NO974061D0 - Fremgangsmåte til fremstilling av prostaglandin E1, E2 og analoger derav ved anvendelse av furylkopperreagenser - Google Patents
Fremgangsmåte til fremstilling av prostaglandin E1, E2 og analoger derav ved anvendelse av furylkopperreagenserInfo
- Publication number
- NO974061D0 NO974061D0 NO974061A NO974061A NO974061D0 NO 974061 D0 NO974061 D0 NO 974061D0 NO 974061 A NO974061 A NO 974061A NO 974061 A NO974061 A NO 974061A NO 974061 D0 NO974061 D0 NO 974061D0
- Authority
- NO
- Norway
- Prior art keywords
- prostaglandin
- furyl
- analogs
- preparation
- copper reagents
- Prior art date
Links
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 title 2
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 title 1
- -1 Furyl Copper Chemical compound 0.000 title 1
- 229960000711 alprostadil Drugs 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 229910052802 copper Inorganic materials 0.000 title 1
- 239000010949 copper Substances 0.000 title 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 title 1
- 229960002986 dinoprostone Drugs 0.000 title 1
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/403,251 US5618959A (en) | 1995-03-10 | 1995-03-10 | Process for preparing prostaglandin E1, E2 and analogs thereof using furylcopper reagents |
| PCT/US1996/003090 WO1996028419A1 (en) | 1995-03-10 | 1996-03-07 | Process for preparing prostaglandin e1, e2 and analogs thereof using furylcopper reagents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO974061D0 true NO974061D0 (no) | 1997-09-04 |
| NO974061L NO974061L (no) | 1997-09-10 |
Family
ID=23595087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO974061A NO974061L (no) | 1995-03-10 | 1997-09-04 | Fremgangsmåte til fremstilling av prostaglandin E1, E2 og analoger derav ved anvendelse av furylkopperreagenser |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5618959A (no) |
| EP (1) | EP0815076A1 (no) |
| JP (1) | JP2840457B2 (no) |
| KR (1) | KR19980702884A (no) |
| AU (1) | AU696027B2 (no) |
| BR (1) | BR9607364A (no) |
| CA (1) | CA2215000A1 (no) |
| CZ (1) | CZ278597A3 (no) |
| HU (1) | HUP9801428A3 (no) |
| NO (1) | NO974061L (no) |
| NZ (1) | NZ305104A (no) |
| PL (1) | PL322160A1 (no) |
| SK (1) | SK121597A3 (no) |
| TR (1) | TR199700929T1 (no) |
| WO (1) | WO1996028419A1 (no) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6030959A (en) * | 1997-04-04 | 2000-02-29 | Monsanto Company | Gastro-specific prodrugs |
| US6413945B1 (en) * | 1997-04-04 | 2002-07-02 | Pharmacia Corporation | Gastro-specific prodrugs |
| AR071312A1 (es) * | 2008-04-09 | 2010-06-09 | Scinopharm Taiwan Ltd | Proceso para la preparacion de analogos de prostaglandina y sus intermediarios |
| CN102351767B (zh) * | 2011-09-20 | 2013-03-06 | 海南美兰史克制药有限公司 | 一种前列地尔化合物及其制法 |
| JP6488472B2 (ja) | 2013-09-30 | 2019-03-27 | パテオン エーピーアイ サービシーズ インコーポレイテッドＰａｔｈｅｏｎ Ａｐｉ Ｓｅｒｖｉｃｅｓ Ｉｎｃ． | メタセシスを用いるプロスタグランジンおよびプロスタグランジン中間体の新規合成経路 |
| HU231185B1 (hu) | 2017-07-11 | 2021-07-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Eljárás Misoprostol előállítására és tisztítására |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4031129A (en) * | 1972-01-26 | 1977-06-21 | Wisconsin Alumni Research Foundation | 15-Deoxy-PGE1 and method for preparing same |
| US4535180A (en) * | 1972-07-24 | 1985-08-13 | American Cyanamid Company | 11-Deoxy-11-substituted prostaglandins of the E and F series |
| US4410720A (en) * | 1973-08-06 | 1983-10-18 | Hoffmann-La Roche Inc. | 16-Fluoro prostaglandins |
| US4087621A (en) * | 1974-03-26 | 1978-05-02 | G. D. Searle & Co. | 7-{3-Hydroxy-2β-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1α-yl}hept-5-cis-enoic acids and related compounds |
| AU3437478A (en) * | 1977-03-30 | 1979-09-27 | American Cyanamid Co | Prostanoic acids and congeners |
| US4149007A (en) * | 1977-06-23 | 1979-04-10 | Miles Laboratories, Inc. | C14 Phenyl-substituted derivatives of prostaglandin analogues |
| GB2006186A (en) * | 1977-08-29 | 1979-05-02 | American Cyanamid Co | 15-Deoxy-16-substituted prostanoic acids |
| US4282372A (en) * | 1978-11-01 | 1981-08-04 | Sumitomo Chemical Company, Limited | Process for producing cyclopentenolones |
| US4452994A (en) * | 1981-03-02 | 1984-06-05 | G. D. Searle & Co. | Process for isolating organic compounds and lithium salt complexes useful in said process |
| US4474979A (en) * | 1981-05-21 | 1984-10-02 | American Cyanamid Company | Synthesis of d1-(methyl)-16,16-(dimethyl-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans,trans-prostadienoates |
| US5166369A (en) * | 1981-05-21 | 1992-11-24 | American Cyanamid Company | Precursors and synthesis of D1-(methyl)-16,16-(dimethyl)-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans, trans-prostadienoates |
| US4983753A (en) * | 1981-05-21 | 1991-01-08 | Floyd Jr Middleton B | Precursors and synthesis of di-(methyl)-16,16-(dimethyl)-11-alpha,15-alpha beta-dihydroxy-9-oxo-2,13-trans,trans-prostadienoates |
| US4360688A (en) * | 1981-05-21 | 1982-11-23 | American Cyanamid Company | Precursors and synthesis of d1-(methyl)-16,16-(dimethyl)-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans, trans-prostadienoates |
| US4644079A (en) * | 1981-05-21 | 1987-02-17 | American Cyanamid Company | Precursors and synthesis of d1-(methyl)-16,16-(dimethyl)-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans, trans-prostadienoates |
| US4543421A (en) * | 1983-05-11 | 1985-09-24 | Miles Laboratories, Inc. | Conjugate addition of organocuprates generated from copper (I) cyanide and vinyl stannanes useful in prostaglandin analog synthesis |
| JPH0669984B2 (ja) * | 1986-09-19 | 1994-09-07 | 住友化学工業株式会社 | シクロペンテノン誘導体の製造法 |
| US4785124A (en) * | 1987-06-08 | 1988-11-15 | G. D. Searle & Co. | Process for preparing higher order cuprate complexes |
| US4904820A (en) * | 1987-06-09 | 1990-02-27 | G. D. Searle & Co. | Process for substituting a hydrocarbon group |
| US4952710A (en) * | 1988-10-07 | 1990-08-28 | G. D. Searle & Co. | Cyclopenteneheptenoic acid derivatives and method of preparation thereof |
| US5191109A (en) * | 1990-02-02 | 1993-03-02 | Sumitomo Chemical Company, Limited | Process for preparing optically active cyclopentenones |
| US5055604A (en) * | 1990-04-17 | 1991-10-08 | G. D. Searle & Co. | Process for preparing prostaglandin analogs using organozirconium compounds |
-
1995
- 1995-03-10 US US08/403,251 patent/US5618959A/en not_active Expired - Fee Related
-
1996
- 1996-03-07 CZ CZ972785A patent/CZ278597A3/cs unknown
- 1996-03-07 AU AU53036/96A patent/AU696027B2/en not_active Ceased
- 1996-03-07 CA CA002215000A patent/CA2215000A1/en not_active Abandoned
- 1996-03-07 EP EP96909598A patent/EP0815076A1/en not_active Withdrawn
- 1996-03-07 KR KR1019970706292A patent/KR19980702884A/ko not_active Application Discontinuation
- 1996-03-07 JP JP8527707A patent/JP2840457B2/ja not_active Expired - Lifetime
- 1996-03-07 HU HU9801428A patent/HUP9801428A3/hu unknown
- 1996-03-07 BR BR9607364A patent/BR9607364A/pt unknown
- 1996-03-07 TR TR97/00929T patent/TR199700929T1/xx unknown
- 1996-03-07 NZ NZ305104A patent/NZ305104A/xx unknown
- 1996-03-07 PL PL96322160A patent/PL322160A1/xx unknown
- 1996-03-07 WO PCT/US1996/003090 patent/WO1996028419A1/en not_active Application Discontinuation
- 1996-03-07 SK SK1215-97A patent/SK121597A3/sk unknown
-
1997
- 1997-09-04 NO NO974061A patent/NO974061L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9801428A2 (hu) | 1998-10-28 |
| EP0815076A1 (en) | 1998-01-07 |
| NO974061L (no) | 1997-09-10 |
| HUP9801428A3 (en) | 1999-08-30 |
| PL322160A1 (en) | 1998-01-19 |
| CA2215000A1 (en) | 1996-09-19 |
| CZ278597A3 (cs) | 1998-01-14 |
| TR199700929T1 (xx) | 1998-02-21 |
| BR9607364A (pt) | 1997-12-30 |
| AU5303696A (en) | 1996-10-02 |
| JPH10504321A (ja) | 1998-04-28 |
| SK121597A3 (en) | 1998-01-14 |
| NZ305104A (en) | 1999-02-25 |
| US5618959A (en) | 1997-04-08 |
| MX9706883A (es) | 1997-11-29 |
| WO1996028419A1 (en) | 1996-09-19 |
| AU696027B2 (en) | 1998-08-27 |
| JP2840457B2 (ja) | 1998-12-24 |
| KR19980702884A (ko) | 1998-08-05 |
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