NO976065L - Diglucosylated 1,2-diols as mimetics of sialyl-Lewis X and sialyl-Lewis A - Google Patents
Diglucosylated 1,2-diols as mimetics of sialyl-Lewis X and sialyl-Lewis AInfo
- Publication number
- NO976065L NO976065L NO976065A NO976065A NO976065L NO 976065 L NO976065 L NO 976065L NO 976065 A NO976065 A NO 976065A NO 976065 A NO976065 A NO 976065A NO 976065 L NO976065 L NO 976065L
- Authority
- NO
- Norway
- Prior art keywords
- sialyl
- lewis
- mimetics
- diglucosylated
- diols
- Prior art date
Links
- XBSNXOHQOTUENA-KRAHZTDDSA-N alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](NC(C)=O)C(O)O[C@@H]1CO XBSNXOHQOTUENA-KRAHZTDDSA-N 0.000 title abstract 2
- NIGUVXFURDGQKZ-UQTBNESHSA-N alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O NIGUVXFURDGQKZ-UQTBNESHSA-N 0.000 title abstract 2
- 150000000180 1,2-diols Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101000986989 Naja kaouthia Acidic phospholipase A2 CM-II Proteins 0.000 abstract 1
- -1 aliphatic 1,2-diol Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Cosmetics (AREA)
Abstract
Forbindelser med formel (I) HO OH O OH (D OH OH OH der X er resten av en ikke-glykosidisk, alifatisk 1,2-diol; R, er en S-konfigurert metyl substituert med en karboksylrest og en annen substituent; og R2 er hydrogen, CM2alkyl eller C6aryl. Forbindelsene finner anvendelse som mimetika av sialyl-Lewis X og sialyl-Lewis A.Compounds of formula (I) HO OH O OH (D OH OH OH where X is the residue of a non-glycosidic aliphatic 1,2-diol; R is an S-configured methyl substituted with a carboxyl residue and another substituent; and R 2 is hydrogen, CM 2 alkyl or C 6 aryl The compounds find use as mimetics of sialyl-Lewis X and sialyl-Lewis A.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH191495 | 1995-06-29 | ||
| PCT/EP1996/002785 WO1997001569A1 (en) | 1995-06-29 | 1996-06-26 | Diglycosylated 1,2-diols as mimetics of sialyl-lewis x and sialyl-lewis a |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO976065D0 NO976065D0 (en) | 1997-12-23 |
| NO976065L true NO976065L (en) | 1998-02-17 |
Family
ID=4221546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO976065A NO976065L (en) | 1995-06-29 | 1997-12-23 | Diglucosylated 1,2-diols as mimetics of sialyl-Lewis X and sialyl-Lewis A |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0836610A1 (en) |
| JP (1) | JPH11508548A (en) |
| KR (1) | KR19990028543A (en) |
| CN (1) | CN1196731A (en) |
| AU (1) | AU707474B2 (en) |
| BR (1) | BR9609285A (en) |
| CA (1) | CA2224346A1 (en) |
| CZ (1) | CZ419797A3 (en) |
| EA (1) | EA001356B1 (en) |
| HU (1) | HUP9801805A3 (en) |
| IL (1) | IL118740A0 (en) |
| MX (1) | MX9800218A (en) |
| NO (1) | NO976065L (en) |
| NZ (1) | NZ311686A (en) |
| PL (1) | PL324258A1 (en) |
| SI (1) | SI9620099A (en) |
| SK (1) | SK177897A3 (en) |
| TR (1) | TR199701728T1 (en) |
| WO (1) | WO1997001569A1 (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002217999A1 (en) | 2000-11-01 | 2002-05-15 | Cor Therapeutics, Inc. | Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides |
| EP1534725A2 (en) | 2002-05-16 | 2005-06-01 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
| EP1763533B1 (en) | 2003-11-19 | 2008-01-09 | GlycoMimetics, Inc. | Specific antagonist for both e- and p-selectins |
| EP1577289A1 (en) * | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders |
| ES2375979T3 (en) | 2005-08-09 | 2012-03-07 | Glycomimetics, Inc. | GLICOMIMETIC INHIBITORS OF PA-IL LECTIN, PA-IIL LECTIN OR BOTH LECTINES OF PSEUDOMONES. |
| EP2264043B1 (en) * | 2005-09-02 | 2017-11-08 | GlycoMimetics, Inc. | Heterobifunctional pan-selectin inhibitors |
| EP1764093A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
| EP1764095A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| EP1764096A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel phloroglucinol derivatives having selectin ligand activity |
| EP2074132B1 (en) * | 2006-10-12 | 2013-05-15 | GlycoMimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
| EP2117561A1 (en) * | 2007-02-09 | 2009-11-18 | GlycoMimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
| WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
| ES2655443T7 (en) | 2011-12-22 | 2021-03-22 | Glycomimetics Inc | E-selectin antagonist compounds |
| SI2928476T1 (en) | 2012-12-07 | 2018-06-29 | Glycomimetics, Inc. | Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells |
| CN107108679B (en) | 2014-12-03 | 2020-10-23 | 糖模拟物有限公司 | Heterobifunctional inhibitors of E-selectin and CXCR4 chemokine receptors |
| CA3009836A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
| US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
| JP2019524791A (en) | 2016-08-08 | 2019-09-05 | グリコミメティクス， インコーポレイテッド | Combinations of T cell checkpoint inhibitors with inhibitors of E-selectin or inhibitors of CXCR4 or with heterobifunctional inhibitors of both E-selectin and CXCR4 |
| US11072625B2 (en) | 2016-10-07 | 2021-07-27 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
| JP7272956B2 (en) | 2017-03-15 | 2023-05-12 | グリコミメティクス， インコーポレイテッド | Galactopyranosyl-cyclohexyl derivatives as E-selectin antagonists |
| WO2019108750A1 (en) | 2017-11-30 | 2019-06-06 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| CN111566117A (en) | 2017-12-29 | 2020-08-21 | 糖模拟物有限公司 | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| CN111867601A (en) | 2018-03-05 | 2020-10-30 | 糖模拟物有限公司 | Methods for the treatment of acute myeloid leukemia and related conditions |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5326752A (en) * | 1991-11-27 | 1994-07-05 | Glycomed Incorporated | Substituted lactose and lactosamine derivatives as cell adhesion inhibitors |
| WO1993023031A1 (en) * | 1992-05-08 | 1993-11-25 | The Biomembrane Institute | Multivalent mimetics and peptide mimetics for blocking carbohydrate-dependent cellular interaction and for eliciting anticarbohydrate t-cell response |
| CA2100412A1 (en) * | 1992-07-15 | 1994-01-16 | Yutaka Yamada | Glycolipid derivatives |
-
1996
- 1996-06-26 SK SK1778-97A patent/SK177897A3/en unknown
- 1996-06-26 IL IL11874096A patent/IL118740A0/en unknown
- 1996-06-26 EA EA199800103A patent/EA001356B1/en not_active IP Right Cessation
- 1996-06-26 EP EP96922034A patent/EP0836610A1/en not_active Ceased
- 1996-06-26 CA CA002224346A patent/CA2224346A1/en not_active Abandoned
- 1996-06-26 WO PCT/EP1996/002785 patent/WO1997001569A1/en not_active Application Discontinuation
- 1996-06-26 CN CN96196452A patent/CN1196731A/en active Pending
- 1996-06-26 NZ NZ311686A patent/NZ311686A/en unknown
- 1996-06-26 SI SI9620099A patent/SI9620099A/en unknown
- 1996-06-26 CZ CZ974197A patent/CZ419797A3/en unknown
- 1996-06-26 HU HU9801805A patent/HUP9801805A3/en unknown
- 1996-06-26 BR BR9609285A patent/BR9609285A/en not_active Application Discontinuation
- 1996-06-26 KR KR1019970709861A patent/KR19990028543A/en not_active Application Discontinuation
- 1996-06-26 PL PL96324258A patent/PL324258A1/en unknown
- 1996-06-26 JP JP9504171A patent/JPH11508548A/en active Pending
- 1996-06-26 AU AU63053/96A patent/AU707474B2/en not_active Ceased
- 1996-06-26 TR TR97/01728T patent/TR199701728T1/en unknown
-
1997
- 1997-12-23 NO NO976065A patent/NO976065L/en not_active Application Discontinuation
-
1998
- 1998-01-07 MX MX9800218A patent/MX9800218A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU707474B2 (en) | 1999-07-08 |
| SK177897A3 (en) | 1998-08-05 |
| CA2224346A1 (en) | 1997-01-16 |
| TR199701728T1 (en) | 1998-03-21 |
| NZ311686A (en) | 2000-01-28 |
| EA199800103A1 (en) | 1998-08-27 |
| HUP9801805A3 (en) | 2002-01-28 |
| HUP9801805A2 (en) | 1998-12-28 |
| NO976065D0 (en) | 1997-12-23 |
| PL324258A1 (en) | 1998-05-11 |
| CZ419797A3 (en) | 1998-06-17 |
| SI9620099A (en) | 1998-08-31 |
| WO1997001569A1 (en) | 1997-01-16 |
| MX9800218A (en) | 1998-07-31 |
| BR9609285A (en) | 1999-05-11 |
| IL118740A0 (en) | 1996-10-16 |
| AU6305396A (en) | 1997-01-30 |
| KR19990028543A (en) | 1999-04-15 |
| CN1196731A (en) | 1998-10-21 |
| EA001356B1 (en) | 2001-02-26 |
| JPH11508548A (en) | 1999-07-27 |
| EP0836610A1 (en) | 1998-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |