NO963255L - Sykliske neurokinin-A antagonister - Google Patents
Sykliske neurokinin-A antagonisterInfo
- Publication number
- NO963255L NO963255L NO963255A NO963255A NO963255L NO 963255 L NO963255 L NO 963255L NO 963255 A NO963255 A NO 963255A NO 963255 A NO963255 A NO 963255A NO 963255 L NO963255 L NO 963255L
- Authority
- NO
- Norway
- Prior art keywords
- indolylmethyl
- hydroxybenzyl
- antagonists
- conh
- benzyl
- Prior art date
Links
- HEAUFJZALFKPBA-YRVBCFNBSA-N Neurokinin A Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)O)C1=CC=CC=C1 HEAUFJZALFKPBA-YRVBCFNBSA-N 0.000 title abstract 2
- 102400000097 Neurokinin A Human genes 0.000 title abstract 2
- 101800000399 Neurokinin A Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 125000004122 cyclic group Chemical group 0.000 title abstract 2
- -1 3-indolylmethyl Chemical group 0.000 abstract 4
- 125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Antagonister av neurokinin A som er nye sykliske hexapeptid- og octapeptidforbindelser, er beskrevet. Antagonismen er bekreftet under anvendelse av konvensjonelle konkur- rerende bindings- og kjemiske bestemmelser så vel som konvensjo- nelle fysiologiske tester, og anvendelse av disse derivater i et utall av tilstander hvori neuro- kinin A er involvert, er også beskrevet. Forbindelse av formelen SEQ. ID l hvori R er benzyl, p-hydroxybenzyl eller 3-indolylmethyl; R. er benzy]., 3-indolylmethyl eller (ca^) --CONH-; R- er C, 5 lineær eller forgrenet alkyl og X er H, eller R, og X er forbundet sammen for å danne -(CH,),-; R. er H, benzyl, 3-indolylmethyl eller p-hydroxybenzyl; R,, er H, methyl eller 3-indolylmethyl; forutsatt at når R_ er (CH_)--CONH-, er R, p-hydroxybenzyl og carbonet til hvilket R, er bundet, er i en (R) absolutt konfigurasjon; eller et hydrat, stereoisomer, isoster eller farmasøytisk akseptabelt salt derav.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/191,571 US5521156A (en) | 1994-02-03 | 1994-02-03 | Cyclic neurokinin A antagonists |
| PCT/US1995/000296 WO1995021187A1 (en) | 1994-02-03 | 1995-01-10 | Cyclic neurokinin a antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO963255D0 NO963255D0 (no) | 1996-08-02 |
| NO963255L true NO963255L (no) | 1996-10-02 |
Family
ID=22706020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO963255A NO963255L (no) | 1994-02-03 | 1996-08-02 | Sykliske neurokinin-A antagonister |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5521156A (no) |
| EP (1) | EP0741743B1 (no) |
| JP (2) | JPH09511490A (no) |
| KR (3) | KR100380873B1 (no) |
| CN (1) | CN1139931A (no) |
| AT (1) | ATE172205T1 (no) |
| AU (1) | AU691246B2 (no) |
| CA (1) | CA2182486C (no) |
| DE (1) | DE69505351T2 (no) |
| DK (1) | DK0741743T3 (no) |
| ES (1) | ES2123234T3 (no) |
| FI (1) | FI963074A0 (no) |
| HU (1) | HUT74383A (no) |
| IL (1) | IL112489A0 (no) |
| MX (1) | MX9603194A (no) |
| NO (1) | NO963255L (no) |
| NZ (1) | NZ279595A (no) |
| WO (1) | WO1995021187A1 (no) |
| ZA (1) | ZA95710B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830863A (en) * | 1988-06-20 | 1998-11-03 | Merrell Pharmaceuticals Inc. | Neurokinin A antagonists |
| US5744120A (en) * | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
| US5521156A (en) * | 1994-02-03 | 1996-05-28 | Merrell Pharmaceuticals Inc. | Cyclic neurokinin A antagonists |
| US5879659A (en) * | 1996-03-13 | 1999-03-09 | Dupont Pharmaceuticals Company | Ternary radiopharmaceutical complexes |
| MX9709494A (es) * | 1996-12-04 | 1998-07-31 | Pfizer | Compuestos peptidicos ciclicos, procedimiento para su produccion, composiciones que los contienen y uso de los mismos. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4102877A (en) * | 1976-07-28 | 1978-07-25 | Merck & Co., Inc. | Cyclization of peptides |
| US4659691A (en) * | 1985-02-08 | 1987-04-21 | Merck & Co., Inc. | Novel cyclic Hexapeptide LHRH antagonists |
| IT1233696B (it) * | 1989-05-29 | 1992-04-14 | Menarini Farma Ind | Peptidi di sintesi antagonisti della neurochinina a. loro sali e relativi procedimenti di fabbricazione |
| IT1241761B (it) * | 1990-08-03 | 1994-02-01 | Menarini Farma Ind | Peptidi di sintesi antagonisti della neurochinina a, loro sali e relativi procedimenti di fabbricazione |
| DK0528312T3 (da) * | 1991-08-13 | 1997-12-29 | Takeda Chemical Industries Ltd | Cykliske peptider og anvendelse deraf |
| US5521156A (en) * | 1994-02-03 | 1996-05-28 | Merrell Pharmaceuticals Inc. | Cyclic neurokinin A antagonists |
-
1994
- 1994-02-03 US US08/191,571 patent/US5521156A/en not_active Expired - Fee Related
-
1995
- 1995-01-10 AT AT95908459T patent/ATE172205T1/de not_active IP Right Cessation
- 1995-01-10 KR KR10-2002-7014405A patent/KR100380873B1/ko not_active Expired - Fee Related
- 1995-01-10 WO PCT/US1995/000296 patent/WO1995021187A1/en active IP Right Grant
- 1995-01-10 KR KR10-2002-7014406A patent/KR100380872B1/ko not_active Expired - Fee Related
- 1995-01-10 EP EP95908459A patent/EP0741743B1/en not_active Expired - Lifetime
- 1995-01-10 HU HU9602157A patent/HUT74383A/hu unknown
- 1995-01-10 CA CA002182486A patent/CA2182486C/en not_active Expired - Fee Related
- 1995-01-10 AU AU16771/95A patent/AU691246B2/en not_active Ceased
- 1995-01-10 CN CN95191462A patent/CN1139931A/zh active Pending
- 1995-01-10 KR KR1019960704192A patent/KR100378726B1/ko not_active Expired - Fee Related
- 1995-01-10 DE DE69505351T patent/DE69505351T2/de not_active Expired - Fee Related
- 1995-01-10 DK DK95908459T patent/DK0741743T3/da active
- 1995-01-10 NZ NZ279595A patent/NZ279595A/en unknown
- 1995-01-10 MX MX9603194A patent/MX9603194A/es not_active Application Discontinuation
- 1995-01-10 ES ES95908459T patent/ES2123234T3/es not_active Expired - Lifetime
- 1995-01-10 JP JP7520264A patent/JPH09511490A/ja not_active Ceased
- 1995-01-30 ZA ZA95710A patent/ZA95710B/xx unknown
- 1995-01-31 IL IL11248995A patent/IL112489A0/xx unknown
-
1996
- 1996-08-02 NO NO963255A patent/NO963255L/no unknown
- 1996-08-02 FI FI963074A patent/FI963074A0/fi not_active IP Right Cessation
-
2004
- 2004-09-24 JP JP2004278581A patent/JP2005089471A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN1139931A (zh) | 1997-01-08 |
| IL112489A0 (en) | 1995-03-30 |
| JPH09511490A (ja) | 1997-11-18 |
| AU691246B2 (en) | 1998-05-14 |
| US5521156A (en) | 1996-05-28 |
| KR100380873B1 (ko) | 2003-04-18 |
| HUT74383A (en) | 1996-12-30 |
| JP2005089471A (ja) | 2005-04-07 |
| ES2123234T3 (es) | 1999-01-01 |
| NZ279595A (en) | 1997-12-19 |
| MX9603194A (es) | 1997-05-31 |
| AU1677195A (en) | 1995-08-21 |
| DE69505351D1 (de) | 1998-11-19 |
| CA2182486C (en) | 2002-10-08 |
| FI963074L (fi) | 1996-08-02 |
| CA2182486A1 (en) | 1995-08-10 |
| KR100378726B1 (ko) | 2003-10-04 |
| WO1995021187A1 (en) | 1995-08-10 |
| EP0741743A1 (en) | 1996-11-13 |
| ZA95710B (en) | 1995-10-16 |
| DK0741743T3 (da) | 1999-06-23 |
| ATE172205T1 (de) | 1998-10-15 |
| FI963074A0 (fi) | 1996-08-02 |
| HU9602157D0 (en) | 1996-09-30 |
| DE69505351T2 (de) | 1999-06-02 |
| NO963255D0 (no) | 1996-08-02 |
| EP0741743B1 (en) | 1998-10-14 |
| KR100380872B1 (ko) | 2003-04-18 |
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