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OA06003A - Procédé amélioré de synthèse d'oligonucléotides par la voie triester. - Google Patents

Procédé amélioré de synthèse d'oligonucléotides par la voie triester.

Info

Publication number
OA06003A
OA06003A OA56653A OA56653A OA06003A OA 06003 A OA06003 A OA 06003A OA 56653 A OA56653 A OA 56653A OA 56653 A OA56653 A OA 56653A OA 06003 A OA06003 A OA 06003A
Authority
OA
OAPI
Prior art keywords
triester
oligonucleotides
route
synthesis
improved process
Prior art date
Application number
OA56653A
Other languages
English (en)
French (fr)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of OA06003A publication Critical patent/OA06003A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
OA56653A 1977-11-08 1978-11-08 Procédé amélioré de synthèse d'oligonucléotides par la voie triester. OA06003A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84960877A 1977-11-08 1977-11-08

Publications (1)

Publication Number Publication Date
OA06003A true OA06003A (fr) 1981-06-30

Family

ID=25306107

Family Applications (1)

Application Number Title Priority Date Filing Date
OA56653A OA06003A (fr) 1977-11-08 1978-11-08 Procédé amélioré de synthèse d'oligonucléotides par la voie triester.

Country Status (22)

Country Link
EP (1) EP0002322A3 (pt)
JP (1) JPS5473787A (pt)
AU (1) AU4136078A (pt)
BE (1) BE871781A (pt)
BR (1) BR7807288A (pt)
DD (1) DD141836A5 (pt)
DE (1) DE2848054A1 (pt)
DK (1) DK493678A (pt)
ES (1) ES474850A1 (pt)
FI (1) FI783364A (pt)
FR (1) FR2407939A1 (pt)
GB (1) GB2007670A (pt)
IL (1) IL55893A0 (pt)
LU (1) LU80483A1 (pt)
NL (1) NL7811043A (pt)
NO (1) NO783721L (pt)
OA (1) OA06003A (pt)
PL (1) PL210786A1 (pt)
PT (1) PT68754A (pt)
SE (1) SE7811459L (pt)
ZA (1) ZA786303B (pt)
ZM (1) ZM9478A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO80052B (ro) * 1977-11-08 1985-03-30 Genetech Procedeu pentru prepararea unui vehicul recombinat de clonare pentru transformarea unei gazde bacteriene pentru a deveni generator de polipeptida heterologa
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4474947A (en) * 1982-04-08 1984-10-02 Biosearch Benzazolides and their employment in phosphate ester oligonucleotide synthesis processes
JPS61152695A (ja) * 1984-12-26 1986-07-11 Nippon Shinyaku Co Ltd 長鎖ｄｎａの合成法
US9394333B2 (en) 2008-12-02 2016-07-19 Wave Life Sciences Japan Method for the synthesis of phosphorus atom modified nucleic acids
WO2011005761A1 (en) 2009-07-06 2011-01-13 Ontorii, Inc Novel nucleic acid prodrugs and methods use thereof
EP2620428B1 (en) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
CN107365339A (zh) 2011-07-19 2017-11-21 波涛生命科学有限公司 合成官能化核酸的方法
EP2872485B1 (en) 2012-07-13 2020-12-16 Wave Life Sciences Ltd. Asymmetric auxiliary group
KR101835401B1 (ko) 2012-07-13 2018-03-08 신 니뽄 바이오메디칼 라보라토리즈, 엘티디. 키랄 핵산 어쥬번트
CN112007045A (zh) 2012-07-13 2020-12-01 波涛生命科学有限公司 手性控制
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
EP3095459A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
BR112016016400A2 (pt) 2014-01-16 2017-10-03 Wave Life Sciences Ltd Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos

Also Published As

Publication number Publication date
JPS5473787A (en) 1979-06-13
FI783364A (fi) 1979-05-09
NO783721L (no) 1979-05-09
LU80483A1 (fr) 1979-03-22
ES474850A1 (es) 1979-12-01
PL210786A1 (pl) 1979-07-16
PT68754A (en) 1978-12-01
ZM9478A1 (en) 1980-03-21
DK493678A (da) 1979-07-12
DD141836A5 (de) 1980-05-21
NL7811043A (nl) 1979-05-10
IL55893A0 (en) 1979-01-31
ZA786303B (en) 1979-10-31
AU4136078A (en) 1979-05-17
DE2848054A1 (de) 1979-05-10
GB2007670A (en) 1979-05-23
BE871781A (fr) 1979-05-07
EP0002322A3 (en) 1979-06-27
SE7811459L (sv) 1979-05-09
FR2407939A1 (fr) 1979-06-01
EP0002322A2 (en) 1979-06-13
BR7807288A (pt) 1979-06-12

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