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NZ330034A - Method of treating HIV in mammals by administering cells bearing CD4 decoy receptors - Google Patents

Method of treating HIV in mammals by administering cells bearing CD4 decoy receptors

Info

Publication number
NZ330034A
NZ330034A NZ330034A NZ33003495A NZ330034A NZ 330034 A NZ330034 A NZ 330034A NZ 330034 A NZ330034 A NZ 330034A NZ 33003495 A NZ33003495 A NZ 33003495A NZ 330034 A NZ330034 A NZ 330034A
Authority
NZ
New Zealand
Prior art keywords
hiv
mammals
treating hiv
cells bearing
decoy receptors
Prior art date
Application number
NZ330034A
Inventor
Brian Seed
Babak Banapour
Charles Romeo
Waldemar Kolanus
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/284,391 external-priority patent/US5851828A/en
Priority claimed from US08/394,388 external-priority patent/US6753162B1/en
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Priority claimed from NZ291017A external-priority patent/NZ291017A/en
Publication of NZ330034A publication Critical patent/NZ330034A/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The use and preparation of medicaments for treating HIV in a mammal by administering an effective amount of therapeutic cells, the therapeutic cells expressing a membrane-bound, proteinaceous chimeric receptor comprising: 1. an extracellular portion which includes a fragment of CD4 that is capable of specifically recognising and binding an HIV-infected cell but does not mediate HIV infection; and 2. an intracellular portion that is capable of signaling the therapeutic cell to destroy the receptor-bound HIV-infected cell.
NZ330034A 1994-08-02 1995-07-26 Method of treating HIV in mammals by administering cells bearing CD4 decoy receptors NZ330034A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/284,391 US5851828A (en) 1991-03-07 1994-08-02 Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US08/394,388 US6753162B1 (en) 1991-03-07 1995-02-24 Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
NZ291017A NZ291017A (en) 1994-08-02 1995-07-26 Cells bearing cd-4 receptors, related molecules

Publications (1)

Publication Number Publication Date
NZ330034A true NZ330034A (en) 2000-08-25

Family

ID=27353792

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ330034A NZ330034A (en) 1994-08-02 1995-07-26 Method of treating HIV in mammals by administering cells bearing CD4 decoy receptors

Country Status (1)

Country Link
NZ (1) NZ330034A (en)

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