NZ195564A - 5-pyridinyl-2(1h)-pyridinones pharmaceutical compositions intermediate pyridine compounds - Google Patents

5-pyridinyl-2(1h)-pyridinones pharmaceutical compositions intermediate pyridine compounds

Info

Publication number: NZ195564A
Authority: NZ; New Zealand
Prior art keywords: pyridinones; pyridinyl; pharmaceutical compositions; pyridine compounds; intermediate pyridine
Prior art date: 1979-11-26

Application number

NZ195564A

Other languages

English (en)

Inventor

George Yohe Lesher

Richard Everett Philion

Donald Frederick Page

Chester Joseph Opalka Jr

Original Assignee

Sterling Drug Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-11-26

Filing date

1980-11-17

Publication date

1983-09-30

1980-03-28 Priority claimed from US06/135,100 external-priority patent/US4297360A/en

1980-10-20 Priority claimed from US06/198,461 external-priority patent/US4313951A/en

1980-11-17 Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc

1983-09-30 Publication of NZ195564A publication Critical patent/NZ195564A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NZ195564A 1979-11-26 1980-11-17 5-pyridinyl-2(1h)-pyridinones pharmaceutical compositions intermediate pyridine compounds NZ195564A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US9750479A	1979-11-26	1979-11-26
US06/135,100 US4297360A (en)	1980-03-28	1980-03-28	5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use
US06/198,461 US4313951A (en)	1979-11-26	1980-10-20	3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor
US06/204,726 US4312875A (en)	1980-03-28	1980-11-06	5-(Pyridinyl)-6-(lower-alkyl)-2(1H)-pyridinones, 1,2-dihydro-2-oxo-5-(pyridinyl)-6-(lower-alkyl)nicotinic acids and lower-alkyl esters thereof, and cardiotonic use thereof

Publications (1)

Publication Number	Publication Date
NZ195564A true NZ195564A (en)	1983-09-30

Family

ID=27492921

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NZ195564A NZ195564A (en)	1979-11-26	1980-11-17	5-pyridinyl-2(1h)-pyridinones pharmaceutical compositions intermediate pyridine compounds

Country Status (20)

Country	Link
AT (1)	AT379387B (xx)
CH (1)	CH649535A5 (xx)
DE (1)	DE3044568A1 (xx)
DK (1)	DK151799C (xx)
ES (1)	ES507620A0 (xx)
FI (1)	FI76564C (xx)
FR (2)	FR2470124B1 (xx)
GB (2)	GB2065642B (xx)
GR (1)	GR71608B (xx)
HK (2)	HK31189A (xx)
IE (1)	IE50632B1 (xx)
IL (2)	IL61501A (xx)
IT (1)	IT1148740B (xx)
LU (1)	LU82957A1 (xx)
MX (1)	MX155904A (xx)
NL (2)	NL192202C (xx)
NO (2)	NO154345C (xx)
NZ (1)	NZ195564A (xx)
PT (1)	PT72106B (xx)
SE (1)	SE442398B (xx)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4305948A (en) *	1980-12-22	1981-12-15	Sterling Drug Inc.	N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and their cardiotonic use
US4465686A (en) *	1981-09-08	1984-08-14	Sterling Drug Inc.	5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation
FR2529891A1 (fr) *	1982-07-12	1984-01-13	Nativelle Sa Ets	Derives du pyridyl-3 alcoxy-5 pyrazole, procede de preparation et application en therapeutique
IL69407A (en) *	1982-08-23	1987-10-20	Warner Lambert Co	2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them
IL70169A0 (en) *	1982-11-18	1984-02-29	Sterling Drug Inc	2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them
GB8414220D0 (en) *	1984-06-04	1984-07-11	Sterwin Ag	Medicaments in unit dose form
ATE120753T1 (de) *	1990-08-21	1995-04-15	Upjohn Co	Bisphosphonsäurederivate als antiarthritische mittel.
CZ403592A3 (en) *	1992-02-20	1993-12-15	Hoechst Ag	Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
MX2007007330A (es) *	2004-12-16	2007-10-04	Vertex Pharma	Piridonas de utilidad como inhibidores de quinasas .
KR20080065704A (ko)	2005-11-09	2008-07-14	콤비네이토릭스, 인코포레이티드	의학적 이상의 치료 방법들, 조성물들, 및 키트들
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US20100120694A1 (en)	2008-06-04	2010-05-13	Synergy Pharmaceuticals, Inc.	Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US7879802B2 (en)	2007-06-04	2011-02-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es)	2011-03-01	2018-06-27	Synergy Pharmaceuticals Inc Star	Proceso de preparacion de agonistas c de guanilato ciclasa.
WO2013023250A1 (en)	2011-08-16	2013-02-21	Baker Idi Heart & Diabetes Institute Holdings Limited	Controlled-release formulation
WO2013106547A1 (en)	2012-01-10	2013-07-18	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
US9545446B2 (en)	2013-02-25	2017-01-17	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
CA2905438A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
EP3004138B1 (en)	2013-06-05	2024-03-13	Bausch Health Ireland Limited	Ultra-pure agonists of guanylate cyclase c, method of making and using same
JP6694385B2 (ja)	2013-08-09	2020-05-13	アーデリクス，インコーポレーテッド	リン酸塩輸送阻害のための化合物及び方法
CN107530337B (zh)	2014-12-22	2021-07-09	贝克心脏与糖尿病研究所	治疗方法
US20200368223A1 (en)	2019-05-21	2020-11-26	Ardelyx, Inc.	Methods for inhibiting phosphate transport

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4004012A (en) *	1975-10-14	1977-01-18	Sterling Drug Inc.	3-Cyano-5-(pyridinyl)-2(1H)-pyridinones
US4072746A (en) *	1975-10-14	1978-02-07	Sterling Drug Inc.	3-Amino-5-(pyridinyl)-2(1H)-pyridinones

1980
- 1980-11-17 NZ NZ195564A patent/NZ195564A/xx unknown
- 1980-11-17 IL IL61501A patent/IL61501A/xx not_active IP Right Cessation
- 1980-11-18 MX MX9577A patent/MX155904A/es unknown
- 1980-11-24 NL NL8006399A patent/NL192202C/nl not_active IP Right Cessation
- 1980-11-24 FI FI803652A patent/FI76564C/fi not_active IP Right Cessation
- 1980-11-24 IE IE2430/80A patent/IE50632B1/en not_active IP Right Cessation
- 1980-11-25 SE SE8008252A patent/SE442398B/sv not_active IP Right Cessation
- 1980-11-25 NO NO803550A patent/NO154345C/no unknown
- 1980-11-25 FR FR8024998A patent/FR2470124B1/fr not_active Expired
- 1980-11-25 IT IT26218/80A patent/IT1148740B/it active
- 1980-11-25 PT PT72106A patent/PT72106B/pt unknown
- 1980-11-25 DK DK501180A patent/DK151799C/da not_active IP Right Cessation
- 1980-11-26 DE DE19803044568 patent/DE3044568A1/de active Granted
- 1980-11-26 LU LU82957A patent/LU82957A1/fr unknown
- 1980-11-26 GB GB8037856A patent/GB2065642B/en not_active Expired
- 1980-11-26 GR GR63461A patent/GR71608B/el unknown
- 1980-11-26 CH CH8783/80A patent/CH649535A5/fr not_active IP Right Cessation
- 1980-11-26 AT AT0578080A patent/AT379387B/de not_active IP Right Cessation
1981
- 1981-12-01 ES ES507620A patent/ES507620A0/es active Granted
1983
- 1983-06-10 GB GB08315983A patent/GB2131421B/en not_active Expired
- 1983-09-28 IL IL69847A patent/IL69847A0/xx unknown
1984
- 1984-10-25 FR FR8416357A patent/FR2553767B1/fr not_active Expired
1985
- 1985-10-09 NO NO85854001A patent/NO156127C/no unknown
1989
- 1989-04-13 HK HK311/89A patent/HK31189A/xx not_active IP Right Cessation
1990
- 1990-10-11 HK HK830/90A patent/HK83090A/xx not_active IP Right Cessation
1997
- 1997-07-24 NL NL970028C patent/NL970028I2/nl unknown

Also Published As

Publication number	Publication date
IL61501A (en)	1984-06-29
FI76564C (fi)	1988-11-10
NL192202B (nl)	1996-11-01
IT8026218A0 (it)	1980-11-25
ES8301920A1 (es)	1982-11-16
PT72106A (fr)	1980-12-01
GB2131421A (en)	1984-06-20
HK83090A (en)	1990-10-19
FR2553767B1 (fr)	1987-01-16
FR2470124A1 (fr)	1981-05-29
FR2470124B1 (fr)	1986-12-19
DK151799B (da)	1988-01-04
NO803550L (no)	1981-05-27
NO154345C (no)	1986-09-03
FR2553767A1 (fr)	1985-04-26
SE442398B (sv)	1985-12-23
GR71608B (xx)	1983-06-17
PT72106B (fr)	1981-09-29
ATA578080A (de)	1985-05-15
SE8008252L (sv)	1981-05-27
IE802430L (en)	1981-05-26
GB8315983D0 (en)	1983-07-13
GB2065642A (en)	1981-07-01
FI76564B (fi)	1988-07-29
ES507620A0 (es)	1982-11-16
FI803652L (fi)	1981-05-27
IE50632B1 (en)	1986-05-28
DK501180A (da)	1981-05-27
NO156127C (no)	1987-07-29
IL69847A0 (en)	1983-12-30
GB2065642B (en)	1984-04-04
NO156127B (no)	1987-04-21
CH649535A5 (fr)	1985-05-31
NL970028I1 (nl)	1997-10-01
NL192202C (nl)	1997-03-04
GB2131421B (en)	1985-06-26
NL970028I2 (nl)	1998-03-02
DE3044568C2 (xx)	1990-11-29
DE3044568A1 (de)	1981-08-27
IL61501A0 (en)	1981-05-20
NL8006399A (nl)	1981-06-16
NO154345B (no)	1986-05-26
LU82957A1 (fr)	1981-06-04
IT1148740B (it)	1986-12-03
HK31189A (en)	1989-04-21
DK151799C (da)	1988-06-20
AT379387B (de)	1985-12-27
NO854001L (no)	1981-05-27
MX155904A (es)	1988-05-23

Publication	Publication Date	Title
NZ195564A (en)	1983-09-30	5-pyridinyl-2(1h)-pyridinones pharmaceutical compositions intermediate pyridine compounds
GB2065145B (en)	1983-07-20	Controlled long-acting pharmaceutical compositions
ZA781398B (en)	1979-02-28	Pharmaceutical compositions
ZA785682B (en)	1979-09-26	Pharmaceutical compositions
GB2003028B (en)	1982-02-03	Pharmaceutical compositions
IL55930A0 (en)	1979-01-31	1,9-dihydroxyoctahydrophenanthrenes, pharmaceutical compositions containing them and intermediates for their preparation
GB2044099B (en)	1983-10-19	Anticoccidial compositions
NZ194421A (en)	1982-05-31	3-amino-sydnone-imines pharmaceutical compositions
PH16443A (en)	1983-10-12	Substituted tetraazetricyclic compounds and their pharmaceutical compositions
GB2008403B (en)	1982-07-28	Pharmaceutical compositions
ZA784470B (en)	1980-04-30	Pharmaceutical compositions including antithormbotic compositions
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