and disorders
EP1384786B1 (en) 2001-04-02 2010-01-27 Glycomedics, Inc. Process for producing oligosaccharide chains
JP4741189B2 (ja) * 2002-02-08 2011-08-03 ユニヴァーシティ オブ サウス フロリダ 増殖した細胞系およびその使用方法
ATE365793T1 (de) 2002-02-19 2007-07-15 Medipost Co Ltd Verfahren zur isolierung und kulturexpansion mesenchymaler stamm-/vorläuferzellen aus nabelschnurblut sowie verfahren zur differenzierung von aus nabelschnurblut stammenden mesenchymalen stamm-/vorläuferzellen in unterschiedliche mesenchymgewebe
JP2003259862A (ja) * 2002-03-12 2003-09-16 Fuji Photo Film Co Ltd 細胞培養担体
AU2003265094A1 (en) 2002-08-26 2004-03-11 Neuronova Ab Method for culturing stem cells
GB0222846D0 (en) * 2002-10-03 2002-11-06 Choo Yen Cell culture
US9579351B2 (en) 2003-06-27 2017-02-28 DePuy Synthes Products, Inc. Postpartum cells derived from placental tissue, and methods of making and using the same
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US8790637B2 (en) * 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US7875272B2 (en) * 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
EP1660629A4 (en) * 2003-07-17 2015-04-08 Global Cell Solutions Llc SYSTEM AND METHOD FOR AUTOMATIC CELL CULTURE
JP4575654B2 (ja) * 2003-09-05 2010-11-04 エスエス製薬株式会社 溶解性と流動性を改善した医薬組成物
DE102004043256B4 (de) 2004-09-07 2013-09-19 Rheinische Friedrich-Wilhelms-Universität Bonn Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension
EP1812557A4 (en) 2004-10-29 2009-11-04 Centocor Ortho Biotech Inc COMPOSITIONS OF CHEMICALLY DEFINED MEDIA
US20060166361A1 (en) 2004-12-21 2006-07-27 Agnieszka Seyda Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
ES2621847T3 (es) * 2004-12-23 2017-07-05 DePuy Synthes Products, Inc. Células posparto derivadas de tejido de cordón umbilical, y métodos de elaboración y uso de las mismas
DK1835924T3 (da) 2004-12-23 2013-11-04 Ethicon Inc Behandling af parkinsons sygdom og beslægtede sygdomme under anvendelse af postpartum opnåede celler
US20060182724A1 (en) * 2005-02-15 2006-08-17 Riordan Neil H Method for expansion of stem cells
CN103361300B (zh) * 2005-03-31 2015-04-01 斯丹姆涅恩有限公司 用高度纯化来自羊膜的细胞群制备的条件培养基
JP5289970B2 (ja) * 2005-12-16 2013-09-11 エシコン・インコーポレイテッド 組織適合性不適合な移植における逆免疫反応を抑制するための組成物および方法
US8741638B2 (en) * 2005-12-19 2014-06-03 DePuy Synthes Products, LLC In vitro expansion of postpartum-derived cells in roller bottles
WO2007108003A2 (en) 2006-03-23 2007-09-27 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
CA2656175C (en) 2006-06-26 2018-08-28 Lifescan, Inc. Conditioned media obtained from amniotic fluid-derived cells for pluripotent stem cell culture
PL2089511T3 (pl) 2006-11-13 2015-02-27 Depuy Synthes Products Llc Rozrost in vitro komórek pochodzących z tkanki pępowinowej wykorzystujących mikronośniki
US10179900B2 (en) * 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
PT2379087E (pt) 2008-12-19 2014-12-02 Depuy Synthes Products Llc Células derivadas do tecido do cordão umbilical para o tratamento da dor neuropática e espasticidade
WO2010071863A1 (en) 2008-12-19 2010-06-24 Ethicon, Incorporated Regeneration and repair of neural tissue following injury
WO2010111663A1 (en) * 2009-03-26 2010-09-30 Ethicon, Inc. Human umbilical cord tissue cells as therapy for alzheimer' s disease

Also Published As

Publication number Publication date
US20080166328A1 (en) 2008-07-10
CN101611139A (zh) 2009-12-23
ES2524443T3 (es) 2014-12-09
JP5670053B2 (ja) 2015-02-18
CN101611139B (zh) 2012-07-04
JP2010508851A (ja) 2010-03-25
CA2669589A1 (en) 2008-05-22
US9102915B2 (en) 2015-08-11
WO2008060541A3 (en) 2008-08-28
WO2008060541A2 (en) 2008-05-22
EP2089511A2 (en) 2009-08-19
CA2669589C (en) 2016-01-12
AU2007319820A1 (en) 2008-05-22
EP2089511B1 (en) 2014-09-17
AU2007319820B2 (en) 2013-09-05
JP2014236755A (ja) 2014-12-18

Similar Documents

Publication Publication Date Title
PL2089511T3 (pl) Rozrost in vitro komórek pochodzących z tkanki pępowinowej wykorzystujących mikronośniki
IL276146B1 (en) Laboratory methods for increasing the vitality of the cells of the immune system
IL194438A (en) Diarrhylthiohydantoin Compounds, Pharmaceuticals Containing Them, Syntheses Methods and In Vitro Methods for Contacting them with Mammalian Cells
IL221384A0 (en) Improving il-15 and il-15r-alpha for expression in mammalian cells
GB0605450D0 (en) Cell co-culture
SG10201405107YA (en) Compositions and methods useful for culturing differentiable cells
IL200622A0 (en) Use of copper and glutamate in cell culture for production of polypeptides
GB0622394D0 (en) Differentiation of pluripotent cells
EP2064324A4 (en) SUBSTRATES FOR CELL CULTURE AND MANUFACTURING METHOD THEREFOR
IL241906B (en) Methods for the production and uses of pluripotent cell populations and differentiated cell populations
EP2089507A4 (en) DEVICES AND METHODS PARTICULARLY EFFECTIVE IN CELL CULTURE
PL2046946T3 (pl) Hodowla pluripotencjalnych komórek macierzystych
PL3323883T3 (pl) Zdefiniowane powierzchnie do hodowli komórkowej i sposoby użycia
SG10201510384UA (en) Cell culture improvements
HUE069139T2 (hu) Elektroporációs eszközök sejtek elektroporálására emlõsökben
HK1138374A1 (en) Methods of evaluating cells and cell cultures
IL194894A0 (en) Substrate for the growth of cultured cells in three dimensions
EP2069477A4 (en) CHEMOREPULSION OF CELLS
EP2227540A4 (en) DIFFERENTIATION OF HUMAN CELLS
ZA200902007B (en) In vivo transformation of pancreatic acinar cells into insulin-producing cells
GB0606671D0 (en) Cell Culture
IL196803A0 (en) Differential labeling of cells
HK1130076A1 (en) Method of proliferating lak cell lak
EP1923457A4 (en) CULTURE SUPPORT FOR CELLS THAT CAN BE IMPLANTED IN VIVO
GB0718226D0 (en) Method of in vitro diagnosing