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PE20061394A1 - Metabolitos de n-(2-cloro-6-metilfenil)-2-[[6-[4-(2-hidroxietil)-1-piperazinil]-2-metil-4-pirimidinil]amino]-5-tiazolcarboxamidas - Google Patents

Metabolitos de n-(2-cloro-6-metilfenil)-2-[[6-[4-(2-hidroxietil)-1-piperazinil]-2-metil-4-pirimidinil]amino]-5-tiazolcarboxamidas

Info

Publication number
PE20061394A1
PE20061394A1 PE2006000282A PE2006000282A PE20061394A1 PE 20061394 A1 PE20061394 A1 PE 20061394A1 PE 2006000282 A PE2006000282 A PE 2006000282A PE 2006000282 A PE2006000282 A PE 2006000282A PE 20061394 A1 PE20061394 A1 PE 20061394A1
Authority
PE
Peru
Prior art keywords
piperazinyl
pyrimidinyl
metabolites
methylphenyl
hydroxyethyl
Prior art date
Application number
PE2006000282A
Other languages
English (en)
Inventor
Vinod Kumar Arora
Lisa Joy Christopher
Donghui Cui
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20061394A1 publication Critical patent/PE20061394A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

REFERIDA A UN METABOLITO DE 'N-(2-CLORO-6-METILFENIL)-2-[[6-[4-(2-HIDROXIETIL)-1-PIPERAZINIL]-2-METIL-4-PIRIMIDINIL]AMINO]-5-TIAZOLCARBOXAMIDA DE FORMULA (I). TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS METABOLITOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES ONCOLOGICAS
PE2006000282A 2005-03-15 2006-03-13 Metabolitos de n-(2-cloro-6-metilfenil)-2-[[6-[4-(2-hidroxietil)-1-piperazinil]-2-metil-4-pirimidinil]amino]-5-tiazolcarboxamidas PE20061394A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66177705P 2005-03-15 2005-03-15
US72873205P 2005-10-20 2005-10-20

Publications (1)

Publication Number Publication Date
PE20061394A1 true PE20061394A1 (es) 2006-12-15

Family

ID=36603642

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000282A PE20061394A1 (es) 2005-03-15 2006-03-13 Metabolitos de n-(2-cloro-6-metilfenil)-2-[[6-[4-(2-hidroxietil)-1-piperazinil]-2-metil-4-pirimidinil]amino]-5-tiazolcarboxamidas

Country Status (6)

Country Link
US (1) US7622473B2 (es)
EP (1) EP1863807A1 (es)
AR (1) AR053169A1 (es)
PE (1) PE20061394A1 (es)
TW (1) TW200700416A (es)
WO (1) WO2006099474A1 (es)

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* Cited by examiner, † Cited by third party
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KR20100058660A (ko) * 2007-10-23 2010-06-03 테바 파마슈티컬 인더스트리즈 리미티드 다사티닙 다형체 및 이의 제조 방법
ES2396366T3 (es) * 2007-12-10 2013-02-21 Concert Pharmaceuticals Inc. Inhibidores heterocíclicos de quinasas
BRPI0800951A2 (pt) * 2008-04-09 2012-02-22 Ems Sa novos compostos derivados de taurina e seus usos, processo de sua preparação e composições farmacêuticas contendo os mesmos
CN102105583A (zh) * 2008-07-23 2011-06-22 奥林巴斯株式会社 从粪便试样中回收核酸的方法、核酸分析方法以及粪便试样处理装置
CN101973989B (zh) * 2010-05-17 2012-07-18 苏州波锐生物医药科技有限公司 一种噻唑酰胺类化合物及其在治疗恶性肿瘤中的药物用途
WO2012129381A1 (en) 2011-03-22 2012-09-27 Concert Pharmaceuticals Inc. Deuterated preladenant
CN103172627B (zh) * 2011-12-26 2015-11-18 南京优科生物医药有限公司 杂环嘧啶苯或吡啶苯类化合物及其应用
GB2508652A (en) * 2012-12-07 2014-06-11 Agency Science Tech & Res Heterocyclic piperazine derivatives
CN103012395B (zh) * 2013-01-04 2015-05-13 南京优科生物医药有限公司 一种杂环嘧啶苯类化合物的制备方法
CN104151321B (zh) * 2013-05-15 2016-09-07 复旦大学 N-(2-氯-6-甲基苯基)-2[(2-甲基嘧啶-4-基)氨基]噻唑-5-甲酰胺化合物及其制备方法和用途
CN103319476B (zh) * 2013-06-13 2015-12-02 济南德爱医药技术有限公司 一种激酶抑制剂
CN105503852B (zh) * 2014-09-26 2018-06-22 山东新时代药业有限公司 噻唑甲酰胺氮氧化物
CN106279143A (zh) * 2015-05-11 2017-01-04 天津国际生物医药联合研究院 噻唑杂环类化合物及其制备方法和应用
CA3044066A1 (en) 2016-12-13 2018-06-21 Princeton Drug Discovery Inc Protein kinase inhibitors
WO2019241504A1 (en) 2018-06-15 2019-12-19 Handa Pharmaceuticals, Llc Kinase inhibitor salts and compositions thereof
CN112402422A (zh) * 2019-08-20 2021-02-26 湖南华纳大药厂股份有限公司 氟取代的2-氨基噻唑-5-芳香族甲酰胺的用途
CN112409349A (zh) * 2019-08-20 2021-02-26 湖南华纳大药厂股份有限公司 激酶抑制剂及其制备、药物组合物和用途
CN119841819A (zh) * 2023-10-16 2025-04-18 北京大学 靶向bcr-abl的降解剂及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2391550T3 (es) * 1999-04-15 2012-11-27 Bristol-Myers Squibb Company Inhibidores cíclicos de la proteína tirosina quinasa
US7125875B2 (en) * 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
US20050009891A1 (en) * 2003-07-09 2005-01-13 Lee Francis Y. Combination of SRC Kinase inhibitors and chemotherapeutic agents for the treatment of proliferative diseases
US7491725B2 (en) * 2004-02-06 2009-02-17 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
US20060069101A1 (en) * 2004-09-27 2006-03-30 Kim Kyoung S Prodrugs of protein tyrosine kinase inhibitors
CA2593803A1 (en) * 2005-01-26 2006-08-03 Irm Llc Thiazole-amide compounds and compsitions as protein kinase inhibitors

Also Published As

Publication number Publication date
WO2006099474A1 (en) 2006-09-21
US7622473B2 (en) 2009-11-24
EP1863807A1 (en) 2007-12-12
US20060211705A1 (en) 2006-09-21
AR053169A1 (es) 2007-04-25
TW200700416A (en) 2007-01-01

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