NZ234563A - N,n'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamides and pharmaceutical compositions - Google Patents
N,n'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamides and pharmaceutical compositionsInfo
- Publication number
- NZ234563A NZ234563A NZ234563A NZ23456390A NZ234563A NZ 234563 A NZ234563 A NZ 234563A NZ 234563 A NZ234563 A NZ 234563A NZ 23456390 A NZ23456390 A NZ 23456390A NZ 234563 A NZ234563 A NZ 234563A
- Authority
- NZ
- New Zealand
- Prior art keywords
- pyridine
- bis
- dicarboxylic acid
- alkoxyalkyl
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboxylic acid diamides of the formula I <IMAGE> where R<1> is linear or branched C1-C4-alkanediyl, R<2> is unbranched C1-C4-alkyl or hydrogen and n is 1 or 2 and R<1'>, R<2'> and n' have the same meanings as R<1>, R<2> and n, where R<1> and R<1'>, R<2> and R<2'>, and n and n' are identical or different, and their physiologically acceptable salts with the exception of N,N'-bis(2-methoxyethyl)pyridine-2,4-dicarboxylic acid diamide and N,N'-bis(2-hydroxyethyl)pyridine-2,4-dicarboxylic acid diamide. The compounds of the formula I inhibit prolin hydroxylase and lysin hydroxylase and are suitable as fibrosuppressants and immunosuppressants.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3924093A DE3924093A1 (en) | 1989-07-20 | 1989-07-20 | N, N'-BIS (ALKOXY-ALKYL) -PYRIDINE-2,4-DICARBONESAUREDIAMIDES, METHOD FOR THE PRODUCTION AND USE THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ234563A true NZ234563A (en) | 1992-12-23 |
Family
ID=6385494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ234563A NZ234563A (en) | 1989-07-20 | 1990-07-18 | N,n'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamides and pharmaceutical compositions |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0409119B1 (en) |
| JP (1) | JPH0776213B2 (en) |
| KR (1) | KR0181945B1 (en) |
| AT (1) | ATE104280T1 (en) |
| AU (1) | AU624978B2 (en) |
| CA (1) | CA2021529C (en) |
| CY (1) | CY1997A (en) |
| CZ (1) | CZ280129B6 (en) |
| DD (1) | DD300429A5 (en) |
| DE (2) | DE3924093A1 (en) |
| DK (1) | DK0409119T3 (en) |
| ES (1) | ES2052112T3 (en) |
| FI (1) | FI94630C (en) |
| HU (1) | HU218274B (en) |
| IE (1) | IE64438B1 (en) |
| IL (1) | IL95121A (en) |
| LT (1) | LT3798B (en) |
| LV (1) | LV10430B (en) |
| NO (1) | NO177187C (en) |
| NZ (1) | NZ234563A (en) |
| PL (1) | PL166307B1 (en) |
| PT (1) | PT94779B (en) |
| RU (1) | RU1836350C (en) |
| SK (1) | SK279199B6 (en) |
| UA (1) | UA19056A (en) |
| ZA (1) | ZA905680B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3707429A1 (en) * | 1987-03-07 | 1988-09-15 | Hoechst Ag | SUBSTITUTED PYRIDINE-2,4-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS |
| DE58908519D1 (en) * | 1988-08-04 | 1994-11-24 | Hoechst Ag | Improved process for the preparation of N, N-bis (alkoxyalkyl) pyridine -2,4-dicarboxylic acid diamides. |
| DE4020570A1 (en) | 1990-06-28 | 1992-01-02 | Hoechst Ag | 2,4- AND 2,5-SUBSTITUTED PYRIDINE-N-OXIDES, METHOD FOR THE PRODUCTION AND USE THEREOF |
| DE4030999A1 (en) * | 1990-10-01 | 1992-04-09 | Hoechst Ag | 4- OR 5-SUBSTITUTED PYRIDINE-2-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT |
| YU9492A (en) * | 1991-02-05 | 1995-03-27 | Hoechst Ag. | 2,4- and 2,5-BIS-TETRAZOLYL pyridines and the process for their preparation |
| TW199147B (en) * | 1991-03-18 | 1993-02-01 | Hoechst Ag | |
| EP0541042A1 (en) * | 1991-11-05 | 1993-05-12 | Hoechst Aktiengesellschaft | 2,4- and 2,5-pyridine-dicarboxylic acid derivatives, process for their preparation and their use |
| TW222585B (en) * | 1992-09-11 | 1994-04-21 | Hoechst Ag | |
| DOP2002000332A (en) * | 2001-02-14 | 2002-08-30 | Warner Lambert Co | MATRIX METALOPROTEINAS PYRIDINE INHIBITORS |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3432094A1 (en) | 1984-08-31 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | ESTER OF PYRIDINE-2,4- AND -2,5-DICARBONIC ACID AS A MEDICINAL PRODUCT FOR INHIBITING PROLIN AND LYSINE HYDROXYLASE |
| DE3703962A1 (en) * | 1987-02-10 | 1988-08-18 | Hoechst Ag | PYRIDINE-2,4- AND 2,5-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS |
| DE3703959A1 (en) * | 1987-02-10 | 1988-08-18 | Hoechst Ag | PYRIDINE-2,4- AND 2,5-DICARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS |
| DE3703963A1 (en) | 1987-02-10 | 1988-08-18 | Hoechst Ag | PYRIDINE-2,4- AND 2,, 5-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF, AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS |
| DE3826471A1 (en) | 1988-08-04 | 1990-02-22 | Hoechst Ag | Improved process for the preparation of N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboximides |
| DE58908519D1 (en) * | 1988-08-04 | 1994-11-24 | Hoechst Ag | Improved process for the preparation of N, N-bis (alkoxyalkyl) pyridine -2,4-dicarboxylic acid diamides. |
| DE3828140A1 (en) | 1988-08-19 | 1990-03-01 | Hoechst Ag | Improved process for the preparation of N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboxamides and use of these compounds for the preparation of orally administrable medicaments |
-
1989
- 1989-07-20 DE DE3924093A patent/DE3924093A1/en not_active Withdrawn
-
1990
- 1990-07-14 ES ES90113528T patent/ES2052112T3/en not_active Expired - Lifetime
- 1990-07-14 DE DE59005328T patent/DE59005328D1/en not_active Expired - Fee Related
- 1990-07-14 AT AT90113528T patent/ATE104280T1/en not_active IP Right Cessation
- 1990-07-14 EP EP90113528A patent/EP0409119B1/en not_active Expired - Lifetime
- 1990-07-14 DK DK90113528.5T patent/DK0409119T3/en active
- 1990-07-18 DD DD342874A patent/DD300429A5/en not_active IP Right Cessation
- 1990-07-18 NZ NZ234563A patent/NZ234563A/en unknown
- 1990-07-18 CZ CS903576A patent/CZ280129B6/en not_active IP Right Cessation
- 1990-07-18 IL IL9512190A patent/IL95121A/en not_active IP Right Cessation
- 1990-07-18 FI FI903624A patent/FI94630C/en not_active IP Right Cessation
- 1990-07-18 SK SK3576-90A patent/SK279199B6/en unknown
- 1990-07-19 UA UA4830947A patent/UA19056A/en unknown
- 1990-07-19 IE IE264290A patent/IE64438B1/en not_active IP Right Cessation
- 1990-07-19 AU AU59144/90A patent/AU624978B2/en not_active Ceased
- 1990-07-19 RU SU904830947A patent/RU1836350C/en active
- 1990-07-19 HU HU549/90A patent/HU218274B/en not_active IP Right Cessation
- 1990-07-19 ZA ZA905680A patent/ZA905680B/en unknown
- 1990-07-19 CA CA002021529A patent/CA2021529C/en not_active Expired - Fee Related
- 1990-07-19 KR KR1019900010938A patent/KR0181945B1/en not_active IP Right Cessation
- 1990-07-19 PL PL90286132A patent/PL166307B1/en unknown
- 1990-07-19 NO NO903235A patent/NO177187C/en not_active IP Right Cessation
- 1990-07-19 JP JP2189620A patent/JPH0776213B2/en not_active Expired - Lifetime
- 1990-07-20 PT PT94779A patent/PT94779B/en not_active IP Right Cessation
-
1993
- 1993-05-07 LV LVP-93-301A patent/LV10430B/en unknown
- 1993-11-12 LT LTIP1462A patent/LT3798B/en not_active IP Right Cessation
-
1997
- 1997-09-05 CY CY199797A patent/CY1997A/en unknown
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