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NO980649L - Bioconjugates of manganese complexes and their use as catalysts - Google Patents

Bioconjugates of manganese complexes and their use as catalysts

Info

Publication number
NO980649L
NO980649L NO980649A NO980649A NO980649L NO 980649 L NO980649 L NO 980649L NO 980649 A NO980649 A NO 980649A NO 980649 A NO980649 A NO 980649A NO 980649 L NO980649 L NO 980649L
Authority
NO
Norway
Prior art keywords
bioconjugates
catalysts
manganese complexes
mimicking
sod
Prior art date
Application number
NO980649A
Other languages
Norwegian (no)
Other versions
NO980649D0 (en
Inventor
William L Neumann
Dennis P Riley
Randy H Weiss
Susan L Henke
Patrick J Lennon
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of NO980649D0 publication Critical patent/NO980649D0/en
Publication of NO980649L publication Critical patent/NO980649L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Biokonjugater av lavmolekylvekt etterligninger av superoksid dismutase (SOD) representert ved formel (I): hvori R, R1, R,, R1,, R2, R'2, R3, R'3, R,,, R'4) R5> R'5) R^, R'6, R7, R'7> R8, R'8> Rg, R'9, X, Y, Z og n er definert heri, er nyttige som terapeutiske midler for inflammatoriske sykdomstilstander og forstyrrelser, så som ischemi/reperfusjonsskade, slag, aterosklerose og alle andre tilstander med oksidant- indusert vevsskade eller andre skader.Low-molecular-weight bioconjugates mimicking superoxide dismutase (SOD) represented by formula (I): wherein R, R1, R ,, R1, R2, R'2, R3, R'3, R ,,, R'4) R5> R'5) R6, R'6, R7, R'7> R8, R'8> Rg, R'9, X, Y, Z and n are defined herein as useful as therapeutic agents for inflammatory disease states and disorders , such as ischemia / reperfusion injury, stroke, atherosclerosis and all other conditions with oxidant-induced tissue injury or other damage.

NO980649A 1995-08-17 1998-02-16 Bioconjugates of manganese complexes and their use as catalysts NO980649L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US242195P 1995-08-17 1995-08-17
PCT/US1996/012767 WO1997006824A2 (en) 1995-08-17 1996-08-14 Bioconjugates of manganese complexes and their application as catalysts

Publications (2)

Publication Number Publication Date
NO980649D0 NO980649D0 (en) 1998-02-16
NO980649L true NO980649L (en) 1998-04-02

Family

ID=21700675

Family Applications (1)

Application Number Title Priority Date Filing Date
NO980649A NO980649L (en) 1995-08-17 1998-02-16 Bioconjugates of manganese complexes and their use as catalysts

Country Status (12)

Country Link
EP (1) EP0844886A2 (en)
JP (1) JP2000513322A (en)
KR (1) KR19990037647A (en)
CN (1) CN1200039A (en)
AU (1) AU700958B2 (en)
BR (1) BR9610347A (en)
CA (1) CA2229799A1 (en)
CZ (1) CZ39898A3 (en)
IL (1) IL123040A0 (en)
NO (1) NO980649L (en)
PL (1) PL324993A1 (en)
WO (1) WO1997006824A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL144503A0 (en) 1999-01-25 2002-05-23 Nat Jewish Med & Res Center Substituted porphyrins
CA2394959A1 (en) 1999-12-23 2001-07-05 Amersham Plc Labelled ascorbic acid derivatives
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
EP1439842A4 (en) 2001-06-01 2009-09-02 Nat Jewish Med & Res Center OXIDIZING SENSORS FOR THE TREATMENT OF DIABETES OR FOR USE IN TRANSPLANTATION OR INDUCING IMMUNE TOLERANCE
CN102088991A (en) 2008-05-13 2011-06-08 堪萨斯大学 Metal abstraction peptide (MAP) tag and associated methods
ES2464728T3 (en) 2008-05-23 2014-06-03 National Jewish Health Compounds for use in the treatment of lesions associated with exposure to an alkylating chemical species
CA2849456C (en) * 2011-09-26 2021-12-07 Galera Therapeutics, Llc Methods for treatment of diseases
WO2013181461A2 (en) 2012-06-01 2013-12-05 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
CN110520107A (en) * 2017-02-15 2019-11-29 加莱拉实验室有限责任公司 The big cyclic rings complex of pentaaza for the delivering of local intestines
CN108752383B (en) * 2018-05-02 2020-10-30 江苏理工学院 A kind of pyrazole carboxylate manganese complex with SOD activity and preparation method thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880832A (en) * 1987-03-06 1989-11-14 Sumitomo Pharmaceuticals Company, Ltd. Liposoluble platinum (II) complex and preparation thereof
DE69224839T2 (en) * 1991-07-19 1998-10-08 Monsanto Co Manganese complexes with nitrogen-containing macrocyclic ligands, effective as superoxide dismutase catalysts.
US6204259B1 (en) * 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
WO1995028968A1 (en) * 1994-04-22 1995-11-02 Monsanto Company Diagnostic image analysis with metal complexes
US6525041B1 (en) * 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
EP0830351A1 (en) * 1995-06-07 1998-03-25 Monsanto Company Process for preparing substituted polyazamacrocycles

Also Published As

Publication number Publication date
CN1200039A (en) 1998-11-25
EP0844886A2 (en) 1998-06-03
KR19990037647A (en) 1999-05-25
WO1997006824A3 (en) 1997-07-03
JP2000513322A (en) 2000-10-10
PL324993A1 (en) 1998-07-06
NO980649D0 (en) 1998-02-16
MX9801322A (en) 1998-05-31
BR9610347A (en) 1999-06-01
CA2229799A1 (en) 1997-02-27
AU6765596A (en) 1997-03-12
CZ39898A3 (en) 1998-07-15
AU700958B2 (en) 1999-01-14
WO1997006824A2 (en) 1997-02-27
IL123040A0 (en) 1998-09-24

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application