PE20020044A1 - Tiazina oxazolidinona - Google Patents
Tiazina oxazolidinonaInfo
- Publication number
- PE20020044A1 PE20020044A1 PE2001000542A PE2001000542A PE20020044A1 PE 20020044 A1 PE20020044 A1 PE 20020044A1 PE 2001000542 A PE2001000542 A PE 2001000542A PE 2001000542 A PE2001000542 A PE 2001000542A PE 20020044 A1 PE20020044 A1 PE 20020044A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- antibiotics
- refers
- compound
- thiazine oxazolidinone
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title 1
- AGIJRRREJXSQJR-UHFFFAOYSA-N 2h-thiazine Chemical compound N1SC=CC=C1 AGIJRRREJXSQJR-UHFFFAOYSA-N 0.000 title 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 abstract 1
- 229930182566 Gentamicin Natural products 0.000 abstract 1
- -1 THIAZINE OXAZOLIDINONE COMPOUND Chemical class 0.000 abstract 1
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 abstract 1
- 229960004821 amikacin Drugs 0.000 abstract 1
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960002182 imipenem Drugs 0.000 abstract 1
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 abstract 1
- 229960002260 meropenem Drugs 0.000 abstract 1
- DMJNNHOOLUXYBV-PQTSNVLCSA-N meropenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](C(=O)N(C)C)C1 DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960000707 tobramycin Drugs 0.000 abstract 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UN COMPUESTO TIAZINA OXAZOLIDINONA DE FORMULA I N-({(5S)-3-[4-(1,1-DIOXIDO-4-TIOMORFOLINIL)-3,5-DIFLUOROFENIL-2-OXO-1,3-OXAZOLIDIN-5-IL}METIL) ACETAMIDA UTIL COMO AGENTE ANTIMICROBIANO QUE SE ADMINISTRA EN UNA CANTIDAD COMPRENDIDA ENTRE 0,1mg/kg A 100 mg/kg DE PESO CORPORAL/DIA . SE REFIERE TAMBIEN A UNA TERAPIA COMBINADA DONDE EL COMPUESTO DE FORMULA I SE ADMINISTRA JUNTO A OTROS ANTIBIOTICOS CON ACTIVIDAD SOBRE MICROORGANISMOS GRAM NEGATIVOS O UNA COMPOSICION COMPOSICION FARMACEUTICA QUE COMPRENDE: a) EL COMPUESTO DE FORMULA I; b) UNO O MAS ANTIBIOTICOS TAL COMO AMIKACINA, GENTAMICINA, TOBRAMICINA, IMIPENEM, MEROPENEM, ENTRE OTROS Y c) UN VEHICULO FARMACEUTICAMENTE ACEPTABLE.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21247400P | 2000-06-16 | 2000-06-16 | |
| US23659500P | 2000-09-29 | 2000-09-29 | |
| US28558701P | 2001-04-20 | 2001-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020044A1 true PE20020044A1 (es) | 2002-01-30 |
Family
ID=27395744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000542A PE20020044A1 (es) | 2000-06-16 | 2001-06-11 | Tiazina oxazolidinona |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6605609B2 (es) |
| EP (1) | EP1294717B1 (es) |
| JP (1) | JP2004501150A (es) |
| KR (1) | KR20030010721A (es) |
| CN (1) | CN1430618A (es) |
| AR (1) | AR028706A1 (es) |
| AT (1) | ATE312098T1 (es) |
| AU (1) | AU2001266567A1 (es) |
| BR (1) | BR0111520A (es) |
| CA (1) | CA2410358A1 (es) |
| DE (1) | DE60115644T2 (es) |
| ES (1) | ES2253392T3 (es) |
| MX (1) | MXPA02012494A (es) |
| PE (1) | PE20020044A1 (es) |
| TW (1) | TW583184B (es) |
| WO (1) | WO2001098297A2 (es) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| PE20020300A1 (es) * | 2000-08-22 | 2002-05-10 | Pharmacia Corp | Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco |
| US6696426B2 (en) * | 2000-08-22 | 2004-02-24 | Pharmacia Corporation | Preservative free ophthalmic oxazolidinone antibiotic drug delivery systems |
| US6541014B2 (en) | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| MXPA03009643A (es) | 2001-04-20 | 2004-05-21 | Upjohn Co | Un metodo para la preparacion de oxazolidinonas. |
| ATE374463T1 (de) | 2001-04-20 | 2007-10-15 | Pharmacia & Upjohn Co Llc | Verfahren zur herstellung von oxazolidinonen |
| CA2453182A1 (en) * | 2001-07-10 | 2003-01-23 | Meredith L. Greene | Crystalline thiazine oxazolidinones |
| AU2003224345A1 (en) * | 2002-04-30 | 2003-11-17 | Orchid Chemicals & Pharmaceuticals | Antibacterial agents |
| KR101033097B1 (ko) * | 2002-05-07 | 2011-05-06 | 더 리서치 파운데이션 오브 스테이트 유니버시티 오브 뉴욕 | 표적 기관지내 요법을 위한 방법, 장치 및 제제 |
| TW200403240A (en) * | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
| US6875784B2 (en) * | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| AU2004258944B2 (en) | 2003-07-21 | 2011-02-10 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| EP1648415A4 (en) | 2003-07-21 | 2011-11-16 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION |
| EP1648407A4 (en) | 2003-07-21 | 2011-08-31 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, CORRESPONDING USE AND FORMULATION |
| JP2007502296A (ja) | 2003-08-11 | 2007-02-08 | アドバンシス ファーマスーティカル コーポレイション | ロバストペレット |
| CA2535398C (en) | 2003-08-12 | 2013-11-12 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
| CA2535780A1 (en) * | 2003-08-29 | 2005-03-17 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
| EP1663169A4 (en) | 2003-09-15 | 2010-11-24 | Middlebrook Pharmaceuticals In | ANTIBIOTICS, ITS USE AND FORMULATION |
| TWI357901B (en) | 2004-03-12 | 2012-02-11 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivati |
| WO2005113520A1 (en) * | 2004-05-20 | 2005-12-01 | Pharmacia & Upjohn Company Llc | Substituted 2,3,5-trifluorphenyl oxazolidinones for use as antibacterial agents |
| AU2005269981A1 (en) | 2004-07-02 | 2006-02-09 | Bonck, John A | Tablet for pulsed delivery |
| US8524734B2 (en) | 2005-05-18 | 2013-09-03 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| US7838532B2 (en) * | 2005-05-18 | 2010-11-23 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| AU2006339058B2 (en) * | 2005-08-11 | 2012-09-06 | Targanta Therapeutics Inc. | Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections |
| US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8299052B2 (en) * | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
| EP2018864A1 (en) | 2007-07-23 | 2009-01-28 | Biomet Deutschland GmbH | Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition |
| HRP20201150T8 (hr) | 2008-10-07 | 2021-06-25 | Horizon Orphan Llc | Inhalacija levofloksacina za smanjenje upale pluća |
| NZ631469A (en) | 2008-10-07 | 2016-06-24 | Raptor Pharmaceuticals Inc | Aerosol fluoroquinolone formulations for improved pharmacokinetics |
| CA2938650C (en) | 2009-09-04 | 2018-01-09 | Raptor Pharmaceuticals Inc. | Use of aerosolized levofloxacin for treating cystic fibrosis |
| US10010758B2 (en) * | 2015-07-20 | 2018-07-03 | Kinetic Furniture Of Vermont, Llc | Exercise chair |
| CN106770222A (zh) * | 2016-11-23 | 2017-05-31 | 百奥森（江苏）食品安全科技有限公司 | 一种食品中甲硝唑的检测试剂盒 |
| CN108239098B (zh) * | 2016-12-26 | 2021-01-12 | 中国医学科学院药物研究所 | 含四氢吡啶的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途 |
| KR20190138858A (ko) * | 2017-04-14 | 2019-12-16 | 날 파마슈티칼 그룹 리미티드 | 목시플록사신이 담긴 사전 충전형 시린지 |
| WO2021184339A1 (en) * | 2020-03-20 | 2021-09-23 | Merck Sharp & Dohme Corp. | Oxazolidinone compound and methods of use thereof as an antibacterial agent |
| CN111870594B (zh) * | 2020-08-27 | 2022-03-22 | 首都医科大学附属北京胸科医院 | 苯乙肼在制备抗偶发分枝杆菌感染的药物中的应用 |
| EP4568961A1 (en) * | 2022-08-10 | 2025-06-18 | Merck Sharp & Dohme LLC | Processes for preparing oxazolidinone compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| JPH11512386A (ja) | 1995-09-01 | 1999-10-26 | ファルマシア・アンド・アップジョン・カンパニー | ４−８員複素環へのｃ−ｃ結合を有するフェニルオキサゾリジノン |
| GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| US6211212B1 (en) * | 1997-03-13 | 2001-04-03 | Smithkline Beecham P.L.C. | Pyrrolidine and thiazole derivatives with metallo-beta-lactamase inhibitory properties |
| AU1572101A (en) | 1999-11-08 | 2001-06-06 | Pharmacia & Upjohn Company | Admixture of linezolid and other antibacterial agents |
-
2001
- 2001-06-11 PE PE2001000542A patent/PE20020044A1/es not_active Application Discontinuation
- 2001-06-12 AR ARP010102780A patent/AR028706A1/es unknown
- 2001-06-14 AT AT01944126T patent/ATE312098T1/de not_active IP Right Cessation
- 2001-06-14 ES ES01944126T patent/ES2253392T3/es not_active Expired - Lifetime
- 2001-06-14 MX MXPA02012494A patent/MXPA02012494A/es not_active Application Discontinuation
- 2001-06-14 AU AU2001266567A patent/AU2001266567A1/en not_active Abandoned
- 2001-06-14 JP JP2002504253A patent/JP2004501150A/ja not_active Withdrawn
- 2001-06-14 BR BR0111520-0A patent/BR0111520A/pt not_active IP Right Cessation
- 2001-06-14 DE DE60115644T patent/DE60115644T2/de not_active Expired - Fee Related
- 2001-06-14 CN CN01809867A patent/CN1430618A/zh active Pending
- 2001-06-14 EP EP01944126A patent/EP1294717B1/en not_active Expired - Lifetime
- 2001-06-14 KR KR1020027017088A patent/KR20030010721A/ko not_active Withdrawn
- 2001-06-14 CA CA002410358A patent/CA2410358A1/en not_active Abandoned
- 2001-06-14 WO PCT/US2001/014854 patent/WO2001098297A2/en active IP Right Grant
- 2001-06-15 US US09/881,189 patent/US6605609B2/en not_active Expired - Fee Related
- 2001-06-15 TW TW090114508A patent/TW583184B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60115644T2 (de) | 2006-07-06 |
| MXPA02012494A (es) | 2003-04-25 |
| US6605609B2 (en) | 2003-08-12 |
| CN1430618A (zh) | 2003-07-16 |
| WO2001098297A3 (en) | 2002-06-13 |
| US20020156072A1 (en) | 2002-10-24 |
| ATE312098T1 (de) | 2005-12-15 |
| KR20030010721A (ko) | 2003-02-05 |
| CA2410358A1 (en) | 2001-12-27 |
| BR0111520A (pt) | 2003-03-18 |
| EP1294717B1 (en) | 2005-12-07 |
| AR028706A1 (es) | 2003-05-21 |
| TW583184B (en) | 2004-04-11 |
| ES2253392T3 (es) | 2006-06-01 |
| DE60115644D1 (en) | 2006-01-12 |
| WO2001098297A2 (en) | 2001-12-27 |
| EP1294717A2 (en) | 2003-03-26 |
| JP2004501150A (ja) | 2004-01-15 |
| AU2001266567A1 (en) | 2002-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |