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PA8529801A1 - Un nuevo compuesto derivado de la triptamina y sus analogos - Google Patents

Un nuevo compuesto derivado de la triptamina y sus analogos

Info

Publication number
PA8529801A1
PA8529801A1 PA20018529801A PA8529801A PA8529801A1 PA 8529801 A1 PA8529801 A1 PA 8529801A1 PA 20018529801 A PA20018529801 A PA 20018529801A PA 8529801 A PA8529801 A PA 8529801A PA 8529801 A1 PA8529801 A1 PA 8529801A1
Authority
PA
Panama
Prior art keywords
disorders
compositions
triptamine
analogs
compounds
Prior art date
Application number
PA20018529801A
Other languages
English (en)
Inventor
Nava Zisapel
Moshe Laudon
Original Assignee
Neurim Pharma 1991
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurim Pharma 1991 filed Critical Neurim Pharma 1991
Publication of PA8529801A1 publication Critical patent/PA8529801A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16Tryptamines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NUEVAS TRIPTAMINAS SUSTITUIDAS Y DERIVADOS RELACIONADOS, COMO ASI TAMBIEN COMPOSICIONES FARMACEUTICAS FORMULADAS CON LOS MISMOS. ESTOS COMPUESTOS, COMPOSICIONES Y SUS SALES PUEDEN SER USADOS EN LA FABRICACION DE MEDICAMENTOS PARA INTERACTUAR CON EL SISTEMA MELATONINERGICO. ESTOS COMPUESTOS Y ESTAS COMPOSICIONES PUEDEN SER USADOS PARA TRATAR DIFERENTES TIPOS DE CONDICIONES MEDICAS, TALES COMO TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL Y PSIQUIATRICOS (TRASTORNOS DEL SUEÑO, EPILEPSIA Y OTROS TRASTORNOS CONVULSIVOS, ANSIEDAD, ENFERMEDADES NEURODEGENERATIVAS), TRASTORNOS CRONOBIOLOGICOS (CRUCE RAPIDO DE ZONAS HORARIAS (JET LAG), SINDROME DE SUEÑO RETARDADO, TRABAJO EN TURNOS, TRASTORNOS AFECTIVO ESTACIONAL), CONDICIONES NEOPLASTICAS Y CONDICIONES ASOCIADAS CON SENESCENCIA.
PA20018529801A 2000-10-03 2001-10-01 Un nuevo compuesto derivado de la triptamina y sus analogos PA8529801A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL138825A IL138825A (en) 2000-10-03 2000-10-03 Pharmaceutical preparations containing tryptamine derivatives and similar compounds, and such new compounds

Publications (1)

Publication Number Publication Date
PA8529801A1 true PA8529801A1 (es) 2002-12-30

Family

ID=11074694

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20018529801A PA8529801A1 (es) 2000-10-03 2001-10-01 Un nuevo compuesto derivado de la triptamina y sus analogos

Country Status (40)

Country Link
US (2) US6780884B2 (es)
EP (1) EP1331935B1 (es)
JP (1) JP2004533986A (es)
KR (1) KR100855385B1 (es)
CN (1) CN100518735C (es)
AR (1) AR035587A1 (es)
AT (1) ATE409474T1 (es)
AU (1) AU9416201A (es)
BG (1) BG107759A (es)
BR (1) BR0114464A (es)
CA (1) CA2423628C (es)
CL (1) CL2001002303A1 (es)
CR (1) CR6968A (es)
CY (1) CY1110417T1 (es)
CZ (1) CZ301098B6 (es)
DE (1) DE60136003D1 (es)
DK (1) DK1331935T3 (es)
EA (1) EA005918B1 (es)
EE (1) EE05192B1 (es)
ES (1) ES2315307T3 (es)
GT (1) GT200100197A (es)
HK (1) HK1074163A1 (es)
HN (1) HN2001000218A (es)
HU (1) HU227163B1 (es)
IL (1) IL138825A (es)
IS (1) IS2607B (es)
MX (1) MXPA03002612A (es)
NO (1) NO20031396D0 (es)
NZ (1) NZ525587A (es)
PA (1) PA8529801A1 (es)
PE (1) PE20020411A1 (es)
PL (1) PL365679A1 (es)
PT (1) PT1331935E (es)
SI (1) SI1331935T1 (es)
SK (1) SK4042003A3 (es)
TW (1) TWI270544B (es)
UA (1) UA75091C2 (es)
UY (1) UY26946A1 (es)
WO (1) WO2002028347A2 (es)
ZA (1) ZA200303113B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2550091A1 (en) * 2003-12-19 2005-07-07 Elixir Pharmaceuticals, Inc. Methods of treating a disorder
US7799817B2 (en) * 2004-02-20 2010-09-21 Lifescape Biosciences Inc Compositions and methods for sleep regulation
MX2007015479A (es) * 2005-06-10 2008-04-09 Bipar Sciences Inc Moduladores de (poli-adp ribosa polimerasa) y tratamiento contra el cancer.
US7622495B2 (en) 2006-10-03 2009-11-24 Neurim Pharmaceuticals (1991) Ltd. Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents
AU2008271911B2 (en) 2007-06-29 2014-08-07 Phovitreal Pty Ltd Treatment or prophylaxis or neurological or neuropsychiatric disorders via ocular administration
US8852630B2 (en) 2008-05-13 2014-10-07 Yale University Chimeric small molecules for the recruitment of antibodies to cancer cells
US8859509B2 (en) * 2008-05-13 2014-10-14 Yale University Chimeric small molecules for the recruitment of antibodies to cancer cells
KR102186667B1 (ko) 2011-05-31 2020-12-08 클라렌슈 피티와이 리미티드 신경학적 병태를 다루는 장치
EP2771341A4 (en) * 2011-10-28 2015-09-23 Univ Texas NEW COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER
CN102816103B (zh) * 2012-08-20 2014-05-07 冉瑞琼 硫化天冬氨酸修饰的退黑素衍生物及其应用
RU2750989C2 (ru) * 2016-03-14 2021-07-07 Сомалоджик, Инк. Композиции и способы синтеза 5-(n-защищенного триптаминкарбоксамида)-2'-дезоксиуридинфосфорамидита для включения в нуклеиновую кислоту
CN116421600B (zh) * 2023-05-29 2024-08-23 重庆医科大学 色醇在制备治疗焦虑的药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79264A0 (en) * 1986-06-27 1986-09-30 Univ Ramot Tryptamine derivatives,pharmaceutical compositions containing them and their use in an assay for melatonin receptors
AUPO274596A0 (en) * 1996-10-04 1996-10-31 Armstrong, Stuart Maxwell Method for the treatment of neurological or neuropsychiatric disorders
US6310085B1 (en) * 1997-10-03 2001-10-30 Clarencew Pty Ltd. Method for the treatment of neurological or neuropsychiatric disorders

Also Published As

Publication number Publication date
WO2002028347A3 (en) 2002-07-04
CY1110417T1 (el) 2015-04-29
ATE409474T1 (de) 2008-10-15
UY26946A1 (es) 2001-11-30
NZ525587A (en) 2005-03-24
IS6752A (is) 2003-03-21
ES2315307T3 (es) 2009-04-01
CN1582147A (zh) 2005-02-16
SK4042003A3 (en) 2003-09-11
US20040029950A1 (en) 2004-02-12
AR035587A1 (es) 2004-06-16
NO20031396L (no) 2003-03-27
HN2001000218A (es) 2002-05-09
KR100855385B1 (ko) 2008-09-04
US20050020664A1 (en) 2005-01-27
DK1331935T3 (da) 2009-02-02
BG107759A (bg) 2004-01-30
CA2423628C (en) 2011-04-26
EA200300436A1 (ru) 2003-10-30
CZ301098B6 (cs) 2009-11-04
EP1331935A2 (en) 2003-08-06
CN100518735C (zh) 2009-07-29
EP1331935B1 (en) 2008-10-01
PL365679A1 (en) 2005-01-10
GT200100197A (es) 2002-05-08
ZA200303113B (en) 2004-07-23
CL2001002303A1 (es) 2010-06-25
EA005918B1 (ru) 2005-06-30
EE200300135A (et) 2003-08-15
EP1331935A4 (en) 2004-12-01
SI1331935T1 (sl) 2009-04-30
PE20020411A1 (es) 2002-05-16
DE60136003D1 (de) 2008-11-13
UA75091C2 (en) 2006-03-15
HK1074163A1 (en) 2005-11-04
NO20031396D0 (no) 2003-03-27
EE05192B1 (et) 2009-08-17
TWI270544B (en) 2007-01-11
CZ2003940A3 (cs) 2003-10-15
CR6968A (es) 2004-02-25
HUP0302616A2 (hu) 2003-11-28
CA2423628A1 (en) 2002-04-11
KR20030051689A (ko) 2003-06-25
IL138825A (en) 2006-06-11
HU227163B1 (en) 2010-09-28
IS2607B (is) 2010-04-15
MXPA03002612A (es) 2004-04-02
BR0114464A (pt) 2004-01-20
WO2002028347A2 (en) 2002-04-11
JP2004533986A (ja) 2004-11-11
US6780884B2 (en) 2004-08-24
PT1331935E (pt) 2009-01-19
AU9416201A (en) 2002-04-15
IL138825A0 (en) 2001-10-31

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