PE20181890A1 - Contorsbody - un ligante de diana monocatenario - Google Patents
Contorsbody - un ligante de diana monocatenarioInfo
- Publication number
- PE20181890A1 PE20181890A1 PE2018002250A PE2018002250A PE20181890A1 PE 20181890 A1 PE20181890 A1 PE 20181890A1 PE 2018002250 A PE2018002250 A PE 2018002250A PE 2018002250 A PE2018002250 A PE 2018002250A PE 20181890 A1 PE20181890 A1 PE 20181890A1
- Authority
- PE
- Peru
- Prior art keywords
- domain
- fusion polypeptide
- polypeptide
- binding domain
- spacer
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 abstract 11
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 11
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 11
- 230000004927 fusion Effects 0.000 abstract 8
- 125000006850 spacer group Chemical group 0.000 abstract 6
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Referido a un polipeptido de fusion dimerico que comprende una primera parte de un dominio de union, una segunda parte de un dominio de union y un dominio espaciador, en el que el domino espaciador es un polipeptido y comprende por lo menos 25 residuos aminoacidos, la primera parte del dominio de union es un polipeptido que se fusiona, directamente o mediante un primer conector, con el extremo N-terminal del dominio espaciador, la segunda parte del dominio de union es un polipeptido que se fusiona, directamente o mediante un segundo conector, con el extremo C-terminal del dominio espaciador, la primera parte del dominio de union y la segunda parte del dominio de union del mismo polipeptido de fusion monocatenario se asocian y forman un sitio de union funcional que se une especificamente a la diana. El polipeptido de fusion dimerico comprende dos polipeptidos de fusion identicos o diferentes, en el que el dominio espaciador del primer polipeptido de fusion se conjuga covalentemente con el dominio espaciador del segundo polipeptido de fusion. Tambien se refiere a una pareja de acidos nucleicos aislados que conjuntamente codifican el polipeptido de fusion dimerico y un metodo para producir el polipeptido de fusion
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16167920 | 2016-05-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20181890A1 true PE20181890A1 (es) | 2018-12-11 |
Family
ID=56008478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2018002250A PE20181890A1 (es) | 2016-05-02 | 2017-05-02 | Contorsbody - un ligante de diana monocatenario |
Country Status (18)
Country | Link |
---|---|
US (3) | US20190389971A1 (es) |
EP (2) | EP3889175A1 (es) |
JP (2) | JP6675017B2 (es) |
KR (1) | KR102523682B1 (es) |
CN (1) | CN109071635B (es) |
AU (1) | AU2017259869A1 (es) |
BR (1) | BR112018069890A2 (es) |
CA (1) | CA3019524A1 (es) |
CL (1) | CL2018003007A1 (es) |
CR (1) | CR20180509A (es) |
IL (1) | IL262523A (es) |
MA (1) | MA56474A (es) |
MX (1) | MX2018013342A (es) |
PE (1) | PE20181890A1 (es) |
RU (1) | RU2018141360A (es) |
SG (1) | SG11201809620UA (es) |
UA (1) | UA123323C2 (es) |
WO (1) | WO2017191101A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2907467T3 (es) * | 2014-12-05 | 2022-04-25 | Xyphos Biosciences Inc | Fragmentos variables insertables de anticuerpos y dominios a1-a2 modificados de ligandos NKG2D |
AU2018353420A1 (en) | 2017-10-20 | 2020-04-16 | F. Hoffmann-La Roche Ag | Method for generating multispecific antibodies from monospecific antibodies |
CN111372947A (zh) | 2017-10-30 | 2020-07-03 | 豪夫迈·罗氏有限公司 | 在体内从单特异性抗体产生多特异性抗体的方法 |
CN111295392A (zh) | 2017-11-01 | 2020-06-16 | 豪夫迈·罗氏有限公司 | Compbody–多价靶结合物 |
CA3079129C (en) * | 2017-11-01 | 2023-02-28 | F. Hoffmann-La Roche Ag | Trifab-contorsbody |
IL272747B2 (en) | 2017-11-01 | 2025-04-01 | Hoffmann La Roche | Bispecific antibodies 1 + 2 |
US12060435B2 (en) | 2018-01-05 | 2024-08-13 | City Of Hope | Multi-specific ligand binders |
BR112021001693A2 (pt) | 2018-08-03 | 2021-05-04 | Chugai Seiyaku Kabushiki Kaisha | molécula de ligação ao antígeno contendo dois domínios de ligação ao antígeno q ligados entre si |
JP2023512390A (ja) | 2020-02-05 | 2023-03-27 | 中外製薬株式会社 | 組換え抗原結合分子を製造するおよび/または濃縮するための方法 |
AR121695A1 (es) | 2020-03-31 | 2022-06-29 | Chugai Pharmaceutical Co Ltd | Moléculas de unión al antígeno multiespecíficas dirigidas a dll3 y sus usos |
CA3184546A1 (en) * | 2020-07-02 | 2022-01-06 | Sanofi | Glp-1r agonist / fgf21 fusion proteins |
KR20220104423A (ko) | 2021-01-18 | 2022-07-26 | 성기봉 | 페달엔진자전거(실용모델) |
KR102604934B1 (ko) * | 2021-10-27 | 2023-11-23 | 주식회사 베르티스 | 피분석물을 검출 또는 측정하기 위한 조성물 |
KR20240062555A (ko) | 2022-11-02 | 2024-05-09 | 성기봉 | 회전 기어 방식의 적용 도르레 |
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-
2017
- 2017-05-02 SG SG11201809620UA patent/SG11201809620UA/en unknown
- 2017-05-02 WO PCT/EP2017/060354 patent/WO2017191101A1/en active Application Filing
- 2017-05-02 RU RU2018141360A patent/RU2018141360A/ru unknown
- 2017-05-02 PE PE2018002250A patent/PE20181890A1/es unknown
- 2017-05-02 MX MX2018013342A patent/MX2018013342A/es unknown
- 2017-05-02 JP JP2018557407A patent/JP6675017B2/ja active Active
- 2017-05-02 CR CR20180509A patent/CR20180509A/es unknown
- 2017-05-02 UA UAA201811685A patent/UA123323C2/uk unknown
- 2017-05-02 AU AU2017259869A patent/AU2017259869A1/en not_active Abandoned
- 2017-05-02 EP EP21153405.2A patent/EP3889175A1/en not_active Withdrawn
- 2017-05-02 CN CN201780027148.6A patent/CN109071635B/zh active Active
- 2017-05-02 BR BR112018069890A patent/BR112018069890A2/pt not_active Application Discontinuation
- 2017-05-02 CA CA3019524A patent/CA3019524A1/en active Pending
- 2017-05-02 MA MA056474A patent/MA56474A/fr unknown
- 2017-05-02 EP EP17723041.4A patent/EP3452502B1/en active Active
- 2017-05-02 KR KR1020187034614A patent/KR102523682B1/ko active Active
-
2018
- 2018-10-22 IL IL262523A patent/IL262523A/en unknown
- 2018-10-23 CL CL2018003007A patent/CL2018003007A1/es unknown
- 2018-11-01 US US16/178,481 patent/US20190389971A1/en not_active Abandoned
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2020
- 2020-03-09 JP JP2020039449A patent/JP6994066B2/ja active Active
-
2021
- 2021-06-25 US US17/358,277 patent/US20210347916A1/en not_active Abandoned
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2023
- 2023-08-25 US US18/238,153 patent/US20240166771A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20210347916A1 (en) | 2021-11-11 |
MA56474A (fr) | 2022-05-11 |
CA3019524A1 (en) | 2017-11-09 |
JP2019521084A (ja) | 2019-07-25 |
CN109071635A (zh) | 2018-12-21 |
RU2018141360A3 (es) | 2020-10-16 |
JP6675017B2 (ja) | 2020-04-01 |
UA123323C2 (uk) | 2021-03-17 |
CN109071635B (zh) | 2023-09-01 |
EP3889175A1 (en) | 2021-10-06 |
JP2020103314A (ja) | 2020-07-09 |
SG11201809620UA (en) | 2018-11-29 |
JP6994066B2 (ja) | 2022-02-04 |
CR20180509A (es) | 2019-02-15 |
KR20190003678A (ko) | 2019-01-09 |
CL2018003007A1 (es) | 2019-02-08 |
KR102523682B1 (ko) | 2023-04-19 |
IL262523A (en) | 2018-12-31 |
RU2018141360A (ru) | 2020-06-03 |
EP3452502A1 (en) | 2019-03-13 |
BR112018069890A2 (pt) | 2019-02-05 |
MX2018013342A (es) | 2019-05-09 |
AU2017259869A1 (en) | 2018-09-27 |
WO2017191101A1 (en) | 2017-11-09 |
US20190389971A1 (en) | 2019-12-26 |
EP3452502B1 (en) | 2021-03-03 |
US20240166771A1 (en) | 2024-05-23 |
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