PE20011374A1 - 4-AMINO-AZEPAN-3-ONA AS PROTEASE INHIBITORS - Google Patents
4-AMINO-AZEPAN-3-ONA AS PROTEASE INHIBITORSInfo
- Publication number
- PE20011374A1 PE20011374A1 PE2001000566A PE2001000566A PE20011374A1 PE 20011374 A1 PE20011374 A1 PE 20011374A1 PE 2001000566 A PE2001000566 A PE 2001000566A PE 2001000566 A PE2001000566 A PE 2001000566A PE 20011374 A1 PE20011374 A1 PE 20011374A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- azepan
- amino
- ona
- het
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- -1 PIPERIDINYL-ETHYL Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010065687 Bone loss Diseases 0.000 abstract 1
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 229960003067 cystine Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- JFSPBVWPKOEZCB-UHFFFAOYSA-N fenfuram Chemical compound O1C=CC(C(=O)NC=2C=CC=CC=2)=C1C JFSPBVWPKOEZCB-UHFFFAOYSA-N 0.000 abstract 1
- 208000007565 gingivitis Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 201000004409 schistosomiasis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
SE REFIERE A COMPUESTOS DE 4-AMINO-AZEPAN-3-ONA DE FORMULA IA DONDE R1 ES R4(R')NCHR3-CO-; R4(R')NC(R3)(R'''')-CO-, GRUPO a; R2 ES ALQUILO C1-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6, R9C(O)- ENTRE OTROS; R3 ES ALQUILO C1-C6; R4 ES R5C(O)-; R5 ES HET-ALQUILO C0-C6 TAL COMO PIPERIDINIL-ETILO, BENZO[1,3]DIOXOLILO, FURANILO, ENTRE OTROS; R9 ES ALQUILO C1-C6, CICLOALQUIL C3-C6-ALQUILO C0-C6, Ar-ALQUILO C0-C6, ENTRE OTROS; R' , R'', R''' SON H; R'''' ES ALQUILO C1-C6, CICLOALQUILO C3-C6-ALQUILO C0-C6, ALQUENILO C2-C6, ENTRE OTROS; n ES 1 A 5. SON COMPUESTOS PREFERIDOS {(S)-1-[(3-FLUORO-BENCENOSULFONIL)-3-OXO-AZEPAN-4-ILCARBAMOIL]-3-METIL-1-BUTIL}-AMIDA DE ACIDO BENZOFURAN-2-CARBOXILICO; 3-[OXO-1-(PIRIDINA-2-SULFONIL)-AZEPAN-4-OL]AMIDA DE ACIDO (S)-4-METIL-2-[3-PIPERIDIN-1-ILPROPANOILAMINO)-PENTANOICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. EL COMPUESTO I ES UN INHIBIDOR DE CISTEINA O SERINA PROTEASA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ENFERMEDADES CON PERDIDA OSEA, PERIODONTITIS, GINGIVITIS, OSTEOARTRITIS, ARTRITIS REUMATOIDE, ESQUISTOSOMIASIS, MALARIAREFERS TO 4-AMINO-AZEPAN-3-ONA COMPOUNDS OF FORMULA IA WHERE R1 IS R4 (R ') NCHR3-CO-; R4 (R ') NC (R3) (R' '' ') - CO-, GROUP a; R2 IS C1-C6 ALKYL, Ar-C0-C6 ALKYL, HET-C0-C6 ALKYL, R9C (O) - AMONG OTHERS; R3 IS C1-C6 ALKYL; R4 IS R5C (O) -; R5 IS C0-C6 HET-ALKYL SUCH AS PIPERIDINYL-ETHYL, BENZO [1,3] DIOXOLYL, FURANIL, AMONG OTHERS; R9 IS C1-C6 ALKYL, C3-C6 CYCLOALKYL-C0-C6 ALKYL, Ar-C0-C6 ALKYL, AMONG OTHERS; R ', R' ', R' '' ARE H; R '' '' IS C1-C6 ALKYL, C3-C6 CYCLOALKYL-C0-C6 ALKYL, C2-C6 ALKYL, AMONG OTHERS; n IS 1 TO 5. ARE PREFERRED COMPOUNDS {(S) -1 - [(3-FLUORO-BENZENOSULFONIL) -3-OXO-AZEPAN-4-ILCARBAMOIL] -3-METHYL-1-BUTYL}-BENZOFURAN ACID AMIDE- 2-CARBOXYL; 3- [OXO-1- (PYRIDINE-2-SULFONIL) -AZEPAN-4-OL] AMIDE OF ACID (S) -4-METHYL-2- [3-PIPERIDIN-1-ILPROPANOYLAMINO) -PENTANOICO, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. COMPOUND I IS AN INHIBITOR OF CYSTINE OR SERINE PROTEASE AND MAY BE USEFUL FOR THE TREATMENT OF DISEASES WITH BONE LOSS, PERIODONTITIS, GINGIVITIS, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, SCHISTOSOMIASIS, MALARIA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59384500A | 2000-06-14 | 2000-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20011374A1 true PE20011374A1 (en) | 2002-04-07 |
Family
ID=24376433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000566A PE20011374A1 (en) | 2000-06-14 | 2001-06-14 | 4-AMINO-AZEPAN-3-ONA AS PROTEASE INHIBITORS |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1307204A4 (en) |
| JP (1) | JP2004503502A (en) |
| KR (1) | KR20030008220A (en) |
| CN (1) | CN1444481A (en) |
| AP (1) | AP2002002671A0 (en) |
| AR (1) | AR032622A1 (en) |
| AU (1) | AU2001268407A1 (en) |
| BG (1) | BG107327A (en) |
| BR (1) | BR0111693A (en) |
| CA (1) | CA2412353A1 (en) |
| CZ (1) | CZ20024086A3 (en) |
| EA (1) | EA200300018A1 (en) |
| EC (1) | ECSP024388A (en) |
| HU (1) | HUP0301231A2 (en) |
| IL (1) | IL153421A0 (en) |
| MA (1) | MA25758A1 (en) |
| MX (1) | MXPA02012442A (en) |
| NO (1) | NO20025786L (en) |
| NZ (1) | NZ522965A (en) |
| OA (1) | OA12288A (en) |
| PE (1) | PE20011374A1 (en) |
| PL (1) | PL360508A1 (en) |
| SK (1) | SK17592002A3 (en) |
| WO (1) | WO2001095911A1 (en) |
| ZA (1) | ZA200209808B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001034159A1 (en) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| WO2001034158A1 (en) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| HUP0301964A3 (en) * | 2000-11-22 | 2007-09-28 | Smithkline Beecham Corp | Protease inhibitors |
| US7709510B2 (en) | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
| WO2002066035A2 (en) | 2001-02-20 | 2002-08-29 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
| US20040157828A1 (en) * | 2001-05-17 | 2004-08-12 | Ren Xie | Protease inhibitors |
| GB0220187D0 (en) * | 2002-08-30 | 2002-10-09 | Novartis Ag | Organic compounds |
| EP1653944B1 (en) * | 2003-08-01 | 2010-11-10 | Chugai Seiyaku Kabushiki Kaisha | Heterocyclic compounds useful as malonyl-coa decarboxylase inhibitors |
| JP4773960B2 (en) | 2003-08-01 | 2011-09-14 | 中外製薬株式会社 | Cyanoguanidine-type azole compounds useful as malonyl-CoA decarboxylase inhibitors |
| ES2309563T3 (en) | 2003-08-01 | 2008-12-16 | Chugai Seiyaku Kabushiki Kaisha | PIPERIDINE COMPOUNDS USED AS INHIBITORS FROM MALONIL COENZIMA TO DESCARBOXYLASE. |
| WO2009087379A2 (en) | 2008-01-09 | 2009-07-16 | Amura Therapeutics Limited | Tetrahydrofuro (3, 2 -b) pyrrol- 3 -one derivatives as inhibitors of cysteine proteinases |
| CN103275070A (en) * | 2013-05-10 | 2013-09-04 | 郑彪 | Tetracyclic compound for adjusting proliferation of mononuclear cells and application of tetracyclic compound |
| US9427441B2 (en) | 2014-02-19 | 2016-08-30 | Indiana University Research And Technology Corporation | Targeting primary cilia to treat glaucoma |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ2285A1 (en) * | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Cysteine protease inhibitors. |
| TR200101869T2 (en) * | 1998-12-23 | 2002-01-21 | Smithkline Beecham Corporation | Protease Inhibitors. |
| JP2003513956A (en) * | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | Protease inhibitor |
| WO2001034158A1 (en) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| JP2004509083A (en) * | 2000-09-01 | 2004-03-25 | スミスクライン・ビーチャム・コーポレイション | Method of treatment |
| HUP0301964A3 (en) * | 2000-11-22 | 2007-09-28 | Smithkline Beecham Corp | Protease inhibitors |
| US20040157828A1 (en) * | 2001-05-17 | 2004-08-12 | Ren Xie | Protease inhibitors |
-
2001
- 2001-06-14 BR BR0111693-2A patent/BR0111693A/en not_active IP Right Cessation
- 2001-06-14 PL PL36050801A patent/PL360508A1/en not_active Application Discontinuation
- 2001-06-14 EA EA200300018A patent/EA200300018A1/en unknown
- 2001-06-14 CA CA002412353A patent/CA2412353A1/en not_active Abandoned
- 2001-06-14 SK SK1759-2002A patent/SK17592002A3/en not_active Application Discontinuation
- 2001-06-14 PE PE2001000566A patent/PE20011374A1/en not_active Application Discontinuation
- 2001-06-14 JP JP2002510089A patent/JP2004503502A/en active Pending
- 2001-06-14 IL IL15342101A patent/IL153421A0/en unknown
- 2001-06-14 AU AU2001268407A patent/AU2001268407A1/en not_active Abandoned
- 2001-06-14 CN CN01813500A patent/CN1444481A/en active Pending
- 2001-06-14 OA OA1200200377A patent/OA12288A/en unknown
- 2001-06-14 WO PCT/US2001/019062 patent/WO2001095911A1/en not_active Ceased
- 2001-06-14 CZ CZ20024086A patent/CZ20024086A3/en unknown
- 2001-06-14 MX MXPA02012442A patent/MXPA02012442A/en unknown
- 2001-06-14 AR ARP010102840A patent/AR032622A1/en not_active Application Discontinuation
- 2001-06-14 HU HU0301231A patent/HUP0301231A2/en unknown
- 2001-06-14 AP APAP/P/2002/002671A patent/AP2002002671A0/en unknown
- 2001-06-14 NZ NZ522965A patent/NZ522965A/en unknown
- 2001-06-14 EP EP01946344A patent/EP1307204A4/en not_active Withdrawn
- 2001-06-14 KR KR1020027017045A patent/KR20030008220A/en not_active Withdrawn
-
2002
- 2002-11-28 BG BG107327A patent/BG107327A/en unknown
- 2002-12-02 NO NO20025786A patent/NO20025786L/en not_active Application Discontinuation
- 2002-12-03 ZA ZA200209808A patent/ZA200209808B/en unknown
- 2002-12-12 EC EC2002004388A patent/ECSP024388A/en unknown
- 2002-12-13 MA MA26952A patent/MA25758A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004503502A (en) | 2004-02-05 |
| EP1307204A4 (en) | 2004-06-02 |
| NZ522965A (en) | 2004-06-25 |
| OA12288A (en) | 2003-12-12 |
| CA2412353A1 (en) | 2001-12-20 |
| BR0111693A (en) | 2004-04-06 |
| WO2001095911A1 (en) | 2001-12-20 |
| IL153421A0 (en) | 2003-07-06 |
| SK17592002A3 (en) | 2003-05-02 |
| PL360508A1 (en) | 2004-09-06 |
| CZ20024086A3 (en) | 2003-05-14 |
| BG107327A (en) | 2003-07-31 |
| NO20025786L (en) | 2003-02-12 |
| KR20030008220A (en) | 2003-01-24 |
| EA200300018A1 (en) | 2003-06-26 |
| EP1307204A1 (en) | 2003-05-07 |
| ZA200209808B (en) | 2004-07-09 |
| AU2001268407A1 (en) | 2001-12-24 |
| HUP0301231A2 (en) | 2003-08-28 |
| ECSP024388A (en) | 2003-02-06 |
| CN1444481A (en) | 2003-09-24 |
| AP2002002671A0 (en) | 2002-12-31 |
| MXPA02012442A (en) | 2003-04-25 |
| AR032622A1 (en) | 2003-11-19 |
| NO20025786D0 (en) | 2002-12-02 |
| MA25758A1 (en) | 2003-04-01 |
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