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OA10339A - Therapeutic compounds - Google Patents

Therapeutic compounds Download PDF

Info

Publication number
OA10339A
OA10339A OA60942A OA60942A OA10339A OA 10339 A OA10339 A OA 10339A OA 60942 A OA60942 A OA 60942A OA 60942 A OA60942 A OA 60942A OA 10339 A OA10339 A OA 10339A
Authority
OA
OAPI
Prior art keywords
formula
compound
dichloro
benzimidazole
mmol
Prior art date
Application number
OA60942A
Other languages
English (en)
Inventor
Stanley Dawes Chamberlain
George Walter Koszalka
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of OA10339A publication Critical patent/OA10339A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
OA60942A 1994-07-07 1996-12-24 Therapeutic compounds OA10339A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9413724A GB9413724D0 (en) 1994-07-07 1994-07-07 Therapeutic nucleosides

Publications (1)

Publication Number Publication Date
OA10339A true OA10339A (en) 1997-10-07

Family

ID=10757983

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60942A OA10339A (en) 1994-07-07 1996-12-24 Therapeutic compounds

Country Status (44)

Country Link
US (4) US6077832A (sh)
EP (1) EP0769017B1 (sh)
JP (1) JP3225045B2 (sh)
KR (1) KR100376075B1 (sh)
CN (2) CN1052010C (sh)
AP (1) AP736A (sh)
AT (1) ATE193298T1 (sh)
AU (1) AU702248B2 (sh)
BG (1) BG63435B1 (sh)
BR (1) BR9508237A (sh)
CY (1) CY2249B1 (sh)
CZ (1) CZ290800B6 (sh)
DE (1) DE69517172T2 (sh)
DK (1) DK0769017T3 (sh)
EE (1) EE03568B1 (sh)
ES (1) ES2147294T3 (sh)
FI (1) FI117629B (sh)
GB (1) GB9413724D0 (sh)
GE (1) GEP20002298B (sh)
GR (1) GR3033744T3 (sh)
HK (1) HK1003711A1 (sh)
HR (1) HRP950382B1 (sh)
HU (1) HU227679B1 (sh)
IL (1) IL114492A (sh)
IS (1) IS1812B (sh)
MD (1) MD1838G2 (sh)
MX (1) MX9606732A (sh)
MY (1) MY117892A (sh)
NO (1) NO308854B1 (sh)
NZ (1) NZ288722A (sh)
OA (1) OA10339A (sh)
PL (1) PL181136B1 (sh)
PT (1) PT769017E (sh)
RO (1) RO117699B1 (sh)
RU (1) RU2145963C1 (sh)
SA (1) SA95160202B1 (sh)
SK (1) SK282046B6 (sh)
TJ (1) TJ270B (sh)
TR (1) TR199500832A2 (sh)
TW (1) TW418196B (sh)
UA (1) UA66744C2 (sh)
WO (1) WO1996001833A1 (sh)
YU (1) YU49443B (sh)
ZA (1) ZA955644B (sh)

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GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
ES2186799T3 (es) * 1995-08-18 2003-05-16 Univ Michigan Bencimidazoles sustituidos en 5' utilizados como agentes antivirales.
GB9518465D0 (en) * 1995-09-09 1995-11-08 Smithkline Beecham Seiyaku Kk Pharmaceuticals
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
US6214801B1 (en) 1996-01-23 2001-04-10 The Regents Of The University Of Michigan Imidazo[1,2-a]pyridine C-nucleosides as antiviral agents
US6475388B1 (en) 1996-11-13 2002-11-05 Transgenomic, Inc. Method and system for RNA analysis by matched ion polynucleotide chromatography
US6576133B2 (en) 1996-11-13 2003-06-10 Transgenomic, Inc Method and system for RNA analysis by matched ion polynucleotide chromatography
GB2319961A (en) * 1996-12-07 1998-06-10 Glaxo Group Ltd Pharmaceutical composition for treatment of restenosis
DE69819695D1 (en) 1997-02-13 2003-12-18 Glaxo Group Ltd Benzimidazolderivate
IL133285A0 (en) 1997-06-10 2001-04-30 Glaxo Group Ltd Benzimidazole derivatives
JP2001512132A (ja) 1997-07-30 2001-08-21 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン 抗ウイルス薬としてのリクソフラノシルベンズイミダゾール
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
GB9807355D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807354D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
US6277830B1 (en) * 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
GB0008939D0 (en) * 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
EP1644011A1 (en) 2003-06-25 2006-04-12 Stephen F. Badylak Conditioned matrix compositions for tissue restoration
CA2550441C (en) * 2003-12-26 2012-08-28 Kissei Pharmaceutical Co., Ltd. Benzimidazole derivatives and medical uses thereof
WO2006115137A1 (ja) * 2005-04-22 2006-11-02 Kissei Pharmaceutical Co., Ltd. ２－アミノベンズイミダゾール誘導体及びその医薬用途
EA008737B1 (ru) * 2005-12-07 2007-08-31 Леонид Андреевич Кожемякин Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения
US8940707B2 (en) 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
US8541391B2 (en) 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
WO2012138907A2 (en) * 2011-04-05 2012-10-11 Translational Genomics Research Institute Solid forms of curcumin
WO2014004939A1 (en) 2012-06-29 2014-01-03 The Procter & Gamble Company Textured fibrous webs, apparatus and methods for forming textured fibrous webs
US9650376B2 (en) 2013-03-15 2017-05-16 Knopp Biosciences Llc Imidazo(4,5-B) pyridin-2-yl amides as KV7 channel activators
EP4289822A3 (en) 2014-09-12 2024-01-24 Biohaven Therapeutics Ltd. Benzoimidazol-1,2-yl amides as kv7 channel activators
EP3223816B1 (en) * 2014-11-26 2020-04-22 The J. David Gladstone Institutes Methods for treating a cytomegalovirus infection
RU2629670C2 (ru) * 2016-08-04 2017-08-31 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа
CN118955401A (zh) 2018-03-19 2024-11-15 诺普生物科学有限责任公司 Kv7通道激活剂组合物和使用方法
CN114096549A (zh) * 2020-06-23 2022-02-25 博美利克斯技术公司 新型苯并咪唑衍生物、其制备方法及其作为抗癌剂或者抗病毒剂的用途
EP4480956A3 (en) 2022-10-12 2025-02-19 Takeda Pharmaceutical Company Limited Viral inhibitors, the synthesis thereof, and intermediates thereto
WO2024103979A1 (zh) * 2022-11-17 2024-05-23 北京凯因科技股份有限公司 一种抑制疱疹病毒的化合物

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DE2130030A1 (de) * 1971-06-18 1972-12-21 Bayer Ag Fungizide und bakterizide Mittel
US4002623A (en) * 1974-08-07 1977-01-11 Pfizer Inc. Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines
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Also Published As

Publication number Publication date
MY117892A (en) 2004-08-30
ES2147294T3 (es) 2000-09-01
TW418196B (en) 2001-01-11
DE69517172T2 (de) 2000-10-19
HRP950382A2 (en) 1997-08-31
WO1996001833A1 (en) 1996-01-25
GB9413724D0 (en) 1994-08-24
IL114492A (en) 2002-05-23
MD1838F2 (en) 2002-01-31
TR199500832A2 (tr) 1996-06-21
CN1236616A (zh) 1999-12-01
CZ290800B6 (cs) 2002-10-16
MD1838G2 (ro) 2002-08-31
AP9600895A0 (en) 1997-01-31
DE69517172D1 (de) 2000-06-29
EP0769017A1 (en) 1997-04-23
JP3225045B2 (ja) 2001-11-05
US20010003744A1 (en) 2001-06-14
BR9508237A (pt) 1999-06-01
US6307043B1 (en) 2001-10-23
SA95160202B1 (ar) 2005-04-16
CN1052010C (zh) 2000-05-03
ZA955644B (en) 1997-01-06
RU2145963C1 (ru) 2000-02-27
FI970032A0 (fi) 1997-01-03
PL181136B1 (pl) 2001-06-29
HRP950382B1 (en) 2000-12-31
US6077832A (en) 2000-06-20
IL114492A0 (en) 1995-11-27
CZ4097A3 (en) 1997-08-13
IS4394A (is) 1996-12-09
SK168896A3 (en) 1997-09-10
JPH10502356A (ja) 1998-03-03
NO970040L (no) 1997-01-29
GR3033744T3 (en) 2000-10-31
IS1812B (is) 2002-05-15
HU227679B1 (en) 2011-11-28
BG63435B1 (bg) 2002-01-31
YU45095A (sh) 1999-03-04
HU9700034D0 (en) 1997-02-28
HK1003711A1 (en) 1998-11-06
AP736A (en) 1999-03-09
NO308854B1 (no) 2000-11-06
BG101118A (en) 1998-04-30
NO970040D0 (no) 1997-01-06
EP0769017B1 (en) 2000-05-24
TJ270B (en) 2000-08-07
EE9700013A (et) 1997-06-16
AU702248B2 (en) 1999-02-18
AU2805195A (en) 1996-02-09
GEP20002298B (en) 2000-11-25
ATE193298T1 (de) 2000-06-15
CY2249B1 (en) 2003-07-04
PL318062A1 (en) 1997-05-12
UA66744C2 (en) 2004-06-15
RO117699B1 (ro) 2002-06-28
EE03568B1 (et) 2001-12-17
HUT77285A (hu) 1998-03-30
FI970032A (fi) 1997-01-03
YU49443B (sh) 2006-03-03
MX9606732A (es) 1997-04-30
NZ288722A (en) 1998-07-28
PT769017E (pt) 2000-09-29
DK0769017T3 (da) 2000-09-11
US5998605A (en) 1999-12-07
CN1159194A (zh) 1997-09-10
KR100376075B1 (ko) 2004-02-18
FI117629B (fi) 2006-12-29
SK282046B6 (sk) 2001-10-08

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