PE20040582A1 - Inhibidores de vasopeptidasa - Google Patents
Inhibidores de vasopeptidasaInfo
- Publication number
- PE20040582A1 PE20040582A1 PE2003000623A PE2003000623A PE20040582A1 PE 20040582 A1 PE20040582 A1 PE 20040582A1 PE 2003000623 A PE2003000623 A PE 2003000623A PE 2003000623 A PE2003000623 A PE 2003000623A PE 20040582 A1 PE20040582 A1 PE 20040582A1
- Authority
- PE
- Peru
- Prior art keywords
- vasopeptidase inhibitors
- aryl
- alkyl
- diabetic
- vasopeptidase
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE A ES H, ALQUILO C1-C8, CH2OCH2CH2OCH3, -(ALQUIL C1-C4)-ARILO; R1 ES H, -CH2OC(O)C(CH3)3, ACILO; R2 ES H, -CH2-C(O)C(CH3)3, ALQUILO C1-C4, ARILO, ENTRE OTROS; X ES -(CH2)n, -S-, -O-, ENTRE OTROS; n ES 0-1; B1 Y B2 SON CADA UNO H, HIDROXI, ARILO, ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE VASOPEPTIDASA UTILES EN EL TRATAMIENTO Y PROFILAXIS DE NEFROPATIAS EN PACIENTES DIABETICOS O NO DIABETICOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2002129180 DE10229180A1 (de) | 2002-06-28 | 2002-06-28 | Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040582A1 true PE20040582A1 (es) | 2004-10-18 |
Family
ID=29795983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000623A PE20040582A1 (es) | 2002-06-28 | 2003-06-20 | Inhibidores de vasopeptidasa |
Country Status (38)
| Country | Link |
|---|---|
| US (2) | US6930103B2 (es) |
| EP (1) | EP1519732B1 (es) |
| JP (1) | JP4564354B2 (es) |
| KR (1) | KR101072235B1 (es) |
| CN (1) | CN100366254C (es) |
| AR (1) | AR040343A1 (es) |
| AT (1) | ATE548040T1 (es) |
| AU (1) | AU2003280440B2 (es) |
| BR (1) | BR0312250A (es) |
| CA (1) | CA2490277C (es) |
| CR (1) | CR7667A (es) |
| CY (1) | CY1112905T1 (es) |
| DE (1) | DE10229180A1 (es) |
| DK (1) | DK1519732T3 (es) |
| EC (1) | ECSP045513A (es) |
| ES (1) | ES2383889T3 (es) |
| HN (1) | HN2003000193A (es) |
| HR (1) | HRP20041212B1 (es) |
| IL (2) | IL165935A0 (es) |
| MA (1) | MA27281A1 (es) |
| MX (1) | MXPA04012230A (es) |
| NO (1) | NO334811B1 (es) |
| NZ (1) | NZ537480A (es) |
| OA (1) | OA12871A (es) |
| PA (1) | PA8576501A1 (es) |
| PE (1) | PE20040582A1 (es) |
| PL (1) | PL218070B1 (es) |
| PT (1) | PT1519732E (es) |
| RS (1) | RS52478B (es) |
| RU (1) | RU2336080C2 (es) |
| SI (1) | SI1519732T1 (es) |
| SV (1) | SV2004001560A (es) |
| TN (1) | TNSN04262A1 (es) |
| TW (1) | TWI326215B (es) |
| UA (1) | UA82845C2 (es) |
| UY (1) | UY27869A1 (es) |
| WO (1) | WO2004002492A1 (es) |
| ZA (1) | ZA200409382B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2482546C2 (ru) * | 2011-04-28 | 2013-05-20 | Общество С Ограниченной Ответственностью "Научно-Производственная Фирма "Материа Медика Холдинг" | Способ коррекции эндотелиальной дисфункции раствором гомеопатических разведений антител к с-концевому фрагменту рецептора ангиотензина ii |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| DE69211133T2 (de) * | 1991-03-01 | 1996-10-31 | Zeria Pharmaceutical Co., Ltd., Tokio/Tokyo | Indan-derivate als thromboxan-antagonisten |
| RU2098411C1 (ru) * | 1991-08-02 | 1997-12-10 | Иституто Лусо Фармако д Италия С.п.А. | Производные пиримидина, способ их получения, фармацевтическая композиция на их основе |
| CA2078758C (en) * | 1991-09-27 | 2003-12-09 | Alan M. Warshawsky | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| KR100276029B1 (ko) * | 1992-02-14 | 2000-12-15 | 슈테펜엘.네스비트 | 아미노아세틸 머캅토아세틸 아미드 유도체 및 이의 제조방법 |
| US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
| DK0751783T3 (da) * | 1994-03-24 | 2000-06-26 | Merrell Pharma Inc | Hypokolesterolæmisk, antiatherosklerotisk og hypotriglyceridæmisk anvendelse af aminoacetylmercaptoderivater |
| AU716519B2 (en) * | 1995-06-30 | 2000-02-24 | Laboratoires Merck Sharp & Dohme - Chibret Snc | Method of treating renal disease using an ace inhibitor and an A II antagonist |
| KR100471351B1 (ko) | 1995-12-27 | 2005-03-14 | 미쯔비시 웰 파마 가부시키가이샤 | 당뇨병성 합병증의 예방·치료제 |
| KR20120055730A (ko) * | 1999-08-30 | 2012-05-31 | 사노피-아벤티스 도이칠란트 게엠베하 | 레닌－안지오텐신 시스템 억제제를 포함하는 심혈관 사고 예방용 약제학적 조성물 |
| US6149915A (en) | 1999-09-29 | 2000-11-21 | Shiva Biomedical, Llc | Treatment of diabetic nephropathy and microalbuminuria |
| NZ528825A (en) * | 2001-04-12 | 2005-04-29 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives, a process for their preparation and their use |
| WO2003013434A2 (en) * | 2001-08-06 | 2003-02-20 | Genomed, Llc | Methods and compositions for treating diseases associated with excesses in ace |
-
2002
- 2002-06-28 DE DE2002129180 patent/DE10229180A1/de not_active Ceased
-
2003
- 2003-06-13 BR BR0312250A patent/BR0312250A/pt not_active IP Right Cessation
- 2003-06-13 ES ES03740247T patent/ES2383889T3/es not_active Expired - Lifetime
- 2003-06-13 PT PT03740247T patent/PT1519732E/pt unknown
- 2003-06-13 EP EP20030740247 patent/EP1519732B1/en not_active Expired - Lifetime
- 2003-06-13 AT AT03740247T patent/ATE548040T1/de active
- 2003-06-13 UA UA2005000743A patent/UA82845C2/xx unknown
- 2003-06-13 CN CNB038153491A patent/CN100366254C/zh not_active Expired - Fee Related
- 2003-06-13 NZ NZ537480A patent/NZ537480A/en not_active IP Right Cessation
- 2003-06-13 DK DK03740247T patent/DK1519732T3/da active
- 2003-06-13 SI SI200332139T patent/SI1519732T1/sl unknown
- 2003-06-13 WO PCT/EP2003/006276 patent/WO2004002492A1/en active IP Right Grant
- 2003-06-13 RS YUP100704 patent/RS52478B/en unknown
- 2003-06-13 PL PL372992A patent/PL218070B1/pl unknown
- 2003-06-13 CA CA 2490277 patent/CA2490277C/en not_active Expired - Fee Related
- 2003-06-13 IL IL16593503A patent/IL165935A0/xx unknown
- 2003-06-13 OA OA1200400333A patent/OA12871A/en unknown
- 2003-06-13 HR HRP20041212AA patent/HRP20041212B1/hr not_active IP Right Cessation
- 2003-06-13 RU RU2005102087A patent/RU2336080C2/ru not_active IP Right Cessation
- 2003-06-13 JP JP2004516596A patent/JP4564354B2/ja not_active Expired - Fee Related
- 2003-06-13 AU AU2003280440A patent/AU2003280440B2/en not_active Ceased
- 2003-06-13 MX MXPA04012230A patent/MXPA04012230A/es active IP Right Grant
- 2003-06-13 KR KR1020047021259A patent/KR101072235B1/ko not_active Expired - Fee Related
- 2003-06-20 PE PE2003000623A patent/PE20040582A1/es not_active Application Discontinuation
- 2003-06-23 SV SV2003001560A patent/SV2004001560A/es not_active Application Discontinuation
- 2003-06-24 PA PA8576501A patent/PA8576501A1/es unknown
- 2003-06-26 AR ARP030102293 patent/AR040343A1/es unknown
- 2003-06-26 TW TW92117352A patent/TWI326215B/zh not_active IP Right Cessation
- 2003-06-26 HN HN2003000193A patent/HN2003000193A/es unknown
- 2003-06-26 US US10/607,521 patent/US6930103B2/en not_active Expired - Lifetime
- 2003-06-27 UY UY27869A patent/UY27869A1/es unknown
-
2004
- 2004-11-22 ZA ZA2004/09382A patent/ZA200409382B/en unknown
- 2004-12-08 MA MA27991A patent/MA27281A1/fr unknown
- 2004-12-22 IL IL16593504A patent/IL165935A/en not_active IP Right Cessation
- 2004-12-27 EC ECSP045513 patent/ECSP045513A/es unknown
- 2004-12-27 TN TNP2004000262A patent/TNSN04262A1/en unknown
-
2005
- 2005-01-25 NO NO20050425A patent/NO334811B1/no not_active IP Right Cessation
- 2005-01-28 CR CR7667A patent/CR7667A/es unknown
- 2005-04-01 US US11/096,790 patent/US7514423B2/en not_active Expired - Lifetime
-
2012
- 2012-05-30 CY CY20121100488T patent/CY1112905T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20070136A1 (es) | COMPUESTOS DERIVADOS DE N-(PIRIDIN-2-IL)-SULFONAMIDA COMO INHIBIDORES DE LA ENZIMA 11-beta-HIDROXIESTEROIDE DESHIDROGENASA HUMANA TIPO 1 | |
| PE20080768A1 (es) | Compuestos de isoindolina 5-sustituidos | |
| NO20055680L (no) | Heksahydropyridoisokinoliner som DPP-IV-inhibitorer | |
| MY142807A (en) | Benzimidazole derivative and use thereof. | |
| PE20081532A1 (es) | Compuestos novedosos | |
| ATE368031T1 (de) | Neue gamma secretase inhibitoren | |
| NO20063275L (no) | Anvendelse av substituerte 2-aminotetraliner for forebyggende behandling av Parkinsons sykdom | |
| IS8058A (is) | Sýklísk súlfónamíð til að hamla gamma seytiasa | |
| GT200300038A (es) | Nuevos derivados de piridina y quinolina | |
| DE60236719D1 (de) | Purinderivate als antagonisten an purinergen rezeptoren | |
| AU2910600A (en) | Phenyl urea and phenyl thiourea derivatives | |
| ATE435219T1 (de) | Heteroaryl substituierte spirocyclische sulfamide zur hemmung von gamma sekretase | |
| BR122017015091B8 (pt) | compostos intermediários para inibidores de c-aril glicosídeo sglt2 | |
| TW200505919A (en) | DPP-IV inhibitors | |
| ATE435199T1 (de) | Diarylharnstoffderivate und deren verwendung als chloridkanalblocker | |
| TW200510405A (en) | Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors | |
| CY1109906T1 (el) | Παραγωγα c3-kyano εποθιλονης | |
| PE20091309A1 (es) | Derivados de ciclohexilo como inhibidores de acetil coenzima a carboxilasa | |
| AR063788A1 (es) | Derivados de 5-hidroximetil-oxazolidin -2-ona | |
| PE20081160A1 (es) | Arilsulfonil-pirrolidinas como inhibidores 5-ht6 | |
| PE20091649A1 (es) | Derivados de pirrolidinilo | |
| BR0208131A (pt) | Derivados biguanida | |
| PE20040582A1 (es) | Inhibidores de vasopeptidasa | |
| PE20080710A1 (es) | Compuestos de tiofeno de bencimidazol | |
| TNSN04121A1 (en) | Acides 3 - (imidazolyl) - 2 - alkoxypropanoiques servant d'inhibiteurs de tafia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |