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NO983100L - 4,5-dihydronaphth £ 1,2-Cisoxazoles and derivatives thereof with CNS activity - Google Patents

4,5-dihydronaphth £ 1,2-Cisoxazoles and derivatives thereof with CNS activity

Info

Publication number
NO983100L
NO983100L NO983100A NO983100A NO983100L NO 983100 L NO983100 L NO 983100L NO 983100 A NO983100 A NO 983100A NO 983100 A NO983100 A NO 983100A NO 983100 L NO983100 L NO 983100L
Authority
NO
Norway
Prior art keywords
dihydronaphth
derivatives
cisoxazoles
cns activity
compounds
Prior art date
Application number
NO983100A
Other languages
Norwegian (no)
Other versions
NO983100D0 (en
Inventor
Nicholas J Hrib
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO983100D0 publication Critical patent/NO983100D0/en
Publication of NO983100L publication Critical patent/NO983100L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

4,5-dihydronafth[l,2-c ] isoxazol- derivater av generell formel (I) hvori A, X og n er som definert og beskrevet her. Slike forbindelser er anvendbare som serotonin 5-HT,- antagonister. Disse forbindelser er anvendbare ved behandling av angst, psykiatriske forstyrrelser, kvalme, brekninger og legemiddelavhengighet.4,5-dihydronaphth [1,2-c] isoxazole derivatives of general formula (I) wherein A, X and n are as defined and described herein. Such compounds are useful as serotonin 5-HT 1 antagonists. These compounds are useful in the treatment of anxiety, psychiatric disorders, nausea, vomiting and drug addiction.

NO983100A 1996-01-05 1998-07-03 4,5-dihydronaphth £ 1,2-Cisoxazoles and derivatives thereof with CNS activity NO983100L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58331996A 1996-01-05 1996-01-05
PCT/US1996/019569 WO1997025317A1 (en) 1996-01-05 1996-12-12 4,5-dihydronaphth[1,2-c]isoxazoles and derivatives thereof having cns activity

Publications (2)

Publication Number Publication Date
NO983100D0 NO983100D0 (en) 1998-07-03
NO983100L true NO983100L (en) 1998-09-04

Family

ID=24332609

Family Applications (1)

Application Number Title Priority Date Filing Date
NO983100A NO983100L (en) 1996-01-05 1998-07-03 4,5-dihydronaphth £ 1,2-Cisoxazoles and derivatives thereof with CNS activity

Country Status (14)

Country Link
EP (1) EP0874833A1 (en)
JP (1) JP3161737B2 (en)
KR (1) KR100308748B1 (en)
CN (1) CN1214046A (en)
AR (1) AR005347A1 (en)
AU (1) AU710059B2 (en)
BR (1) BR9612578A (en)
CA (1) CA2241845C (en)
HU (1) HUP9903706A3 (en)
IL (1) IL125197A0 (en)
NO (1) NO983100L (en)
NZ (1) NZ325587A (en)
WO (1) WO1997025317A1 (en)
ZA (1) ZA9725B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8656101A (en) * 2000-08-21 2002-03-04 Univ Georgetown 2-3-disubstituted quinuclidines as modulators of monoamine transporters and therapeutic and diagnostic methods based thereon
JP4580653B2 (en) * 2002-04-02 2010-11-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Substituted aminoisoxazoline derivatives and their use as antidepressants
TW200409777A (en) * 2002-08-12 2004-06-16 Janssen Pharmaceutica Nv C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants
CN100522972C (en) * 2002-08-15 2009-08-05 詹森药业有限公司 Fused heterocyclic isoxazoline derivatives and their use as anti-depressants
CA2495058C (en) * 2002-08-21 2012-01-03 Janssen Pharmaceutica N.V. C6- and c9-substituted isoxazoline derivatives and their use as anti-depressants
US8025859B2 (en) 2007-05-18 2011-09-27 Cesl Limited Process for gold and silver recovery from a sulphide concentrate
EP2597089A1 (en) 2009-10-29 2013-05-29 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds
WO2018045149A1 (en) 2016-09-02 2018-03-08 Bristol-Myers Squibb Company Substituted tricyclic heterocyclic compounds
US11059784B2 (en) 2017-08-09 2021-07-13 Bristol-Myers Squibb Company Oxime ether compounds
US11046646B2 (en) 2017-08-09 2021-06-29 Bristol-Myers Squibb Company Alkylphenyl compounds
KR102002633B1 (en) 2018-07-19 2019-07-22 김태효 Non slip foot wear with separating cushion part
KR102429797B1 (en) 2019-12-31 2022-08-05 주식회사 제이패션 Functional non-sewn overshoes and manufacturing method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2119977A1 (en) * 1971-04-23 1971-12-16 Teikoku Hormone Manufacturing Co , Ltd, Tokio Antiphlogistic and antisecretory napththisoxazoles - from 1-hydroxyim - 2-carbonyl derivs by intramolecular condensation
ES2076253T3 (en) * 1989-05-19 1995-11-01 Hoechst Roussel Pharma N- (ARYLOXYALKYL) -HETEROARILPIPERIDINES AND -HETEROARILPIPERAZINAS, A PROCEDURE FOR ITS PREPARATION AND USE AS MEDICINES.
JPH08502958A (en) * 1992-10-23 1996-04-02 メルク シヤープ エンド ドーム リミテツド Dopamine receptor subtype ligand

Also Published As

Publication number Publication date
CN1214046A (en) 1999-04-14
BR9612578A (en) 1999-07-27
AR005347A1 (en) 1999-04-28
ZA9725B (en) 1997-07-07
NZ325587A (en) 1999-02-25
HUP9903706A3 (en) 2000-09-28
WO1997025317A1 (en) 1997-07-17
AU1412697A (en) 1997-08-01
IL125197A0 (en) 1999-03-12
HUP9903706A2 (en) 2000-08-28
CA2241845C (en) 2002-10-01
KR100308748B1 (en) 2001-12-12
KR19990077033A (en) 1999-10-25
CA2241845A1 (en) 1997-07-17
NO983100D0 (en) 1998-07-03
JP3161737B2 (en) 2001-04-25
JPH11510816A (en) 1999-09-21
AU710059B2 (en) 1999-09-09
EP0874833A1 (en) 1998-11-04

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application