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PE20010239A1 - GENE DERIVED FROM LAWSONIA AND RELATED POLYPEPTIDES, PEPTIDES AND PROTEINS OF HEMOLYSIN AND THEIR USES - Google Patents

GENE DERIVED FROM LAWSONIA AND RELATED POLYPEPTIDES, PEPTIDES AND PROTEINS OF HEMOLYSIN AND THEIR USES

Info

Publication number
PE20010239A1
PE20010239A1 PE2000000447A PE0004472000A PE20010239A1 PE 20010239 A1 PE20010239 A1 PE 20010239A1 PE 2000000447 A PE2000000447 A PE 2000000447A PE 0004472000 A PE0004472000 A PE 0004472000A PE 20010239 A1 PE20010239 A1 PE 20010239A1
Authority
PE
Peru
Prior art keywords
sequence
polypeptide
amino acids
hemolysin
peptide
Prior art date
Application number
PE2000000447A
Other languages
Spanish (es)
Inventor
Michael Panaccio
Robert G Ankenbauer
Detlef Hasse
Everett L Rosey
Original Assignee
Pfizer Prod Inc
Agriculture Victoria Serv Pty
Pig Res And Dev Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Agriculture Victoria Serv Pty, Pig Res And Dev Corp filed Critical Pfizer Prod Inc
Publication of PE20010239A1 publication Critical patent/PE20010239A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE REFIERE A UN POLIPEPTIDO INMUNOGENICO RECOMBINANTE O AISLADO QUE REACCIONA EN FORMA CRUZADA CON UN EPITOPE DE CELULA B O CELULA T DE UN POLIPEPTIDO DE HEMOLISINA DE LAWSONIA SPP DE PREFERENCIA L. INTRACELLULARIS, CAPAZ DE PRODUCIR LA PRODUCCION DE ANTICUERPOS, CONFERIR UNA RESPUESTA INMUNE PROTECTORA; INDUCIR INMUNIDAD HUMORAL; SE SELECCIONA DE a)UN PEPTIDO, OLIGOPEPTIDO, POLIPEPTIDO QUE COMPRENDE UNA SECUENCIA DE AMINOACIDOS CON 70% DE IDENTIDAD DE LA SECUENCIA SEC ID NO:1 DE 251 AMINOACIDOS O LA SECUENCIA DE AMINOACIDOS CODIFICADA POR LA SECUENCIA DE NUCLEOTIDOS QUE CODIFICA A LA HEMOLISINA DE pALK12(ATCC 207195); b)UN PEPTIDO, OLIGOPEPTIDO, POLIPEPTIDO QUE COMPRENDE UNA SECUENCIA DE AMINOACIDOS QUE TIENE POR LO MENOS 50% DE IDENTIDAD DE LA SECUENCIA CON LOS AMINOACIDOS 1 A 50 DE LA SECUENCIA SEC ID NO:1; c)UN HOMOLOGO, ANALOGO, DERIVADO QUE IMITA A UN EPITOPE DE CELULAS B O CELULAS T DE UN POLIPEPTIDO DE HEMOLISINA DE LAWSONIA SPP. SE REFIERE TAMBIEN A VACUNAS QUE COMPRENDEN ADEMAS UN SEGUNDO COMPONENTE QUE COMPRENDE UN PEPTIDO, POLIPEPTIDO O PROTEINA DE L.INTRACELLULARIS ANTIGENO TAL COMO SodC, OmpH, FlgE, AUTOLISINA; TAMBIEN SE REFIERE A UN VECTOR PARA VACUNAS, UNA MOLECULA DE ADN; UN PLASMIDO DESIGNADO pALK12REFERS TO A RECOMBINANT OR ISOLATED IMMUNOGENIC POLYPEPTIDE THAT CROSS-REACTS WITH AN EPITOPE OF CELL B OR CELL T OF A POLYPEPTIDE OF HEMOLYSIN OF LAWSONIA SPP OF PREFERENCE L. INTRACELLULARIS PRODUCTS INTRACELLULARIS; INDUCE HUMORAL IMMUNITY; SELECTED FROM a) A PEPTIDE, OLIGOPEPTIDE, POLYPEPTIDE THAT INCLUDES A SEQUENCE OF AMINO ACIDS WITH 70% IDENTITY OF THE SEQUENCE ID NO: 1 OF 251 AMINO ACIDS OR THE SEQUENCE OF AMINO ACIDS CODED BY THE SEQUENCE OF NUCLEOTIDES CODED BY THE SEQUENCE OF NUCLEOTIDES TO CODED pALK12 (ATCC 207195); b) A PEPTIDE, OLIGOPEPTIDE, POLYPEPTIDE INCLUDING AN AMINO ACID SEQUENCE THAT HAS AT LEAST 50% SEQUENCE IDENTITY WITH AMINO ACIDS 1 TO 50 OF THE SEQUENCE SEQ ID NO: 1; c) A HOMOLOGICAL, ANALOGUE, DERIVATIVE THAT IMITATES AN EPITOPE OF B-CELLS OR T-CELLS OF A HEMOLYSIN POLYPEPTIDE OF LAWSONIA SPP. IT ALSO REFERS TO VACCINES THAT ALSO INCLUDE A SECOND COMPONENT THAT INCLUDES A PEPTIDE, POLYPEPTIDE OR PROTEIN FROM L. INTRA-CELLULARIS ANTIGEN SUCH AS SodC, OmpH, FlgE, AUTOLYSIN; IT ALSO REFERS TO A VECTOR FOR VACCINES, A DNA MOLECULE; A PLASMID DESIGNATED pALK12

PE2000000447A 1999-05-13 2000-05-12 GENE DERIVED FROM LAWSONIA AND RELATED POLYPEPTIDES, PEPTIDES AND PROTEINS OF HEMOLYSIN AND THEIR USES PE20010239A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13402299P 1999-05-13 1999-05-13

Publications (1)

Publication Number Publication Date
PE20010239A1 true PE20010239A1 (en) 2001-02-28

Family

ID=22461415

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000447A PE20010239A1 (en) 1999-05-13 2000-05-12 GENE DERIVED FROM LAWSONIA AND RELATED POLYPEPTIDES, PEPTIDES AND PROTEINS OF HEMOLYSIN AND THEIR USES

Country Status (6)

Country Link
EP (1) EP1177213A4 (en)
AU (2) AU775323B2 (en)
CA (1) CA2372105A1 (en)
NZ (1) NZ515363A (en)
PE (1) PE20010239A1 (en)
WO (1) WO2000069906A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6605696B1 (en) 1999-10-22 2003-08-12 Pfizer, Inc. Lawsonia intracellularis proteins, and related methods and materials
DK1586646T3 (en) 2000-12-20 2011-06-27 Intervet Int Bv Lawsonia intracellularis vaccine
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
US8398994B2 (en) 2005-07-15 2013-03-19 Boehringer Ingelheim Vetmedica, Inc. Lawsonia vaccine and methods of use thereof
WO2008073464A2 (en) 2006-12-11 2008-06-19 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
TWI551295B (en) * 2008-04-18 2016-10-01 英特威特國際股份有限公司 Vaccine for protection against lawsonia intracellularis
WO2012177520A2 (en) * 2011-06-20 2012-12-27 Matthias Rath Oligopeptides and their use for treating infectious diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5885823A (en) * 1995-06-05 1999-03-23 Nobl Laboratories, Inc. Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents
ATE329031T1 (en) * 1995-11-30 2006-06-15 Agriculture Victoria Serv Pty THERAPEUTIC COMPOSITIONS FOR THE TREATMENT OF LAWSONIA INTRACELLULARIS INFECTIONS

Also Published As

Publication number Publication date
AU775323B2 (en) 2004-07-29
NZ515363A (en) 2003-07-25
AU2004224903A1 (en) 2004-11-25
AU4386100A (en) 2000-12-05
EP1177213A1 (en) 2002-02-06
EP1177213A4 (en) 2002-08-28
CA2372105A1 (en) 2000-11-23
WO2000069906A1 (en) 2000-11-23

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