PE20020346A1 - DERIVATIVES OF PHENOXYBENCILAMINE AS SSRI - Google Patents
DERIVATIVES OF PHENOXYBENCILAMINE AS SSRIInfo
- Publication number
- PE20020346A1 PE20020346A1 PE2001000862A PE2001000862A PE20020346A1 PE 20020346 A1 PE20020346 A1 PE 20020346A1 PE 2001000862 A PE2001000862 A PE 2001000862A PE 2001000862 A PE2001000862 A PE 2001000862A PE 20020346 A1 PE20020346 A1 PE 20020346A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- benzenosulfonamide
- alkyl
- phenoxybencilamine
- ssri
- Prior art date
Links
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 title 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 title 1
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- DXASQZJWWGZNSF-UHFFFAOYSA-N n,n-dimethylmethanamine;sulfur trioxide Chemical compound CN(C)C.O=S(=O)=O DXASQZJWWGZNSF-UHFFFAOYSA-N 0.000 abstract 1
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical compound O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 1
- 230000009103 reabsorption Effects 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Addiction (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE FENOXIBENCILAMINA DE FORMULA I DONDE R1 Y R2 SON H, ALQUILO C1-C6, (CH2)d-(CICLOALQUILO C3-C6) DONDE d ES 0-3; R1 Y R2 JUNTO A N FORMAN UN ANILLO DE AZETIDINA; UNO DE Z O Y ES SR3 Y EL OTRO DE Z O Y ES HALOGENO, R3 DONDE R3 ES ALQUILO C1-C4 CON F EXCEPTO QUE R3 NO ES CF3; R4 Y R5 SON A-X DONDE A ES -CH=CH-, (CH2)p DONDE p ES 1-2; X ES H, F, Cl, Br, I, CONR6R7, SO2NR6R7, ALCOXI C1-C4, ENTRE OTROS; R6 Y R7 SON H, ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS 4-(2,3-DIHIDRO-1-BENZOTIEN-5-ILOXI)-3-[(METILAMINO)METIL]BENCENOSULFONAMIDA, 3-[(DIMETILAMINO)METIL]-4-[3-METIL-4-(METILSULFANIL)FENOXI]BENCENOSULFONAMIDA, 4-(2,3-DIHIDRO-1-BENZOTIEN-5-ILOXI)-3-[(DIMETILAMINO)METIL]BENCENOSULFONAMIDA, ENTRE OTROS.SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES SELECTIVOS DE LA REABSORCION DE SEROTONINA (SSRI) Y SON UTILES PARA EL TRATAMIENTO DE DEPRESION, TRASTORNO DE HIPERACTIVIDAD, TRASTORNO OBSESIVO COMPULSIVO, DISFUNCION SEXUALREFERS TO PHENOXYBENCILAMINE DERIVATIVES OF FORMULA I WHERE R1 AND R2 ARE H, C1-C6 ALKYL, (CH2) d- (C3-C6 CYCLOALKYL) WHERE d IS 0-3; R1 AND R2 TOGETHER WITH N FORM A RING OF AZETHYDINE; ONE OF Z O Y IS SR3 AND THE OTHER OF Z O Y IS HALOGEN, R3 WHERE R3 IS C1-C4 ALKYL WITH F EXCEPT R3 IS NOT CF3; R4 AND R5 ARE A-X WHERE A IS -CH = CH-, (CH2) p WHERE p IS 1-2; X IS H, F, Cl, Br, I, CONR6R7, SO2NR6R7, C1-C4 ALCOXY, AMONG OTHERS; R6 AND R7 ARE H, C1-C6 ALKYL. PREFERRED COMPOUNDS ARE 4- (2,3-DIHYDRO-1-BENZOTHEN-5-ILOXI) -3 - [(METHYLAMINE) METHYL] BENZENOSULFONAMIDE, 3 - [(DIMETHYLAMINE) METHYL] -4- [3-MEthyl-4- ( METHYLSULFANIL) PHENOXY] BENZENOSULFONAMIDE, 4- (2,3-DIHYDRO-1-BENZOTHEN-5-ILOXI) -3 - [(DIMETHYLAMINO) METHYL] BENZENOSULFONAMIDE, AMONG OTHERS. ALSO REFERS TO A PROCEDURE FOR THE PREPARATION. THE MENTIONED COMPOUNDS ARE SELECTIVE SEROTONIN REABSORPTION INHIBITORS (SSRI) AND ARE USEFUL FOR THE TREATMENT OF DEPRESSION, HYPERACTIVITY DISORDER, OBSESSIVE COMPULSIVE DISORDER, SEXUAL DYSFUNCTION
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0021593A GB0021593D0 (en) | 2000-08-31 | 2000-08-31 | Diphenyl ether compounds useful in therapy |
| GB0107116A GB0107116D0 (en) | 2001-03-21 | 2001-03-21 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020346A1 true PE20020346A1 (en) | 2002-05-08 |
Family
ID=26244953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000862A PE20020346A1 (en) | 2000-08-31 | 2001-08-28 | DERIVATIVES OF PHENOXYBENCILAMINE AS SSRI |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP1313701A1 (en) |
| JP (1) | JP2004507523A (en) |
| KR (1) | KR20030029889A (en) |
| CN (1) | CN1449380A (en) |
| AP (1) | AP2001002265A0 (en) |
| AR (1) | AR031867A1 (en) |
| AU (1) | AU2001278650A1 (en) |
| BG (1) | BG107544A (en) |
| BR (1) | BR0113610A (en) |
| CA (1) | CA2420969A1 (en) |
| CZ (1) | CZ2003467A3 (en) |
| DO (1) | DOP2001000242A (en) |
| DZ (1) | DZ3414A1 (en) |
| EA (1) | EA200300206A1 (en) |
| EE (1) | EE200300084A (en) |
| HN (1) | HN2001000191A (en) |
| HR (1) | HRP20030141A2 (en) |
| HU (1) | HUP0303385A2 (en) |
| IL (1) | IL154343A0 (en) |
| IS (1) | IS6704A (en) |
| MA (1) | MA26945A1 (en) |
| MX (1) | MXPA03001848A (en) |
| NO (1) | NO20030842L (en) |
| NZ (1) | NZ523951A (en) |
| OA (1) | OA12372A (en) |
| PA (1) | PA8526701A1 (en) |
| PE (1) | PE20020346A1 (en) |
| PL (1) | PL360743A1 (en) |
| SK (1) | SK2012003A3 (en) |
| TN (1) | TNSN01131A1 (en) |
| UY (1) | UY26924A1 (en) |
| WO (1) | WO2002018333A1 (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6403597B1 (en) * | 1997-10-28 | 2002-06-11 | Vivus, Inc. | Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation |
| US6436938B1 (en) * | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
| US20020107244A1 (en) * | 2001-02-02 | 2002-08-08 | Howard Harry R. | Combination treatment for depression |
| US20020183306A1 (en) * | 2001-05-30 | 2002-12-05 | Pfizer Inc. | Combination treatment for sleep disorders including sleep apnea |
| GB0318706D0 (en) * | 2003-08-08 | 2003-09-10 | Pfizer Ltd | Selective serotonin reuptake inhibitors in the treatment of disease |
| KR100783255B1 (en) | 2004-02-13 | 2007-12-06 | 워너-램버트 캄파니 엘엘씨 | Androgen receptor modulators |
| US7507860B2 (en) | 2004-04-13 | 2009-03-24 | Pfizer Inc. | Androgen modulators |
| CA2562672C (en) | 2004-04-22 | 2009-09-29 | Warner-Lambert Company Llc | 4-cyano-phenoxy derivatives as androgen modulators |
| CA2570047C (en) | 2004-07-08 | 2010-09-28 | Warner-Lambert Company Llc | 4-cycloalkoxy benzonitriles as androgen modulators |
| CA2577448A1 (en) * | 2004-08-18 | 2006-02-23 | Warner-Lambert Company Llc | Androgen modulators |
| BRPI0514675A (en) * | 2004-09-10 | 2008-06-17 | Pfizer Prod Inc | therapeutic diphenyl ether binders |
| TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
| WO2007010350A1 (en) * | 2005-07-19 | 2007-01-25 | Pfizer Products Inc. | Synthesis of therapeutic diphenyl ethers |
| JP4887368B2 (en) | 2005-10-13 | 2012-02-29 | スミスクライン ビーチャム コーポレーション | New heterocyclic compounds |
| US20100048713A1 (en) * | 2006-01-06 | 2010-02-25 | Aarhus Universitet | Compounds acting on the serotonin transporter |
| US20080045508A1 (en) * | 2006-06-29 | 2008-02-21 | Brett Allison | Substituted aminomethyl benzamide compounds |
| CN101511775A (en) | 2006-06-29 | 2009-08-19 | 詹森药业有限公司 | Butyl and butynyl benzyl amine compounds |
| CA2656089A1 (en) * | 2006-06-29 | 2008-01-03 | Janssen Pharmaceutica N.V. | Substituted benzyl amine compounds |
| WO2010059393A1 (en) * | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
| WO2010059390A1 (en) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Modulators of serotonin receptor |
| KR101043200B1 (en) * | 2010-11-08 | 2011-06-21 | 성시민 | Air filling device of breathing air tank |
| CN103329114B (en) | 2011-01-27 | 2015-11-25 | 惠普发展公司，有限责任合伙企业 | The computing equipment be connected with portable equipment |
| EP3936192B1 (en) | 2019-03-06 | 2025-04-09 | Daiichi Sankyo Company, Limited | Pyrrolopyrazole derivative |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA923283B (en) * | 1991-05-29 | 1993-01-27 | Akzo Nv | Phenoxyphenyl derivatives |
| NZ271833A (en) * | 1993-08-19 | 1997-08-22 | Warner Lambert Co | Substituted 2(5h)-furanone (or thiophenone or pyrrolone) derivatives |
| CZ293595A3 (en) * | 1995-11-09 | 1999-12-15 | Farmak A. S. | Derivatives of n,n-dimethyl-2-(arylthio)benzylamine, their salts, processes of their preparation and their use in medicaments |
| EP1071648A2 (en) * | 1998-03-13 | 2001-01-31 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
| AU763884B2 (en) * | 1999-02-23 | 2003-07-31 | Pfizer Products Inc. | Monoamine reuptake inhibitors for treatment of CNS disorders |
| GB0007884D0 (en) * | 2000-03-31 | 2000-05-17 | Pfizer Ltd | Diphenyl ether compounds useful in therapy |
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2001
- 2001-08-22 SK SK201-2003A patent/SK2012003A3/en unknown
- 2001-08-22 EE EEP200300084A patent/EE200300084A/en unknown
- 2001-08-22 JP JP2002523451A patent/JP2004507523A/en active Pending
- 2001-08-22 AU AU2001278650A patent/AU2001278650A1/en not_active Abandoned
- 2001-08-22 HU HU0303385A patent/HUP0303385A2/en unknown
- 2001-08-22 BR BR0113610-0A patent/BR0113610A/en not_active IP Right Cessation
- 2001-08-22 KR KR10-2003-7003011A patent/KR20030029889A/en not_active Application Discontinuation
- 2001-08-22 WO PCT/IB2001/001521 patent/WO2002018333A1/en not_active Application Discontinuation
- 2001-08-22 CN CN01814846A patent/CN1449380A/en active Pending
- 2001-08-22 AP APAP/P/2001/002265A patent/AP2001002265A0/en unknown
- 2001-08-22 OA OA1200300056A patent/OA12372A/en unknown
- 2001-08-22 CZ CZ2003467A patent/CZ2003467A3/en unknown
- 2001-08-22 CA CA002420969A patent/CA2420969A1/en not_active Abandoned
- 2001-08-22 PL PL36074301A patent/PL360743A1/en not_active Application Discontinuation
- 2001-08-22 NZ NZ523951A patent/NZ523951A/en unknown
- 2001-08-22 EA EA200300206A patent/EA200300206A1/en unknown
- 2001-08-22 MX MXPA03001848A patent/MXPA03001848A/en active IP Right Grant
- 2001-08-22 IL IL15434301A patent/IL154343A0/en unknown
- 2001-08-22 EP EP01956734A patent/EP1313701A1/en not_active Withdrawn
- 2001-08-22 DZ DZ013414A patent/DZ3414A1/en active
- 2001-08-24 PA PA20018526701A patent/PA8526701A1/en unknown
- 2001-08-28 HN HN2001000191A patent/HN2001000191A/en unknown
- 2001-08-28 PE PE2001000862A patent/PE20020346A1/en not_active Application Discontinuation
- 2001-08-29 AR ARP010104114A patent/AR031867A1/en unknown
- 2001-08-29 DO DO2001000242A patent/DOP2001000242A/en unknown
- 2001-08-30 TN TNTNSN01131A patent/TNSN01131A1/en unknown
- 2001-08-31 UY UY26924A patent/UY26924A1/en not_active Application Discontinuation
-
2003
- 2003-01-30 IS IS6704A patent/IS6704A/en unknown
- 2003-02-07 BG BG107544A patent/BG107544A/en unknown
- 2003-02-21 MA MA27049A patent/MA26945A1/en unknown
- 2003-02-24 NO NO20030842A patent/NO20030842L/en not_active Application Discontinuation
- 2003-02-26 HR HR20030141A patent/HRP20030141A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HN2001000191A (en) | 2002-03-11 |
| TNSN01131A1 (en) | 2005-11-10 |
| CN1449380A (en) | 2003-10-15 |
| PA8526701A1 (en) | 2003-07-28 |
| IL154343A0 (en) | 2003-09-17 |
| IS6704A (en) | 2003-01-30 |
| PL360743A1 (en) | 2004-09-20 |
| KR20030029889A (en) | 2003-04-16 |
| BR0113610A (en) | 2003-06-24 |
| BG107544A (en) | 2003-10-31 |
| EE200300084A (en) | 2005-02-15 |
| CZ2003467A3 (en) | 2004-04-14 |
| HUP0303385A2 (en) | 2004-03-01 |
| SK2012003A3 (en) | 2004-06-08 |
| MXPA03001848A (en) | 2003-06-04 |
| DOP2001000242A (en) | 2002-05-15 |
| JP2004507523A (en) | 2004-03-11 |
| MA26945A1 (en) | 2004-12-20 |
| AU2001278650A1 (en) | 2002-03-13 |
| DZ3414A1 (en) | 2002-03-07 |
| AR031867A1 (en) | 2003-10-08 |
| CA2420969A1 (en) | 2002-03-07 |
| AP2001002265A0 (en) | 2001-09-30 |
| NO20030842D0 (en) | 2003-02-24 |
| HRP20030141A2 (en) | 2003-04-30 |
| OA12372A (en) | 2006-04-17 |
| NO20030842L (en) | 2003-04-28 |
| UY26924A1 (en) | 2002-03-22 |
| EP1313701A1 (en) | 2003-05-28 |
| WO2002018333A1 (en) | 2002-03-07 |
| NZ523951A (en) | 2004-09-24 |
| EA200300206A1 (en) | 2003-06-26 |
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| Date | Code | Title | Description |
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| FG | Grant, registration | ||
| FD | Application declared void or lapsed |