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PE20221902A1 - ANTI-E-SELECTIN ANTIBODIES, COMPOSITIONS AND METHODS OF USE - Google Patents

ANTI-E-SELECTIN ANTIBODIES, COMPOSITIONS AND METHODS OF USE

Info

Publication number
PE20221902A1
PE20221902A1 PE2022001465A PE2022001465A PE20221902A1 PE 20221902 A1 PE20221902 A1 PE 20221902A1 PE 2022001465 A PE2022001465 A PE 2022001465A PE 2022001465 A PE2022001465 A PE 2022001465A PE 20221902 A1 PE20221902 A1 PE 20221902A1
Authority
PE
Peru
Prior art keywords
compositions
methods
amino acid
acid sequence
selectin antibodies
Prior art date
Application number
PE2022001465A
Other languages
Spanish (es)
Inventor
James Reasoner Apgar
Sheryl Rubio Bowley
Joanne Elizabeth-Ayriss Elwell
Laura Lin
Jatin Narula
Chuenlei Parng
Debra Denene Pittman
Swapnil Rakhe
Chihyi Vincent Yu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20221902A1 publication Critical patent/PE20221902A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UN ANTICUERPO AISLADO, O FRAGMENTO DE FIJACION AL ANTIGENO DE ESTE, QUE SE FIJA ESPECIFICAMENTE A E-SELECTINA HUMANA EL CUAL ESTA DEFINIDO A TRAVES DE LA SECUENCIA AMINOACIDICA DE SUS 6 CDRS (acapites a-i), SECUENCIA AMINOCIDICA DE SU REGION VARIABLE (acapites j - m) Y LA SECUENCIA AMINOACIDICA COMPLETA DE CADENA PESADA Y LIGERA.REFERS TO AN ISOLATED ANTIBODY, OR ANTIGEN-BINDING FRAGMENT OF THIS, WHICH SPECIFICALLY BINDS TO HUMAN E-SELECTIN WHICH IS DEFINED THROUGH THE AMINO ACID SEQUENCE OF ITS 6 CDRS (headings a-i), AMINO ACID SEQUENCE OF ITS VARIABLE REGION (headings j - m) AND THE COMPLETE HEAVY AND LIGHT CHAIN AMINO ACID SEQUENCE.

PE2022001465A 2020-01-24 2021-01-21 ANTI-E-SELECTIN ANTIBODIES, COMPOSITIONS AND METHODS OF USE PE20221902A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202062965688P 2020-01-24 2020-01-24
US202063104213P 2020-10-22 2020-10-22
US202063121467P 2020-12-04 2020-12-04
PCT/IB2021/050464 WO2021148983A1 (en) 2020-01-24 2021-01-21 Anti-e-selectin antibodies, compositions and methods of use

Publications (1)

Publication Number Publication Date
PE20221902A1 true PE20221902A1 (en) 2022-12-21

Family

ID=74236245

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022001465A PE20221902A1 (en) 2020-01-24 2021-01-21 ANTI-E-SELECTIN ANTIBODIES, COMPOSITIONS AND METHODS OF USE

Country Status (14)

Country Link
US (2) US11597770B2 (en)
EP (1) EP4093508A1 (en)
JP (1) JP7449390B2 (en)
KR (1) KR20220131293A (en)
CN (1) CN115190814A (en)
AU (1) AU2021210669A1 (en)
BR (1) BR112022014417A2 (en)
CA (1) CA3168704A1 (en)
CO (1) CO2022010244A2 (en)
IL (1) IL294921A (en)
MX (1) MX2022009130A (en)
PE (1) PE20221902A1 (en)
TW (1) TWI854090B (en)
WO (1) WO2021148983A1 (en)

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US12112588B2 (en) * 2021-04-28 2024-10-08 Dana Automotive Systems Group, Llc Systems and methods for prediction of component degradation
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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Also Published As

Publication number Publication date
CN115190814A (en) 2022-10-14
US20240076386A1 (en) 2024-03-07
WO2021148983A1 (en) 2021-07-29
IL294921A (en) 2022-09-01
US20210246213A1 (en) 2021-08-12
MX2022009130A (en) 2022-08-22
BR112022014417A2 (en) 2022-09-13
TWI854090B (en) 2024-09-01
TW202140558A (en) 2021-11-01
JP7449390B2 (en) 2024-03-13
CA3168704A1 (en) 2021-07-29
EP4093508A1 (en) 2022-11-30
KR20220131293A (en) 2022-09-27
AU2021210669A1 (en) 2022-08-18
JP2023503714A (en) 2023-01-31
US11597770B2 (en) 2023-03-07
CO2022010244A2 (en) 2022-08-09

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