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PE20081503A1 - Miembros de union para il-6 - Google Patents

Miembros de union para il-6

Info

Publication number
PE20081503A1
PE20081503A1 PE2007001694A PE2007001694A PE20081503A1 PE 20081503 A1 PE20081503 A1 PE 20081503A1 PE 2007001694 A PE2007001694 A PE 2007001694A PE 2007001694 A PE2007001694 A PE 2007001694A PE 20081503 A1 PE20081503 A1 PE 20081503A1
Authority
PE
Peru
Prior art keywords
seq
lcdr1
hcdr1
hcdr2
hcdr3
Prior art date
Application number
PE2007001694A
Other languages
English (en)
Inventor
Simon Charles Cruwys
Philip Mallinder
Steven Godfrey Lane
Original Assignee
Astrazeneca Ab
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Medimmune Ltd filed Critical Astrazeneca Ab
Publication of PE20081503A1 publication Critical patent/PE20081503A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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Abstract

SE REFIERE A UN MIEMBRO DE UNION PARA IL-6 (INTERLEUQUINA 6) HUMANA, EL CUAL SE UNE EN EL RESIDUO Phe102 Y/O Ser204, SEGUN LA SEQ ID Nº 161, CARACTERIZADO PORQUE COMPRENDE UN CONJUNTO DE CDR: HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 Y LCDR3, QUE TIENEN 22 ALTERACIONES DE AMINOACIDOS O MENOS, CON RESPECTO A UN CONJUNTO DE CDR DONDE: HCDR1 ES SEQ ID Nº 3, HCDR2 ES SEQ ID Nº 4, HCDR3 ES SEQ ID Nº 115, LCDR1 ES SEQ ID Nº 8, ENTRE OTROS. ADEMAS PRESENTA UN KD DE NO MAS DE 30 pM. TAMBIEN SE REFIERE A UNA MOLECULA DE ANTICUERPO; UN ACIDO NUCLEICO QUE LO CODIFICA; METODO DE PRODUCCION; UNA COMPOSICION FARMACEUTICA QUE LOS COMPRENDE; SIENDO UTIL EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS, TRASTORNOS AUTOINMUNES Y TUMORES ASOCIADOS CON IL-6
PE2007001694A 2006-11-30 2007-11-30 Miembros de union para il-6 PE20081503A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86170406P 2006-11-30 2006-11-30

Publications (1)

Publication Number Publication Date
PE20081503A1 true PE20081503A1 (es) 2008-12-07

Family

ID=39183176

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001694A PE20081503A1 (es) 2006-11-30 2007-11-30 Miembros de union para il-6

Country Status (19)

Country Link
US (6) US8198414B2 (es)
EP (2) EP2628751A3 (es)
JP (3) JP5366818B2 (es)
KR (1) KR101517627B1 (es)
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