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OA11456A - Benzopyran and related LTB4 antagonists. - Google Patents

Benzopyran and related LTB4 antagonists. Download PDF

Info

Publication number
OA11456A
OA11456A OA60543A OA60543A OA11456A OA 11456 A OA11456 A OA 11456A OA 60543 A OA60543 A OA 60543A OA 60543 A OA60543 A OA 60543A OA 11456 A OA11456 A OA 11456A
Authority
OA
OAPI
Prior art keywords
alkyl
formula
carboxy
phenyl
compound
Prior art date
Application number
OA60543A
Other languages
English (en)
Inventor
Kevin Koch
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of OA11456A publication Critical patent/OA11456A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
OA60543A 1992-01-23 1994-07-22 Benzopyran and related LTB4 antagonists. OA11456A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82441292A 1992-01-23 1992-01-23

Publications (1)

Publication Number Publication Date
OA11456A true OA11456A (en) 2003-11-18

Family

ID=25241346

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60543A OA11456A (en) 1992-01-23 1994-07-22 Benzopyran and related LTB4 antagonists.

Country Status (37)

Country Link
US (2) US5552435A (fr)
EP (1) EP0623123B1 (fr)
JP (1) JP2765757B2 (fr)
KR (2) KR0124802B1 (fr)
CN (1) CN1041311C (fr)
AP (1) AP352A (fr)
AT (1) ATE152108T1 (fr)
AU (1) AU666896B2 (fr)
BG (1) BG62331B1 (fr)
BR (1) BR9207061A (fr)
CA (1) CA2126752C (fr)
CZ (1) CZ282400B6 (fr)
DE (1) DE69219364T2 (fr)
DK (1) DK0623123T3 (fr)
EG (1) EG20202A (fr)
FI (1) FI943474A0 (fr)
GR (1) GR3023657T3 (fr)
HK (1) HK1000245A1 (fr)
HU (1) HU221194B1 (fr)
IL (1) IL104386A (fr)
IS (1) IS1795B (fr)
MX (1) MX9300312A (fr)
MY (1) MY109144A (fr)
NO (1) NO306508B1 (fr)
NZ (1) NZ245735A (fr)
OA (1) OA11456A (fr)
PH (1) PH30346A (fr)
PL (1) PL171003B1 (fr)
PT (1) PT101183B (fr)
RO (1) RO112031B1 (fr)
RU (1) RU2114110C1 (fr)
SG (1) SG49813A1 (fr)
SK (1) SK280451B6 (fr)
TW (1) TW213907B (fr)
WO (1) WO1993015067A1 (fr)
YU (1) YU48949B (fr)
ZA (1) ZA93486B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2084547B1 (es) * 1993-07-12 1997-01-16 Pfizer Antagonistas benzopiranicos y relacionados de leucotrieno b4.
WO1996011925A1 (fr) * 1994-10-13 1996-04-25 Pfizer Inc. Composes de benzopyranne et composes benzo-fusionnes, leur preparation et leur utilisation comme antagonistes du leucotriene b4' (ltb4)
JP2983295B2 (ja) * 1994-10-13 1999-11-29 ファイザー・インコーポレーテッド ベンゾピランおよびベンゾ縮合した化合物、それらの製造方法ならびにロイコトリエンｂ▲下４▼（ｌｔｂ▲下４▼）アンタゴニストとしてのそれらの使用
DE69724801T2 (de) * 1996-09-16 2004-06-17 Pfizer Inc. Verfahren und zwischenprodukte zur herstellung substituierter chromanolderivate
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
EP0836850A3 (fr) * 1996-10-17 2000-11-29 Pfizer Inc. Méthode pour prévenir le rejet d'allogreffes
EP0963755A3 (fr) * 1998-04-16 2001-03-14 Pfizer Products Inc. Utilisation des benzopyranes pour la prévention de rejets de graiffes
US6436987B1 (en) * 2000-06-08 2002-08-20 Pfizer Inc. Crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid
CA2427911A1 (fr) 2000-11-03 2002-05-10 Bristol Myers Squibb Company Double imagerie isotopique simultanee d'une perfusion et d'une inflammation cardiaque
BR0206771A (pt) * 2001-01-30 2004-02-25 Pfizer Prod Inc Processos para a preparação de cidos cromanilbenzóicos
AU4239302A (en) * 2001-06-28 2003-01-02 Pfizer Products Inc. Benzoic acid substituted benzopyrans for the treatment of atherosclerosis
JP2008506768A (ja) * 2004-07-22 2008-03-06 ファルマシア コーポレーション Ｃｏｘ−２選択的阻害剤とｌｔｂ４受容体アンタゴニストを組み合わせて用いる炎症および疼痛を治療するための組成物
WO2017095723A1 (fr) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Utilisation d'arylacylsulfonamides en tant qu'antagonistes de blt1
US20190382363A1 (en) 2015-11-30 2019-12-19 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
WO2017095722A1 (fr) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Utilisation d'arylacylsulfonamides en tant qu'antagonistes de blt1
EP3383869B1 (fr) 2015-11-30 2023-06-28 Merck Sharp & Dohme LLC Sulfonamides d'aryle utilisés en tant qu'antagonistes de blt1

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2309282A1 (de) * 1973-02-24 1974-08-29 Hoechst Ag Verfahren zur herstellung von 4-hydroxy-thiochromanen
DE2745305A1 (de) * 1977-10-07 1979-04-19 Bayer Ag Insektizide und akarizide mittel
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
CA1320490C (fr) * 1987-01-12 1993-07-20 Darrel M. Gapinski Agents antiinflammatoires
JPS63292977A (ja) * 1987-05-25 1988-11-30 片山　晋 スキ−用のビンディング固定板
MX13485A (es) * 1987-10-19 1993-05-01 Pfizer Procedimiento para obtener tetralinas, cromados y compuestos relacionados, sustituidos
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
US5298512A (en) * 1989-04-07 1994-03-29 Pfizer Inc. Substituted chromans and their use in the treatment of asthma, arthritis and related diseases
WO1990015801A1 (fr) * 1989-06-22 1990-12-27 Pfizer Inc. Sulfamides substitues et composes apparentes dans le traitement de l'asthme, de l'arthrite et des maladies apparentees
WO1991012253A1 (fr) * 1990-02-07 1991-08-22 Pfizer Inc. Derives de tetraline et de chroman utilises dans le traitement de l'asthme, de l'arthrite et de maladies apparentees
DE69217998T2 (de) * 1992-01-23 1997-06-12 Pfizer Benzopyrane und ähnliche LTB4-Antagonisten
EP0558245A1 (fr) * 1992-02-25 1993-09-01 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Composés hétérobicycliques comme antagonistes des récepteurs alpha-1 adrénergiques et 5HT1A
FR2693196B1 (fr) * 1992-07-03 1994-12-23 Lipha Dérivés de benzopyranone ou de benzothiopyranone, procédé de préparation et composition pharmaceutique les contenant.

Also Published As

Publication number Publication date
US5552435A (en) 1996-09-03
MY109144A (en) 1996-12-31
JPH07502536A (ja) 1995-03-16
RO112031B1 (ro) 1997-04-30
HK1000245A1 (en) 1998-02-13
WO1993015067A1 (fr) 1993-08-05
GR3023657T3 (en) 1997-09-30
CA2126752A1 (fr) 1993-08-05
SG49813A1 (en) 1998-06-15
RU2114110C1 (ru) 1998-06-27
CN1041311C (zh) 1998-12-23
IS3969A (is) 1993-07-24
CZ282400B6 (cs) 1997-07-16
KR950700273A (ko) 1995-01-16
SK280451B6 (sk) 2000-02-14
PT101183A (pt) 1994-03-31
NZ245735A (en) 1995-04-27
DE69219364D1 (de) 1997-05-28
SK84494A3 (en) 1995-05-10
YU3393A (sh) 1996-07-24
ATE152108T1 (de) 1997-05-15
NO942759L (no) 1994-07-22
HUT68790A (en) 1995-07-28
BG98867A (bg) 1995-03-31
NO306508B1 (no) 1999-11-15
RU94035964A (ru) 1997-05-27
PT101183B (pt) 1999-09-30
EP0623123B1 (fr) 1997-04-23
AP352A (en) 1994-08-10
FI943474L (fi) 1994-07-22
CN1075318A (zh) 1993-08-18
IS1795B (is) 2001-12-18
FI943474A0 (fi) 1994-07-22
BR9207061A (pt) 1995-12-26
EG20202A (en) 1997-10-30
HU9401979D0 (en) 1994-09-28
IL104386A0 (en) 1993-05-13
JP2765757B2 (ja) 1998-06-18
PH30346A (en) 1997-04-02
AU3065092A (en) 1993-09-01
KR0124802B1 (ko) 1997-11-25
PL171003B1 (pl) 1997-02-28
CZ176294A3 (en) 1995-02-15
AP9200449A0 (en) 1993-01-31
MX9300312A (es) 1993-07-31
IL104386A (en) 2001-05-20
TW213907B (fr) 1993-10-01
DE69219364T2 (de) 1997-08-07
NO942759D0 (no) 1994-07-22
BG62331B1 (bg) 1999-08-31
YU48949B (sh) 2003-01-31
ZA93486B (en) 1994-07-22
DK0623123T3 (da) 1997-10-13
EP0623123A1 (fr) 1994-11-09
CA2126752C (fr) 2000-05-16
AU666896B2 (en) 1996-02-29
US5684046A (en) 1997-11-04
HU221194B1 (en) 2002-08-28

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