PE20010320A1 - Antagonistas de los receptores de la il-8 - Google Patents
Antagonistas de los receptores de la il-8Info
- Publication number
- PE20010320A1 PE20010320A1 PE2000000592A PE0005922000A PE20010320A1 PE 20010320 A1 PE20010320 A1 PE 20010320A1 PE 2000000592 A PE2000000592 A PE 2000000592A PE 0005922000 A PE0005922000 A PE 0005922000A PE 20010320 A1 PE20010320 A1 PE 20010320A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- group
- receptors
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 102000010681 interleukin-8 receptors Human genes 0.000 title 1
- 108010038415 interleukin-8 receptors Proteins 0.000 title 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 108010012236 Chemokines Proteins 0.000 abstract 1
- 102000019034 Chemokines Human genes 0.000 abstract 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical class NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 1
- 101000973997 Homo sapiens Nucleosome assembly protein 1-like 4 Proteins 0.000 abstract 1
- 101000947178 Homo sapiens Platelet basic protein Proteins 0.000 abstract 1
- 108090001007 Interleukin-8 Proteins 0.000 abstract 1
- 102100036154 Platelet basic protein Human genes 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 abstract 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 241001529453 unidentified herpesvirus Species 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE AL USO DE COMPUESTOS DE GUANIDINA DE FORMULA I, DONDE: Z ES CIANO, OR11, C(O)NR15R16, R18, C(O)R11, S(O)2R17; 1-2 A SON N, Y EL RESTO SON C SUSTITUIDO CON H o R1; R ES UN GRUPO CON H IONIZABLE CON UN PKa DE 10 O MENOS; R1 ES H, HALOGENO, NITRO, CIANO, ALQUILO C1-C10 HALOSUSTITUIDO, ALCOXI C1-C10; AZIDA, (CR8R8)qS(O)tR4, (CR8R8)qNR4R5, ENTRE OTROS; q ES 0-10; t ES 0-2; v ES 1-4; m ES 1-3; R4 Y R5 SON H, ALQUILO C1-C4, ARILO, ARIL-ALQUILO C1-C4, ENTRE OTROS; Y ES H, HALOGENO, NITRO, CIANO, ENTRE OTROS; R8 ES H, ALQUILO C1-C4; R11 ES H, ALQUILO C1-C4, ARILO, ARIL-ALQUILO C1-C4; HETEROARILO, ENTRE OTROS; R13 Y R14 SON H, ALQUILO C1-C4; R15 Y R16 SON H, ALQUILO C1-C4, ARIL-ALQUILO C1-C4, HETEROARILO, HETEROARIL-ALQUILO C1-C4, ENTRE OTROS; R17 ES ALQUILO C1-C4, NR15R16, OR11, ARILO, ARIL-ALQUILO C1-C4, HETEROARILO, ENTRE OTROS; R18 ES ALQUILO C1-C4, ARILO, ARIL-ALQUILO C1-C4, ENTRE OTROS; W1 ES UN GRUPO a, ENTRE OTROS; E ES UN GRUPO b, ENTRE OTROS; EL * ES EL PUNTO DE UNION DEL ANILLO. LOS COMPUESTOS I INHIBEN LA UNION DE LAS QUIMIOQUINAS GROO, GROß, GROÛ, NAP-2 A LOS RECEPTORES O o ß DE LA INTERLEUQUINA 8 IL-8 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE MALARIA, RESTENOSIS, ANGIOGENESIS, ATEROSCLEROSIS, OSTEOPOROSIS, GINGIVITIS, HERPESVIRUS, VIRUS DE LA HEPATITIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14002599P | 1999-06-16 | 1999-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010320A1 true PE20010320A1 (es) | 2001-05-18 |
Family
ID=22489384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000592A PE20010320A1 (es) | 1999-06-16 | 2000-06-14 | Antagonistas de los receptores de la il-8 |
Country Status (6)
| Country | Link |
|---|---|
| AU (1) | AU5622400A (es) |
| CO (1) | CO5190720A1 (es) |
| EC (1) | ECSP003529A (es) |
| PE (1) | PE20010320A1 (es) |
| UY (1) | UY26208A1 (es) |
| WO (1) | WO2000076508A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1917244A2 (de) | 2005-08-24 | 2008-05-07 | Abbott GmbH & Co. KG | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5684032A (en) * | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
| US5780483A (en) * | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| JP2000507556A (ja) * | 1996-03-28 | 2000-06-20 | スミスクライン・ビーチャム・コーポレイション | ケモカインのカルボン酸インドール阻害剤 |
-
2000
- 2000-06-14 PE PE2000000592A patent/PE20010320A1/es not_active Application Discontinuation
- 2000-06-14 CO CO00044292A patent/CO5190720A1/es unknown
- 2000-06-14 UY UY26208A patent/UY26208A1/es not_active Application Discontinuation
- 2000-06-14 EC EC2000003529A patent/ECSP003529A/es unknown
- 2000-06-16 AU AU56224/00A patent/AU5622400A/en not_active Abandoned
- 2000-06-16 WO PCT/US2000/016756 patent/WO2000076508A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| UY26208A1 (es) | 2000-12-29 |
| WO2000076508A1 (en) | 2000-12-21 |
| ECSP003529A (es) | 2002-01-25 |
| AU5622400A (en) | 2001-01-02 |
| CO5190720A1 (es) | 2002-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |