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PE20181890A1 - Contorsbody - un ligante de diana monocatenario - Google Patents

Contorsbody - un ligante de diana monocatenario

Info

Publication number
PE20181890A1
PE20181890A1 PE2018002250A PE2018002250A PE20181890A1 PE 20181890 A1 PE20181890 A1 PE 20181890A1 PE 2018002250 A PE2018002250 A PE 2018002250A PE 2018002250 A PE2018002250 A PE 2018002250A PE 20181890 A1 PE20181890 A1 PE 20181890A1
Authority
PE
Peru
Prior art keywords
domain
fusion polypeptide
polypeptide
binding domain
spacer
Prior art date
Application number
PE2018002250A
Other languages
English (en)
Inventor
Stefan Dengl
Guy Georges
Friederike Hesse
Sabine Imhof-Jung
Josef Platzer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20181890A1 publication Critical patent/PE20181890A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/524CH2 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/526CH3 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/53Hinge
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Referido a un polipeptido de fusion dimerico que comprende una primera parte de un dominio de union, una segunda parte de un dominio de union y un dominio espaciador, en el que el domino espaciador es un polipeptido y comprende por lo menos 25 residuos aminoacidos, la primera parte del dominio de union es un polipeptido que se fusiona, directamente o mediante un primer conector, con el extremo N-terminal del dominio espaciador, la segunda parte del dominio de union es un polipeptido que se fusiona, directamente o mediante un segundo conector, con el extremo C-terminal del dominio espaciador, la primera parte del dominio de union y la segunda parte del dominio de union del mismo polipeptido de fusion monocatenario se asocian y forman un sitio de union funcional que se une especificamente a la diana. El polipeptido de fusion dimerico comprende dos polipeptidos de fusion identicos o diferentes, en el que el dominio espaciador del primer polipeptido de fusion se conjuga covalentemente con el dominio espaciador del segundo polipeptido de fusion. Tambien se refiere a una pareja de acidos nucleicos aislados que conjuntamente codifican el polipeptido de fusion dimerico y un metodo para producir el polipeptido de fusion
PE2018002250A 2016-05-02 2017-05-02 Contorsbody - un ligante de diana monocatenario PE20181890A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16167920 2016-05-02

Publications (1)

Publication Number Publication Date
PE20181890A1 true PE20181890A1 (es) 2018-12-11

Family

ID=56008478

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2018002250A PE20181890A1 (es) 2016-05-02 2017-05-02 Contorsbody - un ligante de diana monocatenario

Country Status (18)

Country Link
US (3) US20190389971A1 (es)
EP (2) EP3889175A1 (es)
JP (2) JP6675017B2 (es)
KR (1) KR102523682B1 (es)
CN (1) CN109071635B (es)
AU (1) AU2017259869A1 (es)
BR (1) BR112018069890A2 (es)
CA (1) CA3019524A1 (es)
CL (1) CL2018003007A1 (es)
CR (1) CR20180509A (es)
IL (1) IL262523A (es)
MA (1) MA56474A (es)
MX (1) MX2018013342A (es)
PE (1) PE20181890A1 (es)
RU (1) RU2018141360A (es)
SG (1) SG11201809620UA (es)
UA (1) UA123323C2 (es)
WO (1) WO2017191101A1 (es)

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ES2907467T3 (es) * 2014-12-05 2022-04-25 Xyphos Biosciences Inc Fragmentos variables insertables de anticuerpos y dominios a1-a2 modificados de ligandos NKG2D
AU2018353420A1 (en) 2017-10-20 2020-04-16 F. Hoffmann-La Roche Ag Method for generating multispecific antibodies from monospecific antibodies
CN111372947A (zh) 2017-10-30 2020-07-03 豪夫迈·罗氏有限公司 在体内从单特异性抗体产生多特异性抗体的方法
CN111295392A (zh) 2017-11-01 2020-06-16 豪夫迈·罗氏有限公司 Compbody–多价靶结合物
CA3079129C (en) * 2017-11-01 2023-02-28 F. Hoffmann-La Roche Ag Trifab-contorsbody
IL272747B2 (en) 2017-11-01 2025-04-01 Hoffmann La Roche Bispecific antibodies 1 + 2
US12060435B2 (en) 2018-01-05 2024-08-13 City Of Hope Multi-specific ligand binders
BR112021001693A2 (pt) 2018-08-03 2021-05-04 Chugai Seiyaku Kabushiki Kaisha molécula de ligação ao antígeno contendo dois domínios de ligação ao antígeno q ligados entre si
JP2023512390A (ja) 2020-02-05 2023-03-27 中外製薬株式会社 組換え抗原結合分子を製造するおよび/または濃縮するための方法
AR121695A1 (es) 2020-03-31 2022-06-29 Chugai Pharmaceutical Co Ltd Moléculas de unión al antígeno multiespecíficas dirigidas a dll3 y sus usos
CA3184546A1 (en) * 2020-07-02 2022-01-06 Sanofi Glp-1r agonist / fgf21 fusion proteins
KR20220104423A (ko) 2021-01-18 2022-07-26 성기봉 페달엔진자전거(실용모델)
KR102604934B1 (ko) * 2021-10-27 2023-11-23 주식회사 베르티스 피분석물을 검출 또는 측정하기 위한 조성물
KR20240062555A (ko) 2022-11-02 2024-05-09 성기봉 회전 기어 방식의 적용 도르레

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