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PE20030949A1 - Formulaciones en aerosol para la administracion pulmonar de medicamentos que producen un efecto sistemico - Google Patents

Formulaciones en aerosol para la administracion pulmonar de medicamentos que producen un efecto sistemico

Info

Publication number
PE20030949A1
PE20030949A1 PE2003000200A PE2003000200A PE20030949A1 PE 20030949 A1 PE20030949 A1 PE 20030949A1 PE 2003000200 A PE2003000200 A PE 2003000200A PE 2003000200 A PE2003000200 A PE 2003000200A PE 20030949 A1 PE20030949 A1 PE 20030949A1
Authority
PE
Peru
Prior art keywords
drugs
produce
pulmonary administration
aerosol formulations
systemic effect
Prior art date
Application number
PE2003000200A
Other languages
English (en)
Inventor
Gaetano Brambilla
David Ganderton
Alessandra Ferraris
Rebecca Jaine Davies
David Andrew Lewis
Brian John Meakin
Tanya Kathleen Church
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of PE20030949A1 publication Critical patent/PE20030949A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

QUE COMPRENDE UNA SOLUCION DE MEDICAMENTO EN UNA MEZCLA DE: a)PROPELENTE HIDROFLUOROALCANO QUE INCLUYE UNO O MAS HFAs SELECCIONADOS DE HFA 134 a Y HFA 227; Y, b)UNO O MAS CONSOLVENTES, COMO ETANOL EN UNA CANTIDAD DE HASTA 30% p/p O UN DERIVADO (POLI)ALCOXILADO SELECCIONADO DE ALCOHOLES POLIALCOXILADOS (TRANSCUTOL) Y ETERES Y ESTERES POLIALCOXILADOS. DONDE, LAS GOTAS DE AEROSOL LIQUIDO QUE SE ADMINISTRAN AL ACTUAR EL INHALADOR TIENEN UN TAMANO DE PARTICULA COMPRENDIDO ENTRE 0,5 um Y 2,5 um, CON UNA MEDIANA DEL DIAMETRO AERODINAMICO EN LA MASA DE APROXIMADAMENTE 1 um A 2 um Y DONDE LA FRACCION DE PARTICULAS FINAS ES DE POR LO MENOS 30%. SE REFIERE TAMBIEN A UN INHALADOR DE AEROSOL QUE CONTIENE UNA FORMULACION COMO LA DESCRITA CARACTERIZADA PORQUE LA VALVULA DEL ACCIONADOR TIENE UN DIAMETRO DE ORIFICIO ENTRE 0,20 mm Y 0,50 mm
PE2003000200A 2002-03-01 2003-02-28 Formulaciones en aerosol para la administracion pulmonar de medicamentos que producen un efecto sistemico PE20030949A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02004786A EP1340492A1 (en) 2002-03-01 2002-03-01 Aerosol formulations for pulmonary administration of medicaments having systemic effects

Publications (1)

Publication Number Publication Date
PE20030949A1 true PE20030949A1 (es) 2004-01-02

Family

ID=27675679

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000200A PE20030949A1 (es) 2002-03-01 2003-02-28 Formulaciones en aerosol para la administracion pulmonar de medicamentos que producen un efecto sistemico

Country Status (27)

Country Link
US (1) US20050129621A1 (es)
EP (2) EP1340492A1 (es)
JP (1) JP2005519094A (es)
KR (1) KR20040091050A (es)
CN (2) CN1638731A (es)
AR (2) AR038643A1 (es)
AT (1) ATE488224T1 (es)
AU (1) AU2003215597B2 (es)
BR (1) BR0303348A (es)
CA (1) CA2477879C (es)
DE (1) DE60334973D1 (es)
EA (1) EA008571B1 (es)
ES (1) ES2358293T3 (es)
GE (1) GEP20063985B (es)
HR (1) HRP20040751A2 (es)
IL (1) IL163842A0 (es)
MA (1) MA27107A1 (es)
MX (1) MXPA04008370A (es)
NO (1) NO20034874L (es)
NZ (1) NZ535019A (es)
PE (1) PE20030949A1 (es)
PL (1) PL372261A1 (es)
TN (1) TNSN04148A1 (es)
TW (1) TW200304833A (es)
UA (2) UA81238C2 (es)
WO (1) WO2003074023A1 (es)
ZA (3) ZA200406918B (es)

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US20010031244A1 (en) * 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
IT1303788B1 (it) * 1998-11-25 2001-02-23 Chiesi Farma Spa Formulazioni di aerosol medicinali.
DZ2947A1 (fr) * 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
US6315985B1 (en) * 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
IT1317720B1 (it) * 2000-01-07 2003-07-15 Chiesi Farma Spa Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
IT1318514B1 (it) * 2000-05-12 2003-08-27 Chiesi Farma Spa Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
US20060257324A1 (en) * 2000-05-22 2006-11-16 Chiesi Farmaceutici S.P.A. Pharmaceutical solution formulations for pressurised metered dose inhalers
UA73986C2 (uk) * 2000-05-22 2005-10-17 К'Єзі Фармачеутічі С.П.А. АЕРОЗОЛЬНА КОМПОЗИЦІЯ, ЩО МІСТИТЬ <font face="Symbol">b</font>2-АДРЕНЕРГІЧНИЙ АГОНІСТ ТРИВАЛОЇ ДІЇ, ДОЗУЮЧИЙ ІНГАЛЯТОР ПІД ТИСКОМ ТА СПОСІБ ЙОГО ЗАПОВНЕННЯ
ES2222294T3 (es) * 2001-07-02 2005-02-01 Chiesi Farmaceutici S.P.A. Formulacion optimizada de tobramicina para administracion en forma de aerosol.
SI3494995T1 (sl) * 2002-03-01 2020-08-31 Chiesi Farmaceutici S.P.A. Superfina formulacija formoterola
EP1415647A1 (en) * 2002-10-23 2004-05-06 CHIESI FARMACEUTICI S.p.A. "Long-acting beta-2 agonists ultrafine formulations"
EP1452179A1 (en) * 2003-02-27 2004-09-01 CHIESI FARMACEUTICI S.p.A. Novel medicament combination of a highly potent long-lasting beta2-agonist and a corticosteroid
GB0311701D0 (en) * 2003-05-21 2003-06-25 Karib Kemi Pharm Liited Improved metered dose inhaler product
WO2005025550A1 (en) * 2003-09-15 2005-03-24 Vectura Limited Pharmaceutical compositions for treating premature ejaculation by pulmonary inhalation
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
IL177103A0 (en) * 2004-02-27 2006-12-10 Chiesi Farma Spa Stable pharmaceutical solution formulations for pressurized metered dose inhalers
EA013428B1 (ru) * 2004-07-02 2010-04-30 Бёрингер Ингельхайм Интернациональ Гмбх РАСПЫЛЯЕМЫЕ В ВИДЕ АЭРОЗОЛЯ СУСПЕНЗИОННЫЕ КОМПОЗИЦИИ С TG 227ea ИЛИ TG 134a В КАЧЕСТВЕ ПРОПЕЛЛЕНТА
RU2457832C2 (ru) * 2005-09-25 2012-08-10 Сипла Лимитед Состав на основе тровентола
US20070243262A1 (en) * 2005-12-21 2007-10-18 Hurley Kevin P Stable S-nitrosothiol formulations
DE102006017320A1 (de) * 2006-04-11 2007-10-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel
EP2011534A1 (en) * 2007-07-03 2009-01-07 CHIESI FARMACEUTICI S.p.A. Metered dose inhaler actuator
UY31235A1 (es) * 2007-07-21 2009-03-02 Nuevos medicamentos pulverulentos que contienen tiotropio y salmeterol, asi como lactosa como excipiente
CA2702094C (en) 2007-10-10 2018-05-01 Parion Sciences, Inc. Delivering osmolytes by nasal cannula
WO2010074753A1 (en) * 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
ES2855159T3 (es) * 2010-07-12 2021-09-23 Xellia Pharmaceuticals Aps Tratamiento de las infecciones pulmonares mediante administración de tobramicina por aerolización
CA2811692C (en) 2010-09-22 2020-02-18 The Board Of Regents Of The University Of Texas System Novel block copolymer and micelle compositions and methods of use thereof
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GB201402513D0 (en) * 2014-02-13 2014-04-02 Cardiff Scintigraphics Ltd Pressurised metered dose inhalers and method of manufacture
AU2015280412B2 (en) 2014-06-26 2018-07-26 Island Breeze Systems Ca, Llc MDI related products and methods of use
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IT1303788B1 (it) * 1998-11-25 2001-02-23 Chiesi Farma Spa Formulazioni di aerosol medicinali.
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IT1317720B1 (it) * 2000-01-07 2003-07-15 Chiesi Farma Spa Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
IT1317846B1 (it) * 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
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IT1318514B1 (it) * 2000-05-12 2003-08-27 Chiesi Farma Spa Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
UA73986C2 (uk) * 2000-05-22 2005-10-17 К'Єзі Фармачеутічі С.П.А. АЕРОЗОЛЬНА КОМПОЗИЦІЯ, ЩО МІСТИТЬ <font face="Symbol">b</font>2-АДРЕНЕРГІЧНИЙ АГОНІСТ ТРИВАЛОЇ ДІЇ, ДОЗУЮЧИЙ ІНГАЛЯТОР ПІД ТИСКОМ ТА СПОСІБ ЙОГО ЗАПОВНЕННЯ
SI3494995T1 (sl) * 2002-03-01 2020-08-31 Chiesi Farmaceutici S.P.A. Superfina formulacija formoterola
EP1595531A1 (en) * 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers

Also Published As

Publication number Publication date
JP2005519094A (ja) 2005-06-30
GEP20063985B (en) 2006-12-11
EA200401006A1 (ru) 2005-04-28
US20050129621A1 (en) 2005-06-16
NO20034874D0 (no) 2003-10-31
AU2003215597B2 (en) 2008-07-31
TNSN04148A1 (en) 2007-03-12
ZA200406918B (en) 2006-06-28
WO2003074023A1 (en) 2003-09-12
EP1480616B1 (en) 2010-11-17
KR20040091050A (ko) 2004-10-27
ES2358293T3 (es) 2011-05-09
ZA200406917B (en) 2006-06-28
ATE488224T1 (de) 2010-12-15
TW200304833A (en) 2003-10-16
AR101593A2 (es) 2016-12-28
NZ535019A (en) 2006-09-29
PL372261A1 (en) 2005-07-11
EP1340492A1 (en) 2003-09-03
MXPA04008370A (es) 2004-11-26
EP1480616A1 (en) 2004-12-01
DE60334973D1 (de) 2010-12-30
IL163842A0 (en) 2005-12-18
HRP20040751A2 (en) 2004-12-31
CN1638731A (zh) 2005-07-13
NO20034874L (no) 2003-12-23
EA008571B1 (ru) 2007-06-29
BR0303348A (pt) 2004-07-13
CN101502500A (zh) 2009-08-12
MA27107A1 (fr) 2004-12-20
UA80695C2 (en) 2007-10-25
UA81238C2 (en) 2007-12-25
ZA200406919B (en) 2006-06-28
AU2003215597A1 (en) 2003-09-16
CA2477879A1 (en) 2003-09-12
CA2477879C (en) 2011-05-03
AR038643A1 (es) 2005-01-19

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