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NZ748858A - Compositions and methods for inhibiting expression of transthyretin - Google Patents

Compositions and methods for inhibiting expression of transthyretin

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Publication number
NZ748858A
NZ748858A NZ748858A NZ74885809A NZ748858A NZ 748858 A NZ748858 A NZ 748858A NZ 748858 A NZ748858 A NZ 748858A NZ 74885809 A NZ74885809 A NZ 74885809A NZ 748858 A NZ748858 A NZ 748858A
Authority
NZ
New Zealand
Prior art keywords
transthyretin
inhibiting expression
compositions
methods
antisense
Prior art date
Application number
NZ748858A
Inventor
Dinah Wen-Yee Sah
Gregory Hinkle
Rene Alvarez
Stuart Milstein
Qinqmin Chen
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Priority to NZ797298A priority Critical patent/NZ797298B2/en
Publication of NZ748858A publication Critical patent/NZ748858A/en

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Abstract

Discloses a double-stranded ribonucleic acid (dsRNA) for inhibiting expression of transthyretin (TTR), wherein the dsRNA comprises a sense strand and an antisense strand and the antisense and sense strands comprise the nucleotide sequences of: AAuACcACCUCUGcAUGCUdTdT and AGcAuGcAGAGGuGGuAuudTdT, UGAAuACcACCUCUGcAUGdTdT and cAuGcAGAGGuGGuAuucAdTdT, or GUGAAuACcACCUCUGcAUdTdT and AuGcAGAGGuGGuAuucAcdTdT.
NZ748858A 2008-10-20 2009-10-20 Compositions and methods for inhibiting expression of transthyretin NZ748858A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ797298A NZ797298B2 (en) 2009-10-20 Compositions and methods for inhibiting expression of transthyretin

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US10695608P 2008-10-20 2008-10-20
US11573808P 2008-11-18 2008-11-18
US15667009P 2009-03-02 2009-03-02
US18554509P 2009-06-09 2009-06-09
US24278309P 2009-09-15 2009-09-15
US24479409P 2009-09-22 2009-09-22
NZ73110909 2009-10-20

Publications (1)

Publication Number Publication Date
NZ748858A true NZ748858A (en) 2023-03-31

Family

ID=86613253

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ748858A NZ748858A (en) 2008-10-20 2009-10-20 Compositions and methods for inhibiting expression of transthyretin

Country Status (1)

Country Link
NZ (1) NZ748858A (en)

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PSEA Patent sealed
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Free format text: PATENT RENEWED FOR 16 YEARS UNTIL 20 OCT 2029 BY IPAN GMBH

Effective date: 20231012