[go: up one dir, main page]

NZ210657A - Phenylacetic acid derivatives and pharmaceutical compositions - Google Patents

Phenylacetic acid derivatives and pharmaceutical compositions

Info

Publication number
NZ210657A
NZ210657A NZ210657A NZ21065784A NZ210657A NZ 210657 A NZ210657 A NZ 210657A NZ 210657 A NZ210657 A NZ 210657A NZ 21065784 A NZ21065784 A NZ 21065784A NZ 210657 A NZ210657 A NZ 210657A
Authority
NZ
New Zealand
Prior art keywords
pharmaceutical compositions
acid derivatives
phenylacetic acid
kbr
degrees
Prior art date
Application number
NZ210657A
Inventor
Wolfgang Grell
Rudolf Hurnaus
Gerhart Griss
Eckhard Rupprecht
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NZ210657A publication Critical patent/NZ210657A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Lubricants (AREA)
  • Glass Compositions (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)

Abstract

1. Two new solid forms of 2-ethoxy-4-[N-(1-(2-piperidino- phenyl)-3-methyl-1-butyl)-aminocarbonylmethyl]-benzoic acid, the form designated (B) being characterised by the melting point of 140-142 degrees C and by the IR(KBr) spectrum according to Figure B' and the form designated (C) being characterised by a melting point of 75-85 degrees C and by the IR(KBr) spectrum according to Figure C'.
NZ210657A 1983-12-30 1984-12-20 Phenylacetic acid derivatives and pharmaceutical compositions NZ210657A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833347565 DE3347565A1 (en) 1983-12-30 1983-12-30 NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE19853522604 DE3522604A1 (en) 1983-12-30 1985-06-25 NEW SOLID FORMS OF 2- (GAMMA) THOXY-4- (N- (1- (2- (2-PIPERIDINO-PHENYL) -3-METHYL-1-BUTYL) -AMINOCARBONYLMETHYL) -BENZOESIC ACID, MEDICINAL PRODUCTS CONTAINING THESE FORMS

Publications (1)

Publication Number Publication Date
NZ210657A true NZ210657A (en) 1988-10-28

Family

ID=37847099

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ210657A NZ210657A (en) 1983-12-30 1984-12-20 Phenylacetic acid derivatives and pharmaceutical compositions
NZ216640A NZ216640A (en) 1983-12-30 1986-06-24 Solid forms of 2-ethoxy-4-(n-(1-(2-piperidino-phenyl) -3-methyl-1-butyl)-aminocarbonylmethyl)-benzoic acid

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ216640A NZ216640A (en) 1983-12-30 1986-06-24 Solid forms of 2-ethoxy-4-(n-(1-(2-piperidino-phenyl) -3-methyl-1-butyl)-aminocarbonylmethyl)-benzoic acid

Country Status (26)

Country Link
EP (2) EP0147850B1 (en)
JP (2) JPH0623200B2 (en)
KR (1) KR900005320B1 (en)
AT (1) ATE44027T1 (en)
AU (2) AU577815B2 (en)
BG (1) BG61519B2 (en)
CA (2) CA1225398A (en)
CS (1) CS409791A3 (en)
DD (1) DD231348A5 (en)
DE (4) DE3347565A1 (en)
DK (2) DK167439B1 (en)
ES (7) ES8605500A1 (en)
FI (2) FI80447C (en)
GR (2) GR82614B (en)
HK (1) HK87492A (en)
HU (1) HU194548B (en)
IE (1) IE57700B1 (en)
IL (2) IL73963A (en)
LU (1) LU90301I2 (en)
MX (1) MX9202772A (en)
NL (1) NL980034I1 (en)
NO (3) NO162819C (en)
NZ (2) NZ210657A (en)
PT (2) PT79772B (en)
SG (1) SG55492G (en)
ZA (2) ZA8410103B (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3523466A1 (en) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3347565A1 (en) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
ES2136600T3 (en) * 1991-06-21 1999-12-01 Boehringer Ingelheim Pharma USE OF ACID (S) (+) - 2-ETOXI-4- (N- (1- (2-PIPERIDINO-FENIL) -3-METHYL-1-BUTYL) AMINO CARBONYL METHYL) -BENZOIC FOR THE PREPARATION OF A LONG ANTIDIABETIC DURATION.
WO1993000337A1 (en) * 1991-06-21 1993-01-07 Dr. Karl Thomae Gmbh (s)(+)-2-ethoxy-4-[n-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid
FR2763590B1 (en) * 1997-05-22 2000-03-24 Synthelabo ACID DERIVATIVES [[[(ARYLMETHYL) AMINO] CARBONYL] ALKYL] - AROMATICS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
EP1741447B1 (en) 2000-01-21 2013-09-18 Novartis AG Combinations comprising dipeptidylpeptidase-IV inhibitors and antidiabetic agents
US20040102477A1 (en) * 2002-08-23 2004-05-27 Dr. Reddy's Laboratories Limited Polymorphic forms of (S)-Repaglinide and the processes for preparation thereof
WO2004101540A2 (en) * 2003-05-14 2004-11-25 Cilag Ag Method for the production of phenylacetic acid derivatives
AU2003237595A1 (en) * 2003-05-26 2004-12-13 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-(n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl)benzoic acid derivatives
PE20050630A1 (en) * 2003-06-09 2005-09-22 Boehringer Ingelheim Int HETEROCYCLIC COMPOUNDS AS PAPILLOMA VIRUS INHIBITORS
FR2875805B1 (en) * 2004-09-27 2006-12-29 Genfit S A SUBSTITUTED N- (BENZYL) PHENYLACETAMIDE DERIVATIVE COMPOUNDS, PREPARATION AND USES
CN1305863C (en) * 2004-12-27 2007-03-21 浙江大学 Method for synthesizing (S)-isopropyl-(2-piperidine) phenyl-methylhistamine
GT200600381A (en) 2005-08-25 2007-03-28 ORGANIC COMPOUNDS
HRP20140091T4 (en) 2005-09-14 2021-12-24 Takeda Pharmaceutical Company Limited Administration of dipeptidyl peptidase inhibitors
EP2177221A1 (en) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of substantially optically pure Repaglinide and precursors thereof
WO2010130773A2 (en) 2009-05-15 2010-11-18 Novartis Ag Benzoxazolone derivatives as aldosterone symthase inhibitors
JP5659224B2 (en) 2009-05-15 2015-01-28 ノバルティス アーゲー Arylpyridines as aldosterone synthase inhibitors
KR20120041702A (en) 2009-05-28 2012-05-02 노파르티스 아게 Substituted aminobutyric derivatives as neprilysin inhibitors
AU2010251967B9 (en) 2009-05-28 2014-04-03 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
EP2501678B1 (en) 2009-11-17 2015-09-23 Novartis AG Aryl-pyridine derivatives as aldosterone synthase inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
EP2507234B1 (en) 2009-11-30 2014-03-12 Novartis AG Imidazole derivatives as aldosterone synthase inhibitors
CN102834393B (en) 2010-02-03 2015-07-22 武田药品工业株式会社 Apoptosis signal-regulating kinase 1 inhibitors
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
WO2012095548A2 (en) 2011-01-13 2012-07-19 Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned) Compounds for treating neurodegenerative disorders
UY35144A (en) 2012-11-20 2014-06-30 Novartis Ag APELINE SYNTHETIC LINEAR MIMETICS FOR THE CARDIAC INSUFFICIENCY TREATMENT
CA2900027A1 (en) 2013-02-14 2014-08-21 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
PE20160878A1 (en) 2013-07-25 2016-09-08 Novartis Ag CYCLIC POLYPEPTIDES FOR THE TREATMENT OF HEART FAILURE
AU2014293387B2 (en) 2013-07-25 2017-04-20 Novartis Ag Bioconjugates of synthetic apelin polypeptides
MX2017009534A (en) 2015-01-23 2018-04-10 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life.
UY38072A (en) 2018-02-07 2019-10-01 Novartis Ag COMPOSITIONS DERIVED FROM BUTANOIC ESTER SUBSTITUTED WITH BISPHENYL AS INHIBITORS OF NEP, COMPOSITIONS AND COMBINATIONS OF THE SAME

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3100575A1 (en) * 1981-01-10 1982-09-02 Dr. Karl Thomae Gmbh, 7950 Biberach "NEW BENZOESAEURS, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS"
DE3100535A1 (en) * 1981-01-10 1982-08-12 Dr. Karl Thomae Gmbh, 7950 Biberach "NEW CARBONIC ACID DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS"
SU1170969A3 (en) * 1982-07-06 1985-07-30 Др.Карл Томэ,Гмбх (Фирма) Method of producing derivatives of phenylacetic acid or their salts
FR2554875B1 (en) * 1983-11-10 1986-02-28 Dba HYDRAULIC BRAKE AMPLIFIER
DE3347565A1 (en) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3523466A1 (en) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
CA1292000C (en) 1991-11-12
ES8604548A1 (en) 1986-02-01
LU90301I2 (en) 1998-12-21
HUT37773A (en) 1986-02-28
EP0207331A1 (en) 1987-01-07
NO162819B (en) 1989-11-13
ES545883A0 (en) 1986-02-01
AU5913986A (en) 1987-01-08
DD231348A5 (en) 1985-12-24
ES556495A0 (en) 1988-04-01
IE843349L (en) 1985-06-30
DK613184A (en) 1985-07-01
ES545880A0 (en) 1986-02-01
MX9202772A (en) 1992-06-30
SG55492G (en) 1992-10-02
NZ216640A (en) 1989-02-24
JPS60158171A (en) 1985-08-19
FI845145A0 (en) 1984-12-28
ZA864695B (en) 1988-02-24
IL73963A0 (en) 1985-03-31
EP0147850A3 (en) 1985-08-07
GR82614B (en) 1985-05-02
DK167573B1 (en) 1993-11-22
FI80447B (en) 1990-02-28
NO162819C (en) 1990-02-21
CS409791A3 (en) 1992-07-15
NO168302C (en) 1992-02-05
DK613184D0 (en) 1984-12-20
BG61519B2 (en) 1997-10-31
ES8604545A1 (en) 1986-02-01
ES8604547A1 (en) 1986-02-01
FI82689B (en) 1990-12-31
JPS62474A (en) 1987-01-06
DE3478682D1 (en) 1989-07-20
ATE44027T1 (en) 1989-06-15
NL980034I1 (en) 1999-02-01
KR850004590A (en) 1985-07-25
ES545881A0 (en) 1986-02-01
IL79217A0 (en) 1986-09-30
FI862650A0 (en) 1986-06-23
JPH0623200B2 (en) 1994-03-30
ES8604544A1 (en) 1986-02-01
PT79772A (en) 1985-01-01
AU3721084A (en) 1985-08-01
KR900005320B1 (en) 1990-07-27
DK296686D0 (en) 1986-06-24
FI862650A (en) 1986-12-26
JPH0739405B2 (en) 1995-05-01
IL73963A (en) 1989-01-31
NO168302B (en) 1991-10-28
DK296686A (en) 1986-12-26
AU583631B2 (en) 1989-05-04
FI845145L (en) 1985-07-01
ES8802145A1 (en) 1988-04-01
NO845282L (en) 1985-07-01
EP0147850A2 (en) 1985-07-10
EP0207331B1 (en) 1990-05-23
AU577815B2 (en) 1988-10-06
PT82832A (en) 1986-07-01
PT79772B (en) 1987-01-05
NO862532D0 (en) 1986-06-24
HU194548B (en) 1988-02-29
FI80447C (en) 1990-06-11
DE3522604A1 (en) 1987-01-08
PT82832B (en) 1988-12-15
FI82689C (en) 1991-04-10
DE19875044I2 (en) 2002-07-18
ES545879A0 (en) 1986-02-01
ZA8410103B (en) 1986-09-24
IE57700B1 (en) 1993-03-10
CA1225398A (en) 1987-08-11
NO1999016I1 (en) 1999-07-20
ES539078A0 (en) 1986-03-16
IL79217A (en) 1991-01-31
DE3347565A1 (en) 1985-07-11
ES545882A0 (en) 1986-02-01
EP0147850B1 (en) 1989-06-14
DK167439B1 (en) 1993-11-01
NO862532L (en) 1986-12-29
HK87492A (en) 1992-11-13
GR861558B (en) 1986-10-17
ES8605500A1 (en) 1986-03-16
ES8604546A1 (en) 1986-02-01

Similar Documents

Publication Publication Date Title
NZ210657A (en) Phenylacetic acid derivatives and pharmaceutical compositions