PE20020216A1 - PRODROGAS 3' DE 2' -DESOXI-ß-L-NUCLEOSIDOS - Google Patents
PRODROGAS 3' DE 2' -DESOXI-ß-L-NUCLEOSIDOSInfo
- Publication number
- PE20020216A1 PE20020216A1 PE2001000584A PE2001000584A PE20020216A1 PE 20020216 A1 PE20020216 A1 PE 20020216A1 PE 2001000584 A PE2001000584 A PE 2001000584A PE 2001000584 A PE2001000584 A PE 2001000584A PE 20020216 A1 PE20020216 A1 PE 20020216A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- refers
- nucleoside
- aryl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A PRODROGAS 3' DE 2' DESOXI-ß-L-NUCLEOSIDOS DONDE EL TERMINO 2'- DESOXI SE REFIERE A UN NUCLEOSIDO QUE NO TIENE SUSTITUYENTES EN POSICION 2' Y EL TERMINO PRODROGA 3' SE REFIERE A UN DESOXI-ß-L-NUCLEOSIDO QUE TIENE UNA PORCION SEPARABLE EN LA POSICION 3' INCLUYENDO ACILO Y UN L-AMINOACIDO. SE REFIERE A UN ß-L NUCLEOSIDO 3'-O-SUSTITUIDO DE FORMULA I DONDE R1 ES H, ALQUILO, CO-ALQUILO, CO-ARILO, CO-ALCOXIALQUILO, ENTRE OTROS; R2 ES ALQUILO, CO-ALQUILO, CO-ARILO, CO-ALCOXIALQUILO, CO-ARILOXIALQUILO, ENTRE OTROS; X ES O, S, SO2, CH2. EL COMPUESTO ß-L NUCLEOSIDO 3'-O-SUSTITUIDO ES UNA ß-L-2'-DESOXIPURINA DE FORMULA II DONDE R1 ES H, ALQUILO, CO-ALQUILO, CO-ARILO, CO-ALCOXIALQUILO, ENTRE OTROS; R2 ES ALQUILO, CO-ALQUILO, CO-ARILO, RESIDUO AMINOACIDO, MONO, DI, O TRIFOSFATO; Y ES OR3, NR3R4, SR3; X1 Y X2 SON H, ALQUILO, CO-ALQUILO, ENTRE OTROS; R3-R6 SON H, ALQUILO, DIALQUILAMINOALQUILENO DE PREFERENCIA DIMETILAMINOMETILENO, CO-ALQUILO ENTRE OTROS.I ADEMAS A COMPUESTOS DE B-L NUCLEOSIDO 3'-O-SUSTITUIDO TAL COMO B-L-2'-DESOXIPURINA, ß-L-2'-DESOXIADENOSINA, B-L-2'-DESO-GUANIDINA, B-L-2'-DESOXIINOSINA, B-L-2'-DESOXIPIRIMIDINA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA PARA EL TRATAMIENTO DE UNA INFECCION POR VIRUS DE HEPATITIS B
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21210000P | 2000-06-15 | 2000-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020216A1 true PE20020216A1 (es) | 2002-04-16 |
Family
ID=22789563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000584A PE20020216A1 (es) | 2000-06-15 | 2001-06-15 | PRODROGAS 3' DE 2' -DESOXI-ß-L-NUCLEOSIDOS |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1296995B1 (es) |
| JP (1) | JP4639032B2 (es) |
| KR (2) | KR20070048277A (es) |
| CN (3) | CN1900104A (es) |
| AP (1) | AP1771A (es) |
| AR (1) | AR035711A1 (es) |
| AT (1) | ATE411332T1 (es) |
| AU (2) | AU6692701A (es) |
| BR (1) | BR0111732A (es) |
| CA (1) | CA2413163C (es) |
| CZ (1) | CZ2003122A3 (es) |
| DE (1) | DE60136181D1 (es) |
| EA (1) | EA005774B1 (es) |
| ES (1) | ES2317912T3 (es) |
| IL (3) | IL153379A0 (es) |
| MA (1) | MA27126A1 (es) |
| MX (1) | MXPA02012443A (es) |
| MY (1) | MY141594A (es) |
| NO (1) | NO20026001L (es) |
| NZ (2) | NZ535246A (es) |
| OA (1) | OA12384A (es) |
| PE (1) | PE20020216A1 (es) |
| PL (1) | PL360404A1 (es) |
| UY (1) | UY26779A1 (es) |
| WO (1) | WO2001096353A2 (es) |
| YU (1) | YU94802A (es) |
| ZA (2) | ZA200300168B (es) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100457118C (zh) | 2000-04-13 | 2009-02-04 | 法玛塞特有限公司 | 用于治疗肝炎病毒感染的3′-或2′-羟甲基取代的核苷衍生物 |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| EA200601591A1 (ru) | 2000-05-26 | 2007-02-27 | Айденикс (Кайман) Лимитед | Применение рибонуклеозидных соединений для лечения флавивирусных и пестивирусных инфекций |
| US6787526B1 (en) | 2000-05-26 | 2004-09-07 | Idenix Pharmaceuticals, Inc. | Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides |
| WO2003026589A2 (en) | 2001-09-28 | 2003-04-03 | Idenix (Cayman) Limited | Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides |
| EP1536804A4 (en) * | 2002-06-28 | 2007-10-31 | Idenix Cayman Ltd | 2'-C-METHYL-3'-O-L-VALINESTER-RIBOFURANOSYLCYTIDINE FOR THE TREATMENT OF FLAVIVIRIDAE INFECTIONS |
| NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| MXPA04012779A (es) * | 2002-06-28 | 2005-08-19 | Idenix Cayman Ltd | Profarmacos de 2'- y 3'-nucleosido para tratar infecciones por flaviviridae. |
| TW200500373A (en) | 2002-06-28 | 2005-01-01 | Idenix Cayman Ltd | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| EP1572095B1 (en) | 2002-09-13 | 2015-06-10 | Novartis AG | Beta-l-2'-deoxynucleosides for use in the treatment of resistant hbv strains |
| JP2006519753A (ja) | 2002-11-15 | 2006-08-31 | イデニクス（ケイマン）リミテツド | ２’−分枝ヌクレオシドおよびフラビウイルス科ウイルス突然変異 |
| US7598373B2 (en) | 2002-12-12 | 2009-10-06 | Idenix Pharmaceuticals, Inc. | Process for the production of 2-C-methyl-D-ribonolactone |
| WO2004084453A2 (en) | 2003-03-20 | 2004-09-30 | Microbiologica Quimica E Farmaceutica Ltd. | METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES |
| CN1812995A (zh) * | 2003-04-28 | 2006-08-02 | 艾登尼科斯（开曼）有限公司 | 工业化规模的核苷合成 |
| EP2345659A1 (en) | 2003-05-30 | 2011-07-20 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
| EP1639121A4 (en) | 2003-06-30 | 2008-04-16 | Idenix Cayman Ltd | SYNTHESIS OF BETA-L-2-DESOXYNUCLEOSIDES |
| CN1980657A (zh) | 2004-05-05 | 2007-06-13 | 耶鲁大学 | 新颖的抗病毒赛菊宁黄质类似物 |
| CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| SG158136A1 (en) | 2004-09-14 | 2010-01-29 | Pharmasset Inc | Preparation of 2`-fluoro-2`- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives |
| US7524831B2 (en) | 2005-03-02 | 2009-04-28 | Schering Corporation | Treatments for Flaviviridae virus infection |
| AU2006259348B2 (en) | 2005-06-17 | 2010-07-22 | Novartis Ag | Use of sanglifehrin in HCV |
| GB0609178D0 (en) | 2006-05-09 | 2006-06-21 | Univ Cardiff | Novel compounds |
| US7897737B2 (en) | 2006-12-05 | 2011-03-01 | Lasergen, Inc. | 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| TW200946541A (en) | 2008-03-27 | 2009-11-16 | Idenix Pharmaceuticals Inc | Solid forms of an anti-HIV phosphoindole compound |
| CA2727709C (en) | 2008-06-11 | 2017-11-14 | Lasergen, Inc. | Nucleotides and nucleosides and methods for their use in dna sequencing |
| BRPI0922508A8 (pt) | 2008-12-23 | 2016-01-19 | Pharmasset Inc | Análogos de nucleosídeo |
| KR20110099138A (ko) | 2008-12-23 | 2011-09-06 | 파마셋 인코포레이티드 | 뉴클레오시드 포스포르아미데이트 |
| CA2748016A1 (en) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Synthesis of purine nucleosides |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| UY33311A (es) | 2010-03-31 | 2011-10-31 | Pharmasset Inc | Fosforamidatos de nucleosidos |
| AR094621A1 (es) | 2010-04-01 | 2015-08-19 | Idenix Pharmaceuticals Inc | Compuestos y composiciones farmacéuticas para el tratamiento de infecciones virales |
| ES2716158T3 (es) | 2010-11-30 | 2019-06-10 | Gilead Pharmasset Llc | 2'-spiro-nucleótidos para el tratamiento de hepatitis C |
| CA2843324A1 (en) | 2011-03-31 | 2012-11-15 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| WO2013039855A1 (en) | 2011-09-12 | 2013-03-21 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| EP3670523B1 (en) | 2011-09-13 | 2021-08-11 | Agilent Technologies, Inc. | 3'-oh unblocked, fast photocleavable terminating nucleotides and their use in methods for nucleic acid sequencing |
| NZ623396A (en) | 2011-09-16 | 2016-07-29 | Gilead Pharmasset Llc | Methods for treating hcv |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| AR090699A1 (es) * | 2012-04-18 | 2014-12-03 | Biocryst Pharm Inc | Compuestos inhibidores de la actividad de la arn polimerasa viral |
| KR20200060782A (ko) | 2013-01-31 | 2020-06-01 | 길리애드 파마셋 엘엘씨 | 두 항바이러스 화합물의 병용 제형물 |
| JP2016529293A (ja) | 2013-08-27 | 2016-09-23 | ギリアド ファーマセット エルエルシー | ２つの抗ウイルス化合物の組合せ製剤 |
| WO2019200340A1 (en) | 2018-04-12 | 2019-10-17 | Modis Therapeutics Inc. | Prodrugs of deoxynucleosides for treatment of diseases cased by unbalanced nucleotide pools |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4958013A (en) * | 1989-06-06 | 1990-09-18 | Northwestern University | Cholesteryl modified oligonucleotides |
| IT1246983B (it) * | 1990-11-13 | 1994-12-12 | Consiglio Nazionale Ricerche | L-2'-desossiuridine e composizioni farmaceutiche che le contengono. |
| US5559101A (en) * | 1994-10-24 | 1996-09-24 | Genencor International, Inc. | L-ribofuranosyl nucleosides |
| SE9603178L (sv) * | 1996-08-30 | 1997-09-22 | Scania Cv Ab | Anordning vid ett fordon för monterbar anfästning av en förarplatsmodul |
| JP4294870B2 (ja) * | 1998-08-10 | 2009-07-15 | インデニックス ファーマシューティカルズ リミティド | Ｂ型肝炎の治療のためのβ−Ｌ−２’−デオキシ−ヌクレオシド |
-
2001
- 2001-06-14 MY MYPI20012807A patent/MY141594A/en unknown
- 2001-06-15 PE PE2001000584A patent/PE20020216A1/es not_active Application Discontinuation
- 2001-06-15 PL PL36040401A patent/PL360404A1/xx not_active Application Discontinuation
- 2001-06-15 YU YU94802A patent/YU94802A/sh unknown
- 2001-06-15 AU AU6692701A patent/AU6692701A/xx active Pending
- 2001-06-15 CN CNA2006100741038A patent/CN1900104A/zh active Pending
- 2001-06-15 CN CNB018138020A patent/CN1295242C/zh not_active Expired - Fee Related
- 2001-06-15 KR KR1020077009124A patent/KR20070048277A/ko not_active Ceased
- 2001-06-15 EP EP01944522A patent/EP1296995B1/en not_active Expired - Lifetime
- 2001-06-15 AU AU2001266927A patent/AU2001266927B2/en not_active Ceased
- 2001-06-15 WO PCT/US2001/019147 patent/WO2001096353A2/en active Application Filing
- 2001-06-15 CZ CZ2003122A patent/CZ2003122A3/cs unknown
- 2001-06-15 AR ARP010102881A patent/AR035711A1/es not_active Application Discontinuation
- 2001-06-15 BR BR0111732-7A patent/BR0111732A/pt not_active IP Right Cessation
- 2001-06-15 OA OA1200200374A patent/OA12384A/en unknown
- 2001-06-15 NZ NZ535246A patent/NZ535246A/en unknown
- 2001-06-15 CN CNA2006101495863A patent/CN101012259A/zh active Pending
- 2001-06-15 IL IL15337901A patent/IL153379A0/xx active IP Right Grant
- 2001-06-15 KR KR1020027017018A patent/KR20030032967A/ko active IP Right Grant
- 2001-06-15 NZ NZ523632A patent/NZ523632A/en unknown
- 2001-06-15 CA CA002413163A patent/CA2413163C/en not_active Expired - Lifetime
- 2001-06-15 MX MXPA02012443A patent/MXPA02012443A/es active IP Right Grant
- 2001-06-15 AT AT01944522T patent/ATE411332T1/de not_active IP Right Cessation
- 2001-06-15 EA EA200300023A patent/EA005774B1/ru not_active IP Right Cessation
- 2001-06-15 AP APAP/P/2003/002713A patent/AP1771A/en active
- 2001-06-15 DE DE60136181T patent/DE60136181D1/de not_active Expired - Lifetime
- 2001-06-15 ES ES01944522T patent/ES2317912T3/es not_active Expired - Lifetime
- 2001-06-15 JP JP2002510494A patent/JP4639032B2/ja not_active Expired - Lifetime
- 2001-06-15 UY UY26779A patent/UY26779A1/es not_active Application Discontinuation
-
2002
- 2002-12-11 IL IL153379A patent/IL153379A/en not_active IP Right Cessation
- 2002-12-13 NO NO20026001A patent/NO20026001L/no unknown
-
2003
- 2003-01-02 MA MA26989A patent/MA27126A1/fr unknown
- 2003-01-07 ZA ZA200300168A patent/ZA200300168B/en unknown
-
2004
- 2004-06-01 ZA ZA200404306A patent/ZA200404306B/xx unknown
-
2006
- 2006-10-25 IL IL178864A patent/IL178864A0/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |