NO990472L - Fluorholdige 1,4-disubstituerte piperidinderivater - Google Patents
Fluorholdige 1,4-disubstituerte piperidinderivaterInfo
- Publication number
- NO990472L NO990472L NO990472A NO990472A NO990472L NO 990472 L NO990472 L NO 990472L NO 990472 A NO990472 A NO 990472A NO 990472 A NO990472 A NO 990472A NO 990472 L NO990472 L NO 990472L
- Authority
- NO
- Norway
- Prior art keywords
- group
- substituted
- hydrogen atoms
- fluorine
- atoms
- Prior art date
Links
- 229910052731 fluorine Inorganic materials 0.000 title abstract 4
- -1 1,4-disubstituted piperidine Chemical class 0.000 title abstract 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title abstract 2
- 239000011737 fluorine Substances 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000001153 fluoro group Chemical group F* 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004447 heteroarylalkenyl group Chemical group 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 abstract 1
- 102000007202 Muscarinic M3 Receptor Human genes 0.000 abstract 1
- 108010008405 Muscarinic M3 Receptor Proteins 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001079 digestive effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Nye fluorholdige 1,4-disubstituerte piperidinderivater som representeres ved den generelle formel [I] Ar --<- R* [I] R og farmasøytisk akseptable salter derav [hvor: Ar betyr en arylgruppe eller en heteroarylgruppe som har 1-2 heteroatomer utvalgt fra gruppen omfattende nitrogen, oksygen og svovel (hvilket eller hvilke som helst 1-3 hydrogenatomer på ringen av aryl- eller hete- roarylgruppen kan være substituert med lavere alkyl osv.); R1 betyr et C3-C«-cykloalkyl hvor hvilket eller hvilke som helst 1-4 hydrogenatomer kan være substituert med et fluoratom; R2 betyr mettede eller umettede alifatiske c5-Cl5-hydro- karbongrupper hvor hvilket eller hvilke som helst 1-6 hydrogenatomer kan være substituert med et fluoratom eller en aralkyl-, arylalkenyl-, heteroarylalkyl- eller heteroarylalkenylgruppe som har 1-2 heteroatomer valgt fra gruppen omfattende nitrogen, oksygen og svovel (valgfritt kan hvilket eller hvilke som helst 1-3 hydrogenatomer på ringen i aralkyl-, arylalkenyl-, heteroarylalkyl- eller heteroarylalkenylgruppen være substituert med lavere alkyl, trifluormetyl, cyano, hydroksyl, nitro, lavere alkoksykarbonyl, halogen, lavere alkoksy eller amino osv.); og X betyr O eller NH; forutsatt at minst en av R1 og R2 inneholder ett eller flere fluoratomer]. Forbindelsene har en selektiv antagonistisk aktivitet mot muskarin M3-receptorer og oppviser en utmerket oral aktivitet, virkningsvarighet og farmakokinetiske egen- skaper, slik at de har få bivirkninger og er sikre og virksomme. De er derfor nyttige for behandling eller forebyggelse av respiratoriske sykdommer, urinære syk- dommer og fordøyelsessykdommer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21943696 | 1996-08-01 | ||
| JP5397997 | 1997-02-21 | ||
| PCT/JP1997/002600 WO1998005641A1 (fr) | 1996-08-01 | 1997-07-28 | Derives de piperidine fluores a disubstitution en position 1,4 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO990472L true NO990472L (no) | 1999-02-01 |
| NO990472D0 NO990472D0 (no) | 1999-02-01 |
Family
ID=26394715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO990472A NO990472D0 (no) | 1996-08-01 | 1999-02-01 | Fluorholdige 1,4-disubstituerte piperidinderivater |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5948792A (no) |
| EP (1) | EP0930298B1 (no) |
| JP (1) | JP3063164B2 (no) |
| KR (1) | KR20000022214A (no) |
| CN (1) | CN1226888A (no) |
| AR (3) | AR008272A1 (no) |
| AT (1) | ATE229941T1 (no) |
| AU (1) | AU716050B2 (no) |
| BG (1) | BG103114A (no) |
| BR (1) | BR9711108A (no) |
| CA (1) | CA2261680C (no) |
| CO (1) | CO4960641A1 (no) |
| CZ (1) | CZ33199A3 (no) |
| DE (1) | DE69718026T2 (no) |
| EE (1) | EE9900038A (no) |
| ES (1) | ES2188961T3 (no) |
| HR (1) | HRP970426A2 (no) |
| HU (1) | HUP9902381A3 (no) |
| ID (1) | ID17259A (no) |
| IL (1) | IL127685A0 (no) |
| IS (1) | IS4960A (no) |
| NO (1) | NO990472D0 (no) |
| NZ (1) | NZ333842A (no) |
| PE (1) | PE92198A1 (no) |
| PL (1) | PL331431A1 (no) |
| SK (1) | SK12299A3 (no) |
| TR (2) | TR200001482T2 (no) |
| WO (1) | WO1998005641A1 (no) |
| YU (1) | YU1299A (no) |
Families Citing this family (56)
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| US6180823B1 (en) | 1998-11-06 | 2001-01-30 | Sepracor Inc. | Stereoselective process for alkyl phenylglycolic acids |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| AU4194500A (en) | 1999-04-08 | 2000-11-14 | Banyu Pharmaceutical Co., Ltd. | Diastereoselective preparation of michael adducts |
| WO2000066579A1 (fr) * | 1999-04-28 | 2000-11-09 | Banyu Pharmaceutical Co., Ltd. | Methodes de preparation de derives de piperidylmethylpyridine |
| CO5440228A1 (es) * | 1999-08-23 | 2004-09-30 | Lunbeck As H | Tratamiento de la incontinencia urinaria |
| EP1235802B1 (en) | 1999-12-07 | 2005-07-13 | Theravance, Inc. | Carbamate derivatives having muscarinic receptor antagonist activity |
| UA73543C2 (uk) | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
| JP4782342B2 (ja) * | 1999-12-17 | 2011-09-28 | サノフィ−アベンティス | フェノキシプロパノールアミン類、それらの製造方法およびそれらを含む医薬組成物 |
| US6403818B1 (en) | 2000-02-28 | 2002-06-11 | Eisai Co., Ltd. | Process for producing α-hydroxy-carbonyl compound |
| US6469172B2 (en) | 2000-03-08 | 2002-10-22 | Merck & Co., Inc. | Process for the preparation of chemical compounds |
| US6403584B1 (en) * | 2000-06-22 | 2002-06-11 | Merck & Co., Inc. | Substituted nipecotyl derivatives as inhibitors of cell adhesion |
| US6846835B2 (en) * | 2000-07-11 | 2005-01-25 | Banyu Pharmaceutical Co., Ltd. | Ester derivatives |
| SI1345937T1 (sl) | 2000-12-22 | 2006-02-28 | Almirall Prodesfarma Ag | Derivati kinulidinkarbamata in njihova uporaba kot M3 antagonisti |
| CN1250545C (zh) | 2000-12-28 | 2006-04-12 | 阿尔米雷尔普罗迪斯制药有限公司 | 新的奎宁环衍生物类及含有这类衍生物的药物组合物 |
| DE10111843A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von inflammatorischen Erkrankungen |
| JP2005503424A (ja) * | 2001-09-27 | 2005-02-03 | ファルマシア アクチボラグ | 尿疾患の治療用医薬組成物 |
| ES2203327B1 (es) | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2204295B1 (es) * | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
| WO2004004629A2 (en) | 2002-07-08 | 2004-01-15 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
| DE60226906D1 (de) | 2002-07-31 | 2008-07-10 | Ranbaxy Lab Ltd | 3,6-disubstituierte azabicyclo ä3.1.0ühexanderivate, die sich als muscarinrezeptorantagonisten eignen |
| US7410993B2 (en) | 2002-08-09 | 2008-08-12 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane deriviatives useful as muscarinic receptor antagonists |
| US6583103B1 (en) | 2002-08-09 | 2003-06-24 | S.C. Johnson & Son, Inc. | Two part cleaning formula resulting in an effervescent liquid |
| WO2004018422A1 (en) | 2002-08-23 | 2004-03-04 | Ranbaxy Laboratories Limited | Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists |
| CA2502532A1 (en) * | 2002-10-29 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Quaternary ammonium compounds as muscarinic receptor antagonists |
| TWI295669B (en) | 2002-10-30 | 2008-04-11 | Theravance Inc | Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds |
| ATE400553T1 (de) * | 2002-12-10 | 2008-07-15 | Ranbaxy Lab Ltd | 3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors |
| SI1572173T1 (sl) | 2002-12-13 | 2010-08-31 | Warner Lambert Co | Alfa-2-delta ligand za zdravljenje simptomov spodnjega dela sečil |
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| WO2004056811A1 (en) | 2002-12-23 | 2004-07-08 | Ranbaxy Laboratories Limited | Flavaxate derivatives as muscarinic receptor antagonists |
| US7488748B2 (en) | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
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| EP1618091A1 (en) | 2003-04-09 | 2006-01-25 | Ranbaxy Laboratories, Ltd. | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| WO2004089899A1 (en) * | 2003-04-10 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| BR0318242A (pt) | 2003-04-10 | 2006-04-04 | Ranbaxy Lab Ltd | derivados de azabiciclo hexano substituìdo como antagonistas de receptores muscarìnicos e processo para sua preparação |
| US20070021487A1 (en) * | 2003-04-11 | 2007-01-25 | Mohammad Salman | Azabicyclo derivatives as muscarinic receptor antagonists |
| WO2004091597A2 (en) * | 2003-04-15 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Method of treating irritable bowel syndrome (ibs) |
| JP2007524641A (ja) | 2003-07-11 | 2007-08-30 | セラヴァンス， インコーポレーテッド | 置換４−アミノ−１−ベンジルピペリジン化合物 |
| CN100569760C (zh) | 2003-11-21 | 2009-12-16 | 施万制药 | 具有β2肾上腺素能受体激动剂和毒蕈碱性受体拮抗剂活性的化合物 |
| KR20060105872A (ko) * | 2003-12-29 | 2006-10-11 | 반유 세이야꾸 가부시끼가이샤 | 신규한 2-헤테로아릴 치환된 벤즈이미다졸 유도체 |
| ATE419246T1 (de) * | 2004-06-16 | 2009-01-15 | Ranbaxy Lab Ltd | Als antagonisten des muscarinrezeptors geeignete xanthinderivate |
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| BRPI0517232A (pt) | 2004-11-02 | 2008-10-07 | Banyu Pharma Co Ltd | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, ativador da glicocinase, e, agentes terapêuticos e/ou profiláticos para diabetes e para obesidade |
| WO2006054162A1 (en) * | 2004-11-19 | 2006-05-26 | Ranbaxy Laboratories Limited | Azabicyclic muscarinic receptor antagonists |
| WO2006064304A1 (en) * | 2004-12-15 | 2006-06-22 | Ranbaxy Laboratories Limited | Acid addition salts of muscarinic receptor antagonists |
| WO2006117754A1 (en) * | 2005-05-03 | 2006-11-09 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives as muscarinic receptor antagonists |
| US7799820B2 (en) * | 2005-09-30 | 2010-09-21 | Banyu Pharmaceutical Co., Ltd. | 2-Heterocycle-substituted indole derivatives for treating diabetes and associated conditions |
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| JP2009512676A (ja) | 2005-10-19 | 2009-03-26 | ランバクシー ラボラトリーズ リミテッド | ムスカリン性受容体アンタゴニストの医薬組成物 |
| GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
| JP2008081492A (ja) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体 |
| US20090010923A1 (en) * | 2007-04-24 | 2009-01-08 | University Of Maryland, Baltimore | Treatment of cancer with anti-muscarinic receptor agents |
| CA2697752C (en) | 2007-09-07 | 2016-01-26 | Theravance, Inc. | Guanidine-containing compounds useful as muscarinic receptor antagonists |
| PT2234600E (pt) * | 2007-12-21 | 2014-09-25 | Hoffmann La Roche | Formulação de anticorpos |
| CN104876854B (zh) * | 2015-04-16 | 2017-03-01 | 御盛隆堂药业有限责任公司 | 羟基乙酸酯衍生物及其用途 |
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|---|---|---|---|---|
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| AU700837B2 (en) * | 1995-04-28 | 1999-01-14 | Banyu Pharmaceutical Co., Ltd. | 1,4-di-substituted piperidine derivatives |
| CA2179574A1 (en) * | 1995-06-26 | 1996-12-27 | Tomomi Okada | Substituted piperidine derivative and medicine comprising the same |
| ATE205490T1 (de) * | 1995-10-13 | 2001-09-15 | Banyu Pharma Co Ltd | Substituierte heteroaromatische derivate |
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1997
- 1997-07-24 PE PE1997000659A patent/PE92198A1/es not_active Application Discontinuation
- 1997-07-28 DE DE69718026T patent/DE69718026T2/de not_active Expired - Lifetime
- 1997-07-28 BR BR9711108A patent/BR9711108A/pt not_active IP Right Cessation
- 1997-07-28 CZ CZ99331A patent/CZ33199A3/cs unknown
- 1997-07-28 AU AU36351/97A patent/AU716050B2/en not_active Ceased
- 1997-07-28 TR TR2000/01482T patent/TR200001482T2/xx unknown
- 1997-07-28 IL IL12768597A patent/IL127685A0/xx unknown
- 1997-07-28 HU HU9902381A patent/HUP9902381A3/hu unknown
- 1997-07-28 EP EP97933037A patent/EP0930298B1/en not_active Expired - Lifetime
- 1997-07-28 PL PL97331431A patent/PL331431A1/xx unknown
- 1997-07-28 CN CN97196911A patent/CN1226888A/zh active Pending
- 1997-07-28 ES ES97933037T patent/ES2188961T3/es not_active Expired - Lifetime
- 1997-07-28 KR KR1019980710633A patent/KR20000022214A/ko not_active Application Discontinuation
- 1997-07-28 YU YU1299A patent/YU1299A/sh unknown
- 1997-07-28 SK SK122-99A patent/SK12299A3/sk unknown
- 1997-07-28 WO PCT/JP1997/002600 patent/WO1998005641A1/ja not_active Application Discontinuation
- 1997-07-28 AT AT97933037T patent/ATE229941T1/de not_active IP Right Cessation
- 1997-07-28 CA CA002261680A patent/CA2261680C/en not_active Expired - Fee Related
- 1997-07-28 JP JP10507794A patent/JP3063164B2/ja not_active Expired - Fee Related
- 1997-07-28 TR TR1999/00204T patent/TR199900204T2/xx unknown
- 1997-07-28 EE EEP199900038A patent/EE9900038A/xx unknown
- 1997-07-30 HR HR53,979/97A patent/HRP970426A2/hr not_active Application Discontinuation
- 1997-07-31 US US08/903,768 patent/US5948792A/en not_active Expired - Lifetime
- 1997-07-31 ID IDP972666A patent/ID17259A/id unknown
- 1997-08-01 CO CO97044382A patent/CO4960641A1/es unknown
- 1997-08-01 AR ARP970103516A patent/AR008272A1/es not_active Application Discontinuation
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1998
- 1998-08-25 AR ARP980104218A patent/AR016877A2/es unknown
- 1998-08-25 AR ARP980104219A patent/AR017021A1/es unknown
-
1999
- 1999-01-25 BG BG103114A patent/BG103114A/xx unknown
- 1999-01-28 NZ NZ333842A patent/NZ333842A/en unknown
- 1999-01-29 IS IS4960A patent/IS4960A/is unknown
- 1999-02-01 NO NO990472A patent/NO990472D0/no not_active Application Discontinuation
- 1999-04-13 US US09/290,607 patent/US6040449A/en not_active Expired - Fee Related
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