NZ515351A - Thio-oxindole derivatives - Google Patents
Thio-oxindole derivativesInfo
- Publication number
- NZ515351A NZ515351A NZ515351A NZ51535100A NZ515351A NZ 515351 A NZ515351 A NZ 515351A NZ 515351 A NZ515351 A NZ 515351A NZ 51535100 A NZ51535100 A NZ 51535100A NZ 515351 A NZ515351 A NZ 515351A
- Authority
- NZ
- New Zealand
- Prior art keywords
- optionally substituted
- substituted alkyl
- alkyl
- thio
- propynyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
A thio-oxindole derivative has the formula (I) wherein: R1 and R2 are independently H, optionally substituted alkyl, OH, O-(optionally substituted alkyl), O-Ac or optionally substituted aryl or heteroaryl, alkylaryl, alkylheteroaryl, 1-propynyl, or 3-propynyl or together R1 and R2 form a ring comprising -CH2(CH2)nCH2-, -O(CH2)mCH2-, O(CH2)pO-, -CH2CH2OCH2CH2- or -CH2CH2N(A)CH2CH2- or R1 and R2 together comprise a double bond to C(Me)2, C(cycloalkyl), O or C(cycloether); A is H or alkyl; m is 1 to 4; n is 1 to 5 and p is 1 to 4; R3 is H, OH, NH2, optionally substituted alkyl, alkenyl, optionally substituted alkynyl, or CORA, R4 is H, halogen, CN, NH2 or optionally substituted alkyl, alkoxy or aminoalkyl; R5 is substituted benzene or five or six membered heterocyclic ring with 1, 2, or 3 heteroatoms selected from O, S(O)t or NR6 or an optionally substituted indol-4-yl, indol-7-yl or benzo-2-thiophene moiety; t is 0 to 2; Q1 is S, NR7, or CR8R9 and RA and R6 to R8 are as defined in the specification. The compounds are useful for inducing contraception, for treating dysfunctional bleeding or carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, or prostate.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17225999P | 1999-05-04 | 1999-05-04 | |
| US09/552,033 US6355648B1 (en) | 1999-05-04 | 2000-04-19 | Thio-oxindole derivatives |
| PCT/US2000/011630 WO2000066555A1 (en) | 1999-05-04 | 2000-05-01 | Thio-oxindole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ515351A true NZ515351A (en) | 2004-01-30 |
Family
ID=26867898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ515351A NZ515351A (en) | 1999-05-04 | 2000-05-01 | Thio-oxindole derivatives |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1181275A1 (en) |
| JP (1) | JP2002543182A (en) |
| KR (1) | KR20020000636A (en) |
| CN (1) | CN1143847C (en) |
| AU (1) | AU767762B2 (en) |
| BG (1) | BG106078A (en) |
| BR (1) | BR0010216A (en) |
| CA (1) | CA2371633A1 (en) |
| CZ (1) | CZ20013950A3 (en) |
| EA (1) | EA005034B1 (en) |
| GE (1) | GEP20043266B (en) |
| HU (1) | HUP0200993A3 (en) |
| MX (1) | MXPA01011285A (en) |
| NO (1) | NO320912B1 (en) |
| NZ (1) | NZ515351A (en) |
| PL (1) | PL351407A1 (en) |
| SK (1) | SK15902001A3 (en) |
| TR (1) | TR200103288T2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1732922T3 (en) * | 2004-04-08 | 2009-01-12 | Wyeth Corp | Method for minimizing thioamide impurities |
| ES2317223T3 (en) * | 2004-04-08 | 2009-04-16 | Wyeth | THIOAMIDE DERIVATIVES AS MODULATORS OF THE PROGESTERONE RECEIVER. |
| GB201113538D0 (en) * | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
| WO2014058035A1 (en) * | 2012-10-12 | 2014-04-17 | Okinawa Institute Of Science And Technology School Corporation | Novel spirooxindole derivative and process for producing the same |
| US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| JP7187449B2 (en) * | 2016-09-30 | 2022-12-12 | エピザイム，インコーポレイティド | Substituted Fused Bicyclic or Tricyclic Heterocyclic Compounds as EHMT2 Inhibitors |
-
2000
- 2000-05-01 CZ CZ20013950A patent/CZ20013950A3/en unknown
- 2000-05-01 HU HU0200993A patent/HUP0200993A3/en unknown
- 2000-05-01 TR TR2001/03288T patent/TR200103288T2/en unknown
- 2000-05-01 GE GEAP20006121A patent/GEP20043266B/en unknown
- 2000-05-01 NZ NZ515351A patent/NZ515351A/en unknown
- 2000-05-01 CN CNB008071330A patent/CN1143847C/en not_active Expired - Fee Related
- 2000-05-01 EA EA200101180A patent/EA005034B1/en not_active IP Right Cessation
- 2000-05-01 JP JP2000615386A patent/JP2002543182A/en active Pending
- 2000-05-01 AU AU46814/00A patent/AU767762B2/en not_active Ceased
- 2000-05-01 KR KR1020017014076A patent/KR20020000636A/en not_active Application Discontinuation
- 2000-05-01 CA CA002371633A patent/CA2371633A1/en not_active Abandoned
- 2000-05-01 BR BR0010216-4A patent/BR0010216A/en not_active IP Right Cessation
- 2000-05-01 EP EP00928603A patent/EP1181275A1/en not_active Withdrawn
- 2000-05-01 MX MXPA01011285A patent/MXPA01011285A/en unknown
- 2000-05-01 PL PL00351407A patent/PL351407A1/en not_active Application Discontinuation
- 2000-05-01 SK SK1590-2001A patent/SK15902001A3/en unknown
-
2001
- 2001-11-02 BG BG106078A patent/BG106078A/en unknown
- 2001-11-02 NO NO20015380A patent/NO320912B1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002543182A (en) | 2002-12-17 |
| MXPA01011285A (en) | 2003-09-04 |
| KR20020000636A (en) | 2002-01-05 |
| AU4681400A (en) | 2000-11-17 |
| BR0010216A (en) | 2002-03-19 |
| CA2371633A1 (en) | 2000-11-09 |
| SK15902001A3 (en) | 2002-11-06 |
| BG106078A (en) | 2002-05-31 |
| EA200101180A1 (en) | 2002-04-25 |
| HUP0200993A2 (en) | 2002-07-29 |
| CN1143847C (en) | 2004-03-31 |
| GEP20043266B (en) | 2004-06-25 |
| PL351407A1 (en) | 2003-04-22 |
| NO320912B1 (en) | 2006-02-13 |
| AU767762B2 (en) | 2003-11-20 |
| EA005034B1 (en) | 2004-10-28 |
| HUP0200993A3 (en) | 2003-05-28 |
| CN1349499A (en) | 2002-05-15 |
| TR200103288T2 (en) | 2002-04-22 |
| EP1181275A1 (en) | 2002-02-27 |
| NO20015380D0 (en) | 2001-11-02 |
| CZ20013950A3 (en) | 2002-06-12 |
| NO20015380L (en) | 2002-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| ASS | Change of ownership |
Owner name: WYETH, US Free format text: OLD OWNER(S): WYETH; LIGAND PHARMACEUTICALS, INC. |