[go: up one dir, main page]

PA8652101A1 - Compuestos de imidazo(1,2-a)piridina, composiciones, usos y métodos relacionados - Google Patents

Compuestos de imidazo(1,2-a)piridina, composiciones, usos y métodos relacionados

Info

Publication number
PA8652101A1
PA8652101A1 PA20058652101A PA8652101A PA8652101A1 PA 8652101 A1 PA8652101 A1 PA 8652101A1 PA 20058652101 A PA20058652101 A PA 20058652101A PA 8652101 A PA8652101 A PA 8652101A PA 8652101 A1 PA8652101 A1 PA 8652101A1
Authority
PA
Panama
Prior art keywords
piridine
compositions
compounds
related methods
imidazo compounds
Prior art date
Application number
PA20058652101A
Other languages
English (en)
Inventor
Albert Palomer
Jose Luis Falco
Antonio Guglietta
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of PA8652101A1 publication Critical patent/PA8652101A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS DE IMIDAZO [1, 2-A) PIRIDINA DE FORMULA GENERAL (I): ASI COMO LAS CORRESPONDIENTE SALES FARMACEUTICAMENTE ACEPTABLES; DONDE R1, R2, R3 Y R4 TIENEN EL SIGNIFICADO DEFINIDO EN LAS REIVINDICACIONES. LOS COMPUESTOS POSEEN AFINIDAD ESPECIFICA POR EL RECEPTOR GABAA Y SON POR LO TANTO UTILES EN EL TRATAMIENTO Y PREVENCION DE LAS ENFERMEDADES MODULADAS POR LAS SUBUNIDADES A1 Y A2 DE LOS RECPTORES GABAA.
PA20058652101A 2004-11-11 2005-11-08 Compuestos de imidazo(1,2-a)piridina, composiciones, usos y métodos relacionados PA8652101A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04105698 2004-11-11

Publications (1)

Publication Number Publication Date
PA8652101A1 true PA8652101A1 (es) 2006-10-13

Family

ID=34929843

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20058652101A PA8652101A1 (es) 2004-11-11 2005-11-08 Compuestos de imidazo(1,2-a)piridina, composiciones, usos y métodos relacionados

Country Status (24)

Country Link
US (1) US20080200473A1 (es)
EP (1) EP1814880B1 (es)
JP (1) JP2008519805A (es)
KR (1) KR20070084026A (es)
CN (1) CN101065377B (es)
AR (1) AR051626A1 (es)
AT (1) ATE421962T1 (es)
AU (1) AU2005303811A1 (es)
BR (1) BRPI0517796A (es)
CA (1) CA2585315A1 (es)
DE (1) DE602005012598D1 (es)
DK (1) DK1814880T3 (es)
ES (1) ES2321858T3 (es)
IL (1) IL182963A0 (es)
MX (1) MX2007005611A (es)
NO (1) NO20072831L (es)
PA (1) PA8652101A1 (es)
PE (1) PE20060967A1 (es)
PL (1) PL1814880T3 (es)
PT (1) PT1814880E (es)
RU (1) RU2007121864A (es)
TW (1) TWI357412B (es)
UY (1) UY29204A1 (es)
WO (1) WO2006051063A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2477604A1 (en) 2002-03-13 2003-09-25 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
EP1843734A4 (en) 2005-02-03 2008-09-10 Signum Biosciences Inc COMPOSITIONS AND METHODS FOR ENHANCING COGNITIVE FUNCTION
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
EP1845098A1 (en) * 2006-03-29 2007-10-17 Ferrer Internacional, S.A. Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
CA2651857A1 (en) * 2006-05-31 2007-12-06 F. Hoffmann-La Roche Ag Aryl-4-ethynyl-isoxazole derivatives
WO2008022396A1 (en) * 2006-08-24 2008-02-28 Australian Nuclear Science & Technology Organisation Fluorinated ligands for targeting peripheral benzodiazepine receptors
WO2009132051A1 (en) 2008-04-21 2009-10-29 Signum Biosciences, Inc. Compounds, compositions and methods for making the same
AU2009249186B2 (en) * 2008-05-19 2014-05-22 Sunovion Pharmaceuticals Inc. Imidazo [1, 2-a] pyridine compounds as GABA-A receptor modulators
WO2010045615A2 (en) 2008-10-16 2010-04-22 Cenomed Biosciences, Llc Treatment of organophosphate exposure with ocinaplon
US20120010188A1 (en) * 2008-12-04 2012-01-12 Promimagen Ltd. Imidazopyridine Compounds
US9309238B2 (en) * 2009-11-05 2016-04-12 University Of Notre Dame Du Lac Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same
EP2617715A4 (en) * 2010-09-17 2014-02-26 Taisho Pharmaceutical Co Ltd GLYCINTRANSPORTERHEMMER
BR112018005208B1 (pt) 2015-09-17 2023-12-12 Marvin J. Miller Compostos heterocíclicos que contêm benzilamina e composições úteis contra infecção micobacteriana
CN106906486B (zh) * 2017-02-22 2018-12-11 华南理工大学 3-溴-2-苯基-咪唑并[1,2-α]吡啶类衍生物的电化学合成方法
EP4096668A4 (en) * 2020-01-29 2024-02-28 Foghorn Therapeutics Inc. Compounds and uses thereof
CN118515663A (zh) * 2023-04-24 2024-08-20 上海赛默罗生物科技有限公司 咪唑并吡啶或咪唑并吡嗪类化合物、其制备方法、药物组合物和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2568880B1 (fr) * 1984-08-07 1986-12-12 Synthelabo Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR2593818B1 (fr) * 1986-02-05 1988-04-29 Synthelabo Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique
FR2593181B1 (fr) * 1986-01-22 1988-04-01 Synthelabo Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
EP0234970B1 (fr) * 1986-01-22 1991-04-17 Synthelabo Dérivés d'acylaminométhyl-3 imidazo[1,2-a]pyridines, leur préparation et leur application en thérapeutique
WO2004066930A2 (en) * 2003-01-27 2004-08-12 Arthur Zaks Method for inducing pain relief using imidazo[1,2-a]pyridine derivatives

Also Published As

Publication number Publication date
TWI357412B (en) 2012-02-01
BRPI0517796A (pt) 2008-10-28
CA2585315A1 (en) 2006-05-18
RU2007121864A (ru) 2008-12-20
PT1814880E (pt) 2009-04-23
KR20070084026A (ko) 2007-08-24
PL1814880T3 (pl) 2009-07-31
WO2006051063A1 (en) 2006-05-18
DE602005012598D1 (de) 2009-03-19
MX2007005611A (es) 2007-07-11
ES2321858T3 (es) 2009-06-12
PE20060967A1 (es) 2006-09-20
EP1814880A1 (en) 2007-08-08
UY29204A1 (es) 2006-01-31
US20080200473A1 (en) 2008-08-21
TW200624432A (en) 2006-07-16
CN101065377A (zh) 2007-10-31
EP1814880B1 (en) 2009-01-28
AR051626A1 (es) 2007-01-24
DK1814880T3 (da) 2009-05-18
AU2005303811A1 (en) 2006-05-18
NO20072831L (no) 2007-08-01
IL182963A0 (en) 2007-08-19
JP2008519805A (ja) 2008-06-12
ATE421962T1 (de) 2009-02-15
CN101065377B (zh) 2011-07-27

Similar Documents

Publication Publication Date Title
PA8652101A1 (es) Compuestos de imidazo(1,2-a)piridina, composiciones, usos y métodos relacionados
SV2006002110A (es) Compuestos terapeuticos ref. pc32293a
EA201170771A1 (ru) Органические соединения
EA200800992A1 (ru) 2-амино-7,8-дигидро-6н-пиридо[4,3-d]пиримидин-5-оны, способ их получения, способ терапии с их помощью, компонент композиции и композиция на их основе, 2,4-диоксопиперидиновые соединения для их получения
GT200500368A (es) Analogos de rapamicina y los usos de los mismos en el tratamiento de trastornos neurologicos, proliferativos e inflamatorios
PE20140390A1 (es) Derivados de imidazo[1,2-b]piridazina e imidazo[4,5-b]piridina como inhibidores de jak
CL2010001486A1 (es) Compuestos derivados de [1,2,4]triazolo[1,5-a]piridina, inhibidores de jak; composicion farmaceutica; kit farmaceutico; su uso en el tratamiento de enfermedades tales como cancer, diabetes, enfermedad de alzheimer, enfermedad hepatica, trastornos del snc, entre otras.
ATE424402T1 (de) Imidazopyridinverbindungen
ECSP099400A (es) Imidazotriazinas e imidazopirimidinas como inhibidores de cinasa
ECSP088413A (es) Preparación y uso de derivados de tetrahidropirrolo[3,2-c]piridin-4-ona para el tratamiento de la obesidad, trastornos psiquiátricos y neurológicos
UY28144A1 (es) Agentes terapéuticos
MX2009010728A (es) Compuestos de imidazo[1,2-a]piridina como inhibidores de la tirosina-cinasa repectora.
CR7932A (es) Pirazolo (1,5-a) (1,3,5) derivados de triazina como ligandos de receptor de cannabinoides
MY152386A (en) Substituted 6a,7,8,9-tetrahydropyrido[3,2-e] pyrrolo[1,2-a]pyrazin-6(5h)-ones
ECSP077424A (es) Derivados de quinuclidina y su uso como antagonistas del receptor muscarínico m3
ECSP055964A (es) Heterociclil-3-sulfonilindazoles como ligandos de 5-hidroxitriptamina-6
CR10682A (es) Compuestos de tiazol pirazolopirimidina
UY28922A1 (es) Ligandos del receptor cb1 útiles en el tratamiento de dolor y/u otros síntomas o enfermedades relacionadas; compuestos farmacéuticos y su preparación.
MX2011008452A (es) Derivados de triazolo [4,3-b] piridazina y sus usos para el cancer de prostata.
IL191763A0 (en) Pyrrolo [2,3-b]pyridine derivatives as h3 receptor modulators
CL2009000957A1 (es) Compuestos derivados de pirrolo[2,3-d]pirimidina; inhibidores de limk2; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos inflamatorios, glaucoma, neurodegeneracion, entre otras.
CR9643A (es) Derivados de n-(arilalquil)-1h-pirrolopiridina-2-carboxamidas, su preparacion y su aplicacion en terapeutica
CR8094A (es) Derivados de imidazol antagonistas del receptor de glutamato
GB0507601D0 (en) Compounds
WO2010011546A3 (en) Pyrrolo [3, 2-b]pyridines and pyrazolo [4, 3 -b] pyridines having 5-ht6 receptor affinity