PE20080774A1 - IMMUNOGENIC COMPOSITION INCLUDING PNAG OF STAPHYLACCOCES CONJUGATED WITH A CARRIER PROTEIN AND CAPSULAR POLYSACCHARIDE OR OLIGOSACCHARIDE OF S. AUREUS - Google Patents
IMMUNOGENIC COMPOSITION INCLUDING PNAG OF STAPHYLACCOCES CONJUGATED WITH A CARRIER PROTEIN AND CAPSULAR POLYSACCHARIDE OR OLIGOSACCHARIDE OF S. AUREUSInfo
- Publication number
- PE20080774A1 PE20080774A1 PE2007000353A PE2007000353A PE20080774A1 PE 20080774 A1 PE20080774 A1 PE 20080774A1 PE 2007000353 A PE2007000353 A PE 2007000353A PE 2007000353 A PE2007000353 A PE 2007000353A PE 20080774 A1 PE20080774 A1 PE 20080774A1
- Authority
- PE
- Peru
- Prior art keywords
- pnag
- carrier protein
- aureus
- conjugated
- immunogenic composition
- Prior art date
Links
- 108010078791 Carrier Proteins Proteins 0.000 title abstract 4
- 102000014914 Carrier Proteins Human genes 0.000 title abstract 3
- 150000004676 glycans Chemical class 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 title abstract 2
- 229920001542 oligosaccharide Polymers 0.000 title abstract 2
- 229920001282 polysaccharide Polymers 0.000 title abstract 2
- 239000005017 polysaccharide Substances 0.000 title abstract 2
- 150000002482 oligosaccharides Chemical class 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 108010064033 elastin-binding proteins Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UNA COMPOSICION INMUNOGENICA QUE COMPRENDE PNAG (POLIGLUCOSAMINA N-ACETILADA) DE ESTAFILOCOCOS QUE ESTA N-ACETILADA EN MENOS DE 40% ,Y POLISACARIDO U OLIGOSACARIDO CAPSULAR DE TIPO 5 Y/U 8 S. AUREUS EN LA QUE LA PNAG ESTA CONJUGADA CON UNA PROTEINA PORTADORA MEDIANTE UN LIGADOR UNIDO A UN GRUPO AMINA EN LA PNAG PARA FORMAR UN CONJUGADO DE PNAG QUE TIENE LA ESTRUCTURA DE FORMULA (I), EN DONDE R1 Y R2 SON INDEPENDIENTEMENTE UNA CADENA AROMATICAQ O ALIFATICA OPCIONALMENTE SUSTITUIDA O UN ENLACE; Y LA PROTEINA PORTADORA CONSTITUYE UNA PROTEINA DE ESTAFILOCOCOS O FRAGMENTO DE LA MISMA SELECCIONADA DEL GRUPO CONSTITUIDO POR RECEPTOR DE LAMININA, PROTEINA DE UNION SALIVA /MntC/SitC, DE UNION ELASTINA, AUTOLISINA, TRANSPORTADOR INMUNODOMINANATE ABC, TOXOIDE TETANICO, TOXOIDE DIFTERICO, CRM197, TOXOIDE ALFA (HIa), ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO DE OBTENCION Y UNA VACUNA; SIENDO UTILES EN EL TRATAMIENTO Y PREVENCION DE INFECCIONES PRODUCIDAS POR ESTAFILOCOCOSIT REFERS TO AN IMMUNOGENIC COMPOSITION INCLUDING PNAG (N-ACETYLATED POLYGLUCOSAMINE) OF STAPHYLOCOCES WHICH IS N-ACETYLATED IN LESS THAN 40%, AND POLYSACCHARIDE OR CAPSULAR OLIGOSACCHARID OF TYPE 5 AND / OR 8 S. AUREUS IS CONJUGATED IN PNAGADA WITH A CARRIER PROTEIN THROUGH A LINKAGER JOINED TO AN AMINE GROUP IN THE PNAG TO FORM A CONJUGATE OF PNAG THAT HAS THE STRUCTURE OF FORMULA (I), WHERE R1 AND R2 ARE INDEPENDENTLY AN OPTIONALLY SUBSTITUTE OR UNDERLY SUBSTITUTE AROMATIC OR ALIPHATIC CHAIN; AND THE CARRIER PROTEIN CONSTITUTES A STAPHYLOCOCAL PROTEIN OR FRAGMENT OF THE SAME SELECTED FROM THE GROUP CONSTITUTED BY LAMININE RECEPTOR, SALIVA / MntC / SitC BINDING PROTEIN, OF ELASTIN BINDING, AUTOLYSIN, ABC19 CRYSTAL, THYMUNETIC TRANSPORTER ALPHA TOXOID (HIa), AMONG OTHERS. IT ALSO REFERS TO A PROCESS OF OBTAINING AND A VACCINE; BEING USEFUL IN THE TREATMENT AND PREVENTION OF INFECTIONS CAUSED BY STAPHYLOCOCES
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78758706P | 2006-03-30 | 2006-03-30 | |
| US78724906P | 2006-03-30 | 2006-03-30 | |
| GB0606416A GB0606416D0 (en) | 2006-03-30 | 2006-03-30 | Immunogenic composition |
| GB0606417A GB0606417D0 (en) | 2006-03-30 | 2006-03-30 | Immunogenic composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080774A1 true PE20080774A1 (en) | 2008-08-08 |
Family
ID=43217117
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011001600A PE20120262A1 (en) | 2006-03-30 | 2007-03-28 | PROCEDURE FOR THE PREPARATION OF IMMUNOCONJUGATES INCLUDING POLYSACCHARIDE OR CAPSULAR OLIGOSACCHARIDE FROM S. AUREUS TOGETHER WITH THE CARRIER PROTEIN |
| PE2007000349A PE20080129A1 (en) | 2006-03-30 | 2007-03-28 | CONJUGATION PROCEDURE |
| PE2007000353A PE20080774A1 (en) | 2006-03-30 | 2007-03-28 | IMMUNOGENIC COMPOSITION INCLUDING PNAG OF STAPHYLACCOCES CONJUGATED WITH A CARRIER PROTEIN AND CAPSULAR POLYSACCHARIDE OR OLIGOSACCHARIDE OF S. AUREUS |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011001600A PE20120262A1 (en) | 2006-03-30 | 2007-03-28 | PROCEDURE FOR THE PREPARATION OF IMMUNOCONJUGATES INCLUDING POLYSACCHARIDE OR CAPSULAR OLIGOSACCHARIDE FROM S. AUREUS TOGETHER WITH THE CARRIER PROTEIN |
| PE2007000349A PE20080129A1 (en) | 2006-03-30 | 2007-03-28 | CONJUGATION PROCEDURE |
Country Status (4)
| Country | Link |
|---|---|
| CL (1) | CL2007000839A1 (en) |
| JO (2) | JO3420B1 (en) |
| PE (3) | PE20120262A1 (en) |
| TW (1) | TWI494124B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102120761B (en) * | 2010-12-24 | 2013-02-06 | 新疆维吾尔自治区畜牧科学院兽医研究所 | Preparation method of acapsular type staphylococcus aureus extracellular polysaccharide-protein conjugate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60038166T2 (en) * | 1999-03-19 | 2009-03-12 | Glaxosmithkline Biologicals S.A., Rixensart | VACCINE AGAINST BACTERIAL ANTIGENE |
| US9296795B2 (en) * | 2003-03-07 | 2016-03-29 | Wyeth Holdings, Llc. | Polysaccharide-staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections |
| DE602004017864D1 (en) * | 2003-06-23 | 2009-01-02 | Baxter Int | CARRIER PROTEINS FOR VACCINES |
-
2007
- 2007-03-28 CL CL2007000839A patent/CL2007000839A1/en unknown
- 2007-03-28 JO JOP/2007/0092A patent/JO3420B1/en active
- 2007-03-28 TW TW096110815A patent/TWI494124B/en active
- 2007-03-28 JO JOP/2007/0087A patent/JO3418B1/en active
- 2007-03-28 PE PE2011001600A patent/PE20120262A1/en active IP Right Grant
- 2007-03-28 PE PE2007000349A patent/PE20080129A1/en active IP Right Grant
- 2007-03-28 PE PE2007000353A patent/PE20080774A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI494124B (en) | 2015-08-01 |
| CL2007000839A1 (en) | 2008-01-25 |
| JO3418B1 (en) | 2019-10-20 |
| PE20120262A1 (en) | 2012-03-30 |
| JO3420B1 (en) | 2019-10-20 |
| TW200806314A (en) | 2008-02-01 |
| PE20080129A1 (en) | 2008-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |