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PE20070591A1 - Derivados de 6-heteroarilpiridoindolona y su preparacion - Google Patents

Derivados de 6-heteroarilpiridoindolona y su preparacion

Info

Publication number
PE20070591A1
PE20070591A1 PE2006001217A PE2006001217A PE20070591A1 PE 20070591 A1 PE20070591 A1 PE 20070591A1 PE 2006001217 A PE2006001217 A PE 2006001217A PE 2006001217 A PE2006001217 A PE 2006001217A PE 20070591 A1 PE20070591 A1 PE 20070591A1
Authority
PE
Peru
Prior art keywords
alkyl
methyl
heteroarylpyridoindolone
compounds
alcoxy
Prior art date
Application number
PE2006001217A
Other languages
English (en)
Inventor
Yvette Muneaux
Samir Jegham
Pierre Casellas
Jean-Marie Derocq
Camille-Georges Wermuth
Paola Ciapetti
Bernard Bourrie
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20070591A1 publication Critical patent/PE20070591A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 6-HETEROARILPIRIDOINDOLONA DE FORMULA (I) DONDE R1 ES H, ALQUILO(C1-C4), CN, CF3 O CHF2; R2 ES H O ALQUILO(C1-C4); R3 ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO ALQUILO O ALCOXI(C1-C4); R4 ES UN HETEROCICLICO SELECCIONADO DE 1,3-TIAZOL, 1,3,4-TIADIAZOL, PIRAZOL, OXAZOL, ISOXAZOL ENTRE OTROS SUSTITUIDOS POR R7; R5 ES H, HALOGENO, ALQUILO O ALCOXI(C1-C4). SON COMPUESTOS PREFERIDOS: 3-(2,4-DICLOROFENIL)-1-METIL-6-(2-METIL-1,3-TIAZOL-4-IL9-1,9-DIHIDRO-2H-PIRIDO 2,3-b INDOL-2-ONA, 6-(2-AMINO-1,3-TIAZOL-4-IL)-3-(2,4-DICLOFENIL)-1-METIL-1,9-DIHIDRO-2H-PIRIDO 2,3b INDOL-2-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE LA PROLIFERACION DE LAS CELULAS TUMORALES Y SON UTILES EN EL TRATAMIENTO DE NEOPLASMAS, CARCINOMAS, SARCOMAS, CANCER DE MAMA, ENTRE OTROS
PE2006001217A 2005-10-20 2006-10-05 Derivados de 6-heteroarilpiridoindolona y su preparacion PE20070591A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0510730A FR2892416B1 (fr) 2005-10-20 2005-10-20 Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
PE20070591A1 true PE20070591A1 (es) 2007-08-03

Family

ID=35953891

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001217A PE20070591A1 (es) 2005-10-20 2006-10-05 Derivados de 6-heteroarilpiridoindolona y su preparacion

Country Status (33)

Country Link
US (1) US8063061B2 (es)
EP (1) EP1940840B1 (es)
JP (1) JP2009512666A (es)
KR (1) KR20080057300A (es)
CN (1) CN101312970A (es)
AR (1) AR056874A1 (es)
AT (1) ATE474840T1 (es)
AU (1) AU2006303210A1 (es)
BR (1) BRPI0617684A2 (es)
CA (1) CA2625502C (es)
CR (1) CR9873A (es)
CY (1) CY1110891T1 (es)
DE (1) DE602006015675D1 (es)
DK (1) DK1940840T3 (es)
DO (1) DOP2006000225A (es)
EA (1) EA014873B1 (es)
EC (1) ECSP088370A (es)
ES (1) ES2348745T3 (es)
FR (1) FR2892416B1 (es)
GT (1) GT200600462A (es)
HR (1) HRP20100572T1 (es)
IL (1) IL190519A0 (es)
MA (1) MA29961B1 (es)
NO (1) NO20082226L (es)
PE (1) PE20070591A1 (es)
PL (1) PL1940840T3 (es)
PT (1) PT1940840E (es)
SI (1) SI1940840T1 (es)
TN (1) TNSN08161A1 (es)
TW (1) TW200734336A (es)
UY (1) UY29879A1 (es)
WO (1) WO2007045758A1 (es)
ZA (1) ZA200803445B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823975B1 (fr) 2001-04-27 2003-05-30 Sanofi Synthelabo Nouvelle utilisation de pyridoindolone
FR2846329B1 (fr) 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique
US7456193B2 (en) 2002-10-23 2008-11-25 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
FR2869316B1 (fr) 2004-04-21 2006-06-02 Sanofi Synthelabo Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique.
AU2013262516B2 (en) * 2012-05-17 2017-10-19 Genentech, Inc. Process for making amino acid compounds
CA2931189C (en) 2013-12-13 2017-09-26 F. Hoffmann-La Roche Ag Inhibitors of bruton's tyrosine kinase
EP3080098B1 (en) 2013-12-13 2017-12-06 F. Hoffmann-La Roche AG Inhibitors of bruton's tyrosine kinase

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268772A (en) 1968-03-15 1972-03-29 Glaxo Lab Ltd NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME
US4263304A (en) 1978-06-05 1981-04-21 Sumitomo Chemical Company, Limited 7 H-indolo[2,3-c]isoquinolines
SU833971A1 (ru) 1979-07-10 1981-05-30 Ленинградский Химико-Фармацевтическийинститут Способ получени 3-фенил-2-оксо- - КАРбОлиНОВ
FR2595701B1 (fr) 1986-03-17 1988-07-01 Sanofi Sa Derives du pyrido-indole, leur application a titre de medicaments et les compositions les renfermant
ATE386131T1 (de) 1994-04-13 2008-03-15 Univ Rockefeller Aav-vermittelte überbringung von dna in zellen des nervensystems
DE19502753A1 (de) 1995-01-23 1996-07-25 Schering Ag Neue 9H-Pyrido[3,4-b]indol-Derivate
FR2765581B1 (fr) 1997-07-03 1999-08-06 Synthelabo Derives de 3-aryl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one, leur preparation et leur application en therapeutique
FR2765582B1 (fr) 1997-07-03 1999-08-06 Synthelabo Derives de 3-alkyl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one leur preparation et leur application en therapeutique
US6291473B1 (en) 1998-04-02 2001-09-18 Neurogen Corporation Aminoalkyl substituted 5,6,7,8-tetrahydro-9H-pyridino [2, 3-B] indole and 5,6,7,8-tetrahydro-9H-pyrimidino [4, 5-B] indole derivatives: CRF1 specific ligands
IT1313592B1 (it) 1999-08-03 2002-09-09 Novuspharma Spa Derivati di 1h-pirido 3,4-b indol-1-one.
US20020156016A1 (en) 2001-03-30 2002-10-24 Gerald Minuk Control of cell growth by altering cell membrane potentials
FR2823975B1 (fr) 2001-04-27 2003-05-30 Sanofi Synthelabo Nouvelle utilisation de pyridoindolone
FR2846329B1 (fr) 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique
FR2846330B1 (fr) * 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par groupe heterocyclique, leur preparation et leur application en therapeutique
US7456193B2 (en) 2002-10-23 2008-11-25 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
FR2869316B1 (fr) 2004-04-21 2006-06-02 Sanofi Synthelabo Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
MA29961B1 (fr) 2008-11-03
SI1940840T1 (sl) 2010-11-30
ZA200803445B (en) 2010-02-24
CA2625502A1 (fr) 2007-04-26
GT200600462A (es) 2007-07-17
EA014873B1 (ru) 2011-02-28
EP1940840A1 (fr) 2008-07-09
CA2625502C (fr) 2012-01-10
EP1940840B1 (fr) 2010-07-21
ES2348745T3 (es) 2010-12-13
KR20080057300A (ko) 2008-06-24
DK1940840T3 (da) 2010-11-22
US8063061B2 (en) 2011-11-22
EA200801123A1 (ru) 2009-02-27
FR2892416A1 (fr) 2007-04-27
PL1940840T3 (pl) 2010-12-31
TNSN08161A1 (en) 2009-10-30
PT1940840E (pt) 2010-10-13
IL190519A0 (en) 2008-11-03
CN101312970A (zh) 2008-11-26
DOP2006000225A (es) 2007-08-31
AR056874A1 (es) 2007-10-31
TW200734336A (en) 2007-09-16
UY29879A1 (es) 2007-05-31
CY1110891T1 (el) 2015-06-10
AU2006303210A1 (en) 2007-04-26
ECSP088370A (es) 2008-05-30
WO2007045758A1 (fr) 2007-04-26
HRP20100572T1 (hr) 2011-01-31
BRPI0617684A2 (pt) 2011-11-01
DE602006015675D1 (de) 2010-09-02
CR9873A (es) 2008-05-05
JP2009512666A (ja) 2009-03-26
US20080262020A1 (en) 2008-10-23
ATE474840T1 (de) 2010-08-15
FR2892416B1 (fr) 2008-06-27
NO20082226L (no) 2008-07-01

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