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PE20142445A1 - Compuestos de pirazol sustituidos como antagonistas de lpar - Google Patents

Compuestos de pirazol sustituidos como antagonistas de lpar

Info

Publication number
PE20142445A1
PE20142445A1 PE2014002212A PE2014002212A PE20142445A1 PE 20142445 A1 PE20142445 A1 PE 20142445A1 PE 2014002212 A PE2014002212 A PE 2014002212A PE 2014002212 A PE2014002212 A PE 2014002212A PE 20142445 A1 PE20142445 A1 PE 20142445A1
Authority
PE
Peru
Prior art keywords
compounds substituted
pirazole
lpar antagonists
lpar
antagonists
Prior art date
Application number
PE2014002212A
Other languages
English (en)
Inventor
Stephen Deems Gabriel
Matthew Michael Hamilton
Yimin Qian
Achyutharao Sidduri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48656033&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20142445(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20142445A1 publication Critical patent/PE20142445A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Referida a un compuesto derivado de pirazol de formula (I), donde X es oxigeno, nitrogeno o carbono; R1 es alquilo inferior; R2 es hidrogeno, halogeno, alcoxi, entre otros; R3 es ciclobutilo, oxetanilo, entre otros. Tambien esta referida a una composicion farmaceutica. Dichos compuestos tienen actividad antagonista del acido lisofosfatidico (LPA) y son utiles para el tratamiento de enfermedades y trastornos inflamatorios, tales como, por ejemplo, fibrosis pulmonar
PE2014002212A 2012-06-20 2013-06-17 Compuestos de pirazol sustituidos como antagonistas de lpar PE20142445A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261661958P 2012-06-20 2012-06-20

Publications (1)

Publication Number Publication Date
PE20142445A1 true PE20142445A1 (es) 2015-01-28

Family

ID=48656033

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014002212A PE20142445A1 (es) 2012-06-20 2013-06-17 Compuestos de pirazol sustituidos como antagonistas de lpar

Country Status (22)

Country Link
US (1) US20150259295A1 (es)
EP (1) EP2864294A1 (es)
JP (1) JP2015520201A (es)
KR (1) KR20150011003A (es)
CN (1) CN104411690A (es)
AU (1) AU2013279510A1 (es)
BR (1) BR112014031108A2 (es)
CA (1) CA2869602A1 (es)
CL (1) CL2014003242A1 (es)
CO (1) CO7160077A2 (es)
CR (1) CR20140516A (es)
EA (1) EA201492283A1 (es)
HK (1) HK1206341A1 (es)
IL (1) IL236091A0 (es)
IN (1) IN2014DN09347A (es)
MA (1) MA37765A1 (es)
MX (1) MX2014014105A (es)
PE (1) PE20142445A1 (es)
PH (1) PH12014502364A1 (es)
SG (1) SG11201407229UA (es)
UA (1) UA109867C2 (es)
WO (1) WO2013189862A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140067048A (ko) 2011-08-15 2014-06-03 인터뮨, 인크. 라이소포스파티드산 수용체 길항제
KR102090231B1 (ko) 2013-03-15 2020-03-17 에피젠 바이오싸이언시즈, 아이엔씨. 질환의 치료에 유용한 헤테로환식 화합물
ES2824801T3 (es) 2014-06-27 2021-05-13 Ube Industries Sal de compuesto heterocíclico sustituido con halógeno
JP7301839B2 (ja) * 2017-12-19 2023-07-03 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのピラゾールｎ－連結のカルバモイルシクロヘキシル酸
CN111434655A (zh) * 2019-01-15 2020-07-21 武汉朗来科技发展有限公司 溶血磷脂酸受体拮抗剂及其制备方法
JP7431961B2 (ja) 2019-11-15 2024-02-15 ギリアード サイエンシーズ， インコーポレイテッド Ｌｐａ受容体アンタゴニストとしてのトリアゾールカルバメートピリジルスルホンアミド及びその使用
TWI838626B (zh) 2020-06-03 2024-04-11 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
AU2021282986B2 (en) 2020-06-03 2024-03-07 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof
WO2022240879A1 (en) * 2021-05-11 2022-11-17 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
CA3238094A1 (en) 2021-12-08 2023-06-15 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063241A1 (ja) * 2003-12-26 2005-07-14 Ono Pharmaceutical Co., Ltd. ミトコンドリアベンゾジアゼピン受容体介在性疾患の予防および／または治療剤
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
US20090036425A1 (en) 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
GB2466121B (en) * 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
GB2470833B (en) * 2009-06-03 2011-06-01 Amira Pharmaceuticals Inc Polycyclic antagonists of lysophosphatidic acid receptors
CN102574822A (zh) * 2009-08-04 2012-07-11 阿米拉制药公司 作为溶血磷脂酸受体拮抗剂的化合物
PH12013501136A1 (en) * 2010-12-07 2013-07-08 Amira Pharmaceuticals Inc Lysophosphatidic acid receptor antagonists and uses thereof
WO2012138648A1 (en) * 2011-04-06 2012-10-11 Irm Llc Compositions and methods for modulating lpa receptors
KR20140067048A (ko) * 2011-08-15 2014-06-03 인터뮨, 인크. 라이소포스파티드산 수용체 길항제

Also Published As

Publication number Publication date
MX2014014105A (es) 2015-03-05
PH12014502364A1 (en) 2015-01-12
IL236091A0 (en) 2015-02-01
HK1206341A1 (en) 2016-01-08
SG11201407229UA (en) 2014-12-30
EA201492283A1 (ru) 2015-04-30
JP2015520201A (ja) 2015-07-16
WO2013189862A1 (en) 2013-12-27
CR20140516A (es) 2014-12-01
CL2014003242A1 (es) 2015-03-20
US20150259295A1 (en) 2015-09-17
CA2869602A1 (en) 2013-12-27
BR112014031108A2 (pt) 2017-06-27
AU2013279510A1 (en) 2014-10-16
UA109867C2 (ru) 2015-10-12
EP2864294A1 (en) 2015-04-29
IN2014DN09347A (es) 2015-07-17
MA37765A1 (fr) 2017-04-28
KR20150011003A (ko) 2015-01-29
CN104411690A (zh) 2015-03-11
CO7160077A2 (es) 2015-01-15

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