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NO963917L - Isolated MAGE-3-Derived Peptides Complexing with HLA-A2 Molecules, and Uses thereof - Google Patents

Isolated MAGE-3-Derived Peptides Complexing with HLA-A2 Molecules, and Uses thereof

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Publication number
NO963917L
NO963917L NO963917A NO963917A NO963917L NO 963917 L NO963917 L NO 963917L NO 963917 A NO963917 A NO 963917A NO 963917 A NO963917 A NO 963917A NO 963917 L NO963917 L NO 963917L
Authority
NO
Norway
Prior art keywords
hla
complexing
molecules
derived peptides
isolated mage
Prior art date
Application number
NO963917A
Other languages
Norwegian (no)
Other versions
NO963917D0 (en
Inventor
Pierre Van Der Bruggen
Thierry Boon-Falleur
Catia Traversari
Katharina Fleischauer
Original Assignee
Ludwig Inst Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/217,187 external-priority patent/US5554506A/en
Application filed by Ludwig Inst Cancer Res filed Critical Ludwig Inst Cancer Res
Publication of NO963917D0 publication Critical patent/NO963917D0/en
Publication of NO963917L publication Critical patent/NO963917L/en

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Tumor-rejeksjonsantigener avledet fra tumor-rejek- sjonsforløper MAGE-3 har blitt identifisert. Disse "TRAS" binder til MHC-klasse I-molekylet HLA-A2, og de dannede komplekser stimulerer produksjonen av cytolytiske T-celle- kloner som lyserer de presenterende celler. Peptidene og kompleksene kan anvendes diagnostisk, terapeutisk og som immunogener for produksjon av antistoff, eller som mål for dannelsen av cytolytiske T-cellekloner.Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "TRAS" bind to the MHC class I molecule HLA-A2, and the complexes formed stimulate the production of cytolytic T-cell clones that lyses the presenting cells. The peptides and complexes can be used diagnostically, therapeutically, and as immunogens for antibody production, or as targets for the formation of cytolytic T cell clones.

NO963917A 1994-03-24 1996-09-19 Isolated MAGE-3-Derived Peptides Complexing with HLA-A2 Molecules, and Uses thereof NO963917L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/217,187 US5554506A (en) 1994-03-24 1994-03-24 Isolated, MAGE-3 derived peptides which complex with HLA-A2 molecules and uses thereof
PCT/US1995/003408 WO1995025739A1 (en) 1994-03-24 1995-03-21 Isolated, mage-3 derived peptides which complex with hla-a2 molecules and uses thereof

Publications (2)

Publication Number Publication Date
NO963917D0 NO963917D0 (en) 1996-09-19
NO963917L true NO963917L (en) 1996-09-23

Family

ID=26789556

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963917A NO963917L (en) 1994-03-24 1996-09-19 Isolated MAGE-3-Derived Peptides Complexing with HLA-A2 Molecules, and Uses thereof

Country Status (1)

Country Link
NO (1) NO963917L (en)

Also Published As

Publication number Publication date
NO963917D0 (en) 1996-09-19

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