PH31290A - Heteroaryl amines as novel acetylcholinesterase inhibitors. - Google Patents

Heteroaryl amines as novel acetylcholinesterase inhibitors.

Info

Publication number: PH31290A
Authority: PH; Philippines
Prior art keywords: acetylcholinesterase inhibitors; heteroaryl amines; novel acetylcholinesterase; novel; heteroaryl
Prior art date: 1991-10-03

Application number

PH44935A

Other languages

English (en)

Inventor

Yuhpyng L Chen

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-03

Filing date

1992-09-15

Publication date

1998-07-06

1992-09-15 Application filed by Pfizer filed Critical Pfizer

1998-07-06 Publication of PH31290A publication Critical patent/PH31290A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Control Of Indicators Other Than Cathode Ray Tubes (AREA)
Control Of El Displays (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PH44935A 1991-10-03 1992-09-15 Heteroaryl amines as novel acetylcholinesterase inhibitors. PH31290A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US77128391A	1991-10-03	1991-10-03

Publications (1)

Publication Number	Publication Date
PH31290A true PH31290A (en)	1998-07-06

Family

ID=25091318

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH44935A PH31290A (en)	1991-10-03	1992-09-15	Heteroaryl amines as novel acetylcholinesterase inhibitors.

Country Status (36)

Country	Link
US (4)	US5574046A (zh)
EP (1)	EP0606248B1 (zh)
JP (1)	JP2546785B2 (zh)
KR (1)	KR0170458B1 (zh)
CN (1)	CN1035615C (zh)
AP (1)	AP314A (zh)
AT (1)	ATE235490T1 (zh)
AU (1)	AU667053B2 (zh)
BG (1)	BG61727B1 (zh)
BR (1)	BR9206577A (zh)
CA (1)	CA2119647C (zh)
CZ (1)	CZ290807B6 (zh)
DE (2)	DE69232976T2 (zh)
DK (1)	DK0606248T3 (zh)
EG (1)	EG21481A (zh)
ES (1)	ES2193137T3 (zh)
FI (1)	FI116939B (zh)
HU (1)	HU225049B1 (zh)
IL (1)	IL103274A (zh)
IS (1)	IS1745B (zh)
MA (1)	MA22672A1 (zh)
MX (1)	MX9205678A (zh)
NO (1)	NO308533B1 (zh)
NZ (1)	NZ244601A (zh)
OA (1)	OA09895A (zh)
PH (1)	PH31290A (zh)
PL (3)	PL171984B1 (zh)
PT (1)	PT100917B (zh)
RO (1)	RO112868B1 (zh)
RU (1)	RU2100357C1 (zh)
SG (1)	SG52618A1 (zh)
TW (1)	TW263504B (zh)
UA (1)	UA41290C2 (zh)
UY (1)	UY23484A1 (zh)
WO (1)	WO1993007140A1 (zh)
ZA (1)	ZA927589B (zh)

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EP0976404A3 (en) *	1998-07-30	2001-06-27	Pfizer Products Inc.	A pharmaceutical composition for the prevention and treatment of diseases of cognitive dysfunction in a mammal
US6218383B1 (en)	1998-08-07	2001-04-17	Targacept, Inc.	Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
NZ510685A (en)	1998-09-30	2003-10-31	Takeda Chemical Industries Ltd	Drugs for improving vesical excretory strength
CN1317276C (zh) *	2000-09-29	2007-05-23	中国科学院上海药物研究所	一类吲哚基哌啶类化合物及其制备方法和用途
KR100823908B1 (ko) *	2000-10-20	2008-04-21	바이오비트럼 에이비(피유비엘)	2-, 3-, 4-, 또는 5-치환-ｎ1-(벤젠술포닐)인돌 및 이의치료 용도
JP2006505571A (ja) *	2002-10-15	2006-02-16	リゲルファーマシューテイカルズ、インコーポレイテッド	置換されたインドール及びｈｃｖ阻害剤としてのその使用
US20060014801A1 (en) *	2002-11-22	2006-01-19	The Johns Hopkins University	Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs
JP2007537294A (ja) *	2004-05-14	2007-12-20	ザ・ジョンズ・ホプキンス・ユニバーシティー	Ｇａｂａｂレセプターアンタゴニストとアセチルコリンエステラーゼインヒビターとの同時投与により認識機能を改善するための方法
EP1600447A1 (en) *	2004-05-28	2005-11-30	Neuropharma S.A.U.	Butyrylcholinesterase selective inhibitors
DE602005010698D1 (de)	2004-06-09	2008-12-11	Glaxo Group Ltd	Pyrrolopyridinderivate
EP1827468B1 (en) *	2004-12-23	2012-08-22	Curaxis Pharmaceutical Corporation	Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease
CN1808106B (zh) *	2005-01-21	2010-11-24	中国科学院上海药物研究所	一种用核磁共振筛选乙酰胆碱酯酶抑制剂的方法
US8846315B2 (en)	2008-08-12	2014-09-30	Zinfandel Pharmaceuticals, Inc.	Disease risk factors and methods of use
US8815508B2 (en)	2008-08-12	2014-08-26	Zinfandel Pharmaceuticals, Inc.	Method of identifying disease risk factors
CN101503414B (zh) *	2009-03-04	2013-10-30	沈阳药科大学	噻唑并[3,2-b]-1,2,4-三嗪衍生物及其应用
KR101907535B1 (ko)	2009-10-02	2018-10-15	아벡신 에이에스	소염제 2-옥소티아졸 및 2-옥소옥사졸
CA2789014C (en)	2010-02-09	2019-01-15	Michela Gallagher	Methods and compositions for improving cognitive function
CN107362165A (zh)	2011-01-10	2017-11-21	金帆德尔制药股份有限公司	用于治疗阿尔茨海默病的方法和药物产品
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
CN110128370A (zh)	2013-01-29	2019-08-16	埃维克辛公司	抗炎症和抗肿瘤的2-氧代噻唑类和2-氧代噻吩类化合物
US11160785B2 (en)	2013-03-15	2021-11-02	Agenebio Inc.	Methods and compositions for improving cognitive function
EP2968237A4 (en)	2013-03-15	2016-08-31	Univ Johns Hopkins	METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
CN103333163A (zh) *	2013-07-09	2013-10-02	广州中医药大学	一种苯并呋喃类衍生物及其制备方法和应用
GB201413695D0 (en)	2014-08-01	2014-09-17	Avexxin As	Compound
EA034167B8 (ru)	2015-05-22	2021-04-27	Эйджинбайо, Инк.	Фармацевтические композиции леветирацетама пролонгированного высвобождения
GB201604318D0 (en)	2016-03-14	2016-04-27	Avexxin As	Combination therapy
CN107141266B (zh) *	2017-06-28	2019-04-09	佳木斯大学附属第一医院	一种用于治疗阿尔茨海默病的杂环化合物及其制备方法
CN115466211B (zh) *	2022-06-09	2024-02-23	中国人民解放军空军军医大学	一种n-苯基喹啉-4-胺类化合物及其应用

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1992
- 1992-08-29 TW TW081106843A patent/TW263504B/zh active
- 1992-08-31 SG SG1996006904A patent/SG52618A1/en unknown
- 1992-08-31 US US08/211,044 patent/US5574046A/en not_active Expired - Lifetime
- 1992-08-31 PL PL92312751A patent/PL171984B1/pl not_active IP Right Cessation
- 1992-08-31 JP JP5506442A patent/JP2546785B2/ja not_active Expired - Fee Related
- 1992-08-31 CZ CZ1994785A patent/CZ290807B6/cs not_active IP Right Cessation
- 1992-08-31 AT AT92918761T patent/ATE235490T1/de not_active IP Right Cessation
- 1992-08-31 EP EP92918761A patent/EP0606248B1/en not_active Expired - Lifetime
- 1992-08-31 PL PL92303096A patent/PL171669B1/pl not_active IP Right Cessation
- 1992-08-31 UA UA94005424A patent/UA41290C2/uk unknown
- 1992-08-31 DE DE69232976T patent/DE69232976T2/de not_active Expired - Fee Related
- 1992-08-31 BR BR9206577A patent/BR9206577A/pt not_active Application Discontinuation
- 1992-08-31 CA CA002119647A patent/CA2119647C/en not_active Expired - Fee Related
- 1992-08-31 WO PCT/US1992/007230 patent/WO1993007140A1/en active IP Right Grant
- 1992-08-31 ES ES92918761T patent/ES2193137T3/es not_active Expired - Lifetime
- 1992-08-31 KR KR1019940701066A patent/KR0170458B1/ko not_active IP Right Cessation
- 1992-08-31 DK DK92918761T patent/DK0606248T3/da active
- 1992-08-31 PL PL92312752A patent/PL171693B1/pl not_active IP Right Cessation
- 1992-08-31 HU HU9400952A patent/HU225049B1/hu unknown
- 1992-08-31 DE DE9290112U patent/DE9290112U1/de not_active Expired - Lifetime
- 1992-08-31 AU AU25196/92A patent/AU667053B2/en not_active Ceased
- 1992-08-31 RO RO94-00533A patent/RO112868B1/ro unknown
- 1992-08-31 RU RU9494019972A patent/RU2100357C1/ru not_active IP Right Cessation
- 1992-09-07 AP APAP/P/1992/000421A patent/AP314A/en active
- 1992-09-15 PH PH44935A patent/PH31290A/en unknown
- 1992-09-24 IL IL10327492A patent/IL103274A/en not_active IP Right Cessation
- 1992-09-25 IS IS3919A patent/IS1745B/is unknown
- 1992-09-30 CN CN92112079A patent/CN1035615C/zh not_active Expired - Fee Related
- 1992-09-30 EG EG58192A patent/EG21481A/xx active
- 1992-10-01 PT PT100917A patent/PT100917B/pt not_active IP Right Cessation
- 1992-10-02 MA MA22956A patent/MA22672A1/fr unknown
- 1992-10-02 UY UY23484A patent/UY23484A1/es not_active IP Right Cessation
- 1992-10-02 MX MX9205678A patent/MX9205678A/es unknown
- 1992-10-02 NZ NZ244601A patent/NZ244601A/en not_active IP Right Cessation
- 1992-10-02 ZA ZA927589A patent/ZA927589B/xx unknown
1994
- 1994-03-18 OA OA60484A patent/OA09895A/en unknown
- 1994-03-30 NO NO941179A patent/NO308533B1/no unknown
- 1994-03-31 BG BG98689A patent/BG61727B1/bg unknown
- 1994-03-31 FI FI941518A patent/FI116939B/fi active IP Right Grant
1997
- 1997-10-24 US US08/957,639 patent/US6124321A/en not_active Expired - Fee Related
1999
- 1999-11-11 US US09/438,712 patent/US6303633B1/en not_active Expired - Fee Related
2001
- 2001-08-23 US US09/935,903 patent/US20020049210A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HU225049B1 (en)	2006-05-29
NZ244601A (en)	1995-03-28
UY23484A1 (es)	1993-03-11
ATE235490T1 (de)	2003-04-15
EG21481A (en)	2001-11-28
CA2119647A1 (en)	1993-04-15
UA41290C2 (uk)	2001-09-17
DE69232976D1 (de)	2003-04-30
PT100917B (pt)	1999-07-30
RU2100357C1 (ru)	1997-12-27
CN1071166A (zh)	1993-04-21
NO941179L (no)	1994-03-30
EP0606248A1 (en)	1994-07-20
JP2546785B2 (ja)	1996-10-23
CN1035615C (zh)	1997-08-13
DE69232976T2 (de)	2003-10-02
BG98689A (bg)	1995-03-31
FI116939B (fi)	2006-04-13
ZA927589B (en)	1994-04-05
BR9206577A (pt)	1995-10-10
EP0606248B1 (en)	2003-03-26
IS3919A (is)	1993-04-04
PL171669B1 (en)	1997-06-30
US6303633B1 (en)	2001-10-16
AP9200421A0 (en)	1992-10-31
DE9290112U1 (de)	1994-06-01
US5574046A (en)	1996-11-12
SG52618A1 (en)	1998-09-28
MA22672A1 (fr)	1993-07-01
IL103274A0 (en)	1993-02-21
MX9205678A (es)	1993-04-01
ES2193137T3 (es)	2003-11-01
DK0606248T3 (da)	2003-06-23
US6124321A (en)	2000-09-26
KR0170458B1 (ko)	1999-02-18
IS1745B (is)	2000-05-18
AP314A (en)	1994-02-04
IL103274A (en)	1996-11-14
WO1993007140A1 (en)	1993-04-15
BG61727B1 (bg)	1998-04-30
NO308533B1 (no)	2000-09-25
CA2119647C (en)	1998-08-04
CZ290807B6 (cs)	2002-10-16
JPH06510788A (ja)	1994-12-01
US20020049210A1 (en)	2002-04-25
PL171693B1 (pl)	1997-06-30
FI941518A (fi)	1994-03-31
AU2519692A (en)	1993-05-03
CZ78594A3 (en)	1995-07-12
PL171984B1 (pl)	1997-07-31
PT100917A (pt)	1993-11-30
HU9400952D0 (en)	1994-06-28
RO112868B1 (ro)	1998-01-30
HUT70544A (en)	1995-10-30
OA09895A (en)	1995-09-15
NO941179D0 (no)	1994-03-30
AU667053B2 (en)	1996-03-07
TW263504B (zh)	1995-11-21
FI941518A0 (fi)	1994-03-31

Publication	Publication Date	Title
OA09895A (en)	1995-09-15	Heteroaryl amines as novel acetylcholinesterase inhibitors.
HU9400258D0 (en)	1994-06-28	Quinazoline derivatives as acetylcholinesterase inhibitors
GR3026740T3 (en)	1998-07-31	Alkylsiloxanes as adjuvants for agriculture.
EP0707488A4 (en)	1998-01-14	CYCLOHEXAPEPTIDYL AMINE COMPOSITION
ATE119535T1 (de)	1995-03-15	Acetylcholinesterase-inhibitoren.
EP0452257A3 (en)	1992-09-02	Novel platelet-aggregation inhibitors
ZA91916B (en)	1992-09-30	Tricyclic-cyclic amines as novel cholinesterase inhibitors
AU2759892A (en)	1993-05-21	N-aryl-n1-azabicyclo-ureas as 5-ht3 antagonists
AU1857492A (en)	1993-01-07	Amine adducts as corrosion inhibitors
EP0409025A3 (en)	1992-01-02	N-(indol-6-yl)-heterocyclic compounds
GB9104839D0 (en)	1991-04-17	Novel compounds
EP0662964A1 (en)	1995-07-19	HETEROCYCLIC AMINES AS CALMODULIN ANTAGONISTE.
CS7592A3 (en)	1992-07-15	Process for preparing diphenylamines
ZA913394B (en)	1992-07-29	Novel compounds substituted benzothienophene pyridines
HU9402436D0 (en)	1994-10-28	2,6-method-2h-quinolizin derivative as 5-ht3-receptor antagonist
GR3033237T3 (en)	2000-09-29	Quinoline derivatives as leukoriene antagonists.
ZA936048B (en)	1994-03-15	Novel 3-oxadiazolyl-1,6-napthyridine derivatives
EP0509219A3 (en)	1993-02-24	Buildings, particularly high buildings
ZA908934B (en)	1991-08-28	Novel pyridyloxazole-2-ones useful as proteinkinase c inhibitors
GB2269747B (en)	1996-06-05	Aroyl-ureas as pharmaceuticals, particularly 5-ht3 antagonists
ZA925660B (en)	1994-01-28	Quinazoline derivatives as acetylcholinesterase inhibitors
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