PE20091779A1 - Tiazolopiridin-2-iloxi-fenil y tiazolopirazin-2-iloxi-fenil aminas como moduladores de leucotrieno a4 hidrolasa - Google Patents
Tiazolopiridin-2-iloxi-fenil y tiazolopirazin-2-iloxi-fenil aminas como moduladores de leucotrieno a4 hidrolasaInfo
- Publication number
- PE20091779A1 PE20091779A1 PE2009000508A PE2009000508A PE20091779A1 PE 20091779 A1 PE20091779 A1 PE 20091779A1 PE 2009000508 A PE2009000508 A PE 2009000508A PE 2009000508 A PE2009000508 A PE 2009000508A PE 20091779 A1 PE20091779 A1 PE 20091779A1
- Authority
- PE
- Peru
- Prior art keywords
- iloxi
- phenyl
- thiazolopirazin
- thiazolopyridin
- leukotriene
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
REFERIDA A UN DERIVADO DE TIAZOLOPIRIDIN-2-ILOXI-FENIL Y TIAZOLOPIRAZIN-2-ILOXI-FENIL AMINA DE FORMULA (I), DONDE X4, X5, X6 Y X7 SON N O NRa; Ra ES H, CH3, CF3 O FLUOR; R1 Y R2 SON H, -(CH2)2-3OCH3, -CH2C(O)NH2, -(CH2)3NH2, ENTRE OTROS; A ES -CH2-, -CH2CH2- O -OCH2CH2. SON COMPUESTOS PREFERIDOS: 2-(4-{2-[4-(PIRIMIDIN-2-ILOXI)PIPERIDIN-1-IL]ETOXI}FENOXI)TIAZOLO[4,5-b]PIRIDINA, 2-{4-[2-(1,3-DIHIDRO-2H-ISOINDOL-2-IL)ETOXI]FENOXI}[1,3]TIAZOLO[4,5-b]PIRIDINA, 2-(4-{2-[4-(FENILSULFANIL)PIPERIDIN-1-IL]ETOXI}FENOXI)[1,3]TIAZOLO[4,5-b]PIRIDINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LEUCOTRIENO A4 HIDROLASA (LTA4H) Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS TALES COMO DERMATITIS ATOPICA, SINDROME DE SJOGREN-LARSSON, ASMA, ENTRE OTRAS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4434908P | 2008-04-11 | 2008-04-11 | |
| US14912909P | 2009-02-02 | 2009-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091779A1 true PE20091779A1 (es) | 2009-11-14 |
Family
ID=41130551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000508A PE20091779A1 (es) | 2008-04-11 | 2009-04-13 | Tiazolopiridin-2-iloxi-fenil y tiazolopirazin-2-iloxi-fenil aminas como moduladores de leucotrieno a4 hidrolasa |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US7939527B2 (es) |
| EP (2) | EP2336125B1 (es) |
| JP (2) | JP5530423B2 (es) |
| KR (1) | KR101228378B1 (es) |
| CN (1) | CN102056933B (es) |
| AR (1) | AR072353A1 (es) |
| AU (1) | AU2009234140B2 (es) |
| BR (1) | BRPI0911336A2 (es) |
| CA (1) | CA2721099C (es) |
| CL (1) | CL2009000877A1 (es) |
| CO (1) | CO6260069A2 (es) |
| CY (1) | CY1114628T1 (es) |
| DK (2) | DK2336125T3 (es) |
| EA (1) | EA018802B1 (es) |
| EC (1) | ECSP10010558A (es) |
| ES (2) | ES2440746T3 (es) |
| HK (2) | HK1152041A1 (es) |
| HN (1) | HN2010002074A (es) |
| HR (2) | HRP20130278T1 (es) |
| IL (2) | IL208480A (es) |
| JO (1) | JO2911B1 (es) |
| MX (1) | MX2010011154A (es) |
| MY (1) | MY157597A (es) |
| NI (1) | NI201000168A (es) |
| NZ (2) | NZ588341A (es) |
| PE (1) | PE20091779A1 (es) |
| PH (1) | PH12013500094B1 (es) |
| PL (2) | PL2268646T3 (es) |
| PT (2) | PT2268646E (es) |
| RS (2) | RS53081B (es) |
| SI (2) | SI2268646T1 (es) |
| SV (1) | SV2010003694A (es) |
| TW (2) | TW201420100A (es) |
| UY (1) | UY31760A (es) |
| WO (1) | WO2009126806A2 (es) |
| ZA (1) | ZA201008054B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1976828T (pt) | 2005-12-29 | 2017-03-10 | Celtaxsys Inc | Derivados de diamina como inibidores de leucotrieno a4 hidrolase |
| AU2009234140B2 (en) * | 2008-04-11 | 2013-04-11 | Janssen Pharmaceutica Nv | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase |
| CN104487435A (zh) | 2012-03-06 | 2015-04-01 | 勃林格殷格翰国际有限公司 | 用于抑制白三烯生成的苯并二氧杂环己烷与其他活性剂的组合 |
| EP2822942B1 (en) * | 2012-03-06 | 2017-05-10 | Boehringer Ingelheim International GmbH | Benzodioxanes for inhibiting leukotriene production |
| WO2014014874A1 (en) | 2012-07-17 | 2014-01-23 | Boehringer Ingelheim International Gmbh | Pyrazole derivatives which inhibit leukotriene production |
| EP2746259A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
| EP2746260A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
| RU2686101C2 (ru) | 2013-03-12 | 2019-04-24 | Селтакссис, Инк. | Способы ингибирования лейкотриен- а4-гидролазы |
| CA2906035A1 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
| JP6562898B2 (ja) * | 2013-03-14 | 2019-08-21 | セルタクシス，インコーポレイテッド | ロイコトリエンａ４加水分解酵素の阻害剤 |
| JP7386815B2 (ja) | 2018-05-31 | 2023-11-27 | セルタクシー、エルエルシー | 呼吸器疾患患者の肺増悪を軽減する方法 |
| EP3908278A4 (en) * | 2019-01-11 | 2022-09-28 | Naegis Pharmaceuticals Inc. | LEUCOTRIENE SYNTHESIS INHIBITORS |
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| US4329466A (en) | 1979-01-16 | 1982-05-11 | Delalande S.A. | Certain nor-tropan-8-amine-3-aryl or heteroaryl derivatives |
| FR2476088A2 (fr) | 1979-01-16 | 1981-08-21 | Delalande Sa | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
| US4321378A (en) | 1979-01-16 | 1982-03-23 | Delalande S.A. | 8-(5-Pyrimidinecarboxamide)nor-tropane derivatives |
| FR2446823A1 (fr) | 1979-01-16 | 1980-08-14 | Delalande Sa | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
| US4352802A (en) | 1980-06-10 | 1982-10-05 | Beecham Group Limited | Bicyclo[3.3.1]nonyl-benzamide |
| NZ199080A (en) | 1980-12-12 | 1984-07-31 | Beecham Group Ltd | 2-alkoxy-4-amino-5-alkylsulphonyl-n-(3beta-(8-hydrocarbyl-8-azabicyclo (3,2,1)octyl))benzamides |
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