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PE20181331A1 - NUEVOS DERIVADOS DE IMIDAZO [4,5-b] PIRIDINA UN PROCESO PARA SU PREPRACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN - Google Patents

NUEVOS DERIVADOS DE IMIDAZO [4,5-b] PIRIDINA UN PROCESO PARA SU PREPRACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN

Info

Publication number
PE20181331A1
PE20181331A1 PE2018000443A PE2018000443A PE20181331A1 PE 20181331 A1 PE20181331 A1 PE 20181331A1 PE 2018000443 A PE2018000443 A PE 2018000443A PE 2018000443 A PE2018000443 A PE 2018000443A PE 20181331 A1 PE20181331 A1 PE 20181331A1
Authority
PE
Peru
Prior art keywords
imidazo
pyridine
pharmaceutical compositions
prepration
hydrogen
Prior art date
Application number
PE2018000443A
Other languages
English (en)
Inventor
Balazs Balint
Andras Kotschy
Melinda Sipos
Csaba Weber
Nicolas Foloppe
David Walmsley
Michael Frank Burbridge
Francisco Humberto Cruzalegui
Original Assignee
Servier Lab
Vernalis Randd Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Vernalis Randd Ltd filed Critical Servier Lab
Publication of PE20181331A1 publication Critical patent/PE20181331A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se refiere a compuestos de formula (I), sus enantiomeros, diasteroisomeros y sus sales de adicion de los mismos farmaceuticamente aceptable; en la que R1 es un grupo ciano, un atomo de halogeno, un grupo alquilo(C1-C6), entre otros; R2 es hidrogeno, grupo alquilo(C1-C6) lineal o ramificado, entre otros; R3 es un atomo de hidrogeno, halogeno, entre otros; R4 y R5 cada uno independientemente de los otros, representan un atomo de hidrogeno o halogeno; estos compuestos son derivados de imidazo [4,5-b] piridina y son inhibidores de DYRK1/CLK1. Es compuesto preferido: 4-[2-metil-3-(3-fenilciclobutil)-3H-imidazo[4,5-b]piridin-5-il]piridina-2,6-diamina, entre otros. Tambien se refiere a procesos para su preparacion, composiciones farmaceuticas y usos de estas, en el tratamiento del cancer, trastornos neurodegenerativos o trastornos metabolicos.
PE2018000443A 2015-09-30 2016-09-30 NUEVOS DERIVADOS DE IMIDAZO [4,5-b] PIRIDINA UN PROCESO PARA SU PREPRACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN PE20181331A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1559252A FR3041639B1 (fr) 2015-09-30 2015-09-30 NOUVEAUX DERIVES D'IMIDAZO[4,5-b]PYRIDINE, PROCEDE POUR LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

Publications (1)

Publication Number Publication Date
PE20181331A1 true PE20181331A1 (es) 2018-08-20

Family

ID=54979755

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2018000443A PE20181331A1 (es) 2015-09-30 2016-09-30 NUEVOS DERIVADOS DE IMIDAZO [4,5-b] PIRIDINA UN PROCESO PARA SU PREPRACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN

Country Status (26)

Country Link
US (1) US20180273528A1 (es)
EP (1) EP3356363A1 (es)
JP (1) JP2018535931A (es)
KR (1) KR20180054858A (es)
CN (1) CN108137581A (es)
AU (1) AU2016333505A1 (es)
BR (1) BR112018006157A2 (es)
CA (1) CA2999935A1 (es)
CL (1) CL2018000783A1 (es)
CO (1) CO2018003473A2 (es)
CR (1) CR20180181A (es)
CU (1) CU20180028A7 (es)
DO (1) DOP2018000083A (es)
EA (1) EA201890821A1 (es)
EC (1) ECSP18023253A (es)
FR (1) FR3041639B1 (es)
HK (1) HK1255804A1 (es)
IL (1) IL258341A (es)
MA (1) MA43020A (es)
MX (1) MX2018003860A (es)
NI (1) NI201800043A (es)
PE (1) PE20181331A1 (es)
PH (1) PH12018500650A1 (es)
SV (1) SV2018005657A (es)
TN (1) TN2018000090A1 (es)
WO (1) WO2017055530A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108822103A (zh) * 2018-07-28 2018-11-16 刘凤娟 一种咪唑并[4,5-b]吡啶化合物及其制备方法和应用
WO2020069418A1 (en) 2018-09-28 2020-04-02 Arizona Board Of Regents On Behalf Of The University Of Arizona Small molecule inhibitors of dyrk1/clk and uses thereof
AU2019373221B2 (en) 2018-10-31 2022-05-26 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having HPK1 inhibitory activity
PE20211655A1 (es) 2018-10-31 2021-08-24 Gilead Sciences Inc Compuestos de 6-azabencimidazol sustituidos como inhibidores de hpk1
US11453681B2 (en) 2019-05-23 2022-09-27 Gilead Sciences, Inc. Substituted eneoxindoles and uses thereof
AU2020345950A1 (en) * 2019-09-11 2022-03-31 Prelude Therapeutics Incorporated CDK inhibitors and their use as pharmaceuticals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2970200A1 (en) * 2013-03-13 2016-01-20 Abbvie Inc. Pyridine cdk9 kinase inhibitors

Also Published As

Publication number Publication date
BR112018006157A2 (pt) 2018-10-09
NI201800043A (es) 2018-06-21
PH12018500650A1 (en) 2018-10-01
JP2018535931A (ja) 2018-12-06
MX2018003860A (es) 2018-08-16
EA201890821A1 (ru) 2018-10-31
SV2018005657A (es) 2018-07-31
AU2016333505A1 (en) 2018-04-19
DOP2018000083A (es) 2018-10-15
WO2017055530A1 (en) 2017-04-06
FR3041639A1 (es) 2017-03-31
CL2018000783A1 (es) 2018-09-21
CA2999935A1 (en) 2017-04-06
EP3356363A1 (en) 2018-08-08
CN108137581A (zh) 2018-06-08
KR20180054858A (ko) 2018-05-24
ECSP18023253A (es) 2018-04-30
CR20180181A (es) 2018-06-22
FR3041639B1 (fr) 2019-01-25
TN2018000090A1 (en) 2019-07-08
CU20180028A7 (es) 2018-07-05
CO2018003473A2 (es) 2018-07-10
US20180273528A1 (en) 2018-09-27
IL258341A (en) 2018-05-31
MA43020A (fr) 2018-08-08
HK1255804A1 (zh) 2019-08-23

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