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PA8481501A1 - 4-CARBOXYAMINO-2-METHYL-1,2,3,4-TETRAHYDROKINOLINS - Google Patents

4-CARBOXYAMINO-2-METHYL-1,2,3,4-TETRAHYDROKINOLINS

Info

Publication number
PA8481501A1
PA8481501A1 PA19998481501A PA8481501A PA8481501A1 PA 8481501 A1 PA8481501 A1 PA 8481501A1 PA 19998481501 A PA19998481501 A PA 19998481501A PA 8481501 A PA8481501 A PA 8481501A PA 8481501 A1 PA8481501 A1 PA 8481501A1
Authority
PA
Panama
Prior art keywords
ldl
trigeres
cholesterol
inhibitors
cholesterols
Prior art date
Application number
PA19998481501A
Other languages
Spanish (es)
Inventor
Michael Paul Deninno
Christian James Mularski
Roger Benjamin Ruggeri
Ronald Thure Wester
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8481501A1 publication Critical patent/PA8481501A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

INHIBIDORES DE LA PROTEINA DE TRASFERENCIA DEL ESTER COLESTERILICO, COMPOSICIONES FARMECEUTICAS QUE CONTIENEN DICHOS INHIBIDORES Y EL USO DE DICHOS INHIBIDORES PARA ELEVAR CIERTOS NIVELES DE LIPIDOS EN PLASMA, TALES COMO LDL-COLESTEROL Y TRIGLICERIDOS, Y POR CONSIGUIENTE PARA TRATAR ENFERMEDADES QUE SON EXACERBADAS POR BAJOS NIVELES DE HDL-COLESTEROL Y/O ALTOS NIVELES DE LDL-COLESTEROL Y TRIGLICERIDOS, TALES COMO ATEROSCLEROSIS Y ENFERMEDADES CARDIOVASCULARES EN ALGUNOS MAMIFEROS, INCLUYENDO SERES HUMANOS.CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INHIBITORS, AND THE USE OF SUCH INHIBITORS TO RAISE CERTAIN LEVELS OF LIPIDS IN PLASMA, AND SITES, AND GLOBALS, FOR SUCH AS LDL-CHOLESTEROLS AND TRIGERES, FOR SUCH AS LDL-CHOLESTEROLS AND TRIGERES, FOR SUCH AS LDL-CHOLESTEROL AND TRIGERES HDL-CHOLESTEROL AND / OR HIGH LEVELS OF LDL-CHOLESTEROL AND TRIGLYCERIDES, SUCH AS ATEROSCLEROSIS AND CARDIOVASCULAR DISEASES IN SOME MAMMALS, INCLUDING HUMAN BEINGS.

PA19998481501A 1998-09-17 1999-09-08 4-CARBOXYAMINO-2-METHYL-1,2,3,4-TETRAHYDROKINOLINS PA8481501A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10092998P 1998-09-17 1998-09-17

Publications (1)

Publication Number Publication Date
PA8481501A1 true PA8481501A1 (en) 2001-12-14

Family

ID=22282259

Family Applications (1)

Application Number Title Priority Date Filing Date
PA19998481501A PA8481501A1 (en) 1998-09-17 1999-09-08 4-CARBOXYAMINO-2-METHYL-1,2,3,4-TETRAHYDROKINOLINS

Country Status (25)

Country Link
US (2) US6147090A (en)
EP (1) EP1114033B1 (en)
JP (1) JP3655193B2 (en)
AR (1) AR021482A1 (en)
AT (1) ATE277906T1 (en)
AU (1) AU5439899A (en)
BR (1) BR9913842A (en)
CA (1) CA2344556A1 (en)
CO (1) CO5150220A1 (en)
DE (1) DE69920727T2 (en)
DK (1) DK1114033T3 (en)
DZ (1) DZ2889A1 (en)
ES (1) ES2228086T3 (en)
GT (1) GT199900149A (en)
HN (1) HN1999000155A (en)
MA (1) MA26687A1 (en)
MY (1) MY121838A (en)
PA (1) PA8481501A1 (en)
PE (1) PE20001048A1 (en)
PT (1) PT1114033E (en)
SI (1) SI1114033T1 (en)
SV (1) SV1999000149A (en)
TN (1) TNSN99172A1 (en)
TW (1) TWI232859B (en)
WO (1) WO2000017166A1 (en)

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