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NZ297230A - Thiepane compounds for detecting HIV protease - Google Patents

Thiepane compounds for detecting HIV protease

Info

Publication number
NZ297230A
NZ297230A NZ297230A NZ29723095A NZ297230A NZ 297230 A NZ297230 A NZ 297230A NZ 297230 A NZ297230 A NZ 297230A NZ 29723095 A NZ29723095 A NZ 29723095A NZ 297230 A NZ297230 A NZ 297230A
Authority
NZ
New Zealand
Prior art keywords
thiepane
useful
compositions
enzymes
compounds
Prior art date
Application number
NZ297230A
Inventor
Norbert W Bischofberger
Choung U Kim
Steven H Krawczyk
Lawrence R Mcgee
Michael J Postich
Wenjin Yang
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/473,876 external-priority patent/US5705524A/en
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Priority claimed from PCT/US1995/014603 external-priority patent/WO1996014314A2/en
Publication of NZ297230A publication Critical patent/NZ297230A/en

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  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Patent 297230 The specification describes tri- and tetra substituted thiepanes of above formula(I) and compositions having use as immunogens and diagnostics. Y is O, S, SO, SO2, N(R1), N(R2)SO2, N(R1)CO, or OSO2. The compositions inhibit proteolytic activity of viral enzymes and are useful for the inhibition of such enzymes as well as in assays for the detection of such enzymes. Embodiments in which antigenic polypeptides are bonded to the compositions are useful in raising antibodies against the thiepane haptens or the polypeptide. Labelled thiepanes are useful as diagnostic reagents.
NZ297230A 1994-11-02 1995-11-03 Thiepane compounds for detecting HIV protease NZ297230A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US52204294A 1994-11-02 1994-11-02
US33447194A 1994-11-04 1994-11-04
US47086495A 1995-06-06 1995-06-06
US08/473,876 US5705524A (en) 1994-11-04 1995-06-07 Thiepane compounds
PCT/US1995/014603 WO1996014314A2 (en) 1994-11-04 1995-11-03 Thiepane compounds inhibiting and detecting hiv protease

Publications (1)

Publication Number Publication Date
NZ297230A true NZ297230A (en) 2000-05-26

Family

ID=27502492

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ297230A NZ297230A (en) 1994-11-02 1995-11-03 Thiepane compounds for detecting HIV protease

Country Status (1)

Country Link
NZ (1) NZ297230A (en)

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