PE2699A1 - Procedimiento para la sintesis de benzotiofenos - Google Patents
Procedimiento para la sintesis de benzotiofenosInfo
- Publication number
- PE2699A1 PE2699A1 PE1997000827A PE00082797A PE2699A1 PE 2699 A1 PE2699 A1 PE 2699A1 PE 1997000827 A PE1997000827 A PE 1997000827A PE 00082797 A PE00082797 A PE 00082797A PE 2699 A1 PE2699 A1 PE 2699A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- cycling
- reaction
- procedure
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000006243 chemical reaction Methods 0.000 abstract 4
- 230000001351 cycling effect Effects 0.000 abstract 4
- -1 CATALYST ACID Chemical compound 0.000 abstract 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000003456 ion exchange resin Substances 0.000 abstract 2
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000004793 Polystyrene Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 102000015694 estrogen receptors Human genes 0.000 abstract 1
- 108010038795 estrogen receptors Proteins 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229920002223 polystyrene Polymers 0.000 abstract 1
- GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000000333 selective estrogen receptor modulator Substances 0.000 abstract 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
Abstract
CARACTERIZADO PORQUE COMPRENDE DOS ETAPAS: DE CICLACION Y DE REDISPOSICION; ESPECIFICAMENTE SE REFIERE AL PROCEDIMIENTO DE PREPARACION DEL COMPUESTO DE FORMULA (Ib), EN DONDE, R ES ALQUILO C1-C6, DE PREFERENCIA ES METILO, QUE COMPRENDE: CICLAR UN COMPUESTO DE FORMULA (II) EN UNA RESINA DE INTERCAMBIO IONICO (COMO CATALIZADOR ACIDO, EN DONDE DE PREFERENCIA DICHA RESINA ES DE ACIDO SULFONICO BASADA EN POLIESTIRENO), EN PRESENCIA DE DISOLVENTES COMO TOLUENO Y ACIDO METANOSULFONICO, LOS CUALES FACILITAN LA REACCION DE REDISPOSICION POSTERIOR, ADICIONALMENTE AGREGAR HEPTANO, COMO DISOLVENTE QUE FACILITA LA CRISTALIZACION; DICHA REACCION DE CICLACION SE LLEVA A CABO, DE PREFERENCIA A TEMPERATURAS DE 70�C A 90�C; AL FINAL DE LA REACCION DE REDISPOSICION DE PREFERENCIA SE ANADE ISOPROPANOL (PARA EXTINGUIR LA REACCION Y MEJORAR LA PUREZA DEL PRODUCTO); TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DEL COMPUESTO DE FORMULA (III) EN DONDE: R1 Y R2 SON ALQUILO C1-C6 o AMBOS JUNTO CON EL NITROGENO AL QUE ESTAN UNIDOS FORMAN PIPERIDINILO, PIRROLIDINILO, ENTRE OTROS; QUE COMPRENDE: CICLAR UN COMPUESTO (II) EN UNA RESINA DE INTERCAMBIO IONICO. ESTE PROCEDIMIENTO MEJORA EL RENDIMIENTO A ESCALA INDUSTRIAL DEL COMPUESTO (Ib) QUE ES INTERMEDIO EN LA SINTESIS DEL RALOXIFENO, UN MODULADOR SELECTIVO DEL RECEPTOR DE ESTROGENOS (SERM)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2669596P | 1996-09-25 | 1996-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE2699A1 true PE2699A1 (es) | 1999-02-04 |
Family
ID=21833302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000827A PE2699A1 (es) | 1996-09-25 | 1997-09-17 | Procedimiento para la sintesis de benzotiofenos |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5977383A (es) |
| EP (1) | EP0832889B1 (es) |
| JP (1) | JP2001501208A (es) |
| KR (1) | KR20000048539A (es) |
| CN (1) | CN1088704C (es) |
| AR (1) | AR013321A1 (es) |
| AT (1) | ATE318805T1 (es) |
| AU (1) | AU718919B2 (es) |
| BR (1) | BR9712844A (es) |
| CA (1) | CA2266617A1 (es) |
| CO (1) | CO4900043A1 (es) |
| CZ (1) | CZ92899A3 (es) |
| DE (1) | DE69735339T2 (es) |
| EA (1) | EA001914B1 (es) |
| EG (1) | EG21037A (es) |
| ES (1) | ES2257761T3 (es) |
| HU (1) | HUP9904228A3 (es) |
| ID (1) | ID21349A (es) |
| IL (1) | IL129001A (es) |
| IN (1) | IN183239B (es) |
| MY (1) | MY118009A (es) |
| NO (1) | NO991193L (es) |
| NZ (1) | NZ334591A (es) |
| PE (1) | PE2699A1 (es) |
| PL (1) | PL332208A1 (es) |
| TR (1) | TR199900672T2 (es) |
| TW (1) | TW472053B (es) |
| UA (1) | UA62938C2 (es) |
| WO (1) | WO1998013363A1 (es) |
| YU (1) | YU15399A (es) |
| ZA (1) | ZA978372B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002230409A1 (en) * | 2000-11-27 | 2002-06-03 | Eli Lilly And Company | Process for preparing 3-aryl-benzo(b)thiophenes |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1138163A (en) * | 1965-05-21 | 1968-12-27 | Bristol Myers Co | Benzothiophene derivatives having anti-fertility properties |
| US3394125A (en) * | 1965-10-23 | 1968-07-23 | Bristol Myers Co | 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group |
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4230862A (en) * | 1975-10-28 | 1980-10-28 | Eli Lilly And Company | Antifertility compounds |
| AT364852B (de) * | 1977-11-05 | 1981-11-25 | Thomae Gmbh Dr K | Verfahren zur herstellung von kondensierten isothiazol-3(2h)-on-1,1-dioxiden und von deren salzen |
| US4436748A (en) * | 1980-10-20 | 1984-03-13 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo[b]thiophenes |
| IL65379A0 (en) * | 1981-04-03 | 1982-05-31 | Lilly Co Eli | Process for preparing acylated benzothiophenes |
| AU555658B2 (en) * | 1981-04-03 | 1986-10-02 | Eli Lilly And Company | Benzothiophene compounds |
| US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| IL65378A (en) * | 1981-04-03 | 1986-02-28 | Lilly Co Eli | Process for preparing 3-(4-aminoethoxybenzoyl)benzo-(b)thiophenes |
| US4358593A (en) * | 1981-04-03 | 1982-11-09 | Eli Lilly And Company | Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes |
| US4544746A (en) * | 1982-05-17 | 1985-10-01 | Ciba-Geigy Corporation | Process for preparing 2-anilinoacridone |
| US4916126A (en) * | 1987-09-25 | 1990-04-10 | Ciba-Geigy Corporation | Diacyl derivatives of 4-(trialkylbenzyl)-piperazinyl compounds |
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| DE4117512A1 (de) * | 1991-05-25 | 1992-11-26 | Schering Ag | 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
| DE4204969A1 (de) * | 1992-02-19 | 1993-08-26 | Basf Ag | Verfahren zur herstellung von benzo(b)thiophenen |
| US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US5523416A (en) * | 1994-07-22 | 1996-06-04 | Eli Lilly And Company | Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes |
| US5606075A (en) * | 1995-06-07 | 1997-02-25 | Eli Lilly And Company | Process for the synthesis of benzo[b]thiophenes |
| US5606076A (en) * | 1995-06-07 | 1997-02-25 | Eli Lilly And Company | Process for the synthesis of benzo[b]thiophenes |
-
1997
- 1997-09-17 PE PE1997000827A patent/PE2699A1/es not_active Application Discontinuation
- 1997-09-17 ZA ZA978372A patent/ZA978372B/xx unknown
- 1997-09-17 MY MYPI97004310A patent/MY118009A/en unknown
- 1997-09-17 AR ARP970104264A patent/AR013321A1/es unknown
- 1997-09-17 IN IN1714CA1997 patent/IN183239B/en unknown
- 1997-09-18 EG EG96197A patent/EG21037A/xx active
- 1997-09-19 NZ NZ334591A patent/NZ334591A/xx unknown
- 1997-09-19 CZ CZ99928A patent/CZ92899A3/cs unknown
- 1997-09-19 WO PCT/US1997/016683 patent/WO1998013363A1/en not_active Application Discontinuation
- 1997-09-19 AU AU43561/97A patent/AU718919B2/en not_active Ceased
- 1997-09-19 CN CN97198100A patent/CN1088704C/zh not_active Expired - Fee Related
- 1997-09-19 EA EA199900330A patent/EA001914B1/ru not_active IP Right Cessation
- 1997-09-19 TR TR1999/00672T patent/TR199900672T2/xx unknown
- 1997-09-19 HU HU9904228A patent/HUP9904228A3/hu unknown
- 1997-09-19 YU YU15399A patent/YU15399A/sh unknown
- 1997-09-19 KR KR1019990702454A patent/KR20000048539A/ko not_active Application Discontinuation
- 1997-09-19 ID IDW990074A patent/ID21349A/id unknown
- 1997-09-19 IL IL12900197A patent/IL129001A/xx not_active IP Right Cessation
- 1997-09-19 PL PL97332208A patent/PL332208A1/xx unknown
- 1997-09-19 BR BR9712844-9A patent/BR9712844A/pt not_active IP Right Cessation
- 1997-09-19 JP JP10515741A patent/JP2001501208A/ja active Pending
- 1997-09-19 CA CA002266617A patent/CA2266617A1/en not_active Abandoned
- 1997-09-19 UA UA99031657A patent/UA62938C2/uk unknown
- 1997-09-22 US US08/934,999 patent/US5977383A/en not_active Expired - Lifetime
- 1997-09-22 AT AT97307377T patent/ATE318805T1/de not_active IP Right Cessation
- 1997-09-22 DE DE69735339T patent/DE69735339T2/de not_active Expired - Lifetime
- 1997-09-22 ES ES97307377T patent/ES2257761T3/es not_active Expired - Lifetime
- 1997-09-22 CO CO97055060A patent/CO4900043A1/es unknown
- 1997-09-22 EP EP97307377A patent/EP0832889B1/en not_active Expired - Lifetime
- 1997-12-26 TW TW086113989A patent/TW472053B/zh not_active IP Right Cessation
-
1999
- 1999-03-11 NO NO991193A patent/NO991193L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |