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NO986087L - Oral preparation comprising an antifungal triazole compound - Google Patents

Oral preparation comprising an antifungal triazole compound

Info

Publication number
NO986087L
NO986087L NO986087A NO986087A NO986087L NO 986087 L NO986087 L NO 986087L NO 986087 A NO986087 A NO 986087A NO 986087 A NO986087 A NO 986087A NO 986087 L NO986087 L NO 986087L
Authority
NO
Norway
Prior art keywords
beads
oral preparation
triazole compound
antifungal
triazol
Prior art date
Application number
NO986087A
Other languages
Norwegian (no)
Other versions
NO986087D0 (en
Inventor
Surendra A Sangekar
Winston A Vadino
Ping I Lee
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO986087D0 publication Critical patent/NO986087D0/en
Publication of NO986087L publication Critical patent/NO986087L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Et farmasøytisk preparat om-. fettende: i) hovedsakelig inerte per- ler; hvori angitte perler er belagt med ii) et antifungalt middel som er (-)- (2R-cis)-4-[4-[4-[4-[[-5-(2,4-difluor- fenyl)-tetrahydro-5-(1H-1,2,4-triazol- 1-ylmetyl)furan-3-yl]metoksy]fenyl]-1- piperazinyl]fenyl]-2,4-dihydro-2-[ (S)- l-etyl-2(S)-hydroksypropyl]-3H-1, 2,4- triazol-3-on; iii) et bindemiddel for å muliggjøre at den antifungale forbin- delse adhereres til angitte perler. Preparatet muliggjør at den antifungale forbindelse, som har meget lav vann- løselighet, får forøkt biotilgjengelig- het i pattedyr slik som mennesker.A pharmaceutical composition about. greasy: i) mainly inert beads; wherein said beads are coated with ii) an antifungal agent which is (-) - (2R-cis) -4- [4- [4- [4 - [[- 5- (2,4-difluorophenyl) tetrahydro] -5- (1H-1,2,4-triazol-1-ylmethyl) furan-3-yl] methoxy] phenyl] -1-piperazinyl] phenyl] -2,4-dihydro-2- [(S) -1 -ethyl-2 (S) -hydroxypropyl] -3H-1,2,4-triazol-3-one; iii) a binder to enable the antifungal compound to be adhered to specified beads. The preparation enables the antifungal compound, which has very low water solubility, to have increased bioavailability in mammals such as humans.

NO986087A 1996-06-28 1998-12-23 Oral preparation comprising an antifungal triazole compound NO986087L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67243296A 1996-06-28 1996-06-28
PCT/US1997/010122 WO1998000116A1 (en) 1996-06-28 1997-06-25 Oral composition comprising a triazole antifungal compound

Publications (2)

Publication Number Publication Date
NO986087D0 NO986087D0 (en) 1998-12-23
NO986087L true NO986087L (en) 1999-02-26

Family

ID=24698529

Family Applications (1)

Application Number Title Priority Date Filing Date
NO986087A NO986087L (en) 1996-06-28 1998-12-23 Oral preparation comprising an antifungal triazole compound

Country Status (16)

Country Link
EP (1) EP0914100A1 (en)
JP (1) JP2000514059A (en)
KR (1) KR20000022294A (en)
CN (1) CN1228693A (en)
AU (1) AU731704B2 (en)
BR (1) BR9710069A (en)
CA (1) CA2258683C (en)
CZ (1) CZ421498A3 (en)
HU (1) HUP9903869A3 (en)
IL (1) IL127780A0 (en)
NO (1) NO986087L (en)
NZ (1) NZ333514A (en)
PL (1) PL330864A1 (en)
SK (1) SK177598A3 (en)
TR (1) TR199802718T2 (en)
WO (1) WO1998000116A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2269501C (en) * 1997-03-26 2005-11-08 Janssen Pharmaceutica N.V. Pellets having a core coated with an antifungal and a polymer
DE1003485T1 (en) * 1998-06-11 2000-11-02 Em Industries, Inc. MICROOSMOTIC CONTROLLED DRUG DELIVERY SYSTEMS
RU2219909C2 (en) * 1998-07-17 2003-12-27 Янссен Фармацевтика Н.В. Granules having nucleus coated with antifungal preparation and polymer
ES2157731B1 (en) * 1998-07-21 2002-05-01 Liconsa Liberacion Controlada ORAL PHARMACEUTICAL PREPARATION OF AN ANTIFUNGIC ACTIVITY COMPOUND AND PROCEDURE FOR PREPARATION.
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US7863331B2 (en) 1999-07-09 2011-01-04 Ethypharm Pharmaceutical composition containing fenofibrate and method for the preparation thereof
FR2795961B1 (en) 1999-07-09 2004-05-28 Ethypharm Lab Prod Ethiques PHARMACEUTICAL COMPOSITION CONTAINING MICRONIZED FENOFIBRATE, A SURFACTANT AND A BINDING CELLULOSIC DERIVATIVE AND PREPARATION METHOD
KR100694667B1 (en) * 1999-12-08 2007-03-14 동아제약주식회사 Itraconazole-containing antifungal agents that improve bioavailability and reduce absorption variation between and in individuals
EP1842532A3 (en) * 2001-02-06 2009-04-22 Stiefel Laboratories, Inc. Oral sparingly water-soluble antifungal formulations and methods of making the same
US6663897B2 (en) * 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
FR2842736B1 (en) 2002-07-26 2005-07-22 Flamel Tech Sa ORAL PHARMACEUTICAL FORMULATION IN THE FORM OF A PLURALITY OF MICROCAPSULES FOR PROLONGED RELEASE OF LOW SOLUBLE ACTIVE (S) PRINCIPLE (S)
ITMI20031096A1 (en) * 2003-05-30 2004-11-30 Eurand Spa MICROCAPS FOR COACERVATION CONTAINING DRUG INCORPORATED IN THE COATING POLYMER
DE10355461A1 (en) 2003-11-27 2005-06-23 Bayer Healthcare Ag Solid, high bioavailabilty oral formulations of N-substituted 5-chloro-2-thiophene-carboxamide derivative in hydrophilized form, useful for combating thrombo-embolic diseases
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
CN105949278B (en) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 Substituted tetrahydrofuran water-soluble derivative and application thereof
EP3544614A4 (en) 2016-11-28 2020-08-05 Lipocine Inc. Oral testosterone undecanoate therapy
AU2019308326A1 (en) 2018-07-20 2021-03-18 Lipocine Inc. Liver disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
CA2179396C (en) * 1993-12-21 2001-04-17 Anil K. Saksena Tetrahydrofuran antifungals

Also Published As

Publication number Publication date
CA2258683C (en) 2007-07-31
AU731704B2 (en) 2001-04-05
TR199802718T2 (en) 1999-03-22
HUP9903869A3 (en) 2000-07-28
KR20000022294A (en) 2000-04-25
WO1998000116A1 (en) 1998-01-08
SK177598A3 (en) 1999-07-12
PL330864A1 (en) 1999-06-07
EP0914100A1 (en) 1999-05-12
CN1228693A (en) 1999-09-15
AU3387497A (en) 1998-01-21
BR9710069A (en) 1999-08-10
CA2258683A1 (en) 1998-01-08
JP2000514059A (en) 2000-10-24
HUP9903869A2 (en) 2000-06-28
NO986087D0 (en) 1998-12-23
CZ421498A3 (en) 1999-06-16
IL127780A0 (en) 1999-10-28
NZ333514A (en) 2000-05-26

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