PE99298A1 - Oligosacaridos modificados - Google Patents
Oligosacaridos modificadosInfo
- Publication number
- PE99298A1 PE99298A1 PE1997000688A PE00068897A PE99298A1 PE 99298 A1 PE99298 A1 PE 99298A1 PE 1997000688 A PE1997000688 A PE 1997000688A PE 00068897 A PE00068897 A PE 00068897A PE 99298 A1 PE99298 A1 PE 99298A1
- Authority
- PE
- Peru
- Prior art keywords
- glcnac
- compounds
- formula
- preferred
- tetrahidropirano
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE: R1 ES UN METILO EN CONFIGURACION S SUSTITUIDO POR UN CARBOXI Y OTRO SUSTITUYENTE o -CH(R4)-COOR3; R2 ES H, ALQUILO C1-C12 o ARILO C6; R3 ES H o My, EN DONDE My es METAL MONO O DIVALENTE, DE PREFERENCIA, Na o K; R4 ES DE PREFERENCIA CH2-C6H5, (CH2)2-C6H5, CICLOHEXILO, METILO, ETILO o ISOPROPILO; "Z" ES UN RADICAL DE FORMULA (IIa), (IIb) o (IIc), EN DONDE: "X" ES CO, COO, CS, C(S)O, ENTRE OTROS; RT1 ES ALQUILO C1-C12, DE PREFERENCIA ES (CH2)8-COO-CH3, (CH2)8-COONa o CH3; RT2 ES CICLOALQUILO C3-C12, HETEROCICLOALQUILO C2-C11, ARILO C6-C10 o HETEROARILO C5-C9, DE PREFERENCIA ES -3,4-(OH)2-C6H3 o -3,4-(OCH3)2-C6H3; RB5 ES AMINO PRIMARIO o AMIDO; R5 ES DE PREFERENCIA CH2OH, CH3 o COONa. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE LOS COMPUESTOS (I), DONDE LA GALACTOSA-(GlcNAc o TETRAHIDROPIRANO) o FUCOSA-(GlcNAc o TETRAHIDROPIRANO) ESTA ENLAZADO CON LA FUCOSA o GALACTOSA RESPECTIVAMENTE. LOS COMPUESTOS DE FORMULA (I) SON DERIVADOS DEL SIALIL LEWIS (LIGANDO NATURAL DE LA E-SELECTINA EN LA ADHESION CELULAR), EN DONDE SE REEMPLAZA EL RESIDUO DEL ACIDO NEURAMINICO Y GlcNAc NATURAL POR R1 Y "Z" RESPECTIVAMENTE, POR LO QUE ACTUARIAN INHIBIENDO EL ENLACE DE E-SELECTINA, SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS O AUTOINMUNES AGUDAS O CRONICAS, ENTRE OTRAS
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96810526 | 1996-08-08 | ||
| EP96810527 | 1996-08-08 | ||
| EP96810636 | 1996-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE99298A1 true PE99298A1 (es) | 1999-01-21 |
Family
ID=27237868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000688A PE99298A1 (es) | 1996-08-08 | 1997-08-07 | Oligosacaridos modificados |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0920437A1 (es) |
| JP (1) | JP2000516224A (es) |
| KR (1) | KR20000029862A (es) |
| CN (1) | CN1227563A (es) |
| AR (1) | AR008283A1 (es) |
| AU (1) | AU720381B2 (es) |
| BR (1) | BR9711117A (es) |
| CA (1) | CA2260854A1 (es) |
| CO (1) | CO4900075A1 (es) |
| CZ (1) | CZ39099A3 (es) |
| ID (1) | ID18010A (es) |
| IL (1) | IL127908A0 (es) |
| NO (1) | NO990497L (es) |
| NZ (1) | NZ334048A (es) |
| PE (1) | PE99298A1 (es) |
| PL (1) | PL331286A1 (es) |
| SK (1) | SK15699A3 (es) |
| TR (1) | TR199900245T2 (es) |
| WO (1) | WO1998006730A1 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5888984A (en) * | 1994-05-12 | 1999-03-30 | Dermal Research Laboratories, Inc. | Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same |
| AU2745700A (en) | 1999-02-01 | 2000-08-18 | Dermal Research Laboratories, Inc. | A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same |
| US7879824B2 (en) | 2001-07-31 | 2011-02-01 | Dermal Research Laboratories, Inc. | Methods of preventing or treating diseases and conditions using complex carbohydrates |
| US20040096396A1 (en) * | 2002-07-03 | 2004-05-20 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
| CA2501842C (en) | 2002-10-11 | 2012-07-17 | Yamanouchi Europe B.V. | Glucose-based compounds with affinity to p-selectin |
| JP2007524658A (ja) * | 2003-11-19 | 2007-08-30 | グリコミメティクス， インコーポレイテッド | Ｅ−およびｐ−セレクチンの両方のための糖模倣物アンタゴニスト |
| WO2006127906A1 (en) * | 2005-05-25 | 2006-11-30 | Glycomimetics, Inc. | Heterobifunctional compounds for selectin inhibition |
| EP1934236B1 (en) | 2005-09-02 | 2012-11-21 | GlycoMimetics, Inc. | Heterobifunctional pan-selectin inhibitors |
| NZ598863A (en) * | 2007-02-09 | 2013-11-29 | Glycomimetics Inc | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
| AU2008336249B2 (en) | 2007-12-10 | 2015-01-29 | The University Of Queensland | Treatment and prophylaxis |
| US8895510B2 (en) | 2008-04-08 | 2014-11-25 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
| CN104039805B (zh) | 2011-12-22 | 2016-11-16 | 糖模拟物有限公司 | E-选择蛋白拮抗剂化合物、组合物及使用方法 |
| PL2928476T3 (pl) | 2012-12-07 | 2018-07-31 | Glycomimetics, Inc. | Związki, kompozycje i sposoby wykorzystujące antagonistów e-selektyny do mobilizacji komórek hematopoietycznych |
| KR102542750B1 (ko) | 2014-12-03 | 2023-06-12 | 글리코미메틱스, 인크. | E-셀렉틴 및 cxcr4 케모카인 수용체의 헤테로이작용성 억제제 |
| EP3405473A1 (en) | 2016-01-22 | 2018-11-28 | GlycoMimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
| WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
| US11433086B2 (en) | 2016-08-08 | 2022-09-06 | Glycomimetics, Inc. | Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4 |
| WO2018068010A1 (en) | 2016-10-07 | 2018-04-12 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
| US11197877B2 (en) | 2017-03-15 | 2021-12-14 | Glycomimetics. Inc. | Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists |
| WO2019108750A1 (en) | 2017-11-30 | 2019-06-06 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| AU2018395417B2 (en) | 2017-12-29 | 2023-07-13 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| CN108299525B (zh) * | 2018-01-05 | 2021-03-26 | 佛山科学技术学院 | 路易斯寡糖-x的合成方法 |
| US11707474B2 (en) | 2018-03-05 | 2023-07-25 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| CN109762032A (zh) * | 2019-01-16 | 2019-05-17 | 天津科技大学 | 一种磺酸化路易斯x三糖及其合成方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993023031A1 (en) * | 1992-05-08 | 1993-11-25 | The Biomembrane Institute | Multivalent mimetics and peptide mimetics for blocking carbohydrate-dependent cellular interaction and for eliciting anticarbohydrate t-cell response |
| WO1994020514A1 (en) * | 1993-03-04 | 1994-09-15 | Mect Corporation | Lewis-associated compound, process for producing the same, and anti-inflammatory |
| EP0698031A4 (en) * | 1993-05-14 | 1997-07-09 | Cytel Corp | SIALYL LEx ANALOGS AS INHIBITORS OF CELLULAR ADHESION |
| CN1176644A (zh) * | 1994-12-28 | 1998-03-18 | 住友制药株式会社 | 路易斯x衍生物及其制备方法 |
-
1997
- 1997-08-06 TR TR1999/00245T patent/TR199900245T2/xx unknown
- 1997-08-06 NZ NZ334048A patent/NZ334048A/xx unknown
- 1997-08-06 IL IL12790897A patent/IL127908A0/xx unknown
- 1997-08-06 BR BR9711117-1A patent/BR9711117A/pt not_active Application Discontinuation
- 1997-08-06 CZ CZ99390A patent/CZ39099A3/cs unknown
- 1997-08-06 KR KR1019997001025A patent/KR20000029862A/ko not_active Application Discontinuation
- 1997-08-06 CA CA002260854A patent/CA2260854A1/en not_active Abandoned
- 1997-08-06 CN CN97197077A patent/CN1227563A/zh active Pending
- 1997-08-06 AU AU43788/97A patent/AU720381B2/en not_active Ceased
- 1997-08-06 SK SK156-99A patent/SK15699A3/sk unknown
- 1997-08-06 WO PCT/EP1997/004279 patent/WO1998006730A1/en not_active Application Discontinuation
- 1997-08-06 AR ARP970103580A patent/AR008283A1/es unknown
- 1997-08-06 JP JP10509358A patent/JP2000516224A/ja active Pending
- 1997-08-06 EP EP97941916A patent/EP0920437A1/en not_active Withdrawn
- 1997-08-06 PL PL97331286A patent/PL331286A1/xx unknown
- 1997-08-07 PE PE1997000688A patent/PE99298A1/es not_active Application Discontinuation
- 1997-08-08 ID IDP972766A patent/ID18010A/id unknown
- 1997-08-08 CO CO97045596A patent/CO4900075A1/es unknown
-
1999
- 1999-02-03 NO NO990497A patent/NO990497L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CO4900075A1 (es) | 2000-03-27 |
| NO990497D0 (no) | 1999-02-03 |
| SK15699A3 (en) | 1999-07-12 |
| NZ334048A (en) | 2000-05-26 |
| AR008283A1 (es) | 1999-12-29 |
| PL331286A1 (en) | 1999-07-05 |
| AU720381B2 (en) | 2000-06-01 |
| WO1998006730A1 (en) | 1998-02-19 |
| EP0920437A1 (en) | 1999-06-09 |
| CZ39099A3 (cs) | 1999-05-12 |
| JP2000516224A (ja) | 2000-12-05 |
| CA2260854A1 (en) | 1998-02-19 |
| BR9711117A (pt) | 1999-09-08 |
| NO990497L (no) | 1999-03-24 |
| IL127908A0 (en) | 1999-11-30 |
| KR20000029862A (ko) | 2000-05-25 |
| AU4378897A (en) | 1998-03-06 |
| TR199900245T2 (xx) | 1999-05-21 |
| CN1227563A (zh) | 1999-09-01 |
| ID18010A (id) | 1998-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |