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PE20070137A1 - Compuestos derivados de benzamidina como moduladores de las hidroxiesteroide deshidrogenasas - Google Patents

Compuestos derivados de benzamidina como moduladores de las hidroxiesteroide deshidrogenasas

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Publication number
PE20070137A1
PE20070137A1 PE2006000679A PE2006000679A PE20070137A1 PE 20070137 A1 PE20070137 A1 PE 20070137A1 PE 2006000679 A PE2006000679 A PE 2006000679A PE 2006000679 A PE2006000679 A PE 2006000679A PE 20070137 A1 PE20070137 A1 PE 20070137A1
Authority
PE
Peru
Prior art keywords
halogen
hydroxiesteroid
dehydrogenases
modulators
benzamidine
Prior art date
Application number
PE2006000679A
Other languages
English (en)
Inventor
Jay P Powers
Michael Degraffenreid
Lisa D Julian
Daqing Sun
Xuelei Yan
Yosup Rew
Dustin L Mcminn
Xiao He
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of PE20070137A1 publication Critical patent/PE20070137A1/es

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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE R1 ES OH, HALOGENO O HALOALQUILO(C1-C6); R2 Y R3 SON HALOGENO, ALQUILO(C1-C8), ALQUENILO(C2-C8), ALCOXI(C1-C8), ENTRE OTROS; R4 ES H, HALOGENO, ALQUILO(C1-C8) O CICLOALQUILO(C3-C8); R5 ES HALOGENO, CN, NO2, ALQUINILO(C2-C8), ENTRE OTROS; R6 ES HALOGENO, CN, NO2, CICLOALQUILO(C3-C8), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-BENCIL-N-METIL-4-(1,1,1-TRIFLUORO-2-HIDROXIPROPAN-2-IL)BENZAMIDA, N-CICLOHEXIL-N-METIL-4-(1,1,1-TRIFLUORO-2-HIDROXIPROPAN-2-IL)BENZAMIDA, N-(3,4-DICLOROFENIL)-N-METIL-4-(1,1,1-TRIFLUORO-2-HIDROXIPROPAN-2-IL)BENZAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LAS ENZIMAS HIDROXIESTEROIDE DESHIDROGENASAS SIENDO UTILES EN EL TRATAMIENTO DE DIABETES, OBESIDAD, OVARIO POLIQUISTICO, HIPERLIPIDEMIA, RESISTENCIA A LA INSULINA
PE2006000679A 2005-06-17 2006-06-16 Compuestos derivados de benzamidina como moduladores de las hidroxiesteroide deshidrogenasas PE20070137A1 (es)

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WO2006138508A2 (en) 2006-12-28
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US20060293392A1 (en) 2006-12-28
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CA2611687A1 (en) 2006-12-28
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US20100069447A1 (en) 2010-03-18
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