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PE20060500A1 - Derivados de heteroaril sulfamida benzo-fusionada como anticonvulsivantes - Google Patents

Derivados de heteroaril sulfamida benzo-fusionada como anticonvulsivantes

Info

Publication number
PE20060500A1
PE20060500A1 PE2005000962A PE2005000962A PE20060500A1 PE 20060500 A1 PE20060500 A1 PE 20060500A1 PE 2005000962 A PE2005000962 A PE 2005000962A PE 2005000962 A PE2005000962 A PE 2005000962A PE 20060500 A1 PE20060500 A1 PE 20060500A1
Authority
PE
Peru
Prior art keywords
sulfamide
benzo
methyl
confusions
derivatives
Prior art date
Application number
PE2005000962A
Other languages
English (en)
Inventor
Michael H Parker
Allen B Reitz
Bruce E Maryanoff
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20060500A1 publication Critical patent/PE20060500A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, HALOGENO, HIDROXI, METOXI, ENTRE OTROS; X-Y SON -S-CH, -S-C(CH3)-, -O-CH-, N-(CH3)-CH-, ENTRE OTROS; A ES -CH2-, -CH(CH3)-; R2 ES H, METILO; R3 Y R4 SON CADA UNO H, ALQUILO C1-C4, O ES UN ANILLO, JUNTO AL N AL QUE ESTAN LIGADOS, DE 5-7 MIEMBROS SATURADA, PARCIAL, INSATURADA O AROMATICA, QUE CONTIENE 1-2 HETEROATOMOS DE N, O, S. SON COMPUESTOS PREFERIDOS: N-(BENZO[b]TIEN-3-ILMETIL)-SULFAMIDA; N-[(2-METIL-3-BENZOFURANIL)METIL]-SULFAMIDA; N-[(4CIANOBENZO[b]TIEN-3-IL)METIL]-SULFAMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE LA EPILEPSIA Y TRASTORNOS RELACIONADOS
PE2005000962A 2004-08-24 2005-08-22 Derivados de heteroaril sulfamida benzo-fusionada como anticonvulsivantes PE20060500A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60413404P 2004-08-24 2004-08-24

Publications (1)

Publication Number Publication Date
PE20060500A1 true PE20060500A1 (es) 2006-07-13

Family

ID=35134694

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000962A PE20060500A1 (es) 2004-08-24 2005-08-22 Derivados de heteroaril sulfamida benzo-fusionada como anticonvulsivantes

Country Status (24)

Country Link
US (1) US20060047001A1 (es)
EP (1) EP1794143B8 (es)
JP (1) JP4912312B2 (es)
KR (1) KR20070057848A (es)
CN (1) CN101090896B (es)
AR (1) AR050530A1 (es)
AT (1) ATE400565T1 (es)
AU (1) AU2005277134A1 (es)
BR (1) BRPI0514278A (es)
CA (1) CA2578407A1 (es)
CR (1) CR9014A (es)
DE (1) DE602005008084D1 (es)
EA (1) EA010977B1 (es)
EC (1) ECSP077275A (es)
ES (1) ES2310366T3 (es)
IL (1) IL181518A0 (es)
MX (1) MX2007002309A (es)
MY (1) MY142329A (es)
NI (1) NI200700056A (es)
NO (1) NO20071549L (es)
PE (1) PE20060500A1 (es)
TW (1) TW200621745A (es)
WO (1) WO2006023861A1 (es)
ZA (1) ZA200702440B (es)

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US8497298B2 (en) * 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
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US20070155823A1 (en) * 2005-12-19 2007-07-05 Smith-Swintosky Virginia L Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents
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US20070191452A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of pain
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US20070293476A1 (en) * 2006-05-19 2007-12-20 Smith-Swintosky Virginia L Co-therapy for the treatment of epilepsy and related disorders
US7897636B2 (en) * 2007-08-08 2011-03-01 Janssen Pharmaceutica Nv Sulfamide derivative useful for the treatment of epilepsy
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US20090247616A1 (en) * 2008-03-26 2009-10-01 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety
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CN101981019A (zh) * 2008-03-26 2011-02-23 詹森药业有限公司 用于制备苯并稠合杂芳基氨基磺酸盐的方法和n-((2s)-6-氯-2,3-二氢-1,4-苯并二噁英-2基)甲基-磺酰胺的晶体形式
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CN101977903A (zh) * 2008-01-07 2011-02-16 詹森药业有限公司 硫酰胺衍生物的制备
US20090247618A1 (en) * 2008-03-26 2009-10-01 Ballentine Scott A Process for preparation of benzo-fused heteroaryl derivatives
US20090247617A1 (en) * 2008-03-26 2009-10-01 Abdel-Magid Ahmed F Process for the preparation of benzo-fused heteroaryl sulfamates
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US20060047001A1 (en) 2006-03-02
JP2008510813A (ja) 2008-04-10
EP1794143B1 (en) 2008-07-09
MY142329A (en) 2010-11-15
DE602005008084D1 (de) 2008-08-21
EP1794143B8 (en) 2008-12-24
CN101090896B (zh) 2011-10-26
CA2578407A1 (en) 2006-03-02
IL181518A0 (en) 2007-07-04
CN101090896A (zh) 2007-12-19
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CR9014A (es) 2009-01-16
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KR20070057848A (ko) 2007-06-07
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BRPI0514278A (pt) 2008-06-10
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ECSP077275A (es) 2007-03-29
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