PE20030688A1 - Preparacion de inhibidor de cetp anhidro - Google Patents
Preparacion de inhibidor de cetp anhidroInfo
- Publication number
- PE20030688A1 PE20030688A1 PE2002000960A PE2002000960A PE20030688A1 PE 20030688 A1 PE20030688 A1 PE 20030688A1 PE 2002000960 A PE2002000960 A PE 2002000960A PE 2002000960 A PE2002000960 A PE 2002000960A PE 20030688 A1 PE20030688 A1 PE 20030688A1
- Authority
- PE
- Peru
- Prior art keywords
- ethyl ester
- trifluorometil
- ethyl
- acid
- metoxicarbonil
- Prior art date
Links
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 title 1
- 229940125881 cholesteryl ester transfer protein inhibitor Drugs 0.000 title 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical class CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- -1 3,5-BIS-TRIFLUOROMETHYL-BENZYL Chemical class 0.000 abstract 1
- KEWSCDNULKOKTG-UHFFFAOYSA-N 4-cyano-4-ethylsulfanylcarbothioylsulfanylpentanoic acid Chemical compound CCSC(=S)SC(C)(C#N)CCC(O)=O KEWSCDNULKOKTG-UHFFFAOYSA-N 0.000 abstract 1
- 102100037637 Cholesteryl ester transfer protein Human genes 0.000 abstract 1
- 101000880514 Homo sapiens Cholesteryl ester transfer protein Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 239000011973 solid acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
SE REFIERE A UN METODO PARA PREPARAR EL ESTER ETILICO DEL ACIDO (2R,4S)-4-[(3,5-BIS-TRIFLUOROMETIL-BENCIL)-METOXICARBONIL-AMINO]-2-ETIL-6-TRIFLUOROMETIL-3,4-DIHIDRO-2H-QUINOLIN-1-CARBOXILICO ANHIDRO INHIBIDOR DE LA CETP QUE COMPRENDE COMBINAR EL ESTER ETILICO DEL ACIDO (2R,4S)-4-[(3,5-BIS-TRIFLUOROMETIL-BENCIL)-METOXICARBONIL-AMINO]-2-ETIL-6-TRIFLUOROMETIL-3,4-DIHIDRO-2H-QUINOLIN-1-CARBOXILICO CON UN DISOLVENTE QUE COMPRENDE HEPTANOS O UNA MEZCLA DE AGUA Y DISOLVENTE POLAR A UNA TEMPERATURA SUFICIENTE PARA DISOLVER DICHO ESTER ETILICO; FORMAR EL ESTER ETILICO DEL ACIDO SOLIDO, ENFRIAR O EVAPORAR EL DISOLVENTE DE DICHA SOLUCION Y AISLAR EL ESTER ETILICO DEL ACIDO (2R,4S)-4-[(3,5-BIS-TRIFLUOROMETIL-BENCIL)-METOXICARBONIL-AMINO]-2-ETIL-6-TRIFLUOROMETIL-3,4-DIHIDRO-2H-QUINOLIN-1-CARBOXILICO ANHIDRO. EL DISOLVENTE COMPRENDE UNA MEZCLA DE 10% A 50% DE AGUA Y ALCANOL C1-C4 COMO ETANOL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32592601P | 2001-09-28 | 2001-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030688A1 true PE20030688A1 (es) | 2003-08-11 |
Family
ID=23270027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000960A PE20030688A1 (es) | 2001-09-28 | 2002-09-27 | Preparacion de inhibidor de cetp anhidro |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6573383B2 (es) |
| EP (1) | EP1503987B1 (es) |
| JP (1) | JP2005505584A (es) |
| KR (1) | KR100629828B1 (es) |
| CN (1) | CN1289485C (es) |
| AR (1) | AR037325A1 (es) |
| AT (1) | ATE346842T1 (es) |
| BR (1) | BR0212916A (es) |
| CA (1) | CA2461686A1 (es) |
| CY (1) | CY1105843T1 (es) |
| CZ (1) | CZ2004415A3 (es) |
| DE (1) | DE60216520T2 (es) |
| DK (1) | DK1503987T3 (es) |
| ES (1) | ES2275902T3 (es) |
| GT (1) | GT200200170A (es) |
| HK (1) | HK1072424A1 (es) |
| HU (1) | HUP0501098A3 (es) |
| IL (1) | IL160026A0 (es) |
| MX (1) | MXPA04002882A (es) |
| MY (1) | MY134349A (es) |
| PA (1) | PA8553801A1 (es) |
| PE (1) | PE20030688A1 (es) |
| PL (1) | PL373611A1 (es) |
| PT (1) | PT1503987E (es) |
| RS (1) | RS12004A (es) |
| UY (1) | UY27454A1 (es) |
| WO (1) | WO2003029220A2 (es) |
| ZA (1) | ZA200400438B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR200483700Y1 (ko) | 2016-02-05 | 2017-06-14 | 이요한 | 젓갈제조용 위생용기 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197786B1 (en) * | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
| CO5271716A1 (es) * | 1999-11-30 | 2003-04-30 | Pfizer Prod Inc | Cristales de 4- carboxamino 1,2,3,4-tetrahidroquinolina 2- sustituida |
-
2002
- 2002-08-20 GT GT200200170A patent/GT200200170A/es unknown
- 2002-08-22 PT PT02760459T patent/PT1503987E/pt unknown
- 2002-08-22 DK DK02760459T patent/DK1503987T3/da active
- 2002-08-22 BR BR0212916-7A patent/BR0212916A/pt not_active IP Right Cessation
- 2002-08-22 RS YUP-120/04A patent/RS12004A/sr unknown
- 2002-08-22 ES ES02760459T patent/ES2275902T3/es not_active Expired - Lifetime
- 2002-08-22 DE DE60216520T patent/DE60216520T2/de not_active Expired - Fee Related
- 2002-08-22 IL IL16002602A patent/IL160026A0/xx unknown
- 2002-08-22 WO PCT/IB2002/003423 patent/WO2003029220A2/en active IP Right Grant
- 2002-08-22 EP EP02760459A patent/EP1503987B1/en not_active Expired - Lifetime
- 2002-08-22 CN CNB02818730XA patent/CN1289485C/zh not_active Expired - Fee Related
- 2002-08-22 HU HU0501098A patent/HUP0501098A3/hu unknown
- 2002-08-22 KR KR1020047004454A patent/KR100629828B1/ko not_active Expired - Fee Related
- 2002-08-22 MX MXPA04002882A patent/MXPA04002882A/es active IP Right Grant
- 2002-08-22 CZ CZ2004415A patent/CZ2004415A3/cs unknown
- 2002-08-22 PL PL02373611A patent/PL373611A1/xx not_active Application Discontinuation
- 2002-08-22 CA CA002461686A patent/CA2461686A1/en not_active Abandoned
- 2002-08-22 JP JP2003532470A patent/JP2005505584A/ja not_active Withdrawn
- 2002-08-22 AT AT02760459T patent/ATE346842T1/de not_active IP Right Cessation
- 2002-08-27 PA PA20028553801A patent/PA8553801A1/es unknown
- 2002-09-25 MY MYPI20023572A patent/MY134349A/en unknown
- 2002-09-25 UY UY27454A patent/UY27454A1/es not_active Application Discontinuation
- 2002-09-26 AR ARP020103632A patent/AR037325A1/es unknown
- 2002-09-27 US US10/256,315 patent/US6573383B2/en not_active Expired - Fee Related
- 2002-09-27 PE PE2002000960A patent/PE20030688A1/es not_active Application Discontinuation
-
2004
- 2004-01-21 ZA ZA2004/00438A patent/ZA200400438B/en unknown
-
2005
- 2005-06-15 HK HK05105032A patent/HK1072424A1/xx not_active IP Right Cessation
-
2006
- 2006-12-12 CY CY20061101787T patent/CY1105843T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1289485C (zh) | 2006-12-13 |
| HK1072424A1 (en) | 2005-08-26 |
| AR037325A1 (es) | 2004-11-03 |
| EP1503987B1 (en) | 2006-11-29 |
| WO2003029220A2 (en) | 2003-04-10 |
| US6573383B2 (en) | 2003-06-03 |
| PA8553801A1 (es) | 2003-07-28 |
| CZ2004415A3 (cs) | 2004-12-15 |
| PL373611A1 (en) | 2005-09-05 |
| CA2461686A1 (en) | 2003-04-10 |
| WO2003029220A3 (en) | 2004-11-11 |
| KR20040048906A (ko) | 2004-06-10 |
| CY1105843T1 (el) | 2011-02-02 |
| PT1503987E (pt) | 2007-02-28 |
| UY27454A1 (es) | 2003-06-30 |
| HUP0501098A2 (en) | 2007-11-28 |
| DE60216520T2 (de) | 2007-06-06 |
| DE60216520D1 (de) | 2007-01-11 |
| RS12004A (en) | 2007-02-05 |
| CN1612862A (zh) | 2005-05-04 |
| ZA200400438B (en) | 2005-03-30 |
| EP1503987A2 (en) | 2005-02-09 |
| ATE346842T1 (de) | 2006-12-15 |
| JP2005505584A (ja) | 2005-02-24 |
| BR0212916A (pt) | 2004-10-13 |
| US20030065010A1 (en) | 2003-04-03 |
| ES2275902T3 (es) | 2007-06-16 |
| MY134349A (en) | 2007-12-31 |
| IL160026A0 (en) | 2004-06-20 |
| GT200200170A (es) | 2003-05-23 |
| HUP0501098A3 (en) | 2008-02-28 |
| DK1503987T3 (da) | 2007-03-12 |
| MXPA04002882A (es) | 2004-07-02 |
| KR100629828B1 (ko) | 2006-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |