NO964552L - Benzosykloalkylazoltionderivater - Google Patents
BenzosykloalkylazoltionderivaterInfo
- Publication number
- NO964552L NO964552L NO964552A NO964552A NO964552L NO 964552 L NO964552 L NO 964552L NO 964552 A NO964552 A NO 964552A NO 964552 A NO964552 A NO 964552A NO 964552 L NO964552 L NO 964552L
- Authority
- NO
- Norway
- Prior art keywords
- thioxo
- dihydro
- benzocycloalkylazolethione
- triazol
- substituents
- Prior art date
Links
- -1 1,2,3,4-tetrahydronaphthalenyl Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 108010015720 Dopamine beta-Hydroxylase Proteins 0.000 abstract 1
- 102100033156 Dopamine beta-hydroxylase Human genes 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- CWMRFSSMSXQUJC-UHFFFAOYSA-N pyrrole-2-thione Chemical compound S=C1C=CC=N1 CWMRFSSMSXQUJC-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/42—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Lubricants (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Polarising Elements (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Luminescent Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Pyrane Compounds (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23383594A | 1994-04-26 | 1994-04-26 | |
| US08/233,655 US5438150A (en) | 1994-04-26 | 1994-04-26 | Process for making 1-benzocycloalkyl-1,3-dihydroimidazole-2-thione derivatives |
| US08/403,209 US5538988A (en) | 1994-04-26 | 1995-03-17 | Benzocycloalkylazolethione derivatives |
| PCT/US1995/004783 WO1995029165A2 (en) | 1994-04-26 | 1995-04-25 | Benzocycloalkylaz0lethione derivatives as dopamin beta-hydroxylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO964552D0 NO964552D0 (no) | 1996-10-25 |
| NO964552L true NO964552L (no) | 1996-12-27 |
| NO311720B1 NO311720B1 (no) | 2002-01-14 |
Family
ID=27398461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19964552A NO311720B1 (no) | 1994-04-26 | 1996-10-25 | Benzosykloalkylazoltionforbindelser, farmasöytiske preparater og anvendelse av slike forbindelser ved fremstilling avmedikamenter |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0757677B1 (no) |
| JP (1) | JPH09512269A (no) |
| CN (1) | CN1113874C (no) |
| AT (1) | ATE243199T1 (no) |
| AU (1) | AU687192B2 (no) |
| BR (1) | BR9507517A (no) |
| CA (1) | CA2188748A1 (no) |
| CZ (1) | CZ290082B6 (no) |
| DE (1) | DE69531102T2 (no) |
| DK (1) | DK0757677T3 (no) |
| ES (1) | ES2201104T3 (no) |
| FI (2) | FI20040310A7 (no) |
| HU (1) | HUT76295A (no) |
| IL (1) | IL113480A (no) |
| MX (1) | MX9605145A (no) |
| NO (1) | NO311720B1 (no) |
| NZ (1) | NZ284356A (no) |
| PL (1) | PL185959B1 (no) |
| PT (1) | PT757677E (no) |
| RU (1) | RU2145321C1 (no) |
| WO (1) | WO1995029165A2 (no) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU749214C (en) | 1997-11-21 | 2006-03-30 | Purdue Neuroscience Company | Substituted 2-aminoacetamides and the use thereof |
| AU2298399A (en) * | 1998-02-06 | 1999-08-23 | Yoshitomi Pharmaceutical Industries, Ltd. | Novel azapeptide type hydroxamic acid derivatives |
| JP4978762B2 (ja) * | 2001-03-30 | 2012-07-18 | Ｄｉｃ株式会社 | シクロヘキサ−３−エン−１−オール誘導体の製造方法 |
| GB2393958A (en) * | 2002-10-11 | 2004-04-14 | Portela & Ca Sa | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
| US7125904B2 (en) * | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
| GB0600709D0 (en) * | 2006-01-13 | 2006-02-22 | Portela & Ca Sa | Drug combinations |
| CN101627023A (zh) | 2006-12-12 | 2010-01-13 | 拜尔坡特拉有限公司 | 用于不对称氢化的催化方法 |
| AR065107A1 (es) * | 2007-02-01 | 2009-05-13 | Portevin Bernard | Compuestos inhibidores de dopamina-beta-hidroxilasa |
| EP1977646A1 (en) * | 2007-04-03 | 2008-10-08 | Bayer CropScience AG | Insecticidal hydroxyethyl thlourea derivatives |
| GB0708818D0 (en) * | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
| GB0709695D0 (en) * | 2007-05-21 | 2007-06-27 | Portela & Ca Sa | Process |
| TW200927740A (en) * | 2007-11-13 | 2009-07-01 | Bial Portela & Ca Sa | Process |
| US9346751B2 (en) | 2011-06-29 | 2016-05-24 | Bial-Portela & Ca, S.A. | Process for preparing 1, 3-Dihydroimidazole-2-Thione Derivatives |
| CA2890920C (en) * | 2012-11-14 | 2020-12-15 | Bial - Portela & Ca, S.A. | 1,3-dihydroimidazole-2-thione derivatives for use in the treatment of pulmonary arterial hypertension and lung injury |
| ES2954072T3 (es) * | 2016-07-28 | 2023-11-20 | Jiangsu Yahong Meditech Co Ltd | Usos de inhibidores de la dopamina beta-hidroxilasa (DBH) para el tratamiento del cáncer |
| JOP20190050A1 (ar) | 2016-09-23 | 2019-03-20 | Bial Portela & C? S A | مثبطات دوبامين-b-هيدروكسيلاز تخترق حاجز المخ الدموي |
| SG11202004231YA (en) | 2017-12-04 | 2020-06-29 | BIAL PORTELA & Cª S A | Dopamine-β-hydroxylase inhibitors |
| GB201908044D0 (en) | 2019-06-05 | 2019-07-17 | Bial Portela & Ca Sa | Dopamine-B-Hydroxylase inhibitors |
| KR20230137374A (ko) | 2021-01-26 | 2023-10-04 | 장슈 야홍 메디텍 코퍼레이션 리미티드 | 경로 조절제, 이를 갖는 약학 조성물, 이의 용도 및 이를 이용한 치료 방법 |
| CN113527108B (zh) * | 2021-09-16 | 2022-10-25 | 斯芬克司药物研发（天津）股份有限公司 | 一种制备光学纯的5,7-二氟-1,2,3,4-四氢化萘-2-胺及其盐的方法 |
| CN114920906B (zh) * | 2022-05-23 | 2023-03-21 | 华南理工大学 | 一种含咪唑硫酮单元的聚氨酯及其制备方法和应用 |
| IL319304A (en) * | 2022-09-16 | 2025-04-01 | Jiangsu Yahong Meditech Co Ltd | Polymorphic form of addition salt of nafixit acid, method for its preparation and use |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3485917A (en) * | 1966-04-14 | 1969-12-23 | Janssen Pharmaceutica Nv | Composition and method for combating fungus with imidazole carboxylates |
| MTP837B (en) * | 1977-11-07 | 1979-10-22 | Hoffman La Roche And Co Aktien | Derivatives 2 finino-imidazolidire |
| DK471479A (da) * | 1978-12-13 | 1980-06-14 | Pfizer | Fremgangsmaade til fremstilling af imidazolderivater og salte deraf |
| US4434174A (en) * | 1980-02-11 | 1984-02-28 | Berlex Laboratories, Inc. | Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines |
| GB8516573D0 (en) * | 1985-07-01 | 1985-08-07 | Janssen Pharmaceuticaa Nv | Controlling weeds |
| EP0277384A3 (en) * | 1986-12-24 | 1990-05-23 | Janssen Pharmaceutica N.V. | 1h-imidazole-5-carboxylic acid derivatives |
| SU1598877A3 (ru) * | 1986-12-31 | 1990-10-07 | Жансен Фармасетика Н.В. (Фирма) | Способ получени производных 5-имидазолкарбоновой кислоты, или их стереоизомеров, или их солей |
-
1995
- 1995-04-25 ES ES95916449T patent/ES2201104T3/es not_active Expired - Lifetime
- 1995-04-25 CZ CZ19963109A patent/CZ290082B6/cs not_active IP Right Cessation
- 1995-04-25 JP JP7527727A patent/JPH09512269A/ja not_active Ceased
- 1995-04-25 CA CA002188748A patent/CA2188748A1/en not_active Abandoned
- 1995-04-25 FI FI20040310A patent/FI20040310A7/fi unknown
- 1995-04-25 DK DK95916449T patent/DK0757677T3/da active
- 1995-04-25 NZ NZ284356A patent/NZ284356A/en unknown
- 1995-04-25 CN CN95193567A patent/CN1113874C/zh not_active Expired - Fee Related
- 1995-04-25 HU HU9602946A patent/HUT76295A/hu unknown
- 1995-04-25 MX MX9605145A patent/MX9605145A/es unknown
- 1995-04-25 PT PT95916449T patent/PT757677E/pt unknown
- 1995-04-25 AT AT95916449T patent/ATE243199T1/de not_active IP Right Cessation
- 1995-04-25 EP EP95916449A patent/EP0757677B1/en not_active Expired - Lifetime
- 1995-04-25 PL PL95316856A patent/PL185959B1/pl not_active IP Right Cessation
- 1995-04-25 AU AU22947/95A patent/AU687192B2/en not_active Ceased
- 1995-04-25 DE DE69531102T patent/DE69531102T2/de not_active Expired - Fee Related
- 1995-04-25 RU RU96122779/04A patent/RU2145321C1/ru not_active IP Right Cessation
- 1995-04-25 BR BR9507517A patent/BR9507517A/pt not_active IP Right Cessation
- 1995-04-25 IL IL11348095A patent/IL113480A/xx not_active IP Right Cessation
- 1995-04-25 WO PCT/US1995/004783 patent/WO1995029165A2/en not_active Ceased
-
1996
- 1996-10-25 FI FI964312A patent/FI964312A7/fi not_active IP Right Cessation
- 1996-10-25 NO NO19964552A patent/NO311720B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL113480A0 (en) | 1995-07-31 |
| FI964312A0 (fi) | 1996-10-25 |
| EP0757677A1 (en) | 1997-02-12 |
| RU2145321C1 (ru) | 2000-02-10 |
| MX9605145A (es) | 1997-12-31 |
| NO311720B1 (no) | 2002-01-14 |
| DE69531102D1 (de) | 2003-07-24 |
| CA2188748A1 (en) | 1995-11-02 |
| HUT76295A (en) | 1997-07-28 |
| CZ290082B6 (cs) | 2002-05-15 |
| ES2201104T3 (es) | 2004-03-16 |
| JPH09512269A (ja) | 1997-12-09 |
| AU687192B2 (en) | 1998-02-19 |
| IL113480A (en) | 2000-06-29 |
| NZ284356A (en) | 1997-12-19 |
| PT757677E (pt) | 2003-11-28 |
| HU9602946D0 (en) | 1996-12-30 |
| FI20040310A7 (fi) | 2004-02-27 |
| CZ310996A3 (en) | 1997-06-11 |
| EP0757677B1 (en) | 2003-06-18 |
| CN1151735A (zh) | 1997-06-11 |
| WO1995029165A2 (en) | 1995-11-02 |
| FI964312A7 (fi) | 1996-12-20 |
| PL185959B1 (pl) | 2003-09-30 |
| AU2294795A (en) | 1995-11-16 |
| CN1113874C (zh) | 2003-07-09 |
| DK0757677T3 (da) | 2003-10-13 |
| BR9507517A (pt) | 1997-09-16 |
| NO964552D0 (no) | 1996-10-25 |
| PL316856A1 (en) | 1997-02-17 |
| DE69531102T2 (de) | 2004-04-29 |
| WO1995029165A3 (en) | 1995-12-07 |
| ATE243199T1 (de) | 2003-07-15 |
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